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ORIGINAL RESEARCH

T FFECTS OF CHROMOTHERAPY ON THE COGNITIVE


AGEDH1E
ABILITY OF OLDER ADULTS: A QUASI-EXPERIMENTAL
STUDYAGEDNTE
Emmanuel D. Paragas Jr, DNS, RN,a,b,* Abigail Therese Y. Ng, RN,a Denice Victoria L. Reyes, RNa and
Gerald Andrei B. Reyes, RNa

Objective: This study aimed to assess the effects of chromother- However, the effects were not significantly different between the
apy on the cognitive ability of older adults. red and green lights postintervention (p > 0.05).
Methods: This quasi-experimental pretest and posttest study was Conclusion: The chromotherapy is effective in improving the
conducted among 135 older adults in Ilocos Sur, Philippines, cognitive ability of older adults. Specifically, the red and green
between August and September 2015. The participants were lights are better than the white light in increasing the cognitive
divided into three groups: red, green, and white lights, with 45 ability of older adults.
people in each group. The cognitive ability of older adults was
measured using an adapted MiniMental State Exam (MMSE). Keywords: Chromotherapy, Cognitive ability, Older adults
Results: After the interventions, the red and green light experi-
(Explore 2019; 15:191197 © 2019 Elsevier Inc. All rights reserved.)
mental groups acquired a modest increase in cognitive ability
scores against the comparison white light group (p < 0.001).

What is already known about the topic? whereas the green light significantly improved the registration,
orientation, recall, and attention and calculation scores
 The cognitive impairment among older adults is rising world- among older adults.
wide. Thus, the prevalence of age-related health problems is
becoming a major public health concern.
 Chromotherapy is a centuries-old concept that was practiced
in the ancient times which could play an important role in
INTRODUCTION
improving the cognitive ability of older adults.
 There is a dearth in literature and issues in the use of chromother- Aging comes with deterioration in performance of several cogni-
tive tasks that involve a variety of cognitive processes.23 Cogni-
apy. This present study is one of the first to explore the effects of
tive impairment among older adults is rising worldwide, and it is
chromotherapy on the cognitive ability of older adults.
projected to grow proportionally in developing regions31. In
2050, the number of people older than 60 years will be
What this paper adds?
around 2 billion, or 22% of the world’s population. Projec-
 Chromotherapy is effective and seems promising as an alter- tions suggest that four fifths of older adults will be living in
Asia, Africa, or Latin America34. Furthermore, older adults
native and complementary approach in increasing the cogni-
with cognitive impairment visit hospitals over 3 times more
tive ability among older adults.
 Chromotherapy had a modest effect on increasing the cogni- often than those admitted for other conditions.2 Thus, the
prevalence of age-related health problems is becoming a
tive ability of older adults that implies a high practical signifi-
major public health concern31.
cance.
 The red light is effective in increasing the recall, attention and Improving one’s memory can be one of the most intriguing
queries in contemporary memory research.6 Thus, several inter-
calculation, and language and praxis scores of older adults,
ventions involving the cognitive, social, and physical activity have
been growing, which may lessen the risk of cognitive decline.17
Specifically, cognitive interventions such as cognitive training pro-
a College of Nursing, University of Santo Tomas, Espa~
na Blvd., Sampa-
grams22 and memory training interventions10 are aimed at improv-
loc, Manila, Philippines
b Nursing Services Department, JW Ruby Memorial Hospital, West Virginia ing the cognitive performance of older adults. It is noteworthy
University Medicine, Morgantown, WV, USA that several studies exploring the effects of such interventions
* Corresponding author. have revealed that there is a great potential to modify the cognitive
e-mail: emmanparagasjr@yahoo.com abilities and brain activity among the older adults.14

© 2019 Elsevier Inc. All rights reserved. EXPLORE May/June 2019, Vol. 15, No. 3 191
ISSN 1550-8307/$36.00 https://doi.org/10.1016/j.explore.2019.01.002
However, complementary therapies like chromotherapy could A total of 135 older adults were selected through purposive
play an important role in improving the cognitive ability of sampling. The participants were assigned into the three groups:
older adults. Chromotherapy is a centuries-old concept that was the red group (n = 45), the green group (n = 45), and the white
practiced in ancient Egypt, Greece, India, and China where peo- group (n = 45). Those who were 5580 years old, able to read
ple had faith in the healing properties of colors. It is a system of and write, able to speak and understand Ilokano, and living in
procedures that makes use of the visible spectrum of electromag- Cabugao, Ilocos Sur, were included in the study. However, those
netic radiation in curing ill health.3 It was believed that a per- who had conditions that might cause impairment in memory,
son’s arousal may be affected by color, while the memory may such as but not limited to Alzheimer’s disease and dementia,
be enhanced through arousal.24,13 Hence, several studies in the and patients with eye defects like glaucoma, diabetic retinopa-
past have explored the effects of color on memory, establishing thy, and color blindness, were excluded.
that color has various effects such as an increase in memory
recall,28 memory recognition,33 and memory retrieval.32 How- Interventions
ever, it is remarkable that a hypothesis about color having an The interventions were developed and pretested in a pilot study.
important role in human comprehension and, in effect, on Specifically, this study used LED light for each group: (1) the
thinking and human conduct18 was put into question after a fail- red and (2) the green for the experimental groups; (3) the white
ure to replicate was reported about the color-priming effect on for the comparison group. The LED lights were hung 210 cm
the solution of anagrams.30 Although there is a dearth of litera- above the floor inside a 4 £ 4 well-ventilated room. The partici-
ture on the use of chromotherapy, it might yield an increase pants entered the room by group, and then each group was
in the cognitive aspects of memory.3 This present study is one of exposed to its assigned 2500 lux LED light for 15 min. The older
the first that explores the effects of chromotherapy on the cogni- adults were instructed to avoid direct eye contact with the LED
tive ability of older adults. light to prevent the risk of blindness. The researchers prepared
for immediate medical assistance in case of any emergency. How-
Chromotherapy conceptual framework ever, there was no noted event of any medical emergency
This study used the concepts from Florence Nightingale’s philos- throughout the course of the study.
ophy of nursing regarding the environment.20 Nightingale pro- The older adults remained seated for only 15 min while being
posed that the nurse could manipulate the environment to exposed to the assigned LED light to prevent possible skin and
initiate a positive response from the patient. Specifically, the optical damage due to the degenerative changes as part of their
effects of variety and light could transform the environment to aging process. Each group was exposed to either red, green, or
be more conducive for healing. Variety is the changing of envi- white LED light for a single time. Then, the effects of the LED
ronmental factors in order to achieve a positive response, while lights on the cognitive ability were assessed immediately using a
the light serves as one of the factors comprising the “designed valid and reliable instrument after the older adults were exposed
environment”.35 Hence, this idea suggests that healing is to their assigned intervention.
achieved in the sense that the environment stimulates the per-
son’s well-being positively. Nightingale cited an example about Instruments
the need for changes in color and form by bringing brightly col- The participants were required to provide a sociodemographic
ored flowers and exposing the patients to the sunlight, allowing and medical history, such as such as age, sex, year of birth, and
them to show a positive response with regard to their health con- locality. A checklist was also used to identify the following dis-
ditions.35 In this study, Nightingale’s philosophy about the envi- eases: Alzheimer’s, dementia, diabetic retinopathy, Huntington’s
ronment was utilized by using the combination of variety and chorea, amnesia, delirium, vascular stroke, schizophrenia, and
light through the use of chromotherapy in inducing an improve- brain trauma.
ment in the cognitive ability of older adults. Furthermore, the study adapted the MiniMental State Exam
(2nd ed.), Standard Version, to identify the cognitive ability of
the older adults. Psychological Assessment Resources (PAR)
Aim
states that the MMSE is well-known to aid in clinical cognitive
This study aimed to assess the effects of chromotherapy on the
mental state examination. A forward translation to Ilokano and a
cognitive ability of older adults in the province of Ilocos Sur in
back-translation to English were performed by two independent
the Philippines. Specifically, it was hypothesized that chromo-
professional translators. Then, the final Ilokano version of the
therapy would significantly improve the cognitive ability of
MMSE was validated by a panel of experts: a psychologist, a psy-
older adults.
chiatric nurse, and a psychiatrist with a scale-level content valid-
ity index of 1.00. The panel-modified Ilokano version acquired a
Cronbach’s alpha of 0.88 after it was pilot-tested among 45 older
MATERIALS AND METHODS adults.
The MMSE examines the older adult’s mental state on these
Study design and participants specific areas: (1) orientation to time and place; (2) capacity to
This study used quasi-experimental pretest and posttest design register and recall information through familiarization of three
with two experimental groups (red and green) and a comparison unrelated objects; (3) attention and calculation abilities by being
group (white). The sample size estimate was determined on the asked to subtract or add seven from 100; (4) naming ability by
priori power analysis (medium effect size = 0.5; significance being asked to identify the name of an object that the interviewer
level = 0.05; power = 80%) using G*Power software in Mac OS. is pointing at; (5) repetition by being asked to repeat certain

192 EXPLORE May/June 2019, Vol. 15, No. 3 Effects of Chromotherapy on the Cognitive Ability of Older Adults
sentences mentioned by the interviewer; (6) comprehension by Ethical considerations
being asked to point out a geometric figure that is similar to a The study was approved by the Ethics Review Board in the Col-
picture to which the interviewer is referring; (7) reading, writing, lege of Nursing at the University of Santo Tomas (USTCON-
and drawing by being asked to write a sentence and copy two 2015-SR31), and the office of the mayor of Cabuago, Ilocos Sur.
intersecting figures in the stimulus page. One point is given for Also, the study was conducted in accordance with the Helsinki
each correct answer, with a perfect score being 30 points. Higher Declaration of 1995. A signed informed consent was secured
scores represent better mental states in the older adults. Specifi- from all of the participants, with an assurance of privacy, ano-
cally, the interpretation of the scores are as follows: a score of nymity, and confidentiality. In addition, the researchers
017 indicates severe cognitive defect, a score of 1823 signifies obtained permission from the office of the PAR to use and trans-
mild cognitive impairment, and a score of 2430 implies no late the MMSE into Ilocano.
cognitive impairment.7
Data analyses
Data collection The descriptive statistics were used to describe the demographics
The Senior Citizen Center in the town of Cabugao, Ilocos Sur, of the participants. The mean was used to establish the average
served as the clinical site for pilot testing among 45 older adults. of the pretest and posttest scores in the MMSE among the three
Also, the actual data collection was conducted in the same clini- groups. Paired t-tests were utilized to determine significant differ-
cal site between August and September 2015. ences between the pretest and posttest scores for each group.
The data collection (Fig. 1) was conducted in a 4 £ 4 well-ven- ANOVA determined the significant differences among the post-
tilated room. Excluding the participants from the pilot testing, test scores of the three groups. Then, Tukey’s test was used in the
the actual data collection was conducted over two consecutive post hoc analysis. The level of significance was set at the p-value
Sundays. Specifically, there were two separate sessions on the  0.05. The statistical analyses were performed using IBM SPSS
first Sunday: the morning group was assigned to the white com- Statistics (IBM Corp., Armonk, NY) Version 21.0 and Review
parison group (n = 45), while the afternoon group was Manager (RevMan; Copenhagen: The Nordic Cochrane Centre,
assigned to the green experimental group (n = 45). Subse- The Cochrane Collaboration) for Mac OS X, Version 5.3.
quently, the second Sunday group was allocated to the red
experimental group (n = 45). All of the participants were
blind to whether they belonged to an experimental group or RESULTS
the control group to minimize bias. Overall, the experimen-
tal and control groups received pretesting for cognitive per- Participant characteristics
formance and exposure to the assigned intervention, and A total of 135 older adults were found to be eligible to partici-
participants received a posttest of their cognitive performance pate in the study from the 150 who were screened prior to data
immediately after the intervention. collection (Fig. 1). These older adults were non-randomly

Fig. 1. The flow of participants for each stage in this study.

Effects of Chromotherapy on the Cognitive Ability of Older Adults EXPLORE May/June 2019, Vol. 15, No. 3 193
Table 1. Characteristics of older adults across the three groups
Demographic Red light Green light White light p-value
Age (y), mean (§SD) 67.56 (§ 7.21) 67.16 (§ 7.55) 66 (§ 6.64) 0.56a
Sex
Male, n (%) 13 (29) 12 (27) 16 (14.5) 0.63b
Female, n (%) 32 (71) 33 (73) 29 (18.8)
a
ANOVA.
b
X2 test.

Table 2. Overall MMSE mean scores of older adults in the three groups
MMSE mean score (§SD)
Group Pretest (before the intervention) Posttest (immediately after the intervention) t-value (p-value) SMD (95% CI)
Red light (n=45) 25.02 (§ 3.98) 27.24 (§ 2.46) ¡3.90 (0.001) 0.67 (0.251.09)**
Green light (n=45) 24.29 (§ 5.16) 27.28 (§ 2.75) ¡4.49 (0.001) 0.84 (0.411.27)**
White light (n=45) 25.24 (§ 4.48) 25.64 (§ 3.91) ¡0.68 (0.50) 0.09 (¡0.320.51)
MMSE, Mini mental state exam; SMD, Standardized mean difference; CI, Confidence interval.
** Statistically significant at p <0.001.

assigned equally to the three groups. The mean age of the older that both the red and green light groups obtained significantly
adults were 67.56 § 7.21, 67.16 § 7.55, and 66 § 6.64 in the higher posttest scores when compared to the white light group
red, green, and white light groups, correspondingly. On the (p <0.05). However, no significant difference was found between
other hand, the majority of the participants were female in the posttest scores of the red and green light groups (p >0.05).
the red (71%), green (73%), and white (64%) groups. Both the A comparison of the mean scores of the older adults for each
age and sex in the three groups were found to have no significant MMSE subset was analyzed to further examine the effects of
differences (p >0.05; see Table 1). chromotherapy (Table 4). On the one hand, the older adults in
the red light group acquired a significant change in their posttest
scores specifically in the recall (p <0.001), attention and calcula-
Effects of chromotherapy on the cognitive ability of older
tion (p <0.05), and language and praxis (p <0.05). On the other
adults
hand, the green light group obtained a significant increase in
There were significant differences identified in the overall
four out of five MMSE subsets, such as registration (p <0.001),
MMSE mean scores in both the red and green light groups
orientation (p <0.001), recall (p <0.001), and attention and cal-
before and immediately after their corresponding interventions
culation (p <0.05). However, the white group only attained a sig-
(p <0.001) (Table 2). However, no significant increase was found
nificant change in the recall subset (p <0.05).
in the white light group (p >0.05) (Table 2).
The older adults among the three groups were grouped
The results of the ANOVA (table not shown) revealed no sig-
according to the severity of cognitive impairment based from
nificant difference among the overall pretest MMSE mean scores
their MMSE mean scores (Table 5). It was remarkable that those
of older adults in the three groups (F ratio = 0.54; df = 2,134;
who have severe cognitive impairment before being exposed to
p >0.05). However, a significant change was found among the
chromotherapy significantly improved to mild cognitive
MMSE mean scores of older adults in the three groups after they
impairment (M = 23.73; SD = 4.52; p <0.001), while those older
received their corresponding interventions (F ratio = 5.76;
adults with mild cognitive impairment prior to the intervention
df = 2,134; p <0.05). Tukey’s post hoc analysis in Table 3 revealed
attained a significant increase to no cognitive impairment
(M = 26.28; SD = 3.15; p <0.001), and those who have no cog-
Table 3. Comparison of the cognitive ability scores between groups nitive impairment remained the same after being exposed to
post-interventions chromotherapy (M = 27.58; SD = 2.75; p >0.05).
MMSE posttest
Variable Mean p-valuea SMD (95% CI)
difference DISCUSSION
This quasi-experimental study is one of the first to explore the
Red light vs. Green light 0.53 0.69 ¡0.02 (¡0.430.38)
effects of chromotherapy on the cognitive ability of older adults.
Red light vs. White light 1.60 0.04 0.49 (0.070.91)*
In the initial assessment, the mean MMSE scores of each group
Green light vs. White light 2.13 0.004 0.48 (0.070.90)*
were greater than 24, which suggests that they had no cognitive
MMSE, mini mental state exam; SMD, standardized mean difference; CI, confidence
impairment (Table 2). However, when the subjects from the
interval.
a
Tukey’s test. three groups were grouped according to their respective mean
* Statistically significant at p <0.05. scores, there were older adults who have mild, severe, and no

194 EXPLORE May/June 2019, Vol. 15, No. 3 Effects of Chromotherapy on the Cognitive Ability of Older Adults
Mean a Difference
cognitive impairments (Table 5). On the one hand, it is notewor-

¡0.42 (0.01)*
(p-value)
thy that after the interventions the red and green lights acquired

¡0.04 (0.77)
¡0.00 (1.00)

¡0.00 (1.00)
0.07 (0.68)
a modest increase in the MMSE mean scores against the compar-
ison white light (Table 3). On the other hand, those older adults
with severe and mild cognitive impairment prior to chromother-
apy significantly improved to the level of mild and no cognitive
impairment, respectively (Table 5). These findings corroborated
White Light

2.64 (§ 0.83)
8.91 (§ 1.65)
2.40 (§ 1.01)
3.82 (§ 1.50)
7.87 (§ 1.08)
Post-test M
the significant effects of chromotherapy in the improvement of
(SD)
the cognitive ability among older adults.
In chromotherapy, the color is a form of an electromagnetic
energy and visible light. When the energy enters the cones (pho-
toreceptors) in the retinas, it is translated into colors, which then
2.60 (§ 0.78)
8.91 (§ 1.47)
1.98 (§ 1.16)
3.82 (§ 1.70)
7.93 (§ 1.05)
stimulate the pituitary and pineal glands to produce some hor-
Pre-test M
(SD)

mones that affect various physiological processes such as tuning


the coordination of organ functions and controlling behavioral
rhythms.3,5,8 Specifically, the hormones serotonin and endor-
phins are believed to be produced in response to the light
Mean a Difference

energy; these hormones maintain one’s psychological well-being


¡0.42 (0.001)**
¡1.22 (0.001)**
¡0.78 (0.001)**

and balance mood, feelings, and behaviors.4,9,29 In this study,


¡0.69 (0.01)*
(p-value)

¡0.38 (0.06)

the chromotherapy was used to improve the cognitive ability of


older adults. Specifically, the red light was found to be effective
in increasing the recall, attention and calculation, and language
and praxis scores of older adults, while the green light enhanced
the registration, orientation, recall, and attention and calculation
Green Light

2.96 (§ 0.21)
9.42 (§ 1.08)
2.69 (§ 0.67)
4.51 (§ 1.36)
8.20 (§ 0.87)
Post-test M

scores. However, the white light was only effective in increasing


(SD)

the recall scores in the MMSE (Table 4). The color plays a vital
part in enhancing our attention level, which in turn helps the
memory to be stored in more permanent storage16,21. Further-
more, the hormones produced in response to color may contrib-
Comparison of the mean scores of older adults for each MMSE subset in the three groups

2.53 (§ 0.73)
8.20 (§ 1.90)
1.91 (§ 1.16)
3.82 (§ 1.61)
7.82 (§ 1.17)

ute to alertness and emotional arousal, which have a significant


Pre-test M

relationship with memory.19,16 Specifically, a better retention in


(SD)

long-term recall was found for those with a high level of emo-
tional arousal as well as improvement in short-term and long-
term memory.12,32 The results in this study support the effective-
ness of color therapy in improving the memory of older
Mean a Difference

¡0.64 (0.001)**

adults.32,19,16,6
¡0.64 (0.02)*
¡0.36 (0.04)*
(p-value)
¡0.18 (0.25)
¡0.40 (0.09)

Previous studies have shown that each color produces differ-


ent psychological effects, and age is an important factor affecting
emotional behaviors in response to the color1. The MMSE
scores of both the red and green light groups were found to have
a significant increase against the white light after the intervention
2.69 (§ 0.73)
9.36 (§ 0.83)
2.56 (§ 0.79)
4.24 (§ 1.21)
8.40 (§ 0.72)
Red light

(Table 3). This finding corroborates the effectiveness of the red


Post-test M

and green lights in improving the cognitive ability of older


(SD)

MMSE, Mini mental state exam; M, Mean; SD, Standard deviation

adults. Although the green light obtained a larger effect size than
the red light, the effects were not significantly different between
the two colors (Table 3). The green color brings psychological
2.51 (§ 0.82)
8.96 (§ 1.26)
1.91 (§ 1.04)
3.60 (§ 1.78)
8.04 (§ 1.09)

and emotional harmony that could help stabilize emotions and


Pre-test M

provide a soothing influence in the mind and body, whereas the


(SD)

red color stimulates the release of adrenalin to provide greater


energy and stimulation, helping to energize all the organs and
** Statistically significant at p <0.001.
* Statistically significant at p <0.05.

the senses27. However, a number of studies claim warm colors


especially both the red and green lights could help stimulate
Attention and calculation

one’s brain activity to increase the perceived activation levels


Language and praxis

and vigilance, which have a significant relationship with the


improvement of memory11,15,25,26. Furthermore, it is believed
MMSE subsets

paired t-test.

that chromotherapy uses seven colors of the spectrum to


Registration
Orientation
Table 4.

improve mental being, and all have the ability to affect body
Recall

vibrations and frequencies, which in turn affect health, welfare,


a

and harmony. The red and green lights are included in this

Effects of Chromotherapy on the Cognitive Ability of Older Adults EXPLORE May/June 2019, Vol. 15, No. 3 195
Table 5. Overall MMSE scores of older adults in the three groups according to severity of cognitive impairment
Red, Green, and White groups (n = 135)
Severity of cognitive impairment n (%) Pre-test M (SD) Post-test M (SD) Mean a Difference (p-value)
Severe cognitive impairment 11 (8.1) 14.55 (§ 2.46) 23.73 (§ 4.52) y ¡9.18 (0.001) **
Mild cognitive impairment 39 (28.9) 21.49 (§ 1.68) 26.28 (§ 3.15) z ¡4.80 (0.001) **
No cognitive impairment 85 (63) 27.73 (§ 1.86) 27.58 (§ 2.75) z 0.15 (0.61)
MMSE, Mini mental state exam; M, Mean; SD, Standard deviation
a
paired t-test.
** Statistically significant at p <0.001.
y
Mild cognitive impairment (1823).
z
No cognitive impairment (2430).

spectrum of colors but not the white light, which possibly study recommends the use of chromotherapy to increase the
explains the ineffectiveness of the white light in this study on cognitive ability among older adults.
improving the mental states of older adults27.
In this study, the concepts present in the philosophy of nurs- Practice implications
ing regarding the environment20 form the basis of the therapeu- The nurses could control the environment to initiate a positive
tic effect of chromotherapy in improving the cognitive ability response from their patients. Specifically, chromotherapy could
among older adults. Specifically, the nurse could manipulate the provide an environment that is favorable to enhancing the atten-
environment of the patients to initiate a positive response from tion level and alertness of older adults which could lead to the
the patients. The effects of color and light present in the chro- improvement in their cognitive ability. Thus, this innovative
motherapy provided an environment that is conducive to approach could be adopted by nurses in the community and
enhancing the attention level and alertness of the older adults, long-term care facilities. Furthermore, this study adds to the
which led to significant improvement in their cognitive ability. nursing literature about the positive effects of chromotherapy
Therefore, the findings suggest that nurses could initiate a posi- among older adults in enhancing their cognitive ability. How-
tive response to health from their patients through the manipula- ever, further research is needed on a larger sample size and vari-
tion of environment. ous settings to ascertain the effects of chromotherapy on the
The study has some limitations. The participants were chosen cognitive ability of older adults.
purposively using nonrandom sampling, which could result in
selection bias. This study strictly followed the set inclusion and
exclusion criteria for all the participants and established the simi- DISCLOSURE OF INTEREST
larity in their demographic characteristics to minimize the bias. The authors report no conflict of interest.
Furthermore, the internal factors concerning the memory reten-
tion of participants, such as emotions, mood, and past experien-
ces, were not assessed prior to data collection, which could lead
ACKNOWLEDGMENTS
to maturation bias. However, the average baseline scores before
The authors are grateful to the people of Senior Citizen Center
the intervention were acquired by only one of the researchers,
at Cabugao, Ilocos Sur, most especially to the senior citizens for
who was trained to use the valid and reliable MMSE tool. More-
participating in this study. The authors would also like to express
over, the participants were unaware of group allocation to pre-
their gratitude to the validators and translators of the instru-
vent them from influencing the results or the Hawthorne effect.
ments used in this study as well as to the research board and
The analysis of MMSE scores according to severity of cognitive
ethics review board in the College of Nursing at the University
impairment should be interpreted with caution due to a small
of Santo Tomas for the approval of the study protocol.
sample size of older adults with mild and severe cognitive
impairment among the three groups. However, despite the small
sample size, this study revealed modest effect sizes of the inter-
ventions after addressing several biases. SUPPLEMENTARY MATERIAL
Supplementary material associated with this article can be found,
in the online version, at doi:10.1016/j.explore.2019.01.002.

CONCLUSION
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