Clariant SDS NIPAGIN M Indonesia English

Material Safety Data Sheet
NIPAGIN M Page 1
Substance key: 000000051881 Revision Date: 09.03.2018

Version : 1 - 11 / RI Date of printing : 24.12.2019
1. PRODUCT AND COMPANY IDENTIFICATION
Trade name
NIPAGIN M
Material number: 166901
EC-No.: 202-785-7
Recommended use:
Industry sector : Personal Care
Type of use : Personal Care Preservatives
Supplier name/address/telephone no.:
Clariant Produkte (Deutschland) GmbH
Frankfurt am Main 65926, Germany

Telephone : +49 69 305 18000
Information about the substance/preparation
Product Safety : BU Industrial & Consumer Specialties
Product Stewardship
e-mail: SDS.Europe@clariant.com
Emergency telephone number: 00800-5121 5121
2. HAZARDS IDENTIFICATION
GHS Classification
Chronic aquatic toxicity : Category 3
GHS label elements

Hazard pictograms : None
Signal word : None
Hazard statements : H412 Harmful to aquatic life with long lasting effects.
Precautionary statements :
Prevention:
P273 Avoid release to the environment.
Disposal:
P501 Dispose of contents/ container to an approved waste
disposal plant.
Other hazards which do not result in classification

No additional hazards are known except those derived from the labelling.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance / Mixture : Substance
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NIPAGIN M Page 2

Chemical nature :
Substance name : methyl-4-hydroxybenzoate
CAS-No. : Not Assigned
Hazardous components
Chemical name CAS-No. Concentration (% w/w)
Methyl-4-hydroxy benzoate 99-76-3 >= 60 -<= 100
4. FIRST AID MEASURES
General advice : Remove/Take off immediately all contaminated clothing.

Get medical advice/ attention if you feel unwell.
If inhaled : Remove to fresh air.
In case of skin contact : In case of contact, immediately flush skin with soap and plenty
of water.
In case of eye contact : Rinse immediately with plenty of water, also under the eyelids,
for at least 15 minutes.
Consult a physician.
If swallowed : Rinse mouth with water.

If conscious, give the victim plenty of water to drink.
Get medical advice/ attention.
Most important symptoms : Treat symptomatically.

and effects, both acute and No additional risks are known.
delayed
Notes to physician : Treat symptomatically.
5. FIREFIGHTING MEASURES
Suitable extinguishing media : Water spray jet

Alcohol-resistant foam
Unsuitable extinguishing : High volume water jet

media Carbon dioxide (CO2)
Dry powder
Specific hazards during : In case of fires, hazardous combustion gases are formed:
firefighting Carbon monoxide (CO)
Carbon dioxide (CO2)
Specific extinguishing : Wear full protective clothing and self-contained breathing

methods apparatus.
Special protective equipment : Self-contained breathing apparatus
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NIPAGIN M Page 3

for firefighters Full protective suit
6. ACCIDENTAL RELEASE MEASURES
Personal precautions, : Wear suitable protective clothing.

protective equipment and Ensure adequate ventilation.
emergency procedures Avoid dust formation.
Avoid contact with skin and eyes.
Environmental precautions : If the product contaminates rivers and lakes or drains inform
respective authorities.
Do not empty into drains.
Methods and materials for : Keep in suitable, closed containers for disposal.
containment and cleaning up Take up mechanically
7. HANDLING AND STORAGE
Advice on protection against : Dust can form an explosive mixture in air.

fire and explosion Take measures to prevent the build up of electrostatic charge.
Keep away sources of ignition.
Keep away from heat.
Advice on safe handling : Avoid dust formation.

Avoid dust accumulation in enclosed space.
Provide adequate ventilation.
Conditions for safe storage : Keep only in the original container.

Keep container tightly closed.
Keep container tightly closed in a dry and well-ventilated
place.
Technical : Keep containers tightly closed in a dry, cool and well-

measures/Precautions ventilated place.
Materials to avoid : not required
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Components with workplace control parameters

Contains no substances with occupational exposure limit values.
Personal protective equipment
Respiratory protection : Use respiratory protection in case of insufficient exhaust
ventilation or prolonged exposure
Hand protection
Remarks : Protective gloves complying with EN 374. Minimum thickness
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NIPAGIN M Page 4

(glove): not determined With solid dry substances permeation

is not to be expected, therefore the breakthrough-time for this
protective glove has not been measured.
These types of protective gloves are offered by various

manufacturers. Please note the manufacturers´ detailed
statements, especially about the minimum thickness and the
minimum breakthrough time. Consider also the particular
working conditions under which the gloves are being used.
Eye protection : Safety glasses
Skin and body protection : Wear suitable protective clothing.
Protective measures : Avoid contact with skin and eyes.

Do not breathe dust.
Hygiene measures : Use only in well-ventilated areas.

Take off immediately all contaminated clothing.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance : Crystalline powder
Colour : white
Odour : odourless
Odour Threshold : not tested.
pH : 7 (20 °C)
Concentration: 1 g/l
Melting point : 125 °C

Method: OECD Test Guideline 102
Boiling point (decomposition) : approx. 270 - 280 °C

(1.013 hPa)
Decomposition: yes
Flash point : Not applicable
Evaporation rate : Not applicable
Self-ignition : Method: EC A.16

The substance or mixture is not classified as self heating.
Burning number : 1
Does not catch fire
Upper explosion limit / upper : Not applicable

flammability limit
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NIPAGIN M Page 5

Lower explosion limit / Lower : Not applicable

flammability limit
Vapour pressure : 0,000028 Pa (20 °C)

Relative vapour density : Not applicable
Relative density : not tested.
Density : 1,3775 g/cm3

Bulk density : approx. 880 kg/m3
Solubility(ies)
Water solubility : approx. 1,88 g/l (20 °C)
Partition coefficient: n- : log Pow: 1,98

octanol/water Method: OECD Test Guideline 107
Auto-ignition temperature : not tested.
Decomposition temperature : > 270 - 280 °C

Heating rate: 3 K/min
Decomposition energy (mass): 499 kJ/kg
Method: DSC
No decomposition if used as directed.
Viscosity
Viscosity, dynamic : Not applicable
Explosive properties : Not explosive

Method: Expert judgement
Oxidizing properties : The substance or mixture is not classified as oxidizing.

Method: Tested according to Directive 92/69/EEC.
Surface tension : Based on chemical structure, no surface activity is expected

or can be predicted.
Sublimation point : not determined
Dust deflagration index (Kst) : 197 m.b_/s
Dust explosion class : ST1 Capable of dust explosion
Minimum ignition energy : 3 - 5 mJ (590 °C)
Particle size : 110 - 150 µm

Median value
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NIPAGIN M Page 6

10. STABILITY AND REACTIVITY
Reactivity : See section 10.3. "Possibility of hazardous reactions"
Chemical stability : Stable under normal conditions.
Possibility of hazardous : No dangerous reaction known under conditions of normal use.

reactions Stable
Conditions to avoid : not known
Incompatible materials : not known
Hazardous decomposition : When handled and stored appropriately, no dangerous

products decomposition products are known
11. TOXICOLOGICAL INFORMATION
Acute toxicity
Product:
Acute oral toxicity : LD50 (Rat, male): 2.100 mg/kg
Acute inhalation toxicity : Remarks: no data available
Acute dermal toxicity : Remarks: no data available
Components:
Methyl-4-hydroxy benzoate:
Acute oral toxicity : LD50 (Rat, male): 2.100 mg/kg
Acute inhalation toxicity : Remarks: no data available
Acute dermal toxicity : Remarks: no data available
Skin corrosion/irritation
Product:
Species : Rabbit
Method : Other
Result : No skin irritation
Components:
Species : Rabbit
Method : Other
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NIPAGIN M Page 7

Result : No skin irritation
Serious eye damage/eye irritation

Product:
Species : Rabbit
Result : No eye irritation
Method : Other
Components:
Species : Rabbit
Result : No eye irritation
Method : Other
Respiratory or skin sensitisation

Product:
Test Type : Maurer optimisation test
Species : Guinea pig
Method : OECD Test Guideline 406
Result : Not a skin sensitizer.
Components:
Test Type : Maurer optimisation test
Species : Guinea pig
Method : OECD Test Guideline 406
Result : Not a skin sensitizer.
Germ cell mutagenicity

Product:
Genotoxicity in vitro : Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Test Type: Chromosome aberration test in vitro

Test system: Chinese hamster lung cells
Concentration: 125 μg/mL
Result: negative
Genotoxicity in vivo : Test Type: Dominant lethal assay

Species: Rat (male)
Strain: Sprague-Dawley
Application Route: oral (gavage)
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NIPAGIN M Page 8

Dose: 5, 50, 500 mg/kg/bw

Result: negative
Germ cell mutagenicity - : In vitro tests did not show mutagenic effects
Assessment
Components:
Genotoxicity in vitro : Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: Chromosome aberration test in vitro

Test system: Chinese hamster lung cells
Concentration: 125 μg/mL
Result: negative
Genotoxicity in vivo : Test Type: Dominant lethal assay

Species: Rat (male)
Strain: Sprague-Dawley
Application Route: oral (gavage)
Dose: 5, 50, 500 mg/kg/bw
Result: negative
Germ cell mutagenicity - : In vitro tests did not show mutagenic effects
Assessment
Carcinogenicity
Product:
Species : Rat, male and female
Exposure time : 52 weeks
Frequency of Treatment : twice weekly
: 3,5 mg/kg bw/day
Method : Other
Result : negative
Species : Mouse, male and female

: 2,5 mg/kg body weight
Method : Other
Result : negative
Carcinogenicity - : Not classifiable as a human carcinogen.

Assessment
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NIPAGIN M Page 9

Components:
Exposure time : 52 weeks
Frequency of Treatment : twice weekly
: 3,5 mg/kg bw/day
Method : Other
Result : negative
Species : Mouse, male and female

: 2,5 mg/kg body weight
Method : Other
Result : negative
Carcinogenicity - : Not classifiable as a human carcinogen.

Assessment
Reproductive toxicity
Product:
Effects on fertility : Test Type: Fertility
Species: Rat, male
Application Route: oral (feed)
Dose: 100, 1000, 10000 ppm
General Toxicity - Parent: NOAEL: 1.000 ppm
Method: Other
Effects on foetal : Test Type: reproductive and developmental toxicity study

development Species: Rat
Strain: wistar
Application Route: Oral
Developmental Toxicity: NOAEL: 550 mg/kg body weight
Reproductive toxicity - : No evidence of adverse effects on sexual function and fertility,

Assessment or on development, based on animal experiments.
Components:
Effects on fertility : Test Type: Fertility
Species: Rat, male
Application Route: oral (feed)
Dose: 100, 1000, 10000 ppm
General Toxicity - Parent: NOAEL: 1.000 ppm
Method: Other
Effects on foetal : Test Type: reproductive and developmental toxicity study

development Species: Rat
Strain: wistar
Application Route: Oral
Developmental Toxicity: NOAEL: 550 mg/kg body weight
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NIPAGIN M Page 10

Reproductive toxicity - : No evidence of adverse effects on sexual function and fertility,

Assessment or on development, based on animal experiments.
STOT - single exposure

Product:
Remarks : not tested.
Components:
Remarks : no data available
STOT - repeated exposure

Product:
Remarks : not tested.
Components:
Remarks : no data available
Repeated dose toxicity

Product:
NOAEL : >= 250 mg/kg
Application Route : oral (gavage)
Exposure time : 28 d
Number of exposures : daily
Dose : 50, 250, 1000 mg/kg/day
Method : Other
Components:
NOAEL : >= 250 mg/kg
Application Route : oral (gavage)
Exposure time : 28 d
Number of exposures : daily
Dose : 50, 250, 1000 mg/kg/day
Method : Other
Aspiration toxicity
Product:
no data available
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NIPAGIN M Page 11

Components:
no data available
Further information
Product:
Remarks : Inhalation of dust causes slight irritation of the respiratory
tract.
12. ECOLOGICAL INFORMATION
Ecotoxicity
Product:
Toxicity to fish : LC50 (Oryzias latipes (Orange-red killifish)): 59,5 mg/l
Exposure time: 96 h
Test Type: semi-static test
Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): 11,2 mg/l
aquatic invertebrates Exposure time: 48 h
Test Type: static test
Method: ISO 6341
Toxicity to algae : EC50 (Pseudokirchneriella subcapitata (algae)): 91 mg/l

End point: Growth rate
Exposure time: 72 h
Method: ISO 8692
Toxicity to fish (Chronic : Remarks: no data available

toxicity)
Toxicity to daphnia and other : NOEC (Daphnia magna (Water flea)): 0,2 mg/l
aquatic invertebrates End point: Reproduction rate
(Chronic toxicity) Exposure time: 21 d
Toxicity to microorganisms : Remarks: not tested.
Toxicity to soil dwelling : Remarks: not tested.

organisms
Plant toxicity : Remarks: not tested.
Toxicity to terrestrial : Remarks: not tested.

organisms
11 / 16
NIPAGIN M Page 12

Ecotoxicology Assessment
Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects.
Components:
Toxicity to fish : LC50 (Oryzias latipes (Orange-red killifish)): 59,5 mg/l
Exposure time: 96 h
Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): 11,2 mg/l
aquatic invertebrates Exposure time: 48 h
Method: ISO 6341
Toxicity to algae : EC50 (Pseudokirchneriella subcapitata (algae)): 91 mg/l

End point: Growth rate
Exposure time: 72 h
Method: ISO 8692
Toxicity to fish (Chronic : Remarks: no data available

toxicity)
Toxicity to daphnia and other : NOEC (Daphnia magna (Water flea)): 0,2 mg/l
aquatic invertebrates End point: Reproduction rate
(Chronic toxicity) Exposure time: 21 d
Ecotoxicology Assessment
Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects.
Persistence and degradability

Product:
Biodegradability : Biodegradation: 89 % (CO2 formation in % of theoretical
value)
Exposure time: 28 d
Method: OECD Test Guideline 301B
Remarks: Readily biodegradable, according to appropriate
OECD test.
Biochemical Oxygen : Remarks: not available

Demand (BOD)
Chemical Oxygen Demand : Remarks: not available

(COD)
Dissolved organic carbon : Remarks: not available

(DOC)
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NIPAGIN M Page 13

Physico-chemical : Remarks: not tested.

removability
Photodegradation : Remarks: not tested.
Components:
Biodegradability : Inoculum: activated sludge, domestic, non-adapted
Carbon dioxide (CO2)
Result: Readily biodegradable.
Biodegradation: 89 %
Exposure time: 28 d
Method: OECD Test Guideline 301B
Bioaccumulative potential
Product:
Bioaccumulation : Remarks: Due to the low logPow bioaccumulation is not
expected
Components:
Bioaccumulation : Remarks: Due to the distribution coefficient n-octanol/water,
accumulation in organisms is not expected.
Partition coefficient: n- : log Pow: 1,98 (20 °C)

octanol/water Method: Other
Mobility in soil
Product:
Distribution among : Remarks: Based upon the calculated log Koc, adsorption to
environmental compartments the soil phase is not expected.
Components:
Distribution among : Koc: 280
environmental compartments
Method: estimated
Other adverse effects

Product:
Environmental fate and : Remarks: Due to the distribution coefficient n-octanol/water,
pathways accumulation in organisms is not expected.
Additional ecological : The product should not be allowed to enter drains, water
information courses or the soil.
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NIPAGIN M Page 14

Components:
Results of PBT and vPvB : The substance is not identified as a PBT or as a vPvB
assessment substance.
13. DISPOSAL CONSIDERATIONS
Disposal methods
Waste from residues : In accordance with regulations for hazardous waste, must be
taken to a hazardous waste disposal site
Contaminated packaging : Regulations concerning reuse or disposal of used packaging

materials must be observed.
14. TRANSPORT INFORMATION
IATA not restricted

IMDG not restricted
15. REGULATORY INFORMATION
Safety, health and environmental regulations/legislation specific for the substance or

mixture
Apart from the data/regulations specified in this chapter, no further information is available
concerning safety, health and environmental protection.
Minister of Industry Regulation No. 23/M-IND/PER/4/2013 concerning the Revision of

Minister of Industry Regulation No. 87/M-IND/PER/9/2009 concerning Globally Harmonized
System of Classification and Labelling of Chemicals.
Regulation of the Minister of Health No. 472 of 1996 on the Safeguarding of Substances
Hazardous to Health
Hazardous substances that must be registered : Not applicable
Government Regulation No. 74 of 2001 on the Management of Hazardous and Toxic

Substances
Hazardous substances approved for use : Not applicable
Prohibited substances : Not applicable
Restricted substances : Not applicable
Regulation of the Minister of Trade No. 44 of 2009 on Procurement, Distribution and

Supervision of Hazardous Materials
Types of Hazardous Materials governed by Import : Not applicable
Regulations
14 / 16
NIPAGIN M Page 15

Types of Hazardous Materials of which the Distribution : Not applicable

and Supervision is Regulated
16. OTHER INFORMATION
Further information
Other information : Observe national and local legal requirements
Date format : yyyy/mm/dd
Full text of other abbreviations
AICS - Australian Inventory of Chemical Substances; ANTT - National Agency for Transport by
Land of Brazil; ASTM - American Society for the Testing of Materials; bw - Body weight; CMR -
Carcinogen, Mutagen or Reproductive Toxicant; CPR - Controlled Products Regulations; DIN -
Standard of the German Institute for Standardisation; DSL - Domestic Substances List (Canada);
ECx - Concentration associated with x% response; ELx - Loading rate associated with x%
response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan);
ErCx - Concentration associated with x% growth rate response; ERG - Emergency Response
Guide; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC -
International Agency for Research on Cancer; IATA - International Air Transport Association; IBC
- International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals
in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation
Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial Safety
and Health Law (Japan); ISO - International Organisation for Standardization; KECI - Korea
Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a test population; LD50 -
Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International
Convention for the Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; Nch -
Chilean Norm; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No Observed
(Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NOM - Official Mexican
Norm; NTP - National Toxicology Program; NZIoC - New Zealand Inventory of Chemicals; OECD
- Organization for Economic Co-operation and Development; OPPTS - Office of Chemical Safety
and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS -
Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of
the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals;
SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan
Chemical Substance Inventory; TDG - Transportation of Dangerous Goods; TSCA - Toxic
Substances Control Act (United States); UN - United Nations; UNRTDG - United Nations
Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very
Bioaccumulative; WHMIS - Workplace Hazardous Materials Information System
This information corresponds to the present state of our knowledge and is intended as a general
description of our products and their possible applications. Clariant makes no warranties, express
or implied, as to the information's accuracy, adequacy, sufficiency or freedom from defect and
assumes no liability in connection with any use of this information. Any user of this product is
responsible for determining the suitability of Clariant's products for its particular application.
Nothing included in this information waives any of Clariant's General Terms and Conditions of
15 / 16
NIPAGIN M Page 16

Sale, which control unless it agrees otherwise in writing. Any existing intellectual/industrial
property rights must be observed. Due to possible changes in our products and applicable
national and international regulations and laws, the status of our products could change. Material
Safety Data Sheets providing safety precautions, that should be observed when handling or
storing Clariant products, are available upon request and are provided in compliance with
applicable law. You should obtain and review the applicable Material Safety Data Sheet
information before handling any of these products. For additional information, please contact
Clariant.
ID / EN
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Material Safety Data Sheet

Substance key: 000000051881 Revision Date: 09.03.2018

1. PRODUCT AND COMPANY IDENTIFICATION

Frankfurt am Main 65926, Germany

GHS label elements

Signal word : None

Other hazards which do not result in classification

Substance / Mixture : Substance

Substance key: 000000051881 Revision Date: 09.03.2018

Substance name : methyl-4-hydroxybenzoate

CAS-No. : Not Assigned

4. FIRST AID MEASURES

General advice : Remove/Take off immediately all contaminated clothing.

If inhaled : Remove to fresh air.

If swallowed : Rinse mouth with water.

Most important symptoms : Treat symptomatically.

Notes to physician : Treat symptomatically.

Suitable extinguishing media : Water spray jet

Unsuitable extinguishing : High volume water jet

Specific extinguishing : Wear full protective clothing and self-contained breathing

Special protective equipment : Self-contained breathing apparatus

Substance key: 000000051881 Revision Date: 09.03.2018

for firefighters Full protective suit

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, : Wear suitable protective clothing.

7. HANDLING AND STORAGE

Advice on protection against : Dust can form an explosive mixture in air.

Advice on safe handling : Avoid dust formation.

Conditions for safe storage : Keep only in the original container.

Technical : Keep containers tightly closed in a dry, cool and well-

Materials to avoid : not required

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Components with workplace control parameters

Substance key: 000000051881 Revision Date: 09.03.2018

(glove): not determined With solid dry substances permeation

These types of protective gloves are offered by various

Eye protection : Safety glasses

Skin and body protection : Wear suitable protective clothing.

Protective measures : Avoid contact with skin and eyes.

Hygiene measures : Use only in well-ventilated areas.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance : Crystalline powder

Odour Threshold : not tested.

Melting point : 125 °C

Boiling point (decomposition) : approx. 270 - 280 °C

Flash point : Not applicable

Evaporation rate : Not applicable

Self-ignition : Method: EC A.16

Upper explosion limit / upper : Not applicable

Substance key: 000000051881 Revision Date: 09.03.2018

Lower explosion limit / Lower : Not applicable

Vapour pressure : 0,000028 Pa (20 °C)

Relative vapour density : Not applicable

Relative density : not tested.

Density : 1,3775 g/cm3

Bulk density : approx. 880 kg/m3

Partition coefficient: n- : log Pow: 1,98

Auto-ignition temperature : not tested.

Decomposition temperature : > 270 - 280 °C

Explosive properties : Not explosive

Oxidizing properties : The substance or mixture is not classified as oxidizing.

Surface tension : Based on chemical structure, no surface activity is expected

Sublimation point : not determined