E A

EB BBE 7D 97A 1C 6B3 3AAAC7 B6AA83 DB

7 9 6 B D 9
BB BE7 D97 7A1 1C6 B3AAAC C7B 6A 83D B9 9DA
D C B 6 8 9
BE E7D 97AA1C 6B 3AAAC7 7B6 A83 3DB B99DDA6 67F
9 6 3 B A E
E7 7D9 7A1 1C6 B3AAAC C7B 6A 83DDB9 99DAA67 7FE BBE
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D
7D 7A 1C B AA C7 6 8 DB 9 A 7F B E7 9
97 1 6 3A C B A 3D 9 DA 67 EB BE D 7A

i)
i)
i)
i)
i)

Q.4 a)
Q.3 a)
Q.2 a)
Q.1 a)

b)
ii)
ii)
ii)
97 A1C C6B B3A AC 7B6 6A8 83D B99 9DA 67F FEB BE 7D9 97A 1C
A A 7 B 7 6

iv)
iv)
iv)

iii)
iii)
iii)

62301
7A 1C 6B3 3AA C7 B6AA83 3DB 99DDA6 67FE EBB BE7 D97 7A1 1C6 B3A
1 6 B A C B 8 D 9 A 7 B E D A C B
A1 C6 3A AC 7B 6A 3D B9 9DA 67 FE BE 7D 97A 1C 6B 3A AC7
C B 6 8 9 F B 9 3 A
1C 6B 3AAAC7 7B6 A83 3DB B99DDA6 67F EBB BE7 7D9 7A1 1C6 6B3AAA C7B B6A
3
6B A C B A8 D 9 A 7 EB E D 7A C B A C7 6 83
6B 3A AC 7B6 6A8 3DB B99 9DA 67F FEB BE 7D9 97A 1C6 6B3 3AA C7 B6AA83 DB
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D

examples?
AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A N.B:

A) Receptor
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67F
6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F EB
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67 EB BE
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE B 7D

Explain the terms:

99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE BB E7D 97
DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B E7 9 A1
67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB BE7 D9 7A1 C6
FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB E D 7A C B3

solvent free conditions.

BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE 7D 97A 1C 6B AA
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7D 97A 1C 6B 3A C7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D 97 1 6B 3A AC B
7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7 97 A1 C6 3A AC 7B 6A
1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9 A1 C6 B3A A 7B 6A 83D
6B 3A C B6 A8 DB 99 A 7F EB E D9 7A C6 B3 A C7 6A 83 B
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D

Outline the mevalonate pathway.

Answer any one of the following:

b) Answer any one of the following:
b) Answer any one of the following:
b) Answer any one of the following:

Answer any two of the following:

Answer any two of the following:
Answer any two of the following:
Answer any two of the following:

AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67F
6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F EB
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67 EB BE
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE B 7D
99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE BB E7D 97
B) Therapeutic index

DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B E7 9 A1 i) Give details of factors affecting bioactivity.

67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB BE7 D9 7A1 C6

Give the biosynthesis of saturated fatty acids.

FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB E D 7A C B3
BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE 7D 97A 1C 6B AA
𝟏

Page 1 of 2
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7D 97A 1C 6B 3A C7
1. All questions are compulsory.

D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D 97 1 6B 3A AC B

i) Give the synthesis and one application of cetrizine.

7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7 97 A1 C6 3A AC 7B 6A

Discuss the concept of soft drugs with its properties.

1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9 A1 C6 B3A A 7B 6A 83D

Give the synthesis and one application of Fluoxetine.

iii) Discuss how penicillin was discovered without a lead.

6B 3A C B6 A8 DB 99 A 7F EB E D9 7A C6 B3 A C7 6A 83 B
[Time: 2𝟐 Hours]

3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D
ii) Discuss the basic idea regarding combinatorial synthesis.

AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
2. Figures to the right indicate full marks.

7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67F

Give the biosynthesis of phenylalanine from shikimic acid.

6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F EB
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67 EB BE
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE B 7D

How nanocatalyst acts as a green catalyst? Give its advantages.

99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE BB E7D 97

83DB99DA67FEBBE7D97A1C6B3AAC7B6A
DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B E7 9 A1
67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB BE7 D9 7A1 C6
FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB E D 7A C B3
Describe the modern method of drug design based on bioinformatics.
What is ‘QSAR’? Give the Hancok modification of the Taft equation.

BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE 7D 97A 1C 6B AA
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7D 97A 1C 6B 3A C7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D 97 1 6B 3A AC B
7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7 97 A1 C6 3A AC 7B 6A
Please check whether you have got the right question paper.

i) Give the biosynthesis of cinnamic acid and its derivatives from prephenate.
1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9 A1 C6 B3A A 7B 6A 83D

Discuss the role of dimethyl carbonate as a green reagent in green synthesis.

6B 3A C B6 A8 DB 99 A 7F EB E D9 7A C6 B3 A C7 6A 83 B

Give an account of green solvents and catalysts in designing a green synthesis.

3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D

Give the steps involved in the synthesis of Orsellinic acid from acetate pathway.
AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67
iv) Discuss structure modification to increase potency and therapeutic index of a drug.

6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F
ii) Discuss the methods used to correlate regression parameters with biological activity.

83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67

What are the advantages of solid supported synthesis in green synthesis with suitable
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE
99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE

ii) Starting from Isopentenyl pyrophosphate give the biosynthetic pathway to diterpenoids.
DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B

ii) Explain the microwave assisted organic synthesis with reference to reactions in water and
Give the comparison of traditional as well as green process for the synthesis of ibuprofen.
67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB
FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB
ii) Discuss the physical and chemical parameters solubility and ionization, in drug distribution.

BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D
7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7

04
08
04
08
04
08
04
08
[ Marks:60]

1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9
6B 3A C B6 A8 DB 99 A 7F EB E D9
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7
AC 7B 6A 3D B9 DA 67 FE BE 7D 97A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1
6A 83D B9 9D 6 FE BB 7D 97 1
8
Paper / Subject Code: 74854 / Chemistry: Organic Chemistry Medicinal And Biogenesis Green Chemsitry (R-2018-19

B 9 A 7F B E 9 A C
 E A
EB BBE 7D 97A 1C 6B3 3AAAC7 B6AA83 DB
7 9 6 B D 9
BB BE7 D97 7A1 1C6 B3AAAC C7B 6A 83D B9 9DA
D C B 6 8 9
BE E7D 97AA1C 6B 3AAAC7 7B6 A83 3DB B99DDA6 67F
9 6 3 B A E
E7 7D9 7A1 1C6 B3AAAC C7B 6A 83DDB9 99DAA67 7FE BBE
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D

Q.5
7D 7A 1C B AA C7 6 8 DB 9 A 7F B E7 9
97 1 6 3A C B A 3D 9 DA 67 EB BE D 7A

f)
e)
c)
a)

g)
h)
d)
b)
97 A1C C6B B3A AC 7B6 6A8 83D B99 9DA 67F FEB BE 7D9 97A 1C
A A 7 B 7 6

62301
7A 1C 6B3 3AA C7 B6AA83 3DB 99DDA6 67FE EBB BE7 D97 7A1 1C6 B3A
1 6 B A C B 8 D 9 A 7 B E D A C B
A1 C6 3A AC 7B 6A 3D B9 9DA 67 FE BE 7D 97A 1C 6B 3A AC7
C B 6 8 9 F B 9 3 A
1C 6B 3AAAC7 7B6 A83 3DB B99DDA6 67F EBB BE7 7D9 7A1 1C6 6B3AAA C7B B6A
3
6B A C B A8 D 9 A 7 EB E D 7A C B A C7 6 83
6B 3A AC 7B6 6A8 3DB B99 9DA 67F FEB BE 7D9 97A 1C6 6B3 3AA C7 B6AA83 DB
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D
AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67F
6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F EB
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67 EB BE
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE B 7D
99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE BB E7D 97
DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B E7 9 A1
67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB BE7 D9 7A1 C6
FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB E D 7A C B3
BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE 7D 97A 1C 6B AA
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7D 97A 1C 6B 3A C7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D 97 1 6B 3A AC B
7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7 97 A1 C6 3A AC 7B 6A
1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9 A1 C6 B3A A 7B 6A 83D
6B 3A C B6 A8 DB 99 A 7F EB E D9 7A C6 B3 A C7 6A 83 B
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D
AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
Answer any four of the following:

7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67F

6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F EB
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67 EB BE
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE B 7D
Explain the terms: 1) Biogenesis and

99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE BB E7D 97

DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B E7 9 A1
2) Primary metabolites

67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB BE7 D9 7A1 C6

FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB E D 7A C B3
BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE 7D 97A 1C 6B AA
Define the terms: drug assay and drug potency.

Page 2 of 2
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7D 97A 1C 6B 3A C7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D 97 1 6B 3A AC B
*********

7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7 97 A1 C6 3A AC 7B 6A
Explain the role of ionic liquids as a green solvents.

1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9 A1 C6 B3A A 7B 6A 83D

6B 3A C B6 A8 DB 99 A 7F EB E D9 7A C6 B3 A C7 6A 83 B
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D
Give the synthesis and application of the Esomeprazole.

AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67F
6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F EB
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67 EB BE
How biocatalysts act as a green catalysts? Give two examples.

DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE B 7D
99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE BB E7D 97

83DB99DA67FEBBE7D97A1C6B3AAC7B6A
Explain the use of functional groups in prodrugs with advantages.

DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B E7 9 A1
67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB BE7 D9 7A1 C6
FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB E D 7A C B3
BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE 7D 97A 1C 6B AA
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7D 97A 1C 6B 3A C7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D 97 1 6B 3A AC B
7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7 97 A1 C6 3A AC 7B 6A
1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9 A1 C6 B3A A 7B 6A 83D
6B 3A C B6 A8 DB 99 A 7F EB E D9 7A C6 B3 A C7 6A 83 B
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7A 1C B3 AA C7 B6 83 DB 99D
Explain the pathway involved in the biosynthesis of non-essential amino acids.

AC 7B 6A 3D B9 DA 67 FE BE 7D 97A 1C 6B AA C7 B6 A8 DB 99 A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1C 6B 3AA C7 B6 A8 3DB 99 DA 67
How isomerism is important in changing the level of drug distribution in the body?

6A 83D B9 9D 6 FE BB 7D 97 1 6B 3A C B6 A8 3D 99 DA 67F
83 B 9D A6 7FE BB E7 97 A1 C6B 3A AC 7B A8 3D B9 DA 67
DB 99 A 7F B E D9 A C6 3 A 7B 6A 3D B9 9D 6 FE
99 DA 67F EB BE 7D9 7A 1C6 B3 AA C7B 6A 83D B9 9D A6 7FE
DA 67 EB BE 7D 7A 1C B AA C7 6 83 B 9D A 7F B
67 FEB BE 7D 97A 1C 6B 3AA C7 B6 A83 DB 99D A6 67F EBB
FE B 7D 97 1 6B 3A C B6 A8 D 99 A 7F EB
BB E7 97 A1 C6 3A AC 7B A 3D B9 DA 67 EB BE
E7 D9 A1 C6 B3A AC 7B 6A 83D B9 9DA 67 FE BE 7
D9 7A C6 B3 A 7B 6A 83 B9 9D 6 FE BB 7D
7A 1C B3 AA C7 6A 83 DB 9D A6 7FE BB E7
12

1C 6B AA C7 B6 83 DB 99D A6 7F BB E7 D9
6B 3A C B6 A8 DB 99 A 7F EB E D9
3A AC 7B A8 3D 99 DA 67 EB BE 7D 7
AC 7B 6A 3D B9 DA 67 FE BE 7D 97A
7B 6A 83D B9 9DA 67 FE BBE 7D 97A 1
6A 83D B9 9D 6 FE BB 7D 97 1
8
Paper / Subject Code: 74854 / Chemistry: Organic Chemistry Medicinal And Biogenesis Green Chemsitry (R-2018-19

B 9 A 7F B E 9 A C