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A

SAFETY DATA SHEET


according to Regulation (EC) No. 1907/2006

Product: TETRAHYDROTHIOPHENE (THT) Page: 1 / 9

SDS No.: 001974-001 (Version 3.2 ) Date 19.09.2012 (Cancel and replace : 28.12.2011)

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1. Identification of the product

Substance name:
REACH Registration Name: Tetrahydrothiophene
REACH Registration Number: 01-2119489799-07-0000
EC Nr: 203-728-9
CAS-No.: 110-01-0

1.2. Relevant identified uses of the substance or mixture and uses advised against
Use of the Substance/Mixture :
Sector of use : Product category :
Injection in gas PC28: Perfumes, fragrances
SU23: Electricity, steam, gas water supply and sewage treatment
Distribution of the substance
SU 3: Industrial uses: Uses of substances as such or in preparations
at industrial sites

1.3. Details of the supplier of the safety data sheet

Supplier Arkema
THIOCHIMIE
420 rue d’Estienne d'Orves
92705 Colombes Cedex, France
Téléphone : +33 (0)1 49 00 80 80
Télécopie : +33 (0)1 49 00 83 96
http://www.arkema.com
E-mail address pars-drp-fds@arkema.com

E-mail address : Exposure scenario ARKEMA-THIOCHEM-REACH-USES@arkema.com

1.4. Emergency telephone number

+33 1 49 00 77 77
European emergency phone number : 112

2. HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

Classification (Regulation (EC) No 1272/2008):


Flammable liquids, 2, H225
Oral: Acute toxicity, 4, H302
Dermal: Acute toxicity, 4, H312
Inhalation: Acute toxicity, 4, H332
Skin irritation, 2, H315
Eye irritation, 2, H319
Chronic aquatic toxicity, 3, H412

Classification (Directive 67/548/EEC):

F; R11
Xn; R20/21/22
Xi; R36/38
R52/53

Additional information:
For the full text of the R, H, EUH-phrases mentioned in this Section, see Section 16.

2.2. Label elements

Label elements (REGULATION (EC) No 1272/2008):

Hazardous components which must be listed on the label:

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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SDS No.: 001974-001 (Version 3.2 ) Date 19.09.2012 (Cancel and replace : 28.12.2011)

No. in ANNEXE : 613-087-00-0 tetrahydrothiophene

Hazard pictograms:

Signal word: Danger

Hazard statements:
H225 : Highly flammable liquid and vapour.
H302 : Harmful if swallowed.
H312 : Harmful in contact with skin.
H332 : Harmful if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H412 : Harmful to aquatic life with long lasting effects.

Precautionary statements:
Prevention:
P210 : Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P273 : Avoid release to the environment.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response:
P303 + P361 + P353 : IF ON SKIN (or hair): Remove/ Take off immediately all contaminated clothing. Rinse skin with water/ shower.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Storage:
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.

2.3. Other hazards

Potential health effects:

Ingestion may cause irritation to mucous membranes.


Irritation: Irritating to eyes and skin.
Inhalation: At high vapour/fog concentrations : Irritation of upper respiratory system headache Dizziness Nausea

Environmental Effects:
Harmful to daphnia. Not readily biodegradable. Not bioaccumulable.

Physical and chemical hazards:


Highly flammable. Thermal decomposition giving flammable and toxic products.
Decomposition products: See chapter 10

Other:
Results of PBT and vPvB assessment : According to REACH regulation, annex XIII, the substance does not meet PBT and vPvB criteria.

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1.Substances
1
Chemical name of the substance : TETRAHYDROTHIOPHENE (THT)

Classification
1 Classification
Chemical Name EC-No. CAS-No. Concentration Directive
Regulation (EC) No 1272/2008
67/548/EEC
Tetrahydrothiophene 203-728-9 110-01-0 >= 98 % R52/53 Flam. Liq. 2; H225
Xi; R36/38 Acute Tox. 4 (Oral); H302
Xn; R20/21/22 Acute Tox. 4 (Dermal); H312
F; R11 Acute Tox. 4 (Inhalation); H332
Skin Irrit. 2; H315
Eye Irrit. 2; H319
Aquatic Chronic 3; H412

1
: See chapter 14 for Proper Shipping Name

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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4. FIRST AID MEASURES

4.1. & 4.2. Description of necessary first-aid measures & Most important symptoms/effects, acute and delayed:

General advice:
Take off immediately all contaminated clothing.

Inhalation:
Move to fresh air. Oxygen or artificial respiration if needed. Keep under medical surveillance. In case of problems : Hospitalise.

Skin contact:
Wash off immediately with soap and plenty of water. If significant contact: Keep under medical surveillance. Hospitalise.

Eye contact:
Wash well-open eyes immediately, abundantly and thoroughly with water. Consult an ophthalmologist.

Ingestion:
If the subject is unconscious, do not induce vomiting
Hospitalise.

Protection of first-aiders:
In case of insufficient ventilation, wear suitable respiratory equipment.

4.3.Indication of immediate medical attention and special treatment needed, if necessary : No data available.

5. FIREFIGHTING MEASURES

5.1.Extinguishing media

Suitable extinguishing media: Foam, Dry powder, Carbon dioxide (CO2)

Unsuitable extinguishing media: High volume water jet

5.2. Special hazards arising from the substance or mixture:


Highly flammable, Possible re-ignition of vapours from a distance
Thermal decomposition giving flammable and toxic products :
Hydrogen sulphide, Sulphur oxides, Carbon oxides

5.3. Advice for firefighters:

Specific methods:
Cool containers / tanks with water spray. In case of fire, remove exposed containers.

Special protective actions for fire-fighters:


Wear self-contained breathing apparatus and protective suit.

6. ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures:


Evacuate non-essential staff and those not equipped with individual protection apparatus. Prohibit all sources of sparks and ignition - Do not
smoke. Avoid contact with skin and eyes and inhalation of vapours. Use personal protective equipment. In case of leak, wear a self-contained
breathing apparatus.

6.2. Environmental precautions:


Do not release into the environment. Do not let product enter drains. Dam up with sand or inert earth (do not use combustible materials).

6.3. Methods and materials for containment and cleaning up:

Recovery:
Pump into a labelled inert emergency tank. Absorb the remainder with an inert absorbent material.

Elimination:
Destroy product by oxidation with dilute solutions of : Hydrogen peroxide or sodium hypochlorite
or Destroy the product by incineration (in accordance with local and national regulations).

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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6.4. Reference to other sections: None.

7. HANDLING AND STORAGE

7.1. Precautions for safe handling:

Technical measures/Precautions:
Storage and handling precautions applicable to products: Liquid. Highly flammable Harmful. Irritant. With vapours explosive in air. Provide
appropriate exhaust ventilation at machinery. Provide showers, eye-baths. Provide water supplies near the point of use. Provide self-
contained breathing apparatus nearby.

Safe handling advice:


Keep well away from naked flames. Do not use air for transfers. Prohibit all sources of sparks and ignition - Do not smoke. Take
precautionary measures against static discharges. Only use safety equipment.

Hygiene measures:
Avoid contact with the skin and the eyes. Avoid inhalation of vapours. When using do not eat, drink or smoke.
Wash hands after handling. Remove contaminated clothing and protective equipment before entering eating areas.

7.2. Conditions for safe storage, including any incompatibilities:


Keep containers tightly closed in a cool, well-ventilated place. Store protected from air. Store away from heat and ignition sources. Provide a
catch-tank in a bunded area. Provide electrical earthing of equipment and electrical equipment usable in explosive atmospheres.

Incompatible products:
Strong oxidizing agents

Packaging material:
Recommended: Carbon steel, Stainless steel, Lined metallic drums., Joints : polyethylene, Rilsan ®, polytetrafluoroethylene (PTFE)
To be avoided: Copper and copper alloys

7.3. Specific end uses: None.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters:

Exposure Limit Values

Tetrahydrothiophene
Source Date Value type Value Value Remarks
(ppm) (mg/m3)
ARKEMA 2008 TWA 50 180 Value recommended by the "Exposure Limit Value Committee" of
ARKEMA

Derived No Effect Level (DNEL):

End Use Inhalation Ingestion Skin contact


Workers 180 mg/m3 (ST, LE) 7,5 mg/kg bw/day (LT, SE)
180 mg/m3 (LT, LE, SE)

Consumers 18,5 mg/m3 (LT, SE) 2,7 mg/kg bw/day (LT, SE)
21 mg/m3 (LT, LE)

LE : Local effects, SE : Systemic effects, LT : Long term, ST : Short term

Predicted No Effect Concentration (PNEC):

Compartment: Value:
Fresh water 0,024 mg/l
Marine water 0,0024 mg/l
Water (Intermittent release) 0,24 mg/l
Effects on waste water treatment plants 31 mg/l
Fresh water sediment 0,1361 mg/kg dw
Marine sediment 0,0136 mg/kg dw
Soil 0,132 mg/kg dw

8.2. Exposure controls:

General protective measures: Ensure sufficient air exchange and/or exhaust in work areas

Personal protective equipment:

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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Respiratory protection: Low concentrations or short activity: No special protective equipment required.
High concentrations or prolonged activity: Self contained Breathing Apparatus
Hand protection: Splash contact, intermittent and prolonged Gloves nitrile rubber
Glove thickness: 0,75 mm
Protective gloves complying with EN 374.
Eye/face protection: Safety glasses with side-shields
Skin and body protection: At the workplace : Combination with delayed penetration
Intervention at incident: anti-acid suit

Environmental exposure controls:


See chapter 6

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Appearance:
Physical state (20°C): liquid
Colour: colourless
Odour: stinging
Olfactory threshold: 1 ppb
pH: No data available.
Melting point/range : -96,2 °C
Boiling point/boiling range : 119 - 121 °C
Flash point: 17,5 °C (1.013 hPa) (A9 Method (D. 92/69/ECC))
Evaporation rate: No data available.
Flammability (solid, gas):
Lower flammable limit : 1,1 %(V)
Upper flammable limit : 12,1 %(V)
Vapour pressure: 24 hPa , at 25 °C
Relative vapour density: 3,04 Reference substance: Air=1
Density: 1.000 kg/m3 , at 20 °C
Relative density (Water=1): 1,0 at 20 °C
Water solubility: 5,8 g/l at 20 °C (OECD Test Guideline 105)
Partition coefficient: n-octanol/water: log Kow : 1,8 , at 20 °C (calculated)
Autoignition temperature: 215 °C
Decomposition temperature: 640 °C
Viscosity, dynamic: 1,60 mPa.s , at 20 °C
1,29 mPa.s , at 40 °C
Explosive properties:
Explosivity: Not relevant (due to the chemical structure)
Oxidizing properties: Not relevant (due to the chemical structure)

9.2. Other data:

Solubility in other solvents: Soluble in: Alcohols , Ethyl ether , Acetone , Chloroform , hydrocarbons
3
Henry constant: 36,48E+00 Pa.m /mol (calculated)
Molecular Weight: 88,17 g/mol
Refractive index: 1,505 at 20 °C
Critical point: Critical pressure: 5,6 MPa, Critical temperature: 306 °C

10. STABILITY AND REACTIVITY

10.1. & 10.2. Reactivity & Chemical stability:


The product is stable under normal handling and storage conditions.

10.3. Possibility of hazardous reactions: No data available.

10.4. Conditions to avoid:


Keep away from heat and sources of ignition. Keep in a dry place.

10.5. Incompatible materials to avoid:


• Reacts violently with :, Strong oxidizing agents, Hydrogen peroxide, Nitric acid, Hypochlorites

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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10.6. Hazardous decomposition products:

Thermal decomposition:
Decomposition temperature: 640 °C
Thermal decomposition giving flammable and toxic products :, Hydrogen sulphide, Sulphur oxides, Carbon oxides

11. TOXICOLOGICAL INFORMATION

Toxicokinetics (absorption, metabolism, distribution and elimination):

According to limited available data in animals :


Mainly eliminated in urine.
11.1. Information on toxicological effects:

Acute toxicity:

Inhalation: Practically not harmful by inhalation


• In man : At high vapour/fog concentrations :
headache, Drowsiness, Problems with balance, Nausea
• In animals : LC50/4 h/rat: 22,6 mg/l ( 6270 ppm) (Method: OECD Test Guideline 403) (vapour)

Ingestion: Harmful by ingestion.


• In man : Ingestion may cause irritation to mucous membranes.
• In animals : LD50/rat: 1.850 mg/kg (Method: OECD Test Guideline 401)

Dermal: Practically not harmful in contact with skin


• In animals : No mortality/rabbit: 2.000 mg/kg (Method: OECD Test Guideline 402)

Local effects ( Corrosion / Irritation / Serious eye damage ):

Skin contact: Irritating to skin.


• In animals : Skin irritation (after occlusive contact, rabbit, Exposure time: 4 h)

Eye contact: Irritating to eyes.


• In animals : Eye irritation (OECD Test Guideline 405, rabbit)

Respiratory or skin sensitization:

Inhalation: No data available.

Skin contact:
Through analogy with a comparable product :, Not a skin sensitizer

THIOPHENE :
• In animals : No effect is reported. (Method : OECD Test Guideline 406 Guinea pig maximization test)

CMR effects :

Mutagenicity: According to available experimental data: Not genotoxic

In vitro
Inactive in genotoxic in vitro tests
Ames test in vitro: (Method: OECD Test Guideline 471)
In vitro gene mutations test on mammalian cells: (Method: OECD Test Guideline 476)
In vitro chromosomal abnormality test on human lymphocytes: (Method: OECD Test Guideline 473)

Carcinogenicity: Based on the available data, the substance is not suspected of having carcinogenic potential
No data available.

Reproductive toxicity:

Fertility: Based on the available data, the substance is not suspected of having reprotoxic potential.
• In animals : Repeated administration: Absence of toxic effects upon the reproductive system, NOAEL: 5,2 mg/kg
(rat, By inhalation, 13 Sem.)

Foetal development: Absence of toxic effects for foetal development.


• In animals : Exposure during pregnancy (Method: OECD Test Guideline 414, rat, By inhalation)

No teratogenic effects, Absence of toxic effects for foetal development.


NOAEL: 6888 mg/m3
Maternal concentration without effect: 844 mg/m3

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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Specific target organ toxicity :


Single exposure :

Inhalation:
Olfactory threshold: 1 ppb
• In man : At high vapour/fog concentrations :
Risk of irritation of eyes and respiratory system

Repeated exposure: The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
• In animals : Repeated exposure by inhalation: (rat, 3 months)

At high dose :
Local irritation of the respiratory system
NOAEL= 0,18 mg/l (51ppm)
Maximum concentration with no systemic toxic effect
NOAEL= 5,2 mg/l (1442ppm)

Aspiration hazard: Not relevant

12. ECOLOGICAL INFORMATION

12.1. Toxicity

Fish: Slightly harmful to fish


LC50, 96 h (Danio rerio (zebra fish)) : > 24 mg/l (Method: OECD Test Guideline 203, pH: 7,7 - 8,0, Test
substance: Active ingredient)
NOEC : > 24 mg/l

Aquatic invertebrates: Harmful to daphnia.


EC(I)50, 48 h (Daphnia magna (Water flea)) : 24 mg/l (Method: OECD Test Guideline 202,
Immobilization, Test substance: Active ingredient)

Aquatic plants: Slightly harmful to algae


ErC50, 72 h (Pseudokirchneriella subcapitata) : > 153,2 mg/l (Method: OECD Test Guideline 201, pH:
8,7 - 9,1, growth rate, Test substance: Active ingredient)

Microorganisms:
EC50, 3 h (Activated sludge) : 1.530 mg/l (Method: OECD Test Guideline 209, Respiration inhibition of
activated sludge, Test substance: Active ingredient)
EC10, 3 h : 310 mg/l

Aquatic toxicity / Long term toxicity:


Aquatic plants:
NOEC r (Pseudokirchneriella subcapitata (green algae)) : 29,1 mg/l (Method: OECD Test Guideline
201, Growth inhibition)

12.2. Persistence and degradability :

In water: Not hydrolysable

Stability in water:
Hydrolysis time: 5 d degree of hydrolysis: < 10 %
Test substance: Active ingredient, Method: OECD Test Guideline 111

Biodegradation (In water): Not readily biodegradable.


aerobic: < 10 % after 28 d (Method: OECD Test Guideline 301 F)

Photodegradation (In air):


Degradation by radicals OH: Overall half-life time: 1,8 d

12.3. Bioaccumulative potential :

Bioaccumulation: Does not bioaccumulate.


Partition coefficient: n-octanol/water: log Kow : 1,8 , at 20 °C (Method: calculated)

12.4. Mobility in soil - Distribution among environmental compartments:

Henry constant:
3
36,48E+00 Pa.m /mol, (Method: calculated)

Absorption / desorption:
Mobile in soils , log Koc: 1,32 ( Method: calculated )

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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12.5. Results of PBT and vPvB assessment :

According to REACH regulation, annex XIII, the substance does not meet PBT and vPvB criteria.

12.6. Other adverse effects: None known.

13. DISPOSAL CONSIDERATIONS

13.1. Waste treatment:

Disposal of product: Destroy product by oxidation with dilute solutions of : Hydrogen peroxide or sodium hypochlorite
or Destroy the product by incineration (in accordance with local and national regulations).

14. TRANSPORT INFORMATION

UN Environmentally
Regulation
number
Proper shipping name Class Label PG
hazardous
Other information
ADR 2412 TETRAHYDROTHIOPHENE 3 3 II no

RID 2412 TETRAHYDROTHIOPHENE 3 3 II no


IATA Cargo 2412 Tetrahydrothiophene 3 3 II no
IATA Passenger 2412 Tetrahydrothiophene 3 3 II no
IMDG 2412 TETRAHYDROTHIOPHENE 3 3 II no EmS Number: F-E, S-D

15. REGULATORY INFORMATION

Safety data sheets: according to Regulation (EC) No. 1907/2006


15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture:

15.2. Chemical Safety Assessment:


A Chemical Safety Assessment has been carried out for this substance.

INVENTORIES:
EINECS: Conforms to
TSCA: Conforms to
AICS: Conforms to
DSL: All components of this product are on the Canadian DSL list.
ENCS (JP): Conforms to
KECI (KR): Conforms to
PICCS (PH): Conforms to
IECSC (CN): Conforms to
NZIOC: Conforms to

16. OTHER INFORMATION

Full text of R, H, EUH-phrases referred to under sections 2 and 3

R11 Highly flammable.


R20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R36/38 Irritating to eyes and skin.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
H225 Highly flammable liquid and vapour.
H302 Harmful if swallowed.
H312 Harmful in contact with skin.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H332 Harmful if inhaled.
H412 Harmful to aquatic life with long lasting effects.

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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Further information When used in formulations, contact us for labelling.


Update:

Safety datasheet sections which have been updated: Type:


2 Classification and labelling, Environmental Effects, Potential health effects Additions, Revisions
8 Derived No Effect Level (DNEL), Predicted No Effect Concentration (PNEC) Additions
9 Flammability (solid, gas), Explosive properties, Oxidizing properties, Henry constant Additions
9 Melting point/range, Boiling point/boiling range, Flash point, Vapour pressure, Density, Relative Revisions
density, Water solubility, Partition coefficient: n-octanol/water, Autoignition temperature, Viscosity,
dynamic
9 Lower flammable limit, Upper flammable limit Additions
11 Toxicokinetics (absorption, metabolism, distribution and elimination), Carcinogenicity, Fertility Additions
11 Acute toxicity, Skin contact, Eye contact, Foetal development, Specific Target Organ Toxicant Revisions
12 Stability in water, Biodegradation, Photodegradation, Henry constant, Absorption / desorption, PBT Additions
assessment
12 Aquatic toxicity, Bioaccumulation Revisions
15 Chemical Safety Assessment Additions

Thesaurus:
NOAEL : No Observed Adverse Effect Level (NOAEL)
LOAEL : Lowest Observed Adverse Effect Level (LOAEL)
bw : Body weight
food : oral feed
dw : Dry weight
vPvB : very Persistent and very Bioaccumulative
PBT : Persistent, Bioaccumulative and Toxic

This information applies to the PRODUCT AS SUCH and conforming to specifications of ARKEMA. In case of formulations or mixtures, it is
necessary to ascertain that a new danger will not appear. The information contained is based on our knowledge of the product, at the date of
publishing and it is given quite sincerely. Users are advised of possible additional hazards when the product is used in applications for which it was
not intended. This sheet shall only be used and reproduced for prevention and security purposes. The references to legislative, regulatory and
codes of practice documents cannot be considered as exhaustive. It is the responsibility of the person receiving the product to refer to the totality of
the official documents concerning the use, the possession and the handling of the product. It is also the responsibility of the handlers of the product
to pass on to any subsequent persons who will come into contact with the product (usage, storage, cleaning of containers, other processes) the
totality of the information contained within this safety data sheet and necessary for safety at work, the protection of health and the protection of
environment.

NB: In this document the numerical separator of the thousands is the "." (point), the decimal separator is "," (comma).

ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE


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