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SDS No.: 001974-001 (Version 3.2 ) Date 19.09.2012 (Cancel and replace : 28.12.2011)
Substance name:
REACH Registration Name: Tetrahydrothiophene
REACH Registration Number: 01-2119489799-07-0000
EC Nr: 203-728-9
CAS-No.: 110-01-0
1.2. Relevant identified uses of the substance or mixture and uses advised against
Use of the Substance/Mixture :
Sector of use : Product category :
Injection in gas PC28: Perfumes, fragrances
SU23: Electricity, steam, gas water supply and sewage treatment
Distribution of the substance
SU 3: Industrial uses: Uses of substances as such or in preparations
at industrial sites
Supplier Arkema
THIOCHIMIE
420 rue d’Estienne d'Orves
92705 Colombes Cedex, France
Téléphone : +33 (0)1 49 00 80 80
Télécopie : +33 (0)1 49 00 83 96
http://www.arkema.com
E-mail address pars-drp-fds@arkema.com
+33 1 49 00 77 77
European emergency phone number : 112
2. HAZARDS IDENTIFICATION
F; R11
Xn; R20/21/22
Xi; R36/38
R52/53
Additional information:
For the full text of the R, H, EUH-phrases mentioned in this Section, see Section 16.
Hazard pictograms:
Hazard statements:
H225 : Highly flammable liquid and vapour.
H302 : Harmful if swallowed.
H312 : Harmful in contact with skin.
H332 : Harmful if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H412 : Harmful to aquatic life with long lasting effects.
Precautionary statements:
Prevention:
P210 : Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P273 : Avoid release to the environment.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response:
P303 + P361 + P353 : IF ON SKIN (or hair): Remove/ Take off immediately all contaminated clothing. Rinse skin with water/ shower.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Storage:
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Environmental Effects:
Harmful to daphnia. Not readily biodegradable. Not bioaccumulable.
Other:
Results of PBT and vPvB assessment : According to REACH regulation, annex XIII, the substance does not meet PBT and vPvB criteria.
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1.Substances
1
Chemical name of the substance : TETRAHYDROTHIOPHENE (THT)
Classification
1 Classification
Chemical Name EC-No. CAS-No. Concentration Directive
Regulation (EC) No 1272/2008
67/548/EEC
Tetrahydrothiophene 203-728-9 110-01-0 >= 98 % R52/53 Flam. Liq. 2; H225
Xi; R36/38 Acute Tox. 4 (Oral); H302
Xn; R20/21/22 Acute Tox. 4 (Dermal); H312
F; R11 Acute Tox. 4 (Inhalation); H332
Skin Irrit. 2; H315
Eye Irrit. 2; H319
Aquatic Chronic 3; H412
1
: See chapter 14 for Proper Shipping Name
4.1. & 4.2. Description of necessary first-aid measures & Most important symptoms/effects, acute and delayed:
General advice:
Take off immediately all contaminated clothing.
Inhalation:
Move to fresh air. Oxygen or artificial respiration if needed. Keep under medical surveillance. In case of problems : Hospitalise.
Skin contact:
Wash off immediately with soap and plenty of water. If significant contact: Keep under medical surveillance. Hospitalise.
Eye contact:
Wash well-open eyes immediately, abundantly and thoroughly with water. Consult an ophthalmologist.
Ingestion:
If the subject is unconscious, do not induce vomiting
Hospitalise.
Protection of first-aiders:
In case of insufficient ventilation, wear suitable respiratory equipment.
4.3.Indication of immediate medical attention and special treatment needed, if necessary : No data available.
5. FIREFIGHTING MEASURES
5.1.Extinguishing media
Specific methods:
Cool containers / tanks with water spray. In case of fire, remove exposed containers.
Recovery:
Pump into a labelled inert emergency tank. Absorb the remainder with an inert absorbent material.
Elimination:
Destroy product by oxidation with dilute solutions of : Hydrogen peroxide or sodium hypochlorite
or Destroy the product by incineration (in accordance with local and national regulations).
Technical measures/Precautions:
Storage and handling precautions applicable to products: Liquid. Highly flammable Harmful. Irritant. With vapours explosive in air. Provide
appropriate exhaust ventilation at machinery. Provide showers, eye-baths. Provide water supplies near the point of use. Provide self-
contained breathing apparatus nearby.
Hygiene measures:
Avoid contact with the skin and the eyes. Avoid inhalation of vapours. When using do not eat, drink or smoke.
Wash hands after handling. Remove contaminated clothing and protective equipment before entering eating areas.
Incompatible products:
Strong oxidizing agents
Packaging material:
Recommended: Carbon steel, Stainless steel, Lined metallic drums., Joints : polyethylene, Rilsan ®, polytetrafluoroethylene (PTFE)
To be avoided: Copper and copper alloys
Tetrahydrothiophene
Source Date Value type Value Value Remarks
(ppm) (mg/m3)
ARKEMA 2008 TWA 50 180 Value recommended by the "Exposure Limit Value Committee" of
ARKEMA
Consumers 18,5 mg/m3 (LT, SE) 2,7 mg/kg bw/day (LT, SE)
21 mg/m3 (LT, LE)
Compartment: Value:
Fresh water 0,024 mg/l
Marine water 0,0024 mg/l
Water (Intermittent release) 0,24 mg/l
Effects on waste water treatment plants 31 mg/l
Fresh water sediment 0,1361 mg/kg dw
Marine sediment 0,0136 mg/kg dw
Soil 0,132 mg/kg dw
General protective measures: Ensure sufficient air exchange and/or exhaust in work areas
Respiratory protection: Low concentrations or short activity: No special protective equipment required.
High concentrations or prolonged activity: Self contained Breathing Apparatus
Hand protection: Splash contact, intermittent and prolonged Gloves nitrile rubber
Glove thickness: 0,75 mm
Protective gloves complying with EN 374.
Eye/face protection: Safety glasses with side-shields
Skin and body protection: At the workplace : Combination with delayed penetration
Intervention at incident: anti-acid suit
Appearance:
Physical state (20°C): liquid
Colour: colourless
Odour: stinging
Olfactory threshold: 1 ppb
pH: No data available.
Melting point/range : -96,2 °C
Boiling point/boiling range : 119 - 121 °C
Flash point: 17,5 °C (1.013 hPa) (A9 Method (D. 92/69/ECC))
Evaporation rate: No data available.
Flammability (solid, gas):
Lower flammable limit : 1,1 %(V)
Upper flammable limit : 12,1 %(V)
Vapour pressure: 24 hPa , at 25 °C
Relative vapour density: 3,04 Reference substance: Air=1
Density: 1.000 kg/m3 , at 20 °C
Relative density (Water=1): 1,0 at 20 °C
Water solubility: 5,8 g/l at 20 °C (OECD Test Guideline 105)
Partition coefficient: n-octanol/water: log Kow : 1,8 , at 20 °C (calculated)
Autoignition temperature: 215 °C
Decomposition temperature: 640 °C
Viscosity, dynamic: 1,60 mPa.s , at 20 °C
1,29 mPa.s , at 40 °C
Explosive properties:
Explosivity: Not relevant (due to the chemical structure)
Oxidizing properties: Not relevant (due to the chemical structure)
Solubility in other solvents: Soluble in: Alcohols , Ethyl ether , Acetone , Chloroform , hydrocarbons
3
Henry constant: 36,48E+00 Pa.m /mol (calculated)
Molecular Weight: 88,17 g/mol
Refractive index: 1,505 at 20 °C
Critical point: Critical pressure: 5,6 MPa, Critical temperature: 306 °C
Thermal decomposition:
Decomposition temperature: 640 °C
Thermal decomposition giving flammable and toxic products :, Hydrogen sulphide, Sulphur oxides, Carbon oxides
Acute toxicity:
Skin contact:
Through analogy with a comparable product :, Not a skin sensitizer
THIOPHENE :
• In animals : No effect is reported. (Method : OECD Test Guideline 406 Guinea pig maximization test)
CMR effects :
In vitro
Inactive in genotoxic in vitro tests
Ames test in vitro: (Method: OECD Test Guideline 471)
In vitro gene mutations test on mammalian cells: (Method: OECD Test Guideline 476)
In vitro chromosomal abnormality test on human lymphocytes: (Method: OECD Test Guideline 473)
Carcinogenicity: Based on the available data, the substance is not suspected of having carcinogenic potential
No data available.
Reproductive toxicity:
Fertility: Based on the available data, the substance is not suspected of having reprotoxic potential.
• In animals : Repeated administration: Absence of toxic effects upon the reproductive system, NOAEL: 5,2 mg/kg
(rat, By inhalation, 13 Sem.)
Inhalation:
Olfactory threshold: 1 ppb
• In man : At high vapour/fog concentrations :
Risk of irritation of eyes and respiratory system
Repeated exposure: The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
• In animals : Repeated exposure by inhalation: (rat, 3 months)
At high dose :
Local irritation of the respiratory system
NOAEL= 0,18 mg/l (51ppm)
Maximum concentration with no systemic toxic effect
NOAEL= 5,2 mg/l (1442ppm)
12.1. Toxicity
Microorganisms:
EC50, 3 h (Activated sludge) : 1.530 mg/l (Method: OECD Test Guideline 209, Respiration inhibition of
activated sludge, Test substance: Active ingredient)
EC10, 3 h : 310 mg/l
Stability in water:
Hydrolysis time: 5 d degree of hydrolysis: < 10 %
Test substance: Active ingredient, Method: OECD Test Guideline 111
Henry constant:
3
36,48E+00 Pa.m /mol, (Method: calculated)
Absorption / desorption:
Mobile in soils , log Koc: 1,32 ( Method: calculated )
According to REACH regulation, annex XIII, the substance does not meet PBT and vPvB criteria.
Disposal of product: Destroy product by oxidation with dilute solutions of : Hydrogen peroxide or sodium hypochlorite
or Destroy the product by incineration (in accordance with local and national regulations).
UN Environmentally
Regulation
number
Proper shipping name Class Label PG
hazardous
Other information
ADR 2412 TETRAHYDROTHIOPHENE 3 3 II no
INVENTORIES:
EINECS: Conforms to
TSCA: Conforms to
AICS: Conforms to
DSL: All components of this product are on the Canadian DSL list.
ENCS (JP): Conforms to
KECI (KR): Conforms to
PICCS (PH): Conforms to
IECSC (CN): Conforms to
NZIOC: Conforms to
Thesaurus:
NOAEL : No Observed Adverse Effect Level (NOAEL)
LOAEL : Lowest Observed Adverse Effect Level (LOAEL)
bw : Body weight
food : oral feed
dw : Dry weight
vPvB : very Persistent and very Bioaccumulative
PBT : Persistent, Bioaccumulative and Toxic
This information applies to the PRODUCT AS SUCH and conforming to specifications of ARKEMA. In case of formulations or mixtures, it is
necessary to ascertain that a new danger will not appear. The information contained is based on our knowledge of the product, at the date of
publishing and it is given quite sincerely. Users are advised of possible additional hazards when the product is used in applications for which it was
not intended. This sheet shall only be used and reproduced for prevention and security purposes. The references to legislative, regulatory and
codes of practice documents cannot be considered as exhaustive. It is the responsibility of the person receiving the product to refer to the totality of
the official documents concerning the use, the possession and the handling of the product. It is also the responsibility of the handlers of the product
to pass on to any subsequent persons who will come into contact with the product (usage, storage, cleaning of containers, other processes) the
totality of the information contained within this safety data sheet and necessary for safety at work, the protection of health and the protection of
environment.
NB: In this document the numerical separator of the thousands is the "." (point), the decimal separator is "," (comma).