PHARMACOLOGICAL SHEET

Name of Patient: Patient S Date Admitted: 9/11/11

Age: 72 Time admitted: 9:40 PM
Sex: Male Attending Physician: Dr. Catro
Admission Diagnosis: UGIB, PUD, type 2 DM infection

NAME OF DRUG DRUG CLASS ACTION INDICATION CONTRAINDICATION ADVERSE EFFECT NURSING
RESPONSIBILITIES

TRANEXAMIC ACID Anti-fibrinolytic, Tranexamic acid is a  Treating heavy  Allergic reaction to  Pregnancy. Tranexamic  Unusual change in
Hemostan, Fibrinon, antihemorrhagic synthetic derivative of
menstrual bleeding the drug or acid crosses the bleeding pattern
Cyklokapron, Lysteda, the amino acid lysine. It
Transamin exerts its  Hemorrhage hypersensitivity placenta. should be
antifibrinolytic effect following dental  Presence of blood  Lactation. Tranexamic immediately
through the reversible and/or oral surgery clots (eg, in the acid is distributed into reported to the
blockade of lysine-
binding sites on in patients leg, lung, eye, breast milk; physician.
plasminogen with hemophilia brain), have a concentrations reach  For women who are
molecules. Anti-  Management of history of blood approximately 1% of taking Tranexamic
fibrinolytic drug inhibits hemophilic patients clots, or are at risk the maternal plasma acid to control heavy
endometrial
plasminogen activator (those having Factor for blood clots concentration. bleeding, the
and thus prevents VIII or Factor IX  Current  Contraceptives, medication should
fibrinolysis and the deficiency) who have administration of estrogen-containing, only be taken during
breakdown of blood
oral mucosal factor IX complex oral or Estrogens. the menstrual
clots. The plasminogen-
plasmin enzyme system bleeding, or are concentrates or Concurrent use with period.
is known to cause undergoing tooth anti-inhibitor tranexamic acid may  Tranexamic Acid
coagulation defects extraction or other coagulant increase the potential should be used with
through lytic activity on
oral surgical concentrates for thrombus extreme caution in
fibrinogen, fibrin and
.
other clotting factors. procedures formation. CHILDREN younger
By inhibiting the action  Surgical: General  Renal function than 18 years old;
of plasmin surgical cases but impairment (medicat safety and
(finronolysin) the anti-
most especially ion may accumulate; effectiveness in
fibrinolytic agents
reduce excessive operative dosage adjustment these children have
breakdown of fibrin procedures on the based on the degree of not been confirmed.
and effect physiological prostate, uterus, impairment is  The medication can
hemostasis
thyroid, lungs, heart, recommended) be taken with or
ovaries, adrenals,  Hematuria of upper without meals.
kidneys, brain, urinary tract  Swallow Tranexamic
tonsils, lymph nodes origin (risk of Acid whole with
and soft tissues. intrarenal obstruction plenty of liquids. Do
 Obstetrical and secondary to clot not break, crush, or
gynecological: retention in the renal chew before
abortion, post- pelvis and ureters if swallowing.
partum hemorrhage hematuria is massive;  If you miss a dose of
and also, if hematuria is Tranexamic Acid,
menometrorrahgia associated with a take it when you
 Medical: epistaxis, disease of the renal remember, then take
hemoptysis, parenchyma, your next dose at
hematuria, peptic intravascular least 6 hours later.
ulcer with precipitation of fibrin Do not take 2 doses
hemorrhage and may occur and at once.
blood dyscrasias exacerbate the  Inform the client
with hemorrhage disease) that he/she should
 Effective in  inform the physician
promoting immediately if the
hemostasis in following severe side
traumatic injuries. effects occur:
 Preventing
hemorrhage after
orthopedic
surgeries.