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Q.6- All the following enzymes except one require NADP+ as a coenzyme-
a) Glucose- 6-phosphate dehydrogenase
b) Cytosolic Isocitrate dehydrogenase
c) Malic enzyme
d) Glucose-6-phophatase
Q.10- Which one of the following compounds is common to both the oxidative
phase and the non- oxidative phase of the pentose phosphate pathway?
a) Xylulose-5- phosphate
b) Glucose-6-phosphate
c) Ribulose-5-phosphate
d) Glyceraldehyde-3- phosphate
Q.11- Mc Ardle’s syndrome causes muscle cramps and muscle fatigue with
increased muscle glycogen. Which of the following enzyme is deficient?
a) Hepatic hexokinase
b) Muscle Phosphorylase
c) Muscle Debranching enzyme
d) Muscle Hexokinase
Q.12- During starvation, the major source of blood glucose is-
a) Hepatic Glycogenolysis
b) Gluconeogenesis
c) Muscle Glycogenolysis
d) Dietary glucose from intestine
Q.22- The net production of ATP in glycolysis during anaerobic condition is:
a) 2 from glucose and 3 from glycogen
b) 2 from glucose and 4 from glycogen
c) 3 from glucose and 4 from glycogen
d) 3 from glucose and 2 from glycogen ( a )
Q.23- Which of the followings does not generate free glucose during the
enzymatic breakdown of glycogen in skeletal muscles?
a) Phosphorylase
b) α-1-6-amyloglucosidase
c) Debranching enzyme
d) glucose-6-phosphatase ( a )
Q.24- Which of the followings promotes glucose and amino acid uptake by
muscle?
a) Adrenaline
b) Insulin
c) Glucagon
d) Cortisol ( b )
Q.25- In a tissue that metabolizes glucose via the pentose phosphate pathway, C-
1 of glucose would be expected to end up principally in:
a) Carbon dioxide
b) Glycogen
c) Phosphoglycerate
d) Pyruvate
Q.4 – The oxidation of 3 mol of glucose by the pentose phosphate pathway may
result in the production of:
a) 2 mol of pentose, 4 mol of NADPH, and 8mol of CO2.
b) 3 mol of pentose, 4 mol of NADPH, and 3mol of CO2.
c) 3 mol of pentose, 6 mol of NADPH, and 3mol of CO2.
d) 4 mol of pentose, 3 mol of NADPH, and 3mol of CO2. ( c )
Q.5 – How many ATP molecules can be derived from each molecule of acetyl
CoA that enters the Krebs’ Cycle?
a) 6
b) 12
c) 18
d) 38
Q.6 – All of the following vitamins except one participate in the TCA cycle-
a) Pantothenic acid
b) Lipoic acid
c) Folic acid
d) Riboflavin
Q.7 – Why Phosphofructokinase rather than hexokinase is the pacemaker of
Glycolysis?
a) Glucose 6-phosphate is not solely a glycolytic intermediate
b) Hexokinase has low km for glucose
c) Hexokinase is inhibited by feed back inhibition
d) None of the above
Q.8 – All are correct about pyruvate dehydrogenase complex except one-
a) The formation of acetyl CoA from pyruvate is an irreversible step
b) Pyruvate dehydrogenase is switched off when Acetyl co A is in excess
c)Phosphorylation switches off the activity of the complex.
d) Pyruvate as well as ADP (a signal of low energy charge) inhibits the complex.
Q.10 – Which of the following is not an intermediate of the citric acid cycle?
a) Acetoacetate
b) Citrate
c) Oxalosuccinate
d) Succinyl-CoA
Q.11 – In an anaerobic system that is metabolizing glucose as a substrate, which
of the following compounds would you expect to increase in concentration
following the addition of fluoride?
a) 2-phosphoglycerate
b) Glucose
c) Phosphoenolpyruvate
d) Pyruvate
Q.14 – Which of the following statements about the pentose phosphate pathway
is incorrect?
a) Malate dehydrogenase
b) Pyruvate carboxylase
c) Pyruvate kinase
d). Citrate synthase
Q.21 – A medical student developed hemolytic anemia after taking the oxidizing
Antimalarial drug primaquine. This severe reaction is most likely due to
Q.22- Which of the following explains why individuals with hyperlipidemia should
minimize their intake of sucrose and high fructose syrup?
Q.25 – Asians and Native Americans may flush and feel ill after drinking a small
amount of ethanol in alcoholic beverages. This reaction is due to genetic variation
in an enzyme that metabolizes the liver metabolite of alcohol, which is-
a) Methanol
b) Acetone
c) Acetaldehyde
d) Glycerol
Q.26 – Which one of the following enzymes catalyzes the phosphorylation of the
substrate with the use of inorganic phosphate-?
a) Hexokinase
b) Phospho fructokinase
c) Glyceraldehyde-3-phosphate dehydrogenase