RUG STUDY

Generic Name: omeprazole

Brand Name: Omeprazole (RiteMed)

Classification: Proton pump inhibitor

Dosage & Frequency:

Active Duodenal Ulcer

PO:

Adults, Elderly: 20 mg/day for 4–8 weeks.

Symptomatic GERD

PO:

Adults, Elderly, Children weighing 20 kg or more: 20 mg/day for up to 4 weeks.

10–19 kg: 10 mg/day

5–9 kg: 5 mg/day.

Erosive Esophagitis

PO:

Adults, Elderly, Children weighing 20 kg or more: Treatment: 20 mg/day for 4–8

weeks.

Children 1–16 yrs weighing 10–19 kg: 10 mg/day. Weighing 5–9 kg: 5 mg/day.

Children 1–11 mos weighing 10 kg or more: 10 mg/day. Weighing 5–9 kg: 5

mg/day. Weighing 3–4 kg: 2.5 mg/day.

Maintenance: Adults, elderly, children weighing 20 kg or more: 20 mg/day for up

to 12 mos (including treatment period).

Asian patiets, children weighing 10–19 kg: 10 mg/day. Weighing 5–9 kg: 5 mg/day.
 Pathologic Hypersecretory Conditions

Note: Doses more than 80 mg in divided doses.

PO:

Adults, Elderly: Initially, 60 mg/day up to 120 mg 3 times/day.

H. Pylori Duodenal Ulcer

PO:

Adults, Elderly: 40 mg once daily (with clarithromycin) for 14 days or 20 mg twice

daily (with amoxicillin and clarithromycin) for 10 days. Presence of ulcer at initiation

may need 20 mg/day (monotherapy) for 14–18 days following combination

therapy.

Gastric Ulcer

PO:

Adults, Elderly: 40 mg/day for 4–8 weeks.

OTC Use (Frequent Heartburn)

PO:

Adults, Elderly: 20 mg/day for 14 days. May repeat after 4 mos if needed.

Dosage in Renal/Hepatic Impairment

No dose adjustment.

Mechanism of Action: This drug inhibits hydrogen-potassium adenosine triphosphatase

(H+/K+ ATP pump), an enzyme on the surface of gastric parietal cells.

Therapeutic Effect: Increases gastric pH, reduces gastric acid production.

Indications: This drug is given to patients with moderate to severe pain.

Contraindications: This drug is contraindicated for patients who are hypersensitive to

omeprazole, other proton pump inhibitors. Concomitant use with products containing

rilpivirine.

Cautions: May increase risk of fractures, gastrointestinal infections. Hepatic impairment,

patients of Asian descent.

Side Effects:

Frequent (7%): headache

Occasional (3%–2%): diarrhea, abdominal pain, nausea

Rare (2%): dizziness, asthenia, vomiting, constipation, upper respiratory tract

infection, back pain, rash, cough

Adverse Reactions: pancreatitis, hepatotoxicity, interstitial nephritis occur rarely, may

increase risk of C. difficile infection.

10 Nursing Responsibilities:

1. Assess the vital signs of the patient and check his laboratory results.

2. Make sure that the drug will be administered within 30 minutes of the scheduled

time and check the drug label at the time of contact with it, before preparing it, and

after preparing it (3 checks before drug administration).

3. Inform the patient about the drug that she is about to take and also the side and

adverse effects of it.

4. Administer medication to the patient before eating.

5. Document the process as well as the time and the date that the medication was

administered.

6. Question if GI discomfort, nausea, diarrhea occurs.

7. If the patient feels nauseous and about to vomit, offer ice chips and crackers

immediately and if GI upset occurs, advise the patient to take the medication with

meals (Managing Nausea and Vomiting at Home, 2019).

8. When rashes occur, tell the patient to avoid rubbing or scratching the skin and

advise him to take a bath using lukewarm water. Then, apply a topical lubricant

immediately after taking a bath.

9. Educate the patient to swallow capsules whole; do not chew, crush, dissolve, or

divide.

10. Educate the patient or the patient’s family to space the doses evenly and to

continue the medication as ordered by the physician.