11/10/2018 Ascorbic acid: Indication, Dosage, Side Effect, Precaution | MIMS.

com Indonesia

INDONESIA

Concise Info

Ascorbic acid
> Indications > Adverse Drug Reactions
> Dosage > Pregnancy Category (US FDA) Available Brands
> Dosage Details > Overdosage Biferce BSKIN V Li...
> Renal Impairment > Drug Interactions
> Administration > Food Interaction Corbavit Extrace
> Reconstitution > Lab Interference Probio-C S... Prove-C
> Incompatibility > Mechanism of Action Sankorbin Ulvice
> Special Precaution > Storage
> MIMS Class
> ATC Classification Other Known Brands
Askorbin Bekamin C ...
candyvit-C Ceelin
C-Face Whi... Champs C
Fit-C Flavettes
Larce Scott's Ch...
See more brands
Most Read Articles
Indications Scurvy.
Dosage Adult : PO ≥240 mg/day in divided doses. IM/IV/SC 0.5-1 g/day.
1. Apoteker: Trik menangani
pasien yang mungkin
Dosage Details Oral merupakan seorang pecandu
Scurvy oba...
Adult: ≥240 mg daily in divided doses. For preventive therapy, 25-75 mg daily.
2. Fenomena fenotip digital: Era
DRUGS SPECIALTY Child: GENERAL
100-300 mg NEWS EDUCATION
daily. For preventive RESEARCH
therapy: Same as adult dose.
baru teknologi perawatan
Parenteral
kesehatan atau peng...
Scurvy
Adult: 0.5-1 g daily. For preventive therapy, 200-500 mg daily. Doses are given via IM, IV or SC inj. 3. Kontroversi eksperimen di
Child: For curative therapy: 100-300 mg daily. For protective therapy: 30 mg daily. Doses are given via tahun 1932 yang menimbulkan
IM, IV or SC inj. "gangguan darah"
Renal Impairment ESRD: 60-100 mg once daily.
Administration May be taken with or without food. 4. IMARET: From Disaster Relief
to Refugee Heroes
Reconstitution IV inj: Dilute w/ large volume of glucose or normal saline.
Incompatibility Incompatible w/ ferric salts, oxidising agents, salts of heavy metals, particularly copper. Y-site admin:
Incompatible w/ etomidate, propofol, thiopental. Syringe: Incompatible w/ cefazolin, doxapram,
aminophylline, bleomycin sulfate, erythromycin, nitrufurantoin, sodium bicarbonate, nafcillin Na,
5. Addressing the Concerns of a
sulfafurazole diethanolamine.
Pregnant Patient with Hepatitis
B
Special Precautions Patient w/ hyperoxaluria, G6PD deficiency, DM, haemochromatosis. Renal impairment (e.g. renal failure,
renal calculi). Pregnancy and lactation.
Adverse Drug Reactions GI disturbances (e.g. diarrhoea, nausea, vomiting, abdominal cramps, transient colic, flatulent distention),
heartburn, fatigue, flushing, headache, insomnia, sleepiness; hyperoxaluria, renal Ca oxalate calculi
formation; temporary faintness/dizziness (IV); transient mild soreness at the site of inj (IM/SC).
Pregnancy Category (US ROUTE(S) : PO
FDA)

Overdosage
Drug Interactions
Food Interaction
Lab Interference
Mechanism of Action
Storage
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or
embryocidal or other) and there are no controlled studies in women or studies in women and animals are
not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Symptoms: Diarrhoea, hyperoxaluria, renal Ca oxalate calculi formation. Management: Symptomatic
treatment.
Induced tissue desaturation w/ aspirin, nicotine, Fe, phenytoin, tetracycline estrogen from OCs, and some
appetite suppressants and anticonvulsant drugs. Reduced absorption and decreased urinary excretion w/
aspirin. Reduced serum levels w/ OCs. May cause unexpected renal tubular reabsorption of acidic drugs
and decreased reabsorption of basic drugs. May reduce response to oral anticoagulants. May decrease
plasma concentration of fluphenazine. May worsen Fe toxicity to the heart w/ desferrioxamine.
Induced tissue desaturation w/ alcohol.
False-negative results from plasma, stool occult blood (48-72 hr after ingestion), and urinary glucose test.
Description: Ascorbic acid, a water-soluble vitamin, acts as a cofactor and antioxidant. It is essential for
tissue repair and formation of collagen and intercellular materials. Additionally, it is involved in conversion
of folic acid to folinic acid, synthesis of lipids and proteins, carbohydrate metabolism, iron absorption and
storage, and cellular respiration.
Onset: Scurvy symptoms reversal: 2 days to 3 wk.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Distribution: Widely distributed in the body tissues. Crosses the placenta and enters breast milk. Plasma
protein binding: Approx 25%.
Metabolism: Reversibly oxidised to dehydroascorbic acid (DHA), some are metabolised to the inactive
metabolites, ascorbate-2-sulfate and oxalic acid.
Excretion: Via urine (as unchanged drug and as inactive metabolites). Elimination half-life: 10 hr.
Tab/cap/liq: Store at room temp. Soln for inj: Store below 25°C. Protect from light. Do not freeze.

https://www.mims.com/indonesia/drug/info/ascorbic%20acid/?type=brief&mtype=generic 1/2
11/10/2018 Ascorbic acid: Indication, Dosage, Side Effect, Precaution | MIMS.com Indonesia
MIMS Class Vitamin C
ATC Classification A11GA01 - ascorbic acid (vit C) ; Belongs to the class of ascorbic acid (vitamin C). Used as dietary
supplements.

Disclaimer: This information is independently developed by MIMS based on Ascorbic acid from various references and is provided for your reference only.
Therapeutic uses and prescribing information may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing
information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the
use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2018 MIMS. All rights reserved. Powered by MIMS.com

Drug Index A to Z

Browse Alphabetically (Brand)

A B C D E F G H I J K L M N O P Q R S T U V

Browse Alphabetically (Generic)

A B C D E F G H I J K L M N O P Q R S T U V

Connect With Us

Download FREE MIMS A

Corporate Terms of Use Privacy Subscribe Feedback

©2018

https://www.mims.com/indonesia/drug/info/ascorbic%20acid/?type=brief&mtype=generic 2/2