Pharmaceutical calculation

112.-0.8687 g cacl2 in 500 ml solvent, density of the solvent =0.95g\cm3.Find

the molality

a- 0.0165 Molal
b- 0.0156 Molal
c- 0.0165 m
d- 0.0156 m
e- 0.0230 m

Molarity= no. of moles of solute/Liter of Solution

Stept1= determine no. of moles
Molecular weight of Cacl2=111
0.8687g/111g=0.007826 mole
Step2= determine mass of solvent in Kg
M=d*v, 500*0.95, 475g, 475g/1000g=0.475Kg
Cm3=ml
Stept3=determine molality
Step1/step2=0.007826/0.475=0.0165 molal

113- The Molal concentration of 0.559 M is (Mwt=331.23 g/mol& density of

solution =1.157g/ml is:
a-1.882
b-0.882
c-0.559
d-0.575

molarity= no. of moles of solute/ Liter of solution

Step1= determine no. of moles
No. of moles= 0.559 moles
Step2= determine mass of solvent in Kg
Wt. of solute=0.559*331.23=185.157gram
Wt. of solution=d*v=1.157g/ml*1000ml=1157g
Wt.of solvent= 1157-185.157=971.84g, 971.84/1000=0.9718Kg
Step 3=determine molality
Molality= no.of moles of solute/kg of solvent, 0.559/0.9718= 0.575 molal

121- sol contain D5W another one contain D50W we want to prepare sol
contain D15W its

Dr.Fatima Arain
 Pharmaceutical calculation

volume is
450ml how much ml we need of each sol
5% ---------------------------------- 35= (350ml)
15%
50% -------------------------------- (100ml)10

(300)

228- How much lidocaine for solution of 1/1000 to obtain 30 cc:

a- 0.03.
b- 0.3.
c- 30.
d- None of the above.

(417)

43- A solution is made by dissolving 17.52 g of NaCl exactly 2000 ml. What is the
molarity of this solution?
a- 3.33
b- 0.15
c- 1.60
d-3.00 x 10 -4
e-1.6x10 -4
Morality=mole/volume (L)
Mole=molecular weight of subs. In 1 grams
So, molecular weight of NACL=23+34=57
So, Mole=17.52/57=0.307g
So, Morality=0.307/2(L)=0.153g/L

(600)

149 0.5 NS solution contains……….milligram sodium chloride in 30 ml.

a)0.27
b) 270
c) 135
d) 0.135
Calculation:
0.45% NS contains---------450mg of Sodium chloride in 100ml
4500mg --------------1000ml

Dr.Fatima Arain
 Pharmaceutical calculation

450mg-----------------100ml
Xmg---------------------30ml,x=30*450/100=135mg
135 mg are present in 30ml of 0.45% NS
Xmg----------------------0.5% NS
X=135/0.5,=270ml

(2) 179- A pharmacist add 1 pint of Alcohol USP to 1 L of a mouthwash formula.

What is the new percentage of alcohol present if original mouthwash was labeled
as 12% V/V:
a- 30%
b- 38%
c- 45%
d- 57%
e- 59%

180- A prescription calls for the dispensing of 4% Pilocar® solution with the
direction of “ Gtt I OU TID” . How many mg of Pilocarpine HCL is being used per
day ? Assume that the dropper is calibrated to deliver 20 drops to the ml
a- 4mg
b- 6mg
c- 12mg
d- 24mg
e- 60mg

182- A pharmacist dilutes 100ml of Clorox with 1 quart of water Express the
concentration of Sodium Hypochlorite in the final dilution as a W/V ratio.
Commercial Clorox contains 5.25% W/V Sodium Hypochlorate
a- 1/9
b- 1/10
c- 1/100
d- 1/180
e- 1/200

Questions 183 and 184 relate to the following hospital formula for a T-A-C
solution

Dr.Fatima Arain
 Pharmaceutical calculation

Cocaine HCL 4%
Tetracaine HCL 2%
Epinephrine HCL solution 1/2000
Sodium Chloride injection qs 4ml

183- How many mg of Cocaine HCL is in the final solution?

a- 400mg
b- 4mg
c- 20mg
d- 8mg
e- 160mg

184- How many ml of Adrenaline Chloride solution (0.1%) may be used to

prepare the solution?
a- 0.002ml
b- 0.04ml
c- 1ml
d- 2ml
e- 5ml

186- Dopamine (Inotropin®) 200mg in 500ml of Normal Saline at 5 μg/kg/min is

ordered for a 155-lb patient. What is the final concentration of solution in μg/ml
?
a- 0.4micrograms
b- 2.5micrograms/ml
c- 40micrograms/ml
d- 400micrograms/ml
e- 25microgram/ml

Dr.Fatima Arain
 Pharmaceutical calculation

187- The estimated Creatinine clearance rate for a 120lb patient is 40ml/min.
what maintenance dose should be administered if the normal maintenance
dose is 2mg/lb of the body weight?
a- 60mg
b- 100mg
c- 120mg
d- 160mg
e- 240mg

188- A pharmacist repackages 10 lb of an ointment in to jars to be labeled 2

oz(with). How many jars can be filled?
a- 73
b- 80
c- 83
d- 88
e- 100

189- How many ml of Glycerin would be needed to prepare 1 lb of an ointment

containing 5% W/W Glycerin ? (The density of glycerin is 1.25g/ml)
a- 1.2ml
b- 18.2ml
c- 22.7ml
d- 24ml
e- 28.4ml

190- A hospital clinic requests 2 lb of 2% Hydrocortisone ointment. How many

grams of 5% Hydrocortisone ointment could be diluted with White Petrolatum
to prepare this order:
a- 18.2g
b- 27.5g
c- 45.4g
d- 363g
e- 545g

Dr.Fatima Arain
 Pharmaceutical calculation

191- How many grams of Glacial Acetic Acid (99.9% W/V) must be added to 1 gal
Purified Water to prepare an irrigation solution containing 0.25% W/V Acetic
Acid:
a- 1.2g
b- 9.5g
c- 12g
d- 20g
e- 95g

192- What is the decay constant (K) of the Radio-Isotope 32P if its half-life is
14.3 days. Assume that Radiopharmaceutical follow first t- order Kinetics
a- 0.048/day
b- 0.07/day
c- 0.097/day
d- 0.1/day
e- 0.15/day

193- A prescription calls for 25 m. eq. of Potassium Chloride How many grams of
KCL (MW 74.6) are needed?
a- 7.46g
b- 0.746g
c- 8.86g
d- 1.86g
e- 0.186g
74.6*25=1865mg, 1865/1000=1.86g

194- How many milliliters of a 10% KCL (MW 74.6) solution contain 5.0mEq of
K+?
a- 2.100ml
b- 21.000ml
c- 3.730ml
d- 37.300ml

Dr.Fatima Arain
 Pharmaceutical calculation

e- 0.373ml
74.6*5=373, 373/100=3.730ml

196- If a prescription order requires 30 g of concentrated Sulfuric Acid(density is

1.8g/ml) , What volume should the pharmacist measure?
a-1.67ml
b-18.00ml
c-30.00ml
d-16.67ml
e-166.70ml
30/1.8=16.1666ml

197- Calculate the weight of 25ml of Hydrochloric Acid whose density is

1.18g/ml
a- 29.500g
b- 2.950g
c- 0.295g
d- 295.00g
e- None of the above
25*1.18=29.500g

Dr.Fatima Arain
 Pharmaceutical calculation

1. 1Grains=0.0022 ounce
2. 1 grains=0.00014 pounds
3. 1grain=0.000614 gm
4. 1 ounce=28.34 gm
5. 1 ounce=0.0625 pounds
6. 1pound=453.5gm
7. 1 pound=0.45kg
8. Miliequilant=mg/a.weight* valancy
9. Mole=wt/at.wt
10.1 fluid ounce=29.5ml
11. 1 gram=15.43 grains
12.D=M/V
13.Sp Gravity=wt of substance/wt of equal volume of water
14.Grm(wt)=ml*sp gravity
15.Young Rule=age/age+12*adult dose=dose fr child
16.Cowling Rule=age(next year)*adult dose/24=dose for child

Dr.Fatima Arain
 Pharmaceutical calculation

17.Fried Rule=agein month*adult dose/150=infant dose

18.Clarks Rule=wt in pounds*adult dose/150=infant dose
19.Patient dose=patient wt*drug dose/1kg
20.Ptient dose=patient bsa(m2)/1.73m2*drug dose
21.Patient bsa=pat height cm*ptwtinkg/3600(under root of all)
22.Jellifeeqfrcretinine clearance(males)=98-0.8*(pt ageinyear-20)/serum cretnine
mg/dl(females=0.9*answer of male)
23.CrockcroftCreatnineClearnce(males)=(140-pt age in year)*body wt in
kg/72*serum creatnine in mg/dl (females=0.85*answer of male)
24.Phfr acid=pka+log salt/acid
25.Phfr base=pkw-pkb+log base/salt
26.Pkb=-logkb
27.Mg=mili equivalent*at molwt/valncy
28.Mg/ml=m equ/ml(at mowt/valncy
29.Miliosmole=mg of drug*1 mili mole of drug/molwt
30.Rate of flow(drops per min)=vol of infusion*drops per ml/time(min)
31.Bmi=wt in kg/height in m2
32.Vd=d/cp(d is amount of drug in body,,,cp is plasmaconc of drugs

Dr.Fatima Arain