Kieffer CV Jan 2019 PDF

The University of British Columbia
Curriculum Vitae for Faculty Members
Date: Jan, 2019 Initials: _____________
Basic Information
Surname Kieffer First Name Timothy
Middle Name(s) James
Department/School Cellular & Physiological Sciences and Surgery
Faculty Faculty of Medicine
Present Rank Professor (tenure) Since July 2007
Education
Institution Degree/ Training Type Start End

Date Date
Harvard Medical School Postdoctoral Fellow Oct-94 Dec-96
Massachusetts General Hospital Postdoctoral Fellow Jul-94 Jun-96
University of British Columbia Postdoctoral Fellow Jun-94 Sep-94
University of British Columbia Ph.D., Physiology Sep-89 May-94
University of British Columbia B.Sc., Cell Biology Sep-87 May-89
Thompson Rivers University Associate Diploma of Sep-84 May-87
Science
Title of Dissertation and Name of Supervisor:

"Release and Metabolism of GIP" - Dr. Raymond Pederson
Employment Record
Institution Department Position Start End

Date Date
University of British Cellular & Professor, Jul-07
Columbia Physiological Medicine
Sciences and
Surgery
University of British Cellular & Associate Sep-02 Jun-07
Columbia Physiological Professor,
Sciences and Medicine
Surgery
University of Alberta Medicine & Associate Jul-02 Aug-02
Physiology Professor,
Medicine
University of Alberta Medicine & Assistant May-98 Jun-02
Physiology Professor,
Medicine
Curriculum Vitae for Timothy James Kieffer -- Page 1

Harvard Medical School Medicine Instructor of Jul-97 Jun-98
Medicine
Massachusetts General Medicine Assistant in Jan-97 Apr-98
Hospital Medicine
Howard Hughes Medical Research Oct-94 Apr-98
Institute Associate
Date of granting of tenure at UBC: September 2002
Leaves: Center for iPS Cell Research and Application, Kyoto University, July 1, 2016 to July 1 2017.

Teaching & Supervision
Statement of Teaching Philosophy: My objectives as a teacher are to generate in depth knowledge and enthusiasm in the
students for the topics I teach. I also strive to foster critical thinking and problem-solving strategies. In order to facilitate these
objectives, I put a great deal of effort into presenting material such that it “makes sense”. All lecture materials are provided to students
in advance such that they can devote the entire lecture to listening and understanding. The topics I teach – aspects of human
physiology and pathophysiology – can be incredibly complex. However, I have found that presenting a viewpoint that illustrates logic
behind how the body systems work, and why they work in the manner they do, is an effective means to facilitate assimilation of
knowledge. I believe that understanding is critical to promote long-term retention of knowledge and I find it rewarding to connect with
students at this level.
Courses Taught at UBC (not updated)
Session Course Enrollment Hours Taught

Lecture Lab Other
2013/2014
PHYL 449 (Honours Physiology Thesis) Coordinator 8
W
2013/2014 CELL 511 (Cellular & Molecular Mechanisms of
7 21
W Human Disease)
2013/2014
PHYL 430 (Advanced Laboratory in Physiology) 8 30
W
2013/2014 CELL 501 (Cell and Developmental Biology Research
9 2
W Literature)
2013/2014
PHYL 424 (Mammalian Endocrinology) 20 4
W
2013/2014
Responsible Conduct of Research Course 40 3.5
W
2012/2013
W
7 21
W Human Disease)
2012/2013
W
15 2
W Literature)
2012/2013
W
2012/2013 PHYL 423 (Mammalian Renal and Gastrointestinal
13 4
W Physiology)
2011/2012
PHYL 449 (Honours Physiology Thesis) Coordinator 19 20
W
6 21
W Human Disease)
2011/2012
W
15 2
W Literature)
2011/2012 CELL 512 (Gene and Cell-based Therapies for
6 7 14
W Disease)
Lecture Lab Other
2011/2012
W
27 4
W Physiology)
19 2
W Literature)
11 21
W Human Disease)
2010/2011
W
2010/2011
W
2010/2011
W
18 4
W Physiology)
2009/2010 PHYL 423 (Mammalian Renal and Gastrointestinal 27 4
W Physiology)
2009/2010 PHYL 424 (Mammalian Endocrinology) 29 4
W
2009/2010 PHYL 430 (Advanced Laboratory in Physiology) 16 20 20
W
2009/2010 PHYL 449 (Honours Physiology Thesis) Coordinator 16
W
2008/2009 PRIN 401 (Principles of Human Biology) 298 1
W
W Physiology)
W
2008/2009 PHYL 430 (Advanced Laboratory in Physiology) 12 25
W
2008/2009 PHYL 449 (Honours Physiology Thesis) Coordinator 12 10
W
W
W Physiology)
W
W
Lecture Lab Other
W
W
W Physiology)
W
W
W
W
W Physiology)
W
W
W
2004/2005 PRIN 401 (Principles of Human Biology ) 202 1
W
W Physiology)
W
W
W
W
W Physiology)
W
W
W

Continuing Education Activities and Courses Taught Outside UBC
Title Institution Enrollment Hours Taught Start Date End Date
Homeostatic Physiology/PHYSL 402 U of A 7 18 Sep, Apr,
2001 2002
Endocrinology/MED 513 U of A 160 1 Sep, Apr,
2001 2002
Undergraduate Research U of A 13 13 Sep, Apr,
Project/PHYSL 465 2001 2002
Undergraduate Tutorial/PHYSL 466 U of A 13 13 Sep, Apr,
2001 2002
2000 2001
2000 2001
Human Physiology/PHYSL 252 U of A 190 8 Sep, Apr,
2000 2001
Undergraduate Research U of A 15 5 Sep, Apr,
Project/PHYSL 465 2000 2001
Undergraduate Tutorial/PHYSL 466 U of A 15 15 Sep, Apr,
2000 2001
1999 2000
1999 2000
Human Physiology/PHYSL 252 U of A 186 8 Sep, Apr,
1999 2000
1998 1999

Supervisory Activities
U of A = University of Alberta
UBC = University of British Columbia
Undergraduate Students Supervised:
Student Institution Role Start End

Date Date
Freya Orban Lund International Student Jan-19
University
Lasya Vankayala UBC Volunteer Sep-18
Sarah Zhang Earl Marriott High School Co-op Program Dec-18 Dec-18
Secondary
Daniela Laceste Guilford High School Co-op Program Oct-18 Nov-18
Park
Secondary
Kimia Ziafat UBC Work-Learn Student Sep-18
Brayden Wilkinson UBC Student Assistant Sept-18
Amir Shafiee UBC Directed Studies Student Sept-18
Shadan Ashrafi UBC Honours Student (PHYL) Sept-18
Li Qing UBC Honours Student (PHYL) Sept-18
Nazde Edeer UBC Volunteer Sep-18
Joshua Paterson UBC Directed Studies Student Sep-18
David Chen UBC Summer student May-18 Aug-18
Li Qing UBC Volunteer Aug-18 Aug-18
Shadan Ashrafi UBC Volunteer Jul-18 Aug-18
Sherry Fang UBC Volunteer May-18 Aug-18
Amir Shafiee UBC Summer student May-18 Aug-18
Hannah Matheson UBC Volunteer May-18
Kalin Chai UBC Volunteer May-18
Brayden Wilkinson UBC Student Assistant May-18 Aug-18
Nazde Edeer UBC Summer student May-18 Aug-18
Kimia Ziafat UBC Volunteer Mar-18 Aug-18
Brayden Wilkinson UBC Honours Student (BIOL) Sep-17 May-18
Brayden Wilkinson UBC Co-op Student May-17 Sept-17
Stephanie Tarazi UBC Volunteer May-17
Brayden Wilkinson UBC Undergraduate Student Assistant Jan-17 May-17
Iris Lee UBC Volunteer May-17 Jun-17
Janice Pang UBC Volunteer May-17 Oct-17
Jennifer Wang UBC Volunteer Jun-17 Sep-17
Jennifer Wang UBC Work-Learn Student Sep-17 May-18
Jonathan Miranda UBC Intern, MITACS program Jun-17 Aug-17
Joshua Paterson UBC Volunteer Feb-17 Aug-18
Brandon McCrimmon UBC Volunteer Feb-17 Jul-17
Megan Froats Earl Marriott High School Co-op Program Dec-17 Dec-17
Secondary
Melissa Chan UBC Volunteer Sep-17
Nastia Khontiaintseva Earl Marriott High School Co-op Program Dec-17 Dec-17
Secondary
Nazde Edeer UBC Summer Student May-17 Sep-17
Nazde Edeer UBC Volunteer Sep-17 May-18
Niklas von Krosigk UBC Directed Studies Student (BIOL) Sep-16 May-17
Julia Toews UBC Honours Student (BIOC) May-16 May-17
Date Date
Brayden Wilkinson UBC Co-op Student May-16 Sep-16
Victor So UBC Co-op Student May-16 Dec-16
Muna Ibrahim UBC Directed Studies Student (BIOL) Jan-16 Aug-16
Saman Fouladirad UBC Undergraduate Student Assistant Nov-15 Apr-16
Jessica Ho UBC Postundergrad part-time Sep-15 Dec-15
Kina Ellison UBC Honours Student (PHYL) Sep-15 Apr-16
Samantha Yoon UBC Direct Studies Student (BIOL) Sep-15 Apr-16
Hellen Schuster UBC Intern, DAAD program Aug-15 Apr-16
Sean Wong UBC Work-Learn Student May-15 May-16
Jessica Ho UBC Summer Student May-15 Aug-15
Muna Ibrahim UBC Co-op Student May-15 Dec-15
Samantha Yoon UBC Co-op Student May-15 Aug-15
Supun Jayawarden UBC Co-op Student May-15 May-16
Nelly Saber UBC Undergraduate Student Assistant Jan-15 Apr-15
Ann Lee UBC Co-op Student Oct-14 May-16
Kathy Kwan UBC Work-Learn Student Sep-14 Apr-15
Katarina Wind UBC Honours Student (PHYL) Sep-14 Apr-15
Jonathan Dong UBC Co-op Student Sep-14 Aug-15
Jessica Ho UBC Honours Student (BIOL) Sep-14 Apr-15
Campbell Drohan UBC Co-op Student May-14 Dec-14
Ian Miao UBC Co-op Student May-14 Dec-14
Matthew Lund UBC Co-op Student May-14 Aug-15
Nelly Saber UBC Co-op Student May-14 Aug-14
Tom Wang UBC Student Assistant Jan-14 Mar-14
Jordan McGarry UBC Student Assistant Sep-13 Aug-14
Samantha Yoon UBC Work-Learn Student Sep-13 Aug-14
Heidi Streicek UBC Directed Studies Student (BIOC) Sep-13 Apr-14
Fan Yang UBC Co-op Student Sep-13 Apr-14
Eunice Kwok UBC Co-op Student Sep-13 Apr-14
Rudi Tong UBC Intern, DAAD Program Aug-13 Oct-13
Clara Tsui UBC Student Assistant Jul-13 May-15
Marion Philippe UBC Summer Student May-13 Aug-13
Jenna Kara UBC Summer Student May-13 Aug-13
Michelle Kwon UBC Summer Student Apr-13 Aug-13
Jordan McGarry UBC Co-op Student Apr-13 Aug-13
Heidi Streicek UBC Student Assistant Mar-13 Aug-13
Cassandra Jensen UBC Co-op Student Jan-13 Aug-13
Tom Wang UBC Co-op Student Jan-13 Aug-13
Queenie Hui UBC Co-op Student Jan-13 Aug-13
Grace Ho UBC High School Student Dec-12 Mar-13
Nelly Saber UBC Co-op Student Sep-12 Apr-13
Kerry Li UBC Honours Student (BIOC) Sep-12 Apr-13
Naomi Stiansen UBC Honours Student (PHYL) Sep-12 Apr-13
Charlotte Young UBC Work Study Student Sep-12 Apr-13
Joanne Cho UBC Work Study Student Sep-12 Apr-13
Natalie Braun UBC Intern, DAAD Program Jul-12 Sep-12
Naomi Stiansen UBC Summer Student May-12 Aug-12
Whitney Quong UBC Summer Student May-12 Aug-12
Date Date
Mani Vinay UBC Intern, MITACS Program May-12 Jul-12
Mina UBC Work Study Student Apr-12 Jul-12
Phaisaltantiwongs
Sara Sassani UBC Co-op Student Jan-12 Aug-12
Kerry Li UBC Co-op Student Jan-12 Aug-12
Denna al-Mashrawi UBC Work Study Student Jan-12 Apr-12
Ashleigh Richards UBC Work Study Student Oct-11 Dec-11
Whitney Quong UBC Honours Student (PHYL) Sep-11 Apr-12
Maya Nesbit UBC Honours Student (BIOC) Sep-11 Apr-11
Mina UBC Work Study Student May-11 Sep-11
Phaisaltantiwongs
Maya Nesbit UBC Summer Student May-11 Aug-11
Ghazaleh Farrokhyar UBC Volunteer Feb-11 May-11
Brigitte Harder UBC Directed Studies Student (PHYL) Jan-11 Aug-11
Ursula Neumann UBC Honours Student (BIOC) Sep-10 Apr-11
Javier Vela UBC Co-op Student Sep-10 Sep-11
Leanne Leung UBC Co-op Student May-10 Aug-10
Andrew Hurlburt UBC Summer Student May-10 Aug-10
Ursula Neumann UBC Summer Student May-10 Aug-10
Tahara Bhate UBC Summer Student May-09 Aug-09
Andrew Hurlburt UBC Honours Student (PHYL) Sep-09 Apr-10
Tahara Bhate UBC Honours Student (BIOC) Sep-09 May-10
Andrew Hurlburt UBC Summer Student May-09 Aug-09
Catherine Merchant UBC Summer Student May-09 Sep-09
Ashleigh Richards UBC Work Study Student May-09 Apr-11
Catherine Merchant UBC Honours Student Jan-09 Apr-09
Roveena Sequeira UBC Honours Student Sep-08 Apr-09
Simon Hiebert UBC Summer Student Jun-08 Aug-08
Heather Denroche UBC Summer Student May-08 Aug-08
Kathryn Mills UBC Summer Student May-08 Aug-08
Clara Myung UBC Co-op Student May-08 Jul-08
Helen (Chen) Jin UBC Work Study Student Dec-07 May-09
Karan Grewal UBC Directed Studies Student Oct-07 Dec-07
Malcolm Tan UBC Work Study Student Sept-07 Dec-07
Andy Chow UBC Honours Student Sept-07 Apr-07
Anderson Hsu UBC Co-op Student May-07 Aug-07
Andy Chow UBC Summer Student May-07 Aug-07
Arif Jeffa UBC Co-Op Student May-07 Aug-07
Blair Gage UBC Co-op Student Jan-07 Aug-07
Christina Chiu n/a Sanofi Aventis Biotech Challenge Jan-07 Apr-07
Jasna Levi UBC Honours Student Sep-06 Aug-07
Christine McDonald UBC Summer Student May-06 Jun-06
David King UBC Summer Student May-06 Jul-06
Ravi Varshney UBC Summer Student May-06 Jun-06
Jenny Wall UBC Summer Student May-06 Aug-06
Megan McLaughlin UBC Co-op Student Jan-06 Aug-06
Leung (Jack) Chan UBC Work Study Student Sep-05 Aug-07
Hannah Schoichet UBC Directed Studies Student Sep-05 Aug-06
Frank Huynh UBC Co-op Student Sep-05 May-06
Jenny Wall UBC Honours Student Sep-05 Apr-06
Christine Donald UBC Directed Studies Student Sep-05 Apr-06
David King UBC Honours Student Sep-05 Apr-06
Jenny Wall UBC Summer Student May-05 Aug-05
Jenny Wall UBC Volunteer Student Sep-04 Apr-05
Chen Shen UBC Work Study Student Sep-04 Aug-05
Sophia Wong UBC Honours Student Sep-04 Apr-05
Ada Lam UBC Honours Student Sep-04 Apr-05
Virginia Gunn UBC Summer Student May-04 Aug-04
Virginia Gunn UBC Honours Student Sep-03 Apr-04
Eric Eckbo UBC Work Study Student Sep-02 Aug-04
Jeshrun Tse U of A Summer Student Jan-02 Aug-02
John Staples U of A Summer Student May-01 Aug-01
Freda Lo U of A Summer Student May-01 Aug-01
Sharlene Hudson U of A Summer Student May-00 Aug-01
Cynthia Luk U of A Summer Student May-00 Aug-01
Graduate Students Supervised:
Student Type Institution Start End

Date Date
Queenie Hui Ph.D. UBC Jan-19
Diepiriye Iworima Ph.D. UBC Sep-18
Nelly Saber Ph.D. UBC Jan-16
Mitchell Braam Ph.D/ UBC Sep-15
Adam Ramzy MD/PhD UBC Jun-14
Michelle Kwon M.Sc. UBC Sep-13
Chiara Toselli M.Sc. UBC Aug-13
Anna D’souza Ph.D. UBC Sept-11 Aug-17
Ursula Neumann M.Sc. UBC Sept-11 Jun-17
Catherine Merchant M.Sc. UBC Sept-09 Aug-11
Heather Denroche Ph.D. UBC Sep-08 Apr-14
Blair Gage Ph.D. UBC May-08 Aug-14
Frank Huynh Ph.D. UBC May-07 Aug-12
Michael Juan M.Sc. UBC May-07 Nov-09
Jasna Levi M.Sc. UBC May-07 Aug-10
Gary Yang Ph.D. UBC Jul-06 Jun-11
Ada Lam M.Sc. UBC Sep-05 Aug-07
Irene Yu M.Sc. UBC Sep-05 Jan-10
Corinna Lee M.Sc. UBC Sep-03 Sep-05
Oosman Sarah M.Sc. UBC Jul-02 Dec-05
Rhonda Wideman Ph.D. UBC Jul-02 Dec-07
Tanya Binette Ph.D. U of A Nov-99 Oct-02
Ni Lam Ph.D. UBC Sep-98 Nov-04

Post Doctorate Fellows Supervised:

Date Date
Cara Ellis Postdoctoral UBC Sep-15
Fellow
Davide Pacitti Postdoctoral UBC Nov-14 May-17
Fellow
Nina Quiskamp Postdoctoral UBC Mar-14 Dec-17
Fellow
Sandra Pereira Postdoctoral UBC Jun-13
Fellow
Date Date
Suheda Erener Research UBC May-11
Associate
Jennifer Bruin Postdoctoral UBC Jan-10 Jul-15
Fellow
Eva Tuduri Lopez Postdoctoral UBC Sept-09 Sep-13
Fellow
Young Min Cho Visiting Faculty UBC Mar-09 Aug-10
Maria Glavas Research UBC June-08
Associate
Rhonda Wideman Postdoctoral UBC Jan-08 Feb-09
Fellow
Majid Mojibian Postdoctoral UBC Jan-08 Jan-17
Fellow
Sarah Gray Research UBC Oct-06 Sep-07
Associate
Michael Riedel Postdoctoral UBC Jul-06 Aug-10
Fellow
Scott Covey Postdoctoral UBC Sep-04 Jul-07
Fellow
Suraj Unniappan Postdoctoral UBC Feb-04 Dec-06
Fellow
Yukihiro Fujita Postdoctoral UBC Nov-02 Mar-07
Fellow
Anthony Cheung Postdoctoral U of A Nov-99 Sep-01
Fellow
Employees Supervised:
Employee Type Institution Start End Date

Date
Alex Siu Wing Research Technician UBC Jan-16 May-18
Yuen
Diepiriye Iworima Research Technician UBC Jan-16 Sep-18
Shannon O’Dwyer Research Technician UBC Jan-13 Nov-17

Jessica Fox Research Technician UBC Sep-11 Jan-13
Marjolaine Philit Research Technician UBC Apr-11 Aug-11
Ramona Toth Research Assistant UBC Jun-09 Jul-10
Anastasia Research Technician UBC Jun-08 Jul-09
Vlasova
Robert Baker Research Associate UBC Oct-06
Christine Donald Research Technician UBC Sep-06 May-09
Bronwyn Administrative UBC Aug-06 June-09
McConnell Assistant
Ida Zhang Research Technician UBC Jul-06 Aug-07
Jeannie Chui Research Technician UBC Sep-05 Aug-06
Madeleine Speck Research Technician UBC Aug-05 Mar-10
Ali Asadi Research Technician UBC Oct-04 Sep-17
Virginia Gunn Research Assistant UBC Sep-04 Apr-05
Dan Bruch Research Technician UBC May-03 Apr-04
Employee Type Institution Start End Date
Date
Jason Ma Research Technician UBC Sep-02 May-03
Travis Webber Lab Manager UBC Sep-02
Travis Webber Research Technician U of A Oct-01 Aug-02
Barb Hepperle Research Technician U of A Oct-01 Aug-02
Qui-Xia Zhang Research Technician U of A Aug-01 Aug-02
Jason Ma Research Technician U of A Jan-00 Aug-02
Jamie Lewis Research Technician U of A Jul-99 Aug-02
Bama Research Technician U of A Jun-98 Dec-01
Dayanandan

Distinctions Achieved by Trainees
AHFMR = Alberta Heritage Foundation for Medical Research
CDA = Canadian Diabetes Association
CHITBR = Centre for Human Islet Transplantation & Beta-Cell Regeneration
CIHR = Canadian Institute of Health Research
DAAD=German Academic Exchange Service
ISCT = International Society for Cellular Therapy
JDRF = Juvenile Diabetes Research Foundation
Medicine, UBC = Faculty of Medicine, University of British Columbia
MITACS= Mathematics of Information Technology and Complex Systems
MSFHR = Michael Smith Foundation for Health Research
SCN = Stem Cell Network, Networks of Centres of Excellence
Start End
Trainee Award Agency Amount
Date Date
Nelly Saber Travel Award SCN $1,508 2018 2018
Nelly Saber Doctoral Award NSERC $63,000 2018 2021
Canada Summer Jobs
David Chen Govt. of Canada $1,994 2018 2018
program
Summer Student
Nazde Edeer UBC $3,200 2018 2018
Research Program
Adam Ramzy Four Year Fellowship UBC $18,200 2018 2019
Michelle Kwon Travel Award EASD $1,800 2018 2018
Mitchell
Travel Award SCN $1,200 SCN SCN
Braam
Poster Presentation
Chiara Toselli Award, BIG Research UBC $200 2018 2018
Day
Brayden Undergraduate Student
NSERC $4,500 2018 2018
Wilkinson Research Award
Priye Iworima Graduate Award UBC $3,850 2018 2019
Priye Iworima BC MedTech Award UBC $1,400 2018 2019
Priye Iworima Travel Award SCN $1,808 2018 2018
Nelly Saber Travel Award SCN $1,508 2018 2018
Suheda JDRF Advanced
JDRF $278,804 2018 2021
Erener Postdoctoral Fellowship
Nelly Saber Four Year Fellowship UBC $72,800 2017 2021
Mitchell
Accelerate Fellowship MITACS $90,000 2018 2020
Braam
Michelle Kwon Four Year Fellowship UBC $72,800 2015 2019
Postgraduate
Michelle Kwon NSERC $63,000 2016 2019
Scholarship-D
Four Year Doctoral
Chiara Toselli UBC $18,000 2015 2019
Fellowship
MD/PhD Studentship
Adam Ramzy UBC $126,000 2014 2019
Award
UBC Life
Research Day Graduate
Blair Gage Sciences $100 2014 2014
Poster Award
Institute
Campbell
Co-op Student Award SCN $11,000 2014 2015
Drohan
Canada Graduate
Chiara Toselli NSERC $17,500 2014 2015
Scholarship
Best Oral Presentation UBC, Dept of
Jennifer Bruin $150 2014 2014
by a Postdoctoral Fellow CPS
Jennifer BruinTravel Award SCN $2,000 2014 2014
Alexander Graham Bell
Michelle Kwon Canada Graduate NSERC $17,500 2014 2015
Scholarship
Nina Transplant Research
CIHR $20,000 2014 2016
Quiskamp Training Award
Ursula
CGS Doctoral Fellowship NSERC $105,000 2014 2017
Neumann
Ursula
Travel Award EASD €1,940 2014 2014
Neumann
Blair Gage Travel Award SCN $2,000 2013 2013
Blair Gage Travel Grant EASD €1,600 2013 2013
Best Oral Speed Poster UBC, Dept of
Blair Gage $100 2013 2013
Presentation Award CPS
Postdoctoral Fellowship
Frank Huynh NSERC $80,000 2013 2015
(declined)
Heather Outstanding Oral
Islet Society $200 2013 2013
Denroche Presentation
Start End
Date Date
Research Day Best UBC Life
Heather
Senior Graduate Student Sciences $100 2013 2013
Denroche
Presentation Institute
Best Oral Presentation UBC, Dept of
by a Postdoctoral Fellow CPS
Postdoctoral and
UBC, Dept of
Jennifer Bruin Research Scientist of the $750 2013 2013
CPS
Year for 2013
Elevate Postdoctoral
Majid Mojibian MITACS $57,500 2013 2015
Fellowship Award
Graduate Entrance
Michelle Kwon UBC Medicine $750 2013 2014
Scholarship
Undergraduate Research
Michelle Kwon UBC Medicine $2,800 2013 2013
Award
Sandra
4 What Matters UBC $32,000 2013 2014
Pereira
Foundation
Suheda
Postdoctoral fellowship JDRF $93,912 2013 2015
Erener
Suheda
Travel Allowance JDRF $11,000 2013 2015
Erener
Ursula Four Year Fellowship
UBC $72,000 2013 2017
Neumann (declined)
Canadian Graduate
Anna D'souza NSERC $105,000 2012 2015
Scholarship
College of
Interdisciplinary Studies
Blair Gage UBC $1,210 2012 2012
Graduate Student Travel
Award

Heather
Travel Award EASD €1,600 2012 2012
Denroche
Best Senior Oral Alberta/BC Islet
Presentation Award Society
L'Oreal Canada
Research Excellence
Jennifer Bruin for Women in $20,000 2012 2013
Fellowship
Science
Jennifer Bruin Travel Award EASD €1,600 2012 2012
Jennifer Bruin Workshop Bursary SCN $1,000 2012 2012
Natalie Braun Study Scholarship DAAD €3,450 2012 2012
Nelly Saber Co-op Student Award SCN $10,000 2012 2013
Ursula Master's Graduate
NSERC $17,500 2012 2013
Neumann Fellowship
Eva Tuduri-
Postdoctoral Fellowship CDA $94,500 2011 2013
Lopez
Doctoral Student
Frank Huynh Research Award CDA $42,000 2011 2013
(declined 2nd year)
Start End
Date Date
Endocrine Trainee Day Endocrine
Frank Huynh $620 2011 2011
Travel Award Society
Heather Canada Graduate
NSERC $103,000 2011 2014
Denroche Scholarship (Doctoral)
Fellowship in Diabetes
Heather Anne and John
and Obesity Related $3,100 2011 2011
Denroche Brown
Research
Heather
Four Year Fellowship UBC $0 2011 2014
Denroche
Heather Outstanding Student Oral UBC, Dept of
$50 2011 2011
Denroche Presentation Cell Biology
Graduate Student UBC, Dept of
Jasna Levi $500 2011 2011
Researcher of the Year CPS
Jennifer Bruin Postdoctoral Fellowship JDRF $143,184 2011 2014
Jennifer Bruin CIHR $18,750 2011 2011
(declined)
Jennifer Bruin Travel Award SCN $2,000 2011 2011
Swiss National
Suheda
Postdoctoral fellowship Science $95,000 2011 2013
Erener
Foundation
Ursula
CFIS Graduate Award UBC $800 2011 2011
Neumann
Student Summer
Ursula
Research Program UBC $2,800 2011 2011
Neumann
Award
Violet and Blythe Eagles
Ursula
Undergraduate Prize in UBC $100 2011 2011
Neumann
Biochemistry
College of
Blair Gage UBC $1,210 2010 2010
Interdisciplinary Studies

Graduate Award
Institutional Graduate
Blair Gage Student 4 Year UBC $9,560 2010 2013
Fellowship
NSERC Postgraduate
Blair Gage NSERC $42,000 2010 2012
Scholarship
Postgraduate
Scholarship
Blair Gage Travel Award CHITBR $1,000 2010 2010
Catherine
Canada Graduate NSERC $17,500 2010 2011
Merchant
Scholarship
Michael Smith Foreign
Gary Yang NSERC $6,000 2010 2011
Study Supplement
Wah-Sheung Prize in
Gary Yang Physiological and UBC Medicine $600 2010 2010
Cellular Sciences
Start End
Date Date
Best Junior Graduate
Heather UBC, Dept of
Student Poster $200 2010 2010
Denroche Cell Biology
Presentation
College for
Heather
Interdisciplinary Studies UBC $300 2010 2010
Denroche
Graduate Award
BC Preclinical
Jennifer Bruin 1st Place Poster Award Research $0 2010 2010
Symposium
Best Oral Presentation
Jennifer Bruin SCN $1,000 2010 2010
Award
Transplant Research
Jennifer Bruin CIHR $19,500 2010 2012
Training Award
Majid Mojibian Postdoctoral Fellowship JDRF $97,064 2010 2012
Transplant Research
Majid Mojibian JDRF $6,000 2010 2011
Training Award Top Up
Michael Transitional Research
SCN $40,000 2010 2012
Riedel Grant
Student Summer
Ursula
Research Program UBC $2,800 2010 2010
Neumann
Award
Cell and Developmental
Blair Gage Biology Graduate UBC $625 2009 2009
Entrance Scholarship
Junior Graduate
Blair Gage MSFHR $19,000 2009 2011
Scholarship
Blair Gage Travel Award CHITBR $1,000 2009 2009
Eva Tuduri-
Postdoctoral Fellowship MSFHR $80,125 2009 2012
Lopez

Frank Huynh Canada Graduate NSERC $70,000 2009 2011
Scholarship, Doctorate
Faculty of Medicine
Frank Huynh UBC $5,449 2009 2012
Graduate Award
PhD Fellowship
Frank Huynh UBC $64,000 2009 2013
(declined)
Gary Yang Travel Award CHITBR $1,000 2009 2009
Heather Canada Graduate
NSERC $17,500 2009 2010
Denroche Scholarship (Master's)
Heather
Graduate Fellowship UBC $7,000 2009 2009
Denroche
Heather Pacific Century Graduate Government of
$10,000 2009 2009
Denroche Scholarship (declined) BC
Heather University Graduate
UBC $16,000 2009 2010
Denroche Fellowship
Jasna Levi Graduate Award UBC Medicine $886 2009 2009
Post-Graduate
Jasna Levi NSERC $63,000 2009 2012
Scholarship (declined)
Start End
Date Date
University Graduate
Jasna Levi Fellowship Star in UBC $64,000 2009 2013
Physiology
Jasna Levi Travel Award CHITBR $1,000 2009 2009
PhD Fellowship
Jasna Levi UBC $64,000 2009 2013
(declined)
Majid Mojibian Travel Award CHITBR $1,000 2009 2009
Maria Glavas Postdoctoral Fellowship CDA $41,500 2009 2010
PhD Fellowship
Michael Juan UBC $64,000 2009 2013
(declined)
Michael Juan Travel Award CHITBR $1,000 2009 2009
Blair Gage Best AGM Poster SCN $500 2008 2008
Canada Graduate
Scholarship
Cell and Developmental
Blair Gage Biology Graduate UBC $625 2008 2008
Entrance Scholarship
College of
Blair Gage Interdisciplinary Studies UBC $1,210 2008 2008
Graduate Award
Faculty of Graduate
Blair Gage Studies Grant UBC $2,680 2008 2008
Supplement Award
Blair Gage Training Bursary SCN $1,000 2008 2008
Clara Myung Co-op trainee Award SCN $10,000 2008 2008
Frank Huynh PhD Tuition Fee Award UBC $10,549 2008 2012
Frank Huynh Travel Award CHITBR $1,000 2008 2008
Wah-Sheung Prize in
Frank Huynh UBC $283 2008 2008
Physiology
Canada Graduate
Gary Yang NSERC $105,000 2008 2011
Scholarship
Doctoral Award
Gary Yang CDA $63,000 2008 2008
(declined)
National Institutes of
Gary Yang Health Conference Grant NIH $700 2008 2008
R13
Gary Yang Travel Award CHITBR $1,000 2008 2008
College for
Heather
Interdisciplinary Studies UBC $250 2008 2008
Denroche
Graduate Award
Heather
Graduate Fellowship UBC $385 2008 2008
Denroche
Heather Summer Student
UBC Medicine $4,200 2008 2008
Denroche Research Program
Canada Graduate
Irene Yu NSERC $105,000 2008 2011
Scholarship
Wah-Sheung Prize in
Jasna Levi UBC $283 2008 2008
Physiology
Start End
Date Date
Kathryn Mills Summer Studentship CGA/CIHR $6,000 2008 2008
Rhonda Science to Business
CIHR $50,899 2008 2010
Wideman MBA Scholarship
Junior Trainee Award
Ada Lam MSFHR $34,500 2007 2009
(declined)
UBC Medical
Research Forum Poster
Ada Lam Undergrad $100 2007 2007
Award
Society
Anderson Hsu Co-op Trainee Award CGA/CIHR $6,000 2007 2007
Blair Gage Co-op Trainee Award SCN $10,000 2007 2007
Faculty of Medicine
Grant Supplement Award
Graduate Entrance
Scholarship
Greater
Vancouver
Frank Huynh Master's Award $750 2007 2007
Vietnamese
Women's Soc.
Junior Graduate
Frank Huynh MSFHR $19,000 2007 2009
Scholarship, Top-Up
Postgraduate
Frank Huynh NSERC $37,067 2007 2009
Scholarship, Master's
Gary Yang PhD Tuition Fee Award UBC $11,168 2007 2011
Irene Yu Study Scholarship DAAD 7500 2007 2008
Graduate Entrance
Jasna Levi UBC $1,291 2007 2008
Scholarship
Violet and Blythe Eagles
Jasna Levi Undergraduate Prize in UBC $140 2007 2007
Biochemistry

Michael Juan Internship MITACS/enGene $30,000 2007 2008
Michael
Postdoctoral Fellowship SCN/ JDRF $100,000 2007 2009
Riedel
Michael Postdoctoral Fellowship
CDA $6,000 2007 2009
Riedel (Top Up)
Sarah Gray CDA $81,000 2007 2009
(declined)
Scott Covey Travel Award CHITBR $1,000 2007 2007
Transplant Research
Ada Lam Day Podium CIHR/MSFHR $100 2006 2006
Presentation Runner Up
Ada Lam Transplant Scholarship CIHR/MSFHR $10,000 2006 2007
Canadian Graduate
Irene Yu NSERC $17,500 2006 2007
Scholarship
Irene Yu Junior Trainee Award MSFHR $21,500 2006 2009
Michael
Riedel
Suraj
Abstract Award CDA $500 2006 2006
Unniappan
Start End
Date Date
Suraj
Unniappan
Suraj
Travel Award CIHR $1,500 2006 2006
Unniappan
David King Summer Studentship CIHR/MSFHR $4,000 2005 2005
Jenny Wall Summer Studentship UBC Medicine $4,200 2005 2005
Megan
Co-op Trainee Award SCN $10,000 2005 2006
McLaughlin
Rhonda Raymond Pederson
UBC Medicine $500 2005 2005
Wideman Prize in Physiology
Rhonda Research Day Best
CIHR/MSFHR $500 2005 2005
Wideman Presentation Award
Rhonda
Senior Trainee Award MSFHR $49,000 2005 2008
Wideman
Rhonda Wah Sheung Prize in
UBC Medicine $400 2005 2005
Wideman Physiology
Suraj Young Investigator
ISCT $500 2005 2005
Unniappan Travel Award
Junior Graduate
Corinna Lee MSFHR $14,000 2004 2006
Scholarship
Postgraduate
Corinna Lee NSERC $34,600 2004 2006
Scholarship
Rhonda Canadian Graduate
NSERC $70,000 2004 2006
Wideman Scholarship
Suraj
Postdoctoral Fellowship CIHR $135,000 2004 2007
Unniappan
Suraj
Travel Award ISCT $1,500 2004 2004
Unniappan
Virginia Gunn Summer Studentship UBC Medicine $4,800 2004 2004
Yukihiro Fujita Postdoctoral Fellowship CDA $70,000 2004 2006
Rhonda Junior Graduate
MSFHR $14,000 2003 2005
Wideman Scholarship
Virginia Gunn Summer Studentship UBC Medicine $4,800 2003 2003
Rhonda Postgraduate
NSERC $34,600 2002 2004
Wideman Scholarship
Yukihiro Fujita Postdoctoral Fellowship SCN $40,000 2002 2004
Freda Lo Summer Studentship AHRMR $6,000 2001 2001
Ni Lam First, Ntnl. Poster Comp. CIHR $1,000 2001 2001
Ni Lam Travel Award CDA $500 2001 2001
Anthony
2nd Prize, BioContact BioContact $2,000 2000 2000
Cheung
Anthony
Postdoctoral Fellowship CDA $35,000 2000 2001
Cheung
Anthony
Postdoctoral Fellowship AHRMR $38,000 2000 2001
Cheung
Faculty of Medicine
Cynthia Luk AHRMR $250 2000 2000
Research Day Prize
Cynthia Luk Summer Studentship AHRMR $6,000 2000 2000
Start End
Date Date
Sharlene
Summer Studentship AHRMR $6,000 2000 2000
Hudson
Cynthia Luk Summer Studentship AHRMR $6,000 1999 1999
John Staples Summer Studentship AHRMR $6,000 1999 1999
Postgraduate
Ni Lam NSERC $20,000 1999 2002
Scholarship
Ni Lam Studentship AHRMR $20,000 1999 2004
Walter H. Johns
Ni Lam U of A $3,800 1999 2002
Graduate Fellowship
Graduate Student Committees (not yet updated)
Student Deg. Major Institutio Start End Supervisor

n Date Date
Carol Yang M.Sc. Cellular and UBC Jul-09
Phys. Dr. J
Sciences Johnson
Katie Lee M.Sc. Genetics UBC Jun-09 Dr. S. Clee
Kamila Gwiazda M.Sc. Cell and Dev. UBC Sept-08 Dr. J
Biology Johnson
Emilyn Alejandro Ph.D. Cellular and UBC Apr-08
Phys. Dr. J
Sciences Johnson
Farzin Khosrow- M.Sc. Pharmaceutic UBC Aug-07 Jul-08 Dr. L
Khavar al Sciences Marzban
Reza Jalili Ph.D. Surgery UBC Jan-07 Dr. A
Ghahary
Corinne Hoesli Ph.D. Chem. and UBC Aug-06
Bio. Dr. J Piret

Engineering
Meredith Hamilton Ph.D Pathology UBC Aug-06 Dr. B
Verchere
Amy Olver M.Sc. Cellular and UBC Mar-06 Dec-06
Phys. Dr. C
Sciences McIntosh
Kristin Jeffrey M.Sc. Cellular and UBC Nov-05 Dec-06
Phys. Dr. J
Sciences Johnson
Marta Szabat Ph.D. Genetics UBC May-05 Dr. J Piret
Farzad Moein Ph.D. Anesth., UBC Feb-02
Pharm., and
Therap. Dr. I. Laher
Andrei Manolescu M.Sc. Physiology U of A Sep-01 Aug-02 Dr. C
Cheeseman
Hong Choi Ph.D. Physiology U of A Sep-01 Aug-02 Dr. G
Francis
Anastasia Nimchuk Ph.D. Ag., Food U of A Jan-01 Jun-01
and Nut.
Sciences Dr. R Bell
Sameer Ahmed M.Sc. Physiology U of A Jan-00 Dec-01 Dr. S
Harvey
Prasanth Chelikiani Ph.D. Ag., Food U of A Sep-98 Jul-02
and Nut. Dr. J
Sciences Kennelly
Graduate Student Exams (not yet updated)
Student Deg. Major Institutio Role Date

n
Jonathan Smid Ph.D. Regenerative U of O Thesis External Examiner Jul-09
Medicine
Kristen Ph.D. Medical UBC Thesis University Dec-
McKnight Genetics Examiner 08
Heather Heine Ph.D. Pathology UBC Comprehensive Examiner Apr-
07
Theresa Liao Ph.D. Surgery UBC Comprehensive Examiner May-
06
Marta Szabat Ph.D. Genetics UBC Candidacy Examiner Dec-
05
Farzad Moein Ph.D. Anesth., Pharm. UBC Candidacy Examiner Dec-
& Therap. 05
Harish M.Sc. Pharmacy UBC Thesis University Feb-
Vasudevan Examiner 05
Kyle Winter M.Sc. Physiology UBC Thesis Departmental Jul-04
Examiner
Kiristin Laurens Ph.D. Neuroscience UBC Thesis Examination Chair Oct-
03
Jan Ehses Ph.D. Physiology UBC Thesis Departmental Jul-03
Examiner

Francis Lynn Ph.D. Physiology UBC Thesis Departmental Jan-
Examiner 03
Kevin Ph.D. Biology U of V Thesis External Examiner Oct-
Cummings 02
Tanya Binette Ph.D. Surgery U of A Candidacy Examiner Jun-
02
Laura Atkinson Ph.D. Pediatrics U of A Candidacy Examiner Apr-
01
Prasanth Ph.D. Ag., Food and U of A Candidacy Examiner Dec-
Chelikiani Nut. Sciences 00
Antonio Rocca Ph.D. Physiology U of T Thesis External Examiner Oct-
00
Scholarly and Professional Activities

Areas of special interest and accomplishments
The ‘Laboratory of Molecular and Cellular Medicine’ consists of students (graduate & undergraduate),
technicians and postdoctoral fellows dedicated to developing novel and innovative therapeutic approaches for
diabetes. Our research typically involves sophisticated molecular techniques and studies at the cellular and
physiological level. We believe that gene and cell based therapies may be the medicine of the future.

Research or Equivalent Grants
AHFMR = Alberta Heritage Foundation for Medical Research
CDA = Canadian Diabetes Association
CFI = Canadian Foundation for Innovation
CIHR = Canadian Institute of Health Research
IIP = Intellectual Infrastructural Partnership
JDRF = Juvenile Diabetes Research Foundation (amounts in USD)
LS = Lifescan Inc., Johnson & Johnson
MF = Merck Frosst
MSFHR = Michael Smith Foundation for Health Research
SCN = Stem Cell Network, Networks of Centres of Excellence
NSERC = Natural Sciences and Engineering Research Council of Canada
CIHR/NSERC = Collaborative Health Research Projects
NIH = National Institutes of Health (amounts in USD)
Agency Project Title Total Start End Investigators
Amount Date Date
JDRF Implant of Differentiated $899,895 2019 2021 T J Kieffer, Melanie Graham
Pluripotent Stem Cells to
Treat Diabetes
NIH Engineering Stem Cells for $1,205,682 2018 2021 T J Kieffer, K Woltjen, M
Levings
Islet Cell Replacement
SCN Assessment of Cell $100,000 2018 2019 T J Kieffer
Maturation and Function in
Subcutaneous
Macroencapsulation Devices
in Rodents
NSERC / Raman spectroscopy Analysis $311,734 2017 2019 J Piret, T J Kieffer, M W
Blades, R F B Turner
CIHR to improve the validation of
cell therapy manufacturing
NSERC A zebrafish model to $170,000 2017 2022 T J Kieffer
investigate beta-cell functional
maturation and heterogeneity
SCN A stem cell therapy for insulin $500,000 2016 2017 T J Kieffer, G Warnock, M
Levings, D Thompson, G
replacement in patients with Meneilly
diabetes
SCN Optimizing stem cell derived $500,000 2016 2017 T J Kieffer, J Johnson, F Lynn,
B Hoffman
beta-cell therapy for diabetes
SCN Biodistribution of differentiated $100,000 2016 2017 T J Kieffer
stem cells following
subcutaneous transplant
SCN Genetic manipulation of $490,000 2016 2017 C B Verchere, T J Kieffer, F
Lynn, M Levings
hESC-derived insulin-
producing cells to improve
graft outcomes
JDRF Subcutaneous Transplant of $599,995 2016 2018 T J Kieffer
Differentiated Human
Pluripotent Stem Cells to
Treat Diabetes
CIHR Hormonal Regulation of $2,296,306 2015 2022 T J Kieffer
Glucose Homeostasis
CIHR Leptin Regulation of Glucose $781,855 2012 2017 T J Kieffer

Homeostasis
JDRF Treatment of Diabetes with $900,000 2015 2018 T J Kieffer, G Warnock, M
Levings
Stem Cell Derived Islets
Amount Date Date
Gill Family Islet Gene Therapy for $259,580 2014 2015 T J Kieffer
Charitable Diabetes (donation)
Trust
SCN Treatment of Diabetes with $100,000 2014 2015 T J Kieffer
Human Stem Cells
JDRF Encapsulation of Neonatal $1,049,286 2013 2016 G Korbutt, T J Kieffer, B
Verchere, J Piret
Porcine Islets for Clinical
Transplantation
CFI Systems Analysis of Single $7,588,178 2013 2014 F Rossi, T J Kieffer, R
Brinkman, C Eaves, M Hirst, R
Stem Cells Humphries, J Piret, M
Underhill
CIHR Generation of Transplantable $2,327,500 2011 2015 T J Kieffer, J D Johnson, F C
Lynn, C B Verchere, J M Piret
Beta-Cells from Human ES
Cells
CIHR Effects of Early Overnutrition $412,892 2011 2015 T J Kieffer, M M Glavas
on Beta-Cell Function
CDA Islet Gene Therapy for $225,000 2011 2014 T J Kieffer
Diabetes
JDRF Treatment of Diabetes with $725,656 2011 2013 T J Kieffer, J M Piret
Human Pancreatic Precursor
Cells
JDRF Novel Biomarkers for $299,800 2012 2014 T J Kieffer
Diabetes
JDRF Targeted Expression of $495,000 2010 2013 T J Kieffer
Insulin to Intestinal Endocrine
Cells
CFI High-Throughput, High- $614,371 2009 2010 T J Kieffer, J D Johnson
Content Imaging
Infrastructure for Diabetes
Research
JDRF Transgenic Pigs with Insulin $673,178 2009 2011 T J Kieffer
Producing Gut K-Cells USD
SCN Generating Transplantable $999,000 2008 2011 T J Kieffer, J D Johnson,
B Verchere, G Warnock,
beta-Cells for Diabetes M Underhill, J Piret
CDA Pancreatic Alpha-Cells and $270,000 2007 2010 T J Kieffer
Diabetes
Homeostasis
MSFHR Gene and Cell Therapy $500,000 2007 2012 T J Kieffer
Approach to Treat Diabetes

SCN Gene Delivery to Gut Stem $50,000 2007 2008 T J Kieffer
Cells

Amount Date Date
MSFHR The Centre for Human Islet $1,230,000 2006 2010 G Warnock, T J Kieffer,
and 16 others
Transplant and Beta-Cell
Regeneration
Insulin to Intestinal Endocrine USD
Cells
SCN High Content, High $649,250 2006 2008 T J Kieffer, J D Johnson,
B Verchere, G Warnock,
Throughput Screening for R Anderson, M Underhill,
Molecules that Promote Beta- J Piret
Cell Formation
CIHR Beta-Cell Regeneration for $1,500,000 2005 2010 T J Kieffer, J D Johnson,
T Rusung, B Verchere
Diabetes
JDRF Enhancing Islet Function with $118,307 2005 2006 T J Kieffer
GLP1 USD
SCN Production of Insulin from Gut $50,000 2005 2006 T J Kieffer
Stem Cells
LS Production of Insulin from Gut $50,000 2005 2006 T J Kieffer
Stem Cells
MF Merck Distinguished Speaker $5000 2005 2005 T J Kieffer
Series
Homeostasis
CDA GLP-1 Gene Therapy for $150,000 2004 2006 T J Kieffer
Diabetes
CFI Centre for Disease Modeling $19,428,91 2004 2006 H Teh , B B Finlay, R
Hancock, F Jean, W Jefferies,
2 T Kieffer,
L Lefebvre, C S McIntosh,
K M McNagny, J Weinberg
Cells
CDA GLP-1 Gene Therapy for $68,000 2003 2004 T J Kieffer
Diabetes
MSFHR Establishment Grant $125,000 2003 2005 T J Kieffer
CIHR Pancreatic Islet Generation $1,230,000 2002 2007 D J Hill, L Rosenberg, M

Bhatia, G S Korbutt, F
from Human Stem Cells Scott, T J Kieffer
JDRF Gene Therapy for Diabetes - $745,383 2001 2006 T J Kieffer
Insulin Secretion from the Gut
CIHR Leptin Regulation of Beta-Cell $191,496 2001 2004 T J Kieffer
Function

CDA Effect of a GIP Antagonist on $202,182 2001 2003 T J Kieffer
Glucose Tolerance
SCN The Stem Cell Genomics and $21,124,00 2001 2003 R Worton, T J Kieffer, and 53
others
Therapeutics Network 0
Amount Date Date
Cells
CDA Effect of a GIP Antagonist on $120,000 1999 2001 T J Kieffer
Glucose Tolerance
AHFMR Phase 1 Technology $35,000 1999 2000 T J Kieffer
Commercialization Program
CIHR Leptin Regulation of Beta-Cell $251,140 1998 2001 T J Kieffer
Function
IIP Laboratory of Molecular $119,845 1998 1999 T J Kieffer
Endocrinology (establishment)
Contract Research Agreements
Agency Project Title Total Start End

Amount Date Date
CRISPR Evaluation of Cloaked IPS-derived $229,767 2018 2019
Therapeutics Immature Beta Cells in the
Humanized NSG Model
Janssen Cellular Therapies for Diabetes $760,652 2012 2015
Johnson &
Johnson
Janssen Cellular Therapies for Diabetes $2,463,173 2006 2013
Johnson &
Johnson
enGene, Inc Production of Therapeutic Proteins $348,014 2006 2010
from Gut Cells

Awards and Distinctions
Awards
Award Agency Amount Start End
Date Date
Elected Fellow of the Canadian Academy of Health 2018
Academy Sciences
2015 Till & McCulloch The Stem Cell Network 2015 2015
Award
Distinguished Medical UBC Faculty of Medicine 2014 2014
Research Lecturer
Award
Researcher of the Year UBC Dept of Cellular & $1,000 2014 2014
Physiological Sciences
Award for Mentoring UBC Faculty of Medicine 2013 2013
Early Career Faculty
Distinguished UBC Faculty of Medicine 2011 2011
Achievement Award
Canadian Diabetes Young Investigator Award $5,000 2010 2010
Association
Senior Scholarship Michael Smith Foundation for $500,000 2007 2012
Health Research
Distinguished Alumni Thompson Rivers University n/a 2005 2005
Award
Scholarship Research Michael Smith Foundation for $100,000 2003 2007
Award Health Research
Early Career Scholar Peter Wall Institute for $5,500 2003 2004
Award Advanced Studies, UBC
Career Development Juvenile Diabetes Research $750,000 2001 2006
Award Foundation
Scholarship Research Alberta Heritage Foundation $100,000 1998 2002
Award for Medical Research
Scholarship Research Canadian Diabetes $150,000 1998 2001
Award Association

Invited Presentations
Title Conference or Event Location Organization Date

Cell Therapy for Cell Symposia: Los Angeles, Cell Press Dec 3,
Diabetes: Opportunities Translation of Stem Cells CA 2018
and Challenges to Clinic 2018
Research Update: Cell JDRF Research Update Winnipeg MB JDRF Nov 8,

Therapy for Diabetes 2018
Cell Based Insulin DREAM 7th Annual Winnipeg MB Diabetes Nov 8,
Replacement for Diabetes Research Research 2018
Diabetes Symposium Envisioned &
Accomplished
in Manitoba
Stem Cell Transplant Live Well with Diabetes Vancouver UBC Nov 4,
Update Conference Continuing 2018
Professional
Development
Cell Therapy for Invited Seminar University of Institute of Sept 21,
Diabetes Using Helsinki, Biotechnology, 2018
Differentiated Stem Cells Finland University of
Helsinki,
Finland
Islets from Pluripotent World Congress on Edinburgh World July 18,
Stem Cells; Lessons Prevention of Diabetes & Scotland Community for 2018
from Transplant Models its Complications Prevention of
Diabetes
Engineering a Biological Children with Diabetes Orlando, FL Friends for Life July 13,
Cure for T1D 2018
Stem Cell Therapy for Genesis: The launch Vancouver, BC University of May 31,
Diabetes symposium of UBC’s BC 2018
School of Biomedical
Engineering
Targeting Gut Endocrine Gene Therapy New York, NY JDRF / May 22,
Cells for Meal Regulated Approaches to Treat Helmsley Trust 2018
Insulin Replacement Type 1 Diabetes
Cell Therapies for StemCellTalks Vancouver, BC StemCellTalks May 11,
Diabetes 2018
In Vitro Versus In Vivo Key Opinion Leaders Boston, MA IPITA–JDRF– May 7,
Maturation of Stem Cell Meeting on HSCI 2018
Derived Beta-Cells STEM CELL DERIVED
BETA CELLS
Making Functional Islet ISCT 2018 Montreal, QC International May 4,
Cells from Human Society for Cell 2018
Pluripotent Stem Cells Therapy
Research Update: JDRF AGM Toronto, ON JDRF May 2,
Replacement Beta Cells 2018

from Stem Cells
Stem Cell-Derived Beta Type 1 Diabetes Ottawa, ON Health March
Cells for Transplant to Symposium Canada, JDRF 9, 2018
Reverse Diabetes
Gut Stem Cells to Beta International Diabetes Abu Dhabi, International Dec 7,
Cells Federation 2017 United Arab Diabetes 2017
Congress Emirates Federation
Cell-Based Insulin Ray Gall Memorial Edmonton, AB University of Nov 14,

Replacement for Symposium Alberta 2017
Diabetes
Stem Cell Therapy for 2017 Till and McCulloch Mont- Stem Cell Nov 6,
Diabetes: Basic Meetings Tremblant, QC Network 2017
Research to Clinical
Trials
Strategies to Develop a 20th Annual Diabetes Edmonton, AB Diabetes Nov 2,
Renewable Cell Source Canada / CSEM Canada 2017
to Treat Diabetes Professional Conference
Gene and Cell Therapy Invited Seminar Beijing, China Peking Oct 27,
for Diabetes University 2017
Cell Therapy for Health Research Caucus Ottawa, ON Research Oct 16,
Diabetes Reception on Canada 2017
Biotechnology in Health
Research
Islets from Pluripotent Accelerating Pathways to Rochester, MN Mayo Clinic Sept 30,
Stem Cells; Lessons Clinical Trials: An 2017
from Transplant Models International Conference
on Islet Regeneration
and Replacement
Strategies to Make JDRF Research Update Vancouver, BC JDRF Sept 26,
Human Islets to Treat 2017
Diabetes
Pre-Clinical and Clinical UBC Division of Vancouver, BC UBC Division Sept 15,
Studies of a Stem Cell Endocrinology Research of 2017
Based Islet Replacement Fest Endocrinology
for Diabetes
Insulin Replacement for Invited Seminar Tokyo, Japan Juntendo June
Diabetes by Cell Therapy University 16,
2017
Gene and Cell Therapy Invited Seminar Shiga, Japan Shiga June 8,
for Diabetes University of 2017
Medical
Science
Islets from Pluripotent Kyoto Diabetes Mini- Kyoto, Japan Kyoto June 5,
Stem Cells; Lessons Symposium University 2017
from Transplant Models

Research Innovation on 60th Annual Meeting of Nagoya, Japan Japan May 18,
Pancreatic Beta-Cell The Japan Diabetes Diabetes 2017
Differentiation and Society Society
Regeneration
GIP, a Classic but 60th Annual Meeting of Nagoya, Japan Japan May 18,
Emerging Therapeutic The Japan Diabetes Diabetes 2017
Target: from Discovery to Society Society
Current Progress
Treating Diabetes with Invited Seminar Tokyo, Japan University of May 9,
Human Pluripotent Stem Tokyo 2017
Cell-Derived Islet Cells
Treating Diabetes with 44th Annual Congress of Kyoto, Japan Japanese March
Human Pluripotent Stem Japanese Pancreas and Pancreas & 10,
Cell-Derived Islet Cells Islet Transplantation Islet 2017
Association Transplantatio
n Association
Hyperinsulinemia Versus 8th Young Diabetologist Sapporo, Japan Taisho March
Insulin Resistance: Frontier in Hokkaido Toyama 4, 2017
Lessons from Leptin Pharmaceutica
Physiology l Co
Cell Engineering to Cure Science Dialogue Fukui Japan Society Feb 18,
Diabetes – Life of a Prefectural, for the 2017
Scientist Koshi High Promotion of
School Science
The Actions of the Leptin Postgraduate Kyoto, Japan Kyoto Dec 13,
on Glucose Homeostasis Educational Course University 2016
Graduate
School of
Medicine
Making Mature Human 2016 International Seoul, Korea Korean Oct 14,
Islet Cells from Stem Conference on Diabetes Diabetes 2016
Cells to Model Disease and Metabolism Association
and Treat Diabetes
Treating Diabetes and 2016 International Seoul, Korea Korean Society Sept 3,
Obesity with Stem Cell- Congress on Obesity and for the Study of 2016
Derived Pancreatic Cells Metabolic Syndrome Obesity
Role of Hyperinsulinemia 2016 International Seoul, Korea Korean Society Sept 2,
in Weight Gain: Lessons Congress on Obesity and for the Study of 2016
from Engineered Mice Metabolic Syndrome Obesity
Insulin Therapy By Department of Diabetes, Kyoto, Japan Kyoto July 27,
Engineered Cells Endocrinology and University 2016
Nutrition Hospital
Reversal of Diabetes 59th Annual Meeting Kyoto, Japan Japan May 21,
with Stem Cell Derived Diabetes 2016
Beta Cells Society
Insulin Therapy By Sanofi Japan Round Kyoto, Japan Sanofi May 21,

Engineered Cells Table Discussion 2016
Research Update JDRF Research Update Vancouver, BC JDRF Apr 27,
2016
Treating Diabetes with New Therapeutics for La Jolla, CA Keystone Apr 18,
Differentiated Pluripotent Diabetes & Obesity Symposia 2016
Stem Cells
The Amazing Potential of BPP Professor Research Vancouver, BC Biochemistry Feb 24,
Stem Cells for Treating Night Pharmacology 2016
Disease Physiology
Club
UBC
Treatment of Diabetes 2016 Scientific Meeting Edmonton, AB Canadian Feb 19,
with Islet Cells Produced Pediatric 2016
by Human Stem Cells Endocrine
Group
Stem Cell Derived Islets JDRF 2016 Mission San Diego, CA JDRF Jan 29,
for Diabetes Summit 2016
Considerations for the IDF World Diabetes Vancouver, BC International Dec 2,
Clinical Application of Congress Diabetes 2015
Stem Cells for Diabetes Federation
Pluripotent Stem Cell IPITA • IXA • CTS 2015 Melbourne, International Nov 18,
Derived Beta Cells Joint Congress Australia Pancreas and 2015
Islet
Transplant
Association
Insulin Replacement for Till & McCulloch Meeting Toronto, ON Stem Cell Oct 28,
Diabetes by Transplant Foundation 2015
of Differentiated
Pluripotent Stem Cells
Insulin Replacement by The 9th International Seoul, Korea Seoul National Oct 23,
Engineered Gut Conference on Cell University 2015
Endocrine Cells Therapy
Treatment of Diabetes The 9th International Seoul, Korea Seoul National Oct 23,
with Stem Cell Derived Conference on Cell University 2015
Insulin Producing Cells Therapy
Differentiation of Accelerating Pathways to Rochester MN Mayo Clinic Sept 25,
Pluripotent Stem Cells Clinical Trials: An 2015
Into Insulin Producing International Conference
Cells on Islet Regeneration
and Replacement
Progress Towards a JDRF Webinar Webinar JDRF Sept 23,
Stem Cell Therapy for 2015
Diabetes
Treating Diabetes with City-Wide Endocrine Toronto, ON Banting and Sept 11,
Stem Cell Derived Beta- Rounds Best Diabetes 2015
Cells Centre

The State of Directed American Diabetes Boston, MA American June 5,
Differentiation and Association 75th Diabetes 2015
Transdifferentiation to Scientific Sessions Association
Generate Human Beta
Cells
Cell-Based Insulin Laurence Becker Annual Toronto, ON The Hospital June 3,
Replacement for Symposium on Advances for Sick 2015
Diabetes in Laboratory Medicine Children
Beta Cell Replacement Lunenfeld-Tanenbaum Toronto, ON Mount Sinai May 26,
for the Treatment of 2015 International Hospital 2015
Diabetes Symposium
Stem Cell Derived Beta StemCell Talks Vancouver, BC University of May 15,
Cells Versus Islet Donors Vancouver Symposium British 2015
Columbia
Insulin Replacement by Canadian Clinical Trials Toronto, ON JDRF April 30,
Cells Network 2015
Insulin Replacement by JDRF Donor Toronto, ON JDRF April 29,
Cells Appreciation Event 2015
Research Update: Insulin JDRF Annual General Toronto, ON JDRF April 29,
Replacement by Cells Meeting 2015
Cell Based Therapies for Faculty of Medicine Vancouver, BC University of Feb 18,
Diabetes Distinguished Medical British 2015
Research Lecturer Columbia
Award
Cell Based Therapies for 2014 Alberta Diabetes Edmonton, AB University of Sept 30,
Diabetes Institute Research Day Alberta 2014
Cell Based Strategies for Centennial Symposium, Edmonton, AB University of May 30,
Insulin Replacement Department of Alberta 2014
Physiology
Making Islet Cells from 2014 Pediatric Academic Vancouver, BC Pediatric May 4,
Stem Cells to Treat Societies/Asian Society Academic 2014
Diabetes for Pediatric Research Societies &
(PAS/ASPR) Joint Asian Society
Meeting for Pediatric
Research
Targeting the Glucagon Incretin Research Osaka, Japan Incretin Study Apr 19,
Receptor Family for Type Symposium Group / Novo 2014
2 Diabetes Treatment Nordisk
Glucose-Dependent Invited Seminar Osaka, Japan Kansai Electric Apr 18,

Insulinotropic Power Hospital 2014
Polypeptide in Health
and Disease
Treatment of Diabetes Canadian Clinical Trials Vancouver, BC Juvenile Feb 13,
with Stem Cell Derived Network JDRF, WB Diabetes 2014

Islets Family Foundation, Research
Funding Announcement Foundation
& Lab Tour
Engineering Cells for Invited Seminar Sydney, Garvan Feb 6,

Insulin Replacement in Australia Institute of 2014
Diabetes Medical
Research
Using Model Systems to 15th ANZ Zebrafish Sydney, Annual Feb 3,

Guide Production of Islet Conference Australia Australian and 2014
Cells From Human ES New Zealand
Cells Zebrafish
Conference
Cell Interactions in the IDF World Diabetes Melbourne, International Dec 05,
Endocrine Pancreas Congress, Australia Diabetes 2013
Federation
Once Upon a Time we Café Scientifique Vancouver, BC University of Nov 14,
Treated Diabetes with British 2013
Insulin Columbia
Production of Islet Cells Cold Spring Harbor Asia Suzhou. China International Oct 17,
From Human ES Cells to / ISSCR Joint Society for 2013
Treat Diabetes Conference Stem Cell
Research
In Vivo Maturation of International Congress Tehran, Iran Tehran Oct 23,
Pancreatic Precursor on Endocrinology and (by video) University Of 2013
Cells Derived from Metabolism Updates Medical
Human ES Cells Sciences
Treatment of Diabetes JDRF Encapsulation New York, NY Juvenile Oct 21,
with Human Pancreatic Consortium Meeting Diabetes 2013
Precursor Cells Research
Foundation
In Vivo Maturation of EASD Islet Study Group Sitges, Spain European Sept 29,
Pancreatic Precursor Association for 2013
Cells Derived from the Study of
Human ES Cells Diabetes
Beta Cell Replacement Invited Seminar Kyoto, Japan Kyoto Aug 5,
Strategies for Diabetes University 2013
Beta Cell Replacement The 7th Diabetes Otsu, Japan Dainippon Aug 4,
Strategies for Diabetes Leading-Edge Sumitomo 2013
Conference Pharma Co.
Ltd.
Stem Cell Strategies for JDRF Fundraiser at Victoria, BC Juvenile June
Insulin Replacement for Private Residence Diabetes 20,
Diabetes Research 2013
Foundation

Stem Cell Strategies for Canadian Diabetes Toronto, ON Canadian May 29,
Insulin Replacement for Association Diabetes 2013
Diabetes National Office Association
Presentation
Stem Cell Strategies for KAIST Invited Seminar Daejeon, Korea Korea May 6,
Insulin Replacement for Advanced 2013
Diabetes Institute of
Science and
Technology
Making Islets from International Congress of Seoul, Korea Seoul May 4,
Human Embryonic Stem Endocrinology & Korean 2013
Cells to Treat Diabetes Metabolism Endocrine
Society
Targeting Incretin International Congress of Seoul, Korea Seoul May 3,
Producing Cells for Endocrinology & Korean 2013
Insulin Replacement Metabolism Endocrine
Therapy Society
Maturation & Function of 8th Beta Cell Workshop Kyoto, Japan Beta Cell April 25,
Macroencapsulated 2013 Workshop 2013
Human ES-Derived
Pancreatic Progenitor
Cells in Diabetic Mice
Research Update JDRF Research Regina, SK Juvenile April 14,
Symposium & TELUS Diabetes 2013
Walk to Cure Diabetes Research
Foundation
Stem Cells for Diabetes 2013 PEARL Conference Vancouver, BC Pediatric Mar 1,
of Northwest Pediatric Endocrine 2013
Endocrinologists Association for
Research and
Learning
Use of hESC Progenitors JDRF Encapsulation New York, NY Juvenile Mar 14,
in Theracyte-Like Consortium Diabetes 2013
Devices Research
Foundation
Transplants for Diabetes: Public Forum on Latest Vancouver, BC The BC Feb 27,
Past, Present and Future in Organ Transplantation Transplantatio 2013
n Research
Foundation
Using Stem Cells to UBC Division of Vancouver, BC University of Sept 21,
Treat Diabetes Endocrinology and British 2012
Metabolism Research Columbia
Fest
Cell Therapy for Invited Presentation Toronto, ON Donnelly Sept 6,

Diabetes Centre for 2012
Cellular &
Biomolecular
Research,
University of
Toronto
Research Update: JDRF Annual General Toronto, ON Juvenile June
Stem Cells to the Meeting Diabetes 22,
Rescue? Research 2012
Foundation
Cell-Based Insulin 12th IDS Conference Victoria, BC Immunology of June
Replacement Strategies Diabetes 18,
to Treat Type 1 Diabetes Society 2012
Creating Alpha Cells ADA 72nd Scientific Philadelphia, American June
from Sessions PA Diabetes 12,
ES Cells Association 2012
JDRF Ride for Diabetes JDRF 2012 Campaign Vancouver, BC Juvenile May 15,
Research Kickoff Diabetes 2012
“How Close is a Cell Research
Therapy?” Foundation
Reprogramming Gut Progress to Therapy Glasgow, UK Scottish Stem Mar 22,
Cells for Insulin Conference Cell Network 2012
Replacement
Reprogramming UCSD PDRC San Diego, CA UC San Diego Jan 27,
Intestinal Cells for Insulin Symposium Pediatric 2012
Replacement Therapy Diabetes
Research
Center
Cell Based Therapy for 15th Annual Vancouver, BC Department of Dec 5,
Diabetes Transplantation Surgery, 2011
Research Day University of
British
Columbia
New Therapeutic CIHR New Principal St. Adele, QC Canadian Nov 6,
Strategies for Diabetes Investigator Meeting Institutes of 2011
Health
Research
Leptin Actions on National Atherosclerosis Montreal, QC Merck Oct 13,
Glucose and Lipid and Cardiometabolic 2011
Metabolism Forum (NAF)
Insulin Replacement by Departmental Seminar Vancouver BC Department of Sept 22,

Engineered Cells to Cellular & 2011
Treat Diabetes Physiological
Sciences, UBC
Gene and Cell Therapy NSFC-CIHR Canada- Shanghai, National Sept 13,
for Diabetes China Joint Health China Natural 2011
Research Program Science
Scientific Workshop on Foundation of
Diabetes China
Harnessing Incretin 54th Meeting of Japan Sapporo, Japan Japan May 20,
Pathways to Treat Diabetes Society Diabetes 2011
Diabetes Society
Gene and Cell Based UCSF Endocrine Grand San Francisco, University of April 20,
Insulin Replacement for Rounds CA California San 2011
Diabetes Francisco
Regulating and 12th Servier-IGIS St. Jean Cap International April 1,
Engineering GLP-1 and Symposium Ferrat, France Group on 2011
GIP Production Insulin
Secretion
Alternative Biologic JDRF Research Update Kelowna, BC Juvenile Mar 15,
Methods Diabetes 2011
for Insulin Replacement Research
Foundation
Cell Based Insulin CIHR – INMD Advisory Vancouver, BC Canadian Feb 24,
Replacement for Board Meeting Institutes of 2011
Diabetes Health
Research
Research Opportunities BPP Professor Research Vancouver, BC Biochemistry Jan 19,
in the Life Sciences Night Pharmacology 2011
Physiology
Club of UBC
Stem Cell and Gene Stem Cell Talks for High Vancouver BC StemCellTalks Dec 3,
Therapy Approaches to School Students Vancouver 2010
Treat Diabetes
Insulin Replacement by EASD/JDRF Joint Barcelona, European Nov 18,
Engineered Strategic Meeting Spain Association for 2010
Enteroendocrine Cells the Study of
Diabetes
Cell Based Insulin CDA/CSEM Annual Edmonton, AB Canadian Oct 22,
Replacement for Conference Diabetes 2010
Diabetes Association
Cell Based Insulin JDRF Canada AGM Toronto, ON JDRF Jun 18,
Replacement Strategies 2010
for Diabetes
Alternative Biologic Victoria JDRF Chapter Victoria, BC JDRF Mar 25,
Methods for Insulin 2010
Replacement
Diabetes: Causes, CIHR Café Scientifique Vancouver, BC CIHR Jan 26,

Consequences and 2010
Cures?
Eliminating the needle for Pharmaceutical Sciences Vancouver, BC University of Dec 2,

diabetes by making new Seminar British 2009

‘beta-cells’ Columbia
Potential Autoimmune JDRF Beta Cell Boston, MA JDRF Dec 8,
Resistance and Animal Reprogramming 2009
Models Workshop
The GIP Secreting K- University of Toronto Toronto, ON University of Nov 27,
Cell: Biology and Symposium on Incretin Toronto 2009
Therapeutic Potential Biology
Laboratory of Molecular JDRF Calgary Chapter Calgary, AB JDRF Nov 3,

& Cellular Medicine – Private Research 2009
Research Update Reception
Laboratory of Molecular JDRF Vancouver Vancouver, BC JDRF Oct 6,
& Cellular Medicine – Chapter Private 2009
Research Update Research Reception
Gene and cell therapy for 2009 UBC Division of Vancouver, BC University of Sep 18,
diabetes Endocrinology and British 2009
Metabolism Research Columbia
Fest
Incretin Hormones GIP International Congress of Kyoto, Japan IUPS Jul 28,
and GLP-1 Physiological Sciences 2009
Cell Based Insulin Diabetes Research Edmonton, AB JDRF – Apr 19,
Replacement Strategies Symposium Edmonton 2009
for Diabetes Chapter
Targeting Gut Stem Cells Stem Cell Research & San Francisco, University of Apr 15,
to Treat Diabetes Regenerative Medicine, CA California 2009
System-Wide
Technology Transfer
Forum
My Career in Diabetes Speaker Series Vancouver, BC, Science Mar,
Research Canada Undergraduate 2009
Society
Targeting Gut Stem Cells Annual General Meeting Vancouver, BC, Stem Cell Nov,
to Treat Diabetes Canada Network 2008
Engineering Cells to Annual Student Vancouver, BC, Child & Family Jun,
Cure Diabetes Research Forum Canada Research 2008
Institute
Role of GIP in Insulin Annual Professional San Francisco, Endocrine Jun,
Secretion & Islet Biology Conference USA Society 2008
Cell Therapy for 2008 Scientific Toronto, ON, Toronto May,20
Diabetes Symposium Canada Diabetes 08
Association
Cell Therapies for 2008 Scientific Meeting Vancouver, BC, Canadian Apr,
Diabetes Canada Pediatric 2008
Endocrine
Group

Eliminate the Needle - Diabetes Research Vancouver, BC, JDRF Mar,
Gene and Cell Therapies Symposium Canada 2008
for Diabetes
Translational Medicine of UBC President Visit to LSI, UBC Life Sciences Dec,
the Diabetes Group LSI Centre 2007
Gene Therapy Annual Conference Vancouver, BC, CDA Oct,
Approaches for Canada 2007
Generating Surrogate
Beta Cells in Type 1
Diabetes
Insulin Production by Oxford Workshop Oxford, UK EASD/JDRF Aug,
Cells in the Gut 2007
Engineering Gut Cells for Montreal Diabetes Montreal, QC, University of Feb,
Insulin Replacement Research Centre Canada Montreal 2007
Therapy Seminar
Cell Therapy Approaches Austin Chapter Research Austin, TX, USA Juvenile Feb,
for Diabetes Update Dinner Diabetes 2007
Research
Foundation
Latest Innovations and The First Hemispheres Buenos Aires, Nov,
New Pharmaceutical Diabetes Workshop: Argentina 2006
Perspectives in Diabetes Argentina-Canada
Treatment
New Approaches for 2nd Canadian Beta Cell Toronto, ON, Merck Frosst Nov,
Generating a Beta-Cell Working Group Meeting Canada 2006
Setting Up and Running Life Science Post-DocVancouver, BC, University of Jul,
a Research Lab Club Meeting Canada British 2006
Columbia
Preparing for Academic Life Sciences Institute Vancouver, BC, University of Mar,
Interviews Post-Doc Club Meeting Canada British 2006
Columbia
Regenerating Pancreatic Lecture for Health Toronto, ON, Merck Frosst Nov,
Beta-Cells Science Associates Canada 2005
Insulin Production by Transdifferentiation San Diego, CA, Juvenile May,
Meal-Responsive Gut K- Development and Future USA Diabetes 2005
Cells Directions Research
Foundation
Targeting Gut Stem Cells Symposium on Stem Toronto, ON, York University Mar,
to Treat Diabetes Cells Canada 2005
Gene Therapy for Diabetes Research Day, Vancouver, BC, University of Mar,
Diabetes Public Lecture Canada British 2005
Columbia
Gene Therapy for Fellows Research Forum Chantilly, VA, Juvenile Mar,
Diabetes - Insulin United States Diabetes 2005
Secretion from Gut Research
Foundation
Looking to the Gut to Austin Chapter Research Austin, TX, USA Juvenile Mar,
Cure Diabetes Update Dinner Diabetes 2005
Research
Foundation
The Future Look of Cell Surgical Grand Rounds Vancouver, BC, Vancouver Dec,
Replacement for Canada General 2004
Diabetes Hospital
Engineering Your Gut to Vancouver MiniMed Vancouver, BC, Vancouver Nov,
Make Insulin: A New School Canada General 2004
Therapy for Diabetes? Hospital
Targeting GIP in International Symposium Toulouse, Sep,
Diabetes and Obesity on Regulatory Peptides France 2004
Genetic Engineering of German Diabetes Hannover, German May, 2004
Gut Endocrine Cells to Association Conference Germany Diabetes
Treat Diabetes Mellitus Association
Gastro-Intestinal 47th International Paris, France Apr,

Hormones GIP & GLP-1 Conference of Clinical 2004
Endocrinology
Diabetes Research South Central Texas San Antonio, Juvenile Mar,
Update Chapter Research TX, USA Diabetes 2004
Update Dinner Research
Foundation
Engineering Your Gut to Public Lecture Vancouver, BC, BC Research Feb,
Make Insulin: A New Canada Institute for 2004
Therapy for Type 1 Children's and
Diabetes? Women's
Health
Gene and Cell Therapy Biochemistry, Vancouver, BC, University of Jan,
Approaches to Treat Pharmacology and Canada British 2004
Diabetes Physiology Club Columbia
Synthesis and Novel roles of GI Longbeach, CA, American Dec,
Metabolism of GI Hormones USA Diabetes 2003
Hormones Association
Insulin Gene Therapy for Diabetes Institute Pittsburgh, PA, University of Oct,
Diabetes Seminar USA Pittsburgh 2003
GLP-1 and Beta Cell Quebec Association of Montreal, QB, Lilly Sep,
Regeneration Endocrinologists Canada 2003
Career Advice Stem Cell Network Vancouver, BC, Stem Cell Sep,
Annual General Meeting Canada Network 2003
Looking to the Gut as an Public Research Vancouver, BC, Juvenile Sep,
Alternative Source of Conference Canada Diabetes 2003
Beta Cells Research
Foundation
Gene Therapy OBST 506: Seminars in Vancouver, BC, University of Sep,
Approaches to Treat Reproductive Biology Canada British 2003

Diabetes Class Presentation Columbia
Gene Therapy Department of Biology Victoria, BC, University of Oct,
Approaches to Treat Seminar Canada Victoria 2002
Diabetes
Novel Gene Therapeutic German Diabetes Dresden, German May, 2002
Approaches for Association Conference Germany Diabetes
Treatment of Diabetes Association
Diabetes Research Kids and Us Public Edmonton, AB, Juvenile Apr,
Update Conference Canada Diabetes 2002
Research
Foundation
Generation of Insulin Stem Cell Network Montreal, QB, Stem Cell Mar,
Producing Cells from Gut Workshop Canada Network 2002
Stem Cells
Gut K-Cells as Gene Department of Vancouver, BC, University of Feb,
Therapy Targets for Physiology Seminar Canada British 2002
Insulin Replacement to Columbia
Treat Diabetes
Issues/Advice for New Grant Tips Workshop Edmonton, AB, University of Jan,
Investigators Canada Alberta 2002
Engineering K-cells as 6th International Meeting Erice, Italy Focus on: Dec,
Gene Therapy Targets on the Genetics, Diabetes 2001
for Insulin Replacement Pathogenetics,
Prevention, and Therapy
of Type 1 & 2 Diabetes
Gut Endocrine Cells as NIDDK Workshop: Beta Bethesda, MD, National Nov,
Surrogate Beta Cells Cell Biology in the 21st USA Institute of 2001
Century Health
Islet Transplant and Faculty of Medicine Edmonton, AB, Alberta Oct,
Beyond... Public Lecture Canada Heritage 2001
Foundation for
Medical
Research
Engineering Pathology and Vancouver, BC, BCRICWH Oct,
Gastrointestinal Cells to Laboratory Medicine Canada 2001
Produce Insulin for Seminar
Treating Diabetes
Meal Regulated Release Department of Genofte, Hagedorn Sep,
of Insulin from Developmental Biology Denmark Research 2001
Engineered Gut K-cells Seminar Institute
Meal Regulated Release Department of Wurzburg, University of Sep,
of Insulin from Metabolism, Germany Wurzburg 2001
Engineered Gut K-cells Endocrinology &
Molecular Medicine
Seminar
The Enteroinsular Axis 11th Scientific Sessions Philadelphia, American Jun,

and Incretin Action PA, USA Diabetes 2001
Association
Meal-regulated Delivery Technology Evaluation University of Novo Nordisk Apr,
of Therapeutic Proteins Alberta, 2001
for Treating Diabetes Edmonton, AB,
Mellitus Canada
Delivering peptides Technology Evaluation New Brunswick, J&J Corporate Mar,
through genetic NJ, USA Office of 2001
innovations Science &
Technology
Coaxing the Gut to Make Medical Grand Rounds Edmonton, AB, University of Jan,
Insulin - A Novel Canada Alberta 2001
Approach to Treat
Diabetes
Intestinal Gene Therapy City-Wide Endocrine Toronto, ON, Mount Sinai Sep,
for Treatment of Rounds Canada Hospital 2000
Diabetes
Intestinal Gene Therapy Department of Vancouver, BC, University of Jun,
for Diabetes Physiology Seminar Canada British 2000
Columbia
Intestinal Hormones with Collip Club Edmonton, AB, University of Mar,
Therapeutic Potential for Canada Alberta 2000
Diabetes Mellitus
Department of Medicine Edmonton, AB, University of 2000
Canada Alberta
Insulin Secretion From Professional Conference Ottawa, ON, Canadian Oct,
the Beta-Cell: Role of Canada Diabetes 1999
Receptors and Channels Association
41st Annual Conference Edmonton, AB, Canadian Fed. 1998
Canada of Biological
Societies
Department of Edmonton, AB, University of 1998
Physiology Seminar Canada Alberta
Muttart Diabetes Edmonton, AB, University of 1998
Research and Training Canada Alberta
Centre
Department of Medicine, Edmonton, AB, University of 1997
Canada Alberta
Boston-Ithaca Islet Club Woods Hole, 1997
Meeting MA, USA
Endocrine Division Boston Massachusetts 1997
Rounds General
Hospital
11th International Copenhagen, 1996
Symposium on Denmark

Regulatory Peptides
24th New England Dartmouth 1996
Endocrine Conference College,
Hanover, NH,
USA
Conferences and Other Events (not yet updated)
Role Activity Conference or Event Organization Event Dates

Dates
Start End Start End
Conference Oct, Oct, Professional Conference: Canadian Oct 19, Oct 22,
Chair 2004 2005 Session: Future Therapies Diabetes 2005 2005
for Type 2 Diabetes Association
Conference Jun, Jun, 62nd Scientific Sessions: American Jun 14, Jun 18,
Chair 2001 2002 Session: GLP-1 and GIP Diabetes 2002 2002
Association

Service to the University
Memberships on committees (not yet updated)
Type Committee Name Role Dates

Start End
Department Headship Search Committee Professor May, 2009
Representative
Department Merit and Performance Salary Member Jan, 2009
Adjustment Review Committee
Department Animal Facility Committee Member Jan, 2008
Department Appointments, Promotions and Acting Chair Jan, 2008
Tenure Committee
University Life Sciences Centre Member Apr, 2008
Stores/Receiving
Implementation Committee
Child & Family Recruitment Committee Member Nov, 2007
Research
Institute
University Canada Foundation for Reviewer Sep, 2007
Innovation, LOF Grants
Committee
Department Merit/PSA Committee Member Feb, 2007 Mar, 2009
Department Faculty Mentor Committee Mentor Sept, 2005
Department Ike Barber Chair Selection Member Jan, 2005 Jan, 2005
Committee
University Grants Committee Reviewer Jan, 2003
Department Physiology Teaching Committee Member Sep, 2002 Jul, 2004
Department Recruitment Committee Member Sep, 2002

Service to the Community
Memberships on scholarly societies and other organizations
Organization Organization
Endocrine Society Canadian Diabetes Association
American Diabetes Association Canadian Federation of Biological
Societies
American Physiological Society Muttart Diabetes Research and Training
Centre
Canadian Physiological Society
Memberships on scholarly and other committees (not yet updated)

Organization Committee Name Role Dates
Start End
JDRF Medical Science Review Committee (MSRC) Reviewer 2009 2010
CIHR China-Canada Collaborative Teams in Health Research 2009
Research
Michael Smith Biomedical Senior Graduate Studentship Reviewer 2009 2009
Foundation for Evaluation Panel
Health
Research
JDRF Replacement and Regeneration Innovative Grant Reviewer 2009 2009
Study Section
JDRF Innovative Grants Committee: Beta Cell Member 2008 2009
Replacement and Regeneration
CIHR Operating Grants Committee: Metabolism Member 2008
CIHR Grants Committee: Endocrinology Primary 2008
Reviewer
Int. Regulatory Scientific Committee Member 2008
Peptide Society
CIHR Grants Committee: University – Industry Panel Member 2007
CIHR Regenerative Medicine and Nanomedicine Review Scientific 2008 2008
Panel Officer
CIHR Regenerative Medicine and Nanomedicine Review Scientific 2006 2006
Panel Officer
CIHR Metabolism Committee Member 2006 2006
CDA Grants Committee: Committee Islet, Immunology & Chair 2005 2008
Genetics
CDA C&SS Professional Conference Program Member 2005 2005
Committee
National Grants Committee: Centers for Excellence in Member 2005 2005

Organization Committee Name Role Dates
Start End
Institutes for Translational Human Stem Cell Research
Health
CDA National Research Council Member 2004 2008
CDA Grants Committee: Committee B Co-Chair 2004 2005
JDRF Grants Committee: Ad Hoc Committee for Clinical Member 2003 2003
Islet Transplant Centers and Stem Cell Program
Projects
JDRF Grants Committee: Medical Science Review Member 2001 2007
CDA Grants Committee: Committee B Member 2001 2004
University of Research Committee of the University of Alberta Member 2001 2002
Alberta Department of Medicine
CIHR Grants Committee: Metablism and Nutrition Member 2000 2003
ADA American Diabetes Association 61st Scientific Member 2000 2002
Sessions Planning Committee
Northern Biological Sciences Technology Laboratory and Member 1999 2001
Alberta Institute Research Program Advisory Committee
of Technology
Massachusetts Clinical Research Data Search Engine Design Member 1995 1996
General
Hospital
Editorships
Journal Position Dates

Start End
Islets Associate Editor 2013
Physiological Reviews Editorial Board Member 2007
Canadian Journal of Diabetes Associate Editor 2006
e-biomed: The Journal of Regenerative Medicine Associate Editor 2001 2004
Reviewer/Referee (*does not include grants reviewed as part of grant committee duties)
Journal Reviewing/Refereeing
Journal
American Journal of J of Clinical Endocrinol and Regulatory Peptides
Physiology Metab
Diabetes Journal of Clinical Investigation Trends in Endocrinol and Metab
Diabetologia Molecular Therapy Trends in Molecular Medicine
Endocrinology Nature Nature Medicine
Gastroenterology Science

Grant Application Assessment * (not yet updated)
Grant Description Organization # Dates

Assessed Start End
Operating Grant The Wellcome Trust 1 2009
China-Canada Collaborative CIHR/ Ministry of Science and 2009
Teams in Health Research Technology of the People's
Republic of China (MOST)
Operating Grants Swiss National Science 1 2009 2009
Foundation
Operating Grants Wellcome Trust 1 2009 2009
Academic R & D Juvenile Diabetes Foundation 1 2008
Operating Grants Heart and Stroke Foundation of 1 2008
Canada
Collaborative Health Research National Sciences & Engineering 1 2007
Project Research Council of Canada
Leaders Opportunity Fund Canada Foundation for Innovation 1 2007 2007
Leaders Opportunity Fund- UBC Canada Foundation for Innovation 10 2007 2007
Internal Evaluation Committee
Discovery Grants NSERC 2 2005
Centres for Excellence in National Institutes for Health 8 2005 2005
Translational Human Stem Cell
Research
Operating Grants Fondazione Telethon 3 2004
Italy/Juvenile Diabetes Research
Foundation International
Partnership Program in Type 1
Diabetes 
Operating Grants Wellcome Trust 1 2004 2004
The University of British Columbia The University of British Columbia 6 2003
Clinical Islet Transplants Centers Juvenile Diabetes Research 8 2003 2003
and Stem Cell Program Projects Foundation
Operating Grants Department of Veterans Affairs 1 2002 2002
Operating Grants Canadian Diabetes Association 40 2001
Scholarships Canadian Diabetes Association 5 2001
Operating Grants Juvenile Diabetes Research 60 2001
Foundation
Fellowships Juvenile Diabetes Research 20 2001
Foundation
Program Projects Juvenile Diabetes Research 10 2001
Foundation
Operating Grants CIHR 75 2000

Conference Reviewing/Refereeing
Conference Organization # Reviewed Dates

or Refereed Start End
69th Scientific Sessions American Diabetes Association 22 2008 200
9
Annual Professional Conference Canadian Diabetes Association 30 2003
Annual Professional Conference American Diabetes Association 50 2002 200
3
Promotion/Tenure Assessment
Dept./Unit Organization # Assessed Dates

Start End
Medicine Dalhousie University 1 October, October,
2009 2009
Medicine University of Pittsburgh 1 August, August,
2007 2007
Medicine University of Toronto 1 May, 2007 May, 2007
Medicine University of Toronto 1 Aug, 2005 Aug, 2005
Advisory (not yet updated)

Consulting/Advising
Description of Activity Organization Dates

Start End
General Consultant Verio Therapeutics 2009
General Consultant Novo Nordisk 2009
General Consultant Amylin 2008
Pharmaceuticals
Presentations, conference organization, scientific Merck Frosst 2005
strategic platform
Consulting and conducting research on novel program Betalogics/LifeScan 2005
Vice-President Research and Development, Co-Founder enGene, Inc 1999
Interaction with the Public (not yet updated)

Description of Activity Organization Date
Lab Tour and Presentation of Research Christopher family May, 2009
Lab Tour, Presentation of Research and a “Day in the Lab” West Point Grey May, 2009
Experience Academy
Presentation (Cell Based Insulin Replacement Strategies for Edmonton JDRF April, 2009
Diabetes), Diabetes Research Symposium Chapter
Host, Diabetic Summer Student n/a Jun – Aug,
2008
Presentation (Eliminate the Needle - Gene and Cell Vancouver JDRF Mar, 2008
Therapies for Diabetes), Diabetes Research Symposium Chapter
Lab Tour and Presentation of Research Victoria JDRF Youth Oct, 2007
Group
Presentation (Cell Therapy Approaches for Diabetes), Austin JDRF Chapter Feb, 2007
Research Update Dinner
Public Lecture (Gene Therapy for Diabetes), Diabetes UBC Mar, 2005
Research Day
Presentation (Looking to the Gut to Cure Diabetes), Austin JDRF Chapter Mar, 2005
Research Update Dinner
Public Lecture (Engineering Your Gut to Make Insulin: A New VGH Nov, 2004
Therapy for Diabetes?), Vancouver MiniMed School
Presentation (Diabetes Research Update), Research Update Austin JDRF Chapter Mar, 2004
Dinner
Public Lecture (Engineering Your Gut to Make Insulin: A New BC Research Institute Feb, 2004
Therapy for Type 1 Diabetes?) for Children's and
Women's Health
Public Research Conference Presentation (Looking to the Vancouver JDRF Sep, 2003
Gut as an Alternative Source of Beta Cells) Chapter
Kids and Us Public Conference Presentation (Diabetes Edmonton JDRF Apr, 2002
Research Update) Chapter
Public Lecture (Islet Transplant and Beyond.) AHFHR Apr, 2001

Media
Interviews – Broadcast (not yet updated)

Topic Interviewer Program Network First
Broadcast
Diabetes Beatrice Polti Global TV News CityTV Nov 21, 2007
New Year Weight Loss Cindy Leong City News At Six CityTV Jan 6, 2006
Leptin, Obesity and Dr. Rhonda Low Your Health CTV Dec 1, 2004
Diabetes (Vancouver)
Canadian Researcher May Wendy Rigby Eyewitness News KENS 5 Sep 13, 2004
Hold Key to Diabetes Cure (San
Antonio)
Health Matters Breakfast Show Global-TV Dec 8, 2000
(Calgary)
Diabetes Research Big Breakfast CKEM-TV Dec 8, 2000
(Edmonton)
The Drinkable Cure Terry Reith Health Matters CBC-TV Dec 8, 2000
(National)
Diabetes Research ATV News at ATV-TV Dec 8, 2000
Noon (Nova
Scotia)
Diabetes Research News at Noon CKEM-TV Dec 8, 2000
(Edmonton)
Diabetes Research Noon News CFRN-TV Dec 8, 2000
(Edmonton)
Diabetes Research Global News CICT-TV Dec 8, 2000
(Calgary)
Diabetes Research News CFBR-FM Dec 8, 2000
(Edmonton)
Diabetes Research News CKNG-FM Dec 8, 2000
(Edmonton)
Diabetes Research News CHED-AM Dec 8, 2000
(Edmonton)
Diabetes Research News CHFI-FM Dec 8, 2000
(Toronto)
Diabetes Research News CBX-AM Dec 8, 2000
(Edmonton)
Diabetes Research News CKUA-AM Dec 8, 2000
(Edmonton)
Diabetes Research News CHQT-AM Dec 8, 2000
(Edmonton)
Diabetes Research News CBN-AM Dec 8, 2000

(St. John’s)
Diabetes Research News CHQR-AM Dec 8, 2000

Topic Interviewer Program Network First
Broadcast
(Calgary)
Diabetes Research News VOCM-AM Dec 8, 2000
(St. John’s)
Diabetes Research News CBX-AM Dec 8, 2000
(Edmonton)
Diabetes Research Radio Active CBX-AM Dec 8, 2000
(Edmonton)
Diabetes Research Alberta Ce Soir CBCFT-TV Dec 7, 2000
(Edmonton)
Interviews – Textual
Title Interviewer Forum Publication

Date
Gut Instinct SCN – Northern Lights: Apr, 2009
Canadian Innovations in Stem
Cell Therapeutics
A better way to fight type 1 Heather CIHR's Regenerative Medicine Jan, 2009
diabetes Blumenthal and Nanomedicine Initiative
Researcher Profile
Harvard breakthrough an Ben Rogers Georgia Straight Sep 22, 2008
"important step" in improving
diabetes treatment
UBC Lab Accomplishes Charlie Smith Georgia Straight May 22, 2008
Diabetes Breakthrough
Passing the Baton JDRF Countdown Jan, 2008
A better way to fight type 1 Heather CIHR's Regenerative Medicine Nov, 2007
diabetes Blumenthal and Nanomedicine Initiative
Researcher Profile
Diabetes: How Close is a Mark Witten Homemakers Magazine Nov, 2007
Cure?
The Cells of Life Anne Mullens Readers Digest July, 2007
Finding the Treatment, and UBC Reports Jan 4, 2007
Possibly Cure, for Diabetes in
the Human Gut
A New Method to Treat Fie Xie Ming Pao Newspaper Dec 31, 2006
Diabetes (Chinese)
Making Islets Bigger and JDRF Research Frontline Nov, 2006
Bolder
Researchers Find Food-Free Newspick.net Nov, 2006
Route to Obesity
Researchers Find Food-Free Virtual Medicine Centre Oct 25, 2006
Route to Obesity
Dr. Timothy Kieffer: Obesity Judy Nutrition: a Functional Approach Mar 30, 2006
and Diabetes—Is Leptin the Sheeshka
Date
Link?
Diabetes Researchers Hilary UBC Reports Feb 2, 2006
Convert Viruses into Agents Thomson
for Good
Catalyzing Collaboration Stem Cell Network - Annual Dec, 2005
Report
UBC Life Sciences Centre - Medicine Nov, 2005
Fast Track to the Future
The Quiet Epidemic Margret Brady The Vancouver Sun Oct 8, 2005
Beta Cells by Proxy Robert JDRF - Countdown to a Cure Oct, 2005
Dinsmoor
Mysteries of the Hormone CIHR - Institute of Nutrition, Sep, 2005
Leptin Pursued at BC Lab Metabolism and Diabetes
Update
UBC a Patent Powerhouse in Derrick Penner The Vancouver Sun Aug 16, 2005
North America
The Quiet Epidemic Margret Brady The Ottawa Citizen Jul 31, 2005
Researchers in the The Spark - Newsletter of the Mar, 2005
Department of Surgery UBC Centre of Surgical
Research
UBC Prof Seeks Cure for Joel Baglole The Vancouver Sun Jan 11, 2005
Diabetes in Obese People
Do You REALLY Want that Hilary UBC Reports Jan 10, 2005
Bite? Thomson
Residential Programs Peter Wall Institute for Dec, 2004
Advanced Studies
Helping One, Benefitting All Nicole Foy San Antonio Express-news Nov 28, 2004
UBC Health Researchers get Hilary UBC Public Affairs - Media Nov 9, 2004
Federal Funding Booster Shot Thomson Release
Chapter Research Update JDRF - South Central Texas Nov, 2004
Dinner Newsletter
Picture a Cure for Diabetes Melodie Canadian Diabetes Association Nov, 2004
Murray Pacific Area Newsletter
Scientists May Have Found Sharon Kirkey The Vancouver Sun Aug 23, 2004
Key to Insulin Freedom
Diabetes Treatments Get Martina Nature Medicine Oct 10, 2003
Sweet Help from Nature Habeck
Trainees Get a Day of their Stem Cell Network - Cell Lines Oct, 2003
own at Annual Meeting in BC
Researcher Looks to Gut for Stem Cell Network - News Sep, 2003
Diabetes Cure Magazine
Three UBC Researchers on a BC Diabetes Research Update Jun, 2003
Mission to Cure Diabetes
Date
New Faces in the Faculty UBC Reports Dec 5, 2002
In Search of a Cure for Stem Cell Network - Newsletter Oct, 2002
Diabetes
The Faces of Research: Susan Pedwell Diabetes Dialogue Oct, 2002
Who's Who in Canadian
Diabetes Research
Exploring the Future of Health Alberta Heritage Foundation for Jul, 2002
Research in Alberta Medical Research Consultation
Gut Cells Made to Produce Kylie Taggart The Medical Post May 14, 2002
Insulin
News from Medicine: Gut Brad Evenson Reader's Digest Jul, 2001
Reaction
A Cure Just got Closer National Post May 12, 2001
K Cells: A Novel Target for John Corbett TRENDS in Endocrinology & May, 2001
Insulin Gene Therapy for the Metabolism
Prevention of Diabetes
Staking New Territory for Alberta Heritage Foundation for Apr, 2001
Insulin Medical Research Research
News
Researchers Produce Insulin Kylie Taggart The Medical Post Feb 6, 2001
in the Gut
Insulin Mimics Aaron Bouchie Nature Biotechnology Jan 19, 2001
Success in diabetes Phoebe Dey University of Alberta's Express Jan 4, 2001
Research Continues News
Gut Cells Engineered to Abi Berger British Medical Journal Dec 16, 2000
Produce Insulin
Another Breakthrough for Phoebe Dey University of Alberta Folio Dec 15, 2000
Diabetes
A Better Cure for Diabetes on Biotechnology News Dec 15, 2000
the Horizon?
Gene Therapy Advancements JDRF Research News Online Dec 13, 2000
Announced in Canada
Gene Therapy Tested for Tany Talga Toronto Star Dec 12, 2000
Diabetes Treatment
Gene Therapy holds Promise James Butcher The Lancet Dec 9, 2000
for Treatment of Diabetes
Logran Que Ratones de Sociedad Dec 9, 2000
Laboratorio Produzcan
Insulina Mediante Clonacion
Albertans Fool Gut Into Brad Evenson National Post Dec 8, 2000
Making Insulin
Gene Splicing Might Help Adam Marcus American Diabetes Association Dec 8, 2000
Diabetics Health Scout
Date
Alberta Oil Money Boosts Michael Smith Canoe News Dec 8, 2000
Research
Diabetes Gene Therapy BBC News online Dec 7, 2000
Draws Closer
Gene Delivery Successfully University of Alberta News Dec 7, 2000
Used to Induce Intestinal Release
Cells in Mice to Produce
Insulin
New Gene Therapy Approach Maggie Fox Yahoo News Dec 7, 2000
May Treat Diabetes
New Gene Therapy Coaxes Greg Basky WebMD Medical News Dec 7, 2000
Gut Cells into Producing
Insulin
Animal Study Shows Gene Reuters Health Infomation Dec 7, 2000
Therapy May Help Diabetics
Gene Therapy Research - Canadian Diabetes Association Dec 7, 2000
University of Alberta
Gene Delivery Successfully Alberta Heritage Foundation for Dec 7, 2000
Used to Induce intestinal Medical Research News
Cells in Mice to Produce
Insulin
An End to Insulin Shots Via Greg Basky WebMD Medical News Dec 7, 2000
Gene Therapy?
Lucrative Research Grants Johanna Edmonton Journal Apr 27, 2000
Paying Off in Alberta Dietrich
Another Diabetes Andy Ogle Edmonton Journal Jan 8, 2000

Breakthrough at U of A
Glucagon-Like Peptides May David WebMD Medical News Jan 4, 2000
Offer Better Treatment for Holzman
Diabetes and GI Diseases
MGH Researchers Find Link MGH Press Release May 27, 1997
Between Leptin and Beta
Cells of Pancreas
Electronic Media
Video Recordings
1. From Research to Reality: The Campaign to Accelerate the Cure for Diabetes. You Need to
Know about Diabetes. Prod. Shoot for the Top Productions, Inc. Juvenile Diabetes Research
Foundation. 2006.
2. enGene Corporate Video. Prod. Oh Boy Productions. August 2005.

Publications & Other Scholarly Output
Data from Google Scholar (accessed January 2019)
Citations: This is the number of citations to all publications. The second column has the "recent" version of this
metric which is the number of new citations in the last 5 years to all publications.
h-index: h-index is the largest number h such that h publications have at least h citations. The second column
has the "recent" version of this metric which is the largest number h such that h publications have at least h
new citations in the last 5 years.
i10-index: i10-index is the number of publications with at least 10 citations. The second column has the
"recent" version of this metric which is the number of publications that have received at least 10 new citations
in the last 5 years.
Refereed Publications
Journal Articles
1. Shimazu-Kuwahara S, Kanemaru Y, Harada N, Ikeguchi E, Ueda Y, Yamane S, Murata Y, Yasoda A,

Kieffer TJ, Inagaki N. Glucose-dependent insulinotropic polypeptide deficiency reduced fat
accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice. J Diabetes
Investig. 2018 Nov 19. doi: 10.1111/jdi.12978. [Epub ahead of print].
2. Neumann UH, Kwon MM, Baker RK, Kieffer TJ. Leptin contributes to the beneficial effects of insulin
treatment in streptozotocin-diabetic male mice. Am J Physiol Endocrinol Metab. 2018 Oct 9. doi:
10.1152/ajpendo.00159.2018. [Epub ahead of print]
3. Adams WK, D'souza AM, Sussman JL, Kaur S, Kieffer TJ, Winstanley CA. Enhanced amphetamine-
induced motor impulsivity and mild attentional impairment in the leptin-deficient rat model of obesity.
Physiol Behav. 2018 Aug 1;192:134-144.
4. Saber N, Bruin JE, O'Dwyer S, Schuster H, Rezania A, Kieffer TJ. Sex Differences in Maturation of
Human Embryonic Stem Cell-Derived β Cells in Mice. Endocrinology. 2018 Apr 1;159(4):1827-1841
5. Neumann UH, Ho JSS, Chen S, Tam YYC, Cullis PR, Kieffer TJ. Lipid nanoparticle delivery of
glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes. Mol Metab.
2017 Oct;6(10):1161-1172.
6. Ramzy A, Mojibian M, Kieffer TJ. Insulin-deficient mouse β-cells do not fully mature but can be
remedied through insulin replacement by islet transplantation. Endocrinology. 2018 Jan 1;159(1):83-
102.
7. Kieffer TJ. In Memoriam-John C. Brown, PhD, DSc, FRSC, 1938-2016: Discoverer of GIP and Motilin.
Gastroenterology. 2017 Nov;153(5):1169-1171.
8. Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N. Beta-cell replacement strategies for diabetes. J
Diabetes Investig. 2017 Oct 6. doi: 10.1111/jdi.12758. [Epub ahead of print].
9. D'souza AM, Neumann UH, Glavas MM, Kieffer TJ. The glucoregulatory actions of leptin. Mol Metab.
2017 May 4;6(9):1052-1065.
10. Ellis C, Ramzy A, Kieffer TJ. Regenerative medicine and cell-based approaches to restore pancreatic
function. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):612-628.
11. Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L. Amyloid formation disrupts the
balance between interleukin-1β and interleukin-1 receptor antagonist in human islets. Mol Metab. 2017
May 31;6(8):833-844.
12. D'souza AM, Kieffer TJ. Restoration of Lepr in β cells of Lepr null mice does not prevent
hyperinsulinemia and hyperglycemia. Mol Metab. 2017 Apr 11;6(6):585-593.
13. Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera
PL. Insulin and Glucagon: Partners for Life. Endocrinology. 2017 Apr 1;158(4):696-701.
14. Shimazu-Kuwahara S, Harada N, Yamane S, Joo E, Sankoda A, Kieffer TJ, Inagaki N. Attenuated
secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity
and insulin resistance in ob/ob mice. Mol Metab. 2017 Jan 19;6(3):288-294.
15. Erener S, Marwaha A, Tan R, Panagiotopoulos C, Kieffer TJ. Profiling of circulating microRNAs in
children with recent onset of type 1 diabetes. JCI Insight. 2017 Feb 23;2(4):e89656.
16. Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Sakagami H, Kitsunai H, Takiyama Y, Abiko A, Makino Y,
Kieffer TJ, Haneda M. Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma
levels of bioactive GIP than GLP-1 in non-diabetic subjects. Mol Metab. 2016 Dec 31;6(2):226-231.
17. Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L. Dual role of
interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet
transplantation. Diabetes Obes Metab. 2017 May;19(5):682-694.
18. Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X,
Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B.
Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically
Induced Diabetes. Diabetes. 2017 Jan;66(1):45-57.
19. D'souza AM, Johnson JD, Clee SM, Kieffer TJ. Suppressing hyperinsulinemia prevents obesity but
causes rapid onset of diabetes in leptin-deficient Lepob/ob mice. Mol Metab. 2016 Sep 21;5(11):1103-
1112.
20. Neumann UH, Ho JS, Mojibian M, Covey SD, Charron MJ, Kieffer TJ. Glucagon receptor gene deletion
in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival.
Mol Metab. 2016 May 30;5(8):731-6.
21. Denroche HC, Kwon MM, Glavas MM, Tudurí E, Philippe M, Quong WL, Kieffer TJ. The role of
autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy. Mol
Metab. 2016 Jun 24;5(8):716-24.
22. Kieffer TJ. Preface. J Diabetes Investig. 2016 Apr;7 Suppl 1:3.
23. Kieffer TJ. Closing in on Mass Production of Mature Human Beta Cells. Cell Stem Cell. 2016 Jun
2;18(6):699-702.
24. Mojibian M, Glavas MM, Kieffer TJ. Engineering the gut for insulin replacement to treat diabetes. J
Diabetes Investig. 2016 Apr;7 Suppl 1:87-93.
25. Denroche HC, Glavas MM, Tudurí E, Karunakaran S, Quong WL, Philippe M, Britton HM, Clee SM,
Kieffer TJ. Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus
Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity. Endocrinology. 2016
Jul;157(7):2671-85.
26. Wills QF, Boothe T, Asadi A, Ao Z, Warnock GL, Kieffer TJ, Johnson JD. Statistical approaches and
software for clustering islet cell functional heterogeneity. Islets. 2016 Mar 3;8(2):48-56.
27. Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, Tan R, Kieffer TJ,
Verchere CB, Panagiotopoulos C, Levings MK. T regulatory cell chemokine production mediates
pathogenic T cell attraction and suppression. J Clin Invest. 2016 Mar 1;126(3):1039-51.
28. Bruin JE, Saber N, O'Dwyer S, Fox JK, Mojibian M, Arora P, Rezania A, Kieffer TJ. Hypothyroidism
impairs human stem cell-derived pancreatic progenitor cell maturation in mice. Diabetes 2016
May;65(5):1297-309.
29. Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brons C,
Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Duner P, Stancakova A, Kuusisto J,
Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M,
Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsater A, Laakso M, Goncalves I, Groop L,Gomez MF.
Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature
via Endothelin-1 and CREB. Diabetes 65, 239-254 (2016).

30. Quiskamp N, Bruin JE, Kieffer TJ. Differentiation of human pluripotent stem cells into beta-cells:
Potential and challenges. Best Pract Res Clin Endocrinol Metab 29, 833-847 (2015).
21. Neumann UH, Denroche HC, Mojibian M, Covey SD, Kieffer TJ. Insulin knockout mice have extended
survival but volatile blood glucose levels on leptin therapy. Endocrinology, en20151890 (2015).
32. Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Atageldiyeva KK, Takiyama Y, Abiko A, Makino Y, Kieffer
TJ, Haneda M. Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is
upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-
induced hyperglycaemia in mice. Diabetologia [Epub ahead of print] (2015).
33. Bruin JE, Asadi A, Fox JK, Erener S, Rezania A, Kieffer TJ. Accelerated Maturation of Human Stem
Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative
to Mice. Stem Cell Reports 5, 1081-1096 (2015).
34. Gage BK, Asadi A, Baker RK, Webber TD, Wang R, Itoh M, Hayashi M, Miyata R, Akashi T, Kieffer TJ.
The Role of ARX in Human Pancreatic Endocrine Specification. PLoS One 10, e0144100 (2015).
35. Bruin JE, Rezania A, Kieffer TJ. Replacing and safeguarding pancreatic beta cells for diabetes. Sci
Transl Med 7, 316ps323 (2015).
36. Szabat M, Page MM, Panzhinskiy E, Skovso S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ,
Lee JT, Xu EE, Taghizadeh F, O'Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC,
Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD. Reduced Insulin Production
Relieves Endoplasmic Reticulum Stress and Induces beta Cell Proliferation. Cell Metab 23, 179-193
(2015).
37. Kwon MM, O'Dwyer SM, Baker RK, Covey SD, Kieffer TJ. FGF21-Mediated Improvements in Glucose
Clearance Require Uncoupling Protein 1. Cell Rep 13, 1521-1527 (2015).
38. Adams WK, Sussman JL, Kaur S, D'Souza A M, Kieffer TJ, Winstanley CA. Long-term, calorie-
restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D receptor
signaling: two markers of addiction vulnerability. Eur J Neurosci [Epub ahead of print] (2015).
39. Konorov SO, Schulze HG, Gage BK, Kieffer TJ, Piret JM, Blades MW,Turner RF. Process Analytical
Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive
Cells. Anal Chem 87, 10762-10769 (2015).
40. Asadi A, Bruin JE, Kieffer TJ. Characterization of Antibodies to Products of Proinsulin Processing
Using Immunofluorescence Staining of Pancreas in Multiple Species. J Histochem Cytochem 63, 646-
662 (2015).
41. Bruin JE, Saber N, Braun N, Fox JK, Mojibian M, Asadi A, Drohan C, O'Dwyer S, Rosman-Balzer DS,
Swiss VA, Rezania A, Kieffer TJ. Treating diet-induced diabetes and obesity with human embryonic
stem cell-derived pancreatic progenitor cells and antidiabetic drugs. Stem Cell Reports 4, 605-620
(2015).
42. Denroche HC, Kwon MM, Quong WL, Neumann UH, Kulpa JE, Karunakaran S, Clee SM, Brownsey
RW, Covey SD, Kieffer TJ. Leptin induces fasting hypoglycaemia in a mouse model of diabetes
through the depletion of glycerol. Diabetologia 58, 1100-1108 (2015).
43. Gage BK, Baker RK, Kieffer TJ. Overexpression of PAX4 reduces glucagon expression in
differentiating hESCs. Islets 6, e29236 (2014).
44. Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Quiskamp N, Mojibian M,
Albrecht T, Yang YH, Johnson JD, Kieffer TJ. Reversal of diabetes with insulin-producing cells derived
in vitro from human pluripotent stem cells. Nat Biotechnol 32, 1121-1133 (2014).
45. Mojibian M, Lam AW, Fujita Y, Asadi A, Grassl GA, Dickie P, Tan R, Cheung AT, Kieffer TJ. Insulin-
producing intestinal K cells protect nonobese diabetic mice from autoimmune diabetes.
Gastroenterology 147, 162-171 e166 (2014).
46. Tuduri E, Denroche HC, Kara JA, Asadi A, Fox JK, Kieffer TJ. Partial ablation of leptin signaling in
mouse pancreatic alpha-cells does not alter either glucose or lipid homeostasis. Am J Physiol
Endocrinol Metab 306, E748-755 (2014).
47. D'Souza A M, Asadi A, Johnson JD, Covey SD, Kieffer TJ. Leptin deficiency in rats results in
hyperinsulinemia and impaired glucose homeostasis. Endocrinology 155, 1268-1279 (2014).
48. Park YJ, Woo M, Kieffer TJ, Hakem R, Safikhan N, Yang F, Ao Z, Warnock GL,Marzban L. The role of
caspase-8 in amyloid-induced beta cell death in human and mouse islets. Diabetologia 57, 765-775
(2014).

49. Neumann UH, Chen S, Tam YY, Baker RK, Covey SD, Cullis PR, Kieffer TJ. IGFBP2 is neither
sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob
mice. Endocrinology 155, 716-725 (2014).
50. Bruin JE, Erener S, Vela J, Hu X, Johnson JD, Kurata HT, Lynn FC, Piret JM, Asadi A, Rezania A,
Kieffer TJ. Characterization of polyhormonal insulin-producing cells derived in vitro from human
embryonic stem cells. Stem Cell Res 12, 194-208 (2014).
51. Cho YM, Fujita Y, Kieffer TJ. Glucagon-like peptide-1: glucose homeostasis and beyond. Annu Rev
Physiol 76, 535-559 (2014).
52. Cho YM, Wideman RD, Kieffer TJ. Clinical application of glucagon-like Peptide 1 receptor agonists for
the treatment of type 2 diabetes mellitus. Endocrinol Metab (Seoul) 28, 262-274 (2013).
53. Gage BK, Webber TD, Kieffer TJ. Initial cell seeding density influences pancreatic endocrine
development during in vitro differentiation of human embryonic stem cells. PLoS One 8, e82076 (2013).
54. Daoust J, Chen M, Wang M, Williams DE, Garcia Chavez MA, Wang YA, Merchant CE, Fontana A,
Kieffer TJ,Andersen RJ. Sesterterpenoids isolated from a northeastern Pacific Phorbas sp. J Org
Chem 78, 8267-8273 (2013).
55. Tuduri E, Bruin JE, Denroche HC, Fox JK, Johnson JD, Kieffer TJ. Impaired Ca(2+) signaling in beta-
cells lacking leptin receptors by Cre-loxP recombination. PLoS One 8, e71075 (2013).
56. Mojibian M, Harder B, Hurlburt A, Bruin JE, Asadi A, Kieffer TJ. Implanted islets in the anterior
chamber of the eye are prone to autoimmune attack in a mouse model of diabetes. Diabetologia 56,
2213-2221 (2013).
57. Rezania A, Bruin JE, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ. Enrichment of human embryonic
stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-
secreting cells in vivo. Stem Cells 31, 2432-2442 (2013).
58. Bruin JE, Rezania A, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ. Maturation and function of human
embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant
into mice. Diabetologia 56, 1987-1998 (2013).
59. Denroche HC, Quong WL, Bruin JE, Tuduri E, Asadi A, Glavas MM, Fox JK, Kieffer TJ. Leptin
administration enhances islet transplant performance in diabetic mice. Diabetes 62, 2738-2746 (2013).
60. Caron NJ, Gage BK, O'Connor MD, Eaves CJ, Kieffer TJ, Piret JM. A human embryonic stem cell line
adapted for high throughput screening. Biotechnol Bioeng 110, 2706-2716 (2013).
61. Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brons C, Kotova O, Zetterqvist AV,
Stancakova A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez
MF, Poulsen P, Laakso M, Degerman E, Pihlajamaki J, Wierup N, Vaag A, Groop L,Lyssenko V. Link
between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes 62, 2088-2094 (2013).
62. Erener S, Mojibian M, Fox JK, Denroche HC, Kieffer TJ. Circulating miR-375 as a biomarker of beta-
cell death and diabetes in mice. Endocrinology 154, 603-608 (2013).
63. Park YJ, Ao Z, Kieffer TJ, Chen H, Safikhan N, Thompson DM, Meloche M, Warnock GL,Marzban L.
The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide
processing in cultured human islets: implications in type 2 diabetes and islet transplantation.
Diabetologia 56, 508-519 (2013).
64. Cummings BP, Bremer AA, Kieffer TJ, D'Alessio D,Havel PJ. Investigation of the mechanisms
contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin
resistance in rhesus macaques. J Endocrinol 216, 207-215 (2013).
65. Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD. A role for hepatic leptin
signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity
in mice. Hepatology 57, 543-554 (2013).
66. Mehran AE, Templeman NM, Brigidi GS, Lim GE, Chu KY, Hu X, Botezelli JD, Asadi A, Hoffman BG,
Kieffer TJ, Bamji SX, Clee SM,Johnson JD. Hyperinsulinemia drives diet-induced obesity
independently of brain insulin production. Cell Metab 16, 723-737 (2012).
67. Angevine KR, Wuescher LM, Andrews K, Alexander LA, McInerney MF, Kieffer TJ, Mensah-Osman
EJ. Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling in the proximal
duodenum. Nutr Diabetes 2, e55 (2012).
68. Bround MJ, Asghari P, Wambolt RB, Bohunek L, Smits C, Philit M, Kieffer TJ, Lakatta EG, Boheler KR,
Moore ED, Allard MF,Johnson JD. Cardiac ryanodine receptors control heart rate and rhythmicity in
adult mice. Cardiovasc Res 96, 372-380 (2012).

69. Lau DCW, Kieffer TJ, Light P. Islet Biology Key to Our Understanding of Diabetes. Can J Diabetes 36,
219-221 (2012).
70. Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ,
Ao Z, Warnock GL, Kieffer TJ. Maturation of human embryonic stem cell-derived pancreatic
progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes 61, 2016-
2029 (2012).
71. Cho YM, Merchant CE, Kieffer TJ. Targeting the glucagon receptor family for diabetes and obesity
therapy. Pharmacol Ther 135, 247-278 (2012).
72. Szabat M, Lynn FC, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. Maintenance of beta-cell maturity
and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes 61,
1365-1371 (2012).
73. Yang GK, Fredholm BB, Kieffer TJ, Kwok YN. Improved blood glucose disposal and altered insulin
secretion patterns in adenosine A(1) receptor knockout mice. Am J Physiol Endocrinol Metab 303,
E180-190 (2012).
74. Yang GK, Squires PE, Tian F, Kieffer TJ, Kwok YN, Dale N. Glucose decreases extracellular
adenosine levels in isolated mouse and rat pancreatic islets. Islets 4, 64-70 (2012).
75. Denroche HC, Huynh FK, Kieffer TJ. The role of leptin in glucose homeostasis. J Diabetes Investig 3,
115-129 (2012).
76. Tuduri E, Bruin JE, Kieffer TJ. Restoring insulin production for type 1 diabetes. J Diabetes 4, 319-331
(2012).
77. Hoesli CA, Kiang RL, Mocinecova D, Speck M, Moskova DJ, Donald-Hague C, Lacik I, Kieffer TJ,Piret
JM. Reversal of diabetes by betaTC3 cells encapsulated in alginate beads generated by emulsion and
internal gelation. J Biomed Mater Res B Appl Biomater 100, 1017-1028 (2012).
78. Park YJ, Lee S, Kieffer TJ, Warnock GL, Safikhan N, Speck M, Hao Z, Woo M,Marzban L. Deletion of
Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia
(2012).
79. Levi J, Huynh FK, Denroche HC, Neumann UH, Glavas MM, Covey SD, Kieffer TJ. Hepatic leptin
signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma
IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia 55, 752-762 (2012).
80. Gaddy DF, Riedel MJ, Bertera S, Kieffer TJ,Robbins PD. dsAAV8-mediated gene transfer and beta-
cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in
NOD mice. Gene Ther 19, 791-799 (2012).
81. Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer
TJ,Haneda M. Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4
inhibition in a streptozotocin-induced model of diabetes in mice. Diabetologia 55, 404-412 (2012).
82. Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ. Immunohistochemical characterisation of
cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia 55, 372-381
(2012).
83. Szabat M, Kalynyak TB, Lim GE, Chu KY, Yang YH, Asadi A, Gage BK, Ao Z, Warnock GL, Piret JM,
Kieffer TJ,Johnson JD. Musashi expression in beta-cells coordinates insulin expression, apoptosis and
proliferation in response to endoplasmic reticulum stress in diabetes. Cell Death Dis 2, e232 (2011).
84. Tuduri E, Kieffer TJ. Reprogramming gut and pancreas endocrine cells to treat diabetes. Diabetes
Obes Metab 13 Suppl 1, 53-59 (2011).
85. Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis
YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Duner P, Brons C, Stancakova A,
Kuusisto J, Bugliani M, Saxena R, Ahlqvist E, Kieffer TJ, Tuomi T, Isomaa B, Melander O, Sonestedt
E, Orho-Melander M, Nilsson P, Bonetti S, Bonadonna R, Miccoli R, Delprato S, Marchetti P, Madsbad
S, Poulsen P, Vaag A, Laakso M, Gomez MF,Groop L. Pleiotropic effects of GIP on islet function
involve osteopontin. Diabetes 60, 2424-2433 (2011).
86. Levi J, Gray SL, Speck M, Huynh FK, Babich SL, Gibson WT, Kieffer TJ. Acute disruption of leptin
signaling in vivo leads to increased insulin levels and insulin resistance. Endocrinology 152, 3385-3395
(2011).
87. Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ,
Tan R,Verchere CB. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment
to the pancreatic islets. J Clin Invest 121, 3024-3028 (2011).

88. Denroche HC, Levi J, Wideman RD, Sequeira RM, Huynh FK, Covey SD, Kieffer TJ. Leptin therapy
reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin
signaling. Diabetes 60, 1414-1423 (2011).
89. Speck M, Cho YM, Asadi A, Rubino F, Kieffer TJ. Duodenal-jejunal bypass protects GK rats from
{beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing
GIP and GLP-1. Am J Physiol Endocrinol Metab 300, E923-932 (2011).
90. Cho YM, Kieffer TJ. New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1)
enhancer and sensitiser. Diabetologia 54, 219-222 (2011).
91. Rezania A, Riedel MJ, Wideman RD, Karanu F, Ao Z, Warnock GL, Kieffer TJ. Production of functional
glucagon-secreting alpha-cells from human embryonic stem cells. Diabetes 60, 239-247 (2011).
92. Hoesli CA, Raghuram K, Kiang RL, Mocinecova D, Hu X, Johnson JD, Lacik I, Kieffer TJ, Piret JM.
Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation. Biotechnol
Bioeng 108, 424-434 (2011).
93. Yang GK, Yip L, Fredholm BB, Kieffer TJ, Kwok YN. Involvement of adenosine signaling in controlling
the release of ghrelin from the mouse stomach. J Pharmacol Exp Ther 336, 77-86 (2011).
94. Cho YM, Kieffer TJ. K-cells and glucose-dependent insulinotropic polypeptide in health and disease.
Vitam Horm 84, 111-150 (2010).
95. Riedel MJ, Kieffer TJ. Treatment of diabetes with glucagon-like peptide-1 gene therapy. Expert Opin
Biol Ther 10, 1681-1692 (2010).
96. Hill JA, Szabat M, Hoesli CA, Gage BK, Yang YH, Williams DE, Riedel MJ, Luciani DS, Kalynyak TB,
Tsai K, Ao Z, Andersen RJ, Warnock GL, Piret JM, Kieffer TJ, Johnson JD. A multi-parameter, high-
content, high-throughput screening platform to identify natural compounds that modulate insulin and
Pdx1 expression. PLoS One 5, e12958 (2010).
97. Ngai YF, Quong WL, Glier MB, Glavas MM, Babich SL, Innis SM, Kieffer TJ, Gibson WT. Ldlr-/- mice
display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis.
Endocrinology 151, 5226-5236 (2010).
98. Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD,
Kieffer TJ. Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose
intolerance. Diabetes 59, 3032-3040 (2010).
99. Gaddy DF, Riedel MJ, Pejawar-Gaddy S, Kieffer TJ, Robbins PD. In vivo expression of HGF/NK1 and
GLP-1 From dsAAV vectors enhances pancreatic ss-cell proliferation and improves pathology in the
db/db mouse model of diabetes. Diabetes 59, 3108-3116 (2010).
100. Gray SL, Donald C, Jetha A, Covey SD, Kieffer TJ. Hyperinsulinemia precedes insulin resistance in
mice lacking pancreatic beta-cell leptin signaling. Endocrinology 151, 4178-4186 (2010).
101. Gage BK, Riedel MJ, Karanu F, Rezania A, Fujita Y, Webber TD, Baker RK, Wideman RD, Kieffer TJ.
Cellular reprogramming of human amniotic fluid cells to express insulin. Differentiation 80, 130-139
(2010).
102. Daoust J, Fontana A, Merchant CE, de Voogd NJ, Patrick BO, Kieffer TJ, Andersen RJ. Ansellone A, a
sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp.,
activates the cAMP signaling pathway. Org Lett 12, 3208-3211 (2010).
103. Law E, Lu S, Kieffer TJ, Warnock GL, Ao Z, Woo M,Marzban L. Differences between amyloid toxicity
in alpha and beta cells in human and mouse islets and the role of caspase-3. Diabetologia 53, 1415-
1427 (2010).
104. Widenmaier SB, Kim SJ, Yang GK, De Los Reyes T, Nian C, Asadi A, Seino Y, Kieffer TJ, Kwok
YN,McIntosh CH. A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of
diabetes resulting in improved beta-cell function and glycemic control. PLoS One 5, e9590 (2010).
105. Fujita Y, Asadi A, Yang GK, Kwok YN, Kieffer TJ. Differential processing of pro-glucose-dependent
insulinotropic polypeptide in gut. Am J Physiol Gastrointest Liver Physiol 298, G608-614 (2010).
106. Fujita Y, Wideman RD, Asadi A, Yang GK, Baker R, Webber T, Zhang T, Wang R, Ao Z, Warnock GL,
Kwok YN, Kieffer TJ. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet
alpha-cells and promotes insulin secretion. Gastroenterology 138, 1966-1975 (2010).
107. Riedel MJ, Gaddy DF, Asadi A, Robbins PD, Kieffer TJ. DsAAV8-mediated expression of glucagon-like
peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes. Gene Ther 17, 171-180
(2010).
108. Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD,
Kieffer TJ, Abrahani A,Rodrigues B. Cleavage of protein kinase D after acute hypoinsulinemia

prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Diabetes 58, 2464-
2475 (2009).
109. Forestieri R, Merchant CE, de Voogd NJ, Matainaho T, Kieffer TJ, Andersen RJ. Alotaketals A and B,
sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling
pathway. Org Lett 11, 5166-5169 (2009).
110. Wideman RD, Kieffer TJ. Mining incretin hormone pathways for novel therapies. Trends Endocrinol
Metab 20, 280-286 (2009).
111. Unniappan S, Wideman RD, Donald C, Gunn V, Wall JL, Zhang QX, Webber TD, Cheung AT, Kieffer
TJ. Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells. J Mol Med
(Berl) 87, 703-712 (2009).
112. Yang GK, Chen JF, Kieffer TJ, Kwok YN. Regulation of somatostatin release by adenosine in the
mouse stomach. J Pharmacol Exp Ther 329, 729-737 (2009).
113. Riedel MJ, Lee CW, Kieffer TJ. Engineered glucagon-like peptide-1-producing hepatocytes lower
plasma glucose levels in mice. Am J Physiol Endocrinol Metab 296, E936-944 (2009).
114. Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ. Incretin
release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Am J Physiol Endocrinol
Metab 296, E473-479 (2009).
115. Wideman RD, Gray SL, Covey SD, Webb GC, Kieffer TJ. Transplantation of PC1/3-Expressing alpha-
cells improves glucose handling and cold tolerance in leptin-resistant mice. Mol Ther 17, 191-198
(2009).
116. Walia P, Asadi A, Kieffer TJ, Johnson JD,Chanoine JP. Ontogeny of ghrelin, obestatin, preproghrelin,
and prohormone convertases in rat pancreas and stomach. Pediatr Res 65, 39-44 (2009).
117. Fujita Y, Chui JW, King DS, Zhang T, Seufert J, Pownall S, Cheung AT, Kieffer TJ. Pax6 and Pdx1 are
required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L
cells. Am J Physiol Endocrinol Metab 295, E648-657 (2008).
118. Unniappan S, Speck M, Kieffer TJ. Metabolic effects of chronic obestatin infusion in rats. Peptides 29,
1354-1361 (2008).
119. Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey
RW,Laher I. Exercise restores endothelial function independently of weight loss or hyperglycaemic
status in db/db mice. Diabetologia 51, 1327-1337 (2008).
120. Unniappan S, Kieffer TJ. Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad
libitum-fed rats. Am J Physiol Regul Integr Comp Physiol 295, R51-58 (2008).
121. Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS,
Kieffer TJ. Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce
leptin. Mol Ther 16, 1138-1145 (2008).
122. Khazaei M, Moien-Afshari F, Kieffer TJ, Laher I. Effect of exercise on augmented aortic
vasoconstriction in the db/db mouse model of type-II diabetes. Physiol Res 57, 847-856 (2008).
123. Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ. A switch from prohormone convertase
(PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of
proglucagon and improved glucose homeostasis in mice. Diabetes 56, 2744-2752 (2007).
124. Wideman RD, Fujita Y, Kieffer TJ. Insulin-expressing engineered cell lines and primary cells: surrogate
β cells from liver, gut, and other sources. Curr Opin Organ Transplant 12, 67-72 (2007).
125. Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua
SC, Kieffer TJ. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose
homeostasis. Cell Metab 4, 291-302 (2006).
126. Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ. Improving
function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).
Proc Natl Acad Sci U S A 103, 13468-13473 (2006).
127. Unniappan S, McIntosh CH, Demuth HU, Heiser U, Wolf R, Kieffer TJ. Effects of dipeptidyl peptidase
IV on the satiety actions of peptide YY. Diabetologia 49, 1915-1923 (2006).
128. Lam NT, Covey SD, Lewis JT, Oosman S, Webber T, Hsu EC, Cheung AT, Kieffer TJ. Leptin
resistance following over-expression of protein tyrosine phosphatase 1B in liver. J Mol Endocrinol 36,
163-174 (2006).
129. Laubner K, Kieffer TJ, Lam NT, Niu X, Jakob F,Seufert J. Inhibition of preproinsulin gene expression
by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells. Diabetes 54, 3410-
3417 (2005).

130. Nyberg J, Anderson MF, Meister B, Alborn AM, Strom AK, Brederlau A, Illerskog AC, Nilsson O, Kieffer
TJ, Hietala MA, Ricksten A,Eriksson PS. Glucose-dependent insulinotropic polypeptide is expressed in
adult hippocampus and induces progenitor cell proliferation. J Neurosci 25, 1816-1825 (2005).
131. Stock S, Leichner P, Wong AC, Ghatei MA, Kieffer TJ, Bloom SR,Chanoine JP. Ghrelin, peptide YY,
glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic,
obese, and control female adolescents. J Clin Endocrinol Metab 90, 2161-2168 (2005).
132. Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T,Korbutt GS. Enriched human
pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and
duodenal homeobox gene-1 age-dependently. Rev Diabet Stud 1, 66-79 (2004).
133. Wideman RD, Kieffer TJ. Glucose-dependent insulinotropic polypeptide as a regulator of beta cell
function and fate. Horm Metab Res 36, 782-786 (2004).
134. Fujita Y, Cheung AT, Kieffer TJ. Harnessing the gut to treat diabetes. Pediatr Diabetes 5 Suppl 2, 57-
69 (2004).
135. Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G,van der Kooy
D. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and
pancreatic lineages. Nat Biotechnol 22, 1115-1124 (2004).
136. Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio
D,Havel PJ. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression
of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89, 2963-2972 (2004).
137. Kieffer TJ. Gastro-intestinal hormones GIP and GLP-1. Ann Endocrinol (Paris) 65, 13-21 (2004).
138. Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI, Kieffer TJ. Leptin reduces glucose
transport and cellular ATP levels in INS-1 beta-cells. J Mol Endocrinol 32, 415-424 (2004).
139. Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ. Leptin
increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol Endocrinol
18, 1333-1345 (2004).
140. Kieffer TJ. GIP or not GIP? That is the question. Trends Pharmacol Sci 24, 110-112 (2003).
141. Lam NT, Kieffer TJ. The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent.
Minerva Endocrinol 27, 79-93 (2002).
142. Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA. Defective glucose-dependent
insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 50, 1004-1011
(2001).
143. Daniel PB, Kieffer TJ, Leech CA,Habener JF. Novel alternatively spliced exon in the extracellular
ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor
(PAC1R) selectively increases ligand affinity and alters signal transduction coupling during
spermatogenesis. J Biol Chem 276, 12938-12944 (2001).
144. D'Alessio DA, Kieffer TJ, Taborsky GJ, Jr.,Havel PJ. Activation of the parasympathetic nervous system
is necessary for normal meal-induced insulin secretion in rhesus macaques. J Clin Endocrinol Metab
86, 1253-1259 (2001).
145. Cheung AT, Dayanandan B, Lewis JT, Korbutt GS, Rajotte RV, Bryer-Ash M, Boylan MO, Wolfe MM,
Kieffer TJ. Glucose-dependent insulin release from genetically engineered K cells. Science 290, 1959-
1962 (2000).
146. Lewis JT, Dayanandan B, Habener JF, Kieffer TJ. Glucose-dependent insulinotropic polypeptide
confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist.
Endocrinology 141, 3710-3716 (2000).
147. Baggio L, Kieffer TJ, Drucker DJ. Glucagon-like peptide-1, but not glucose-dependent insulinotropic
peptide, regulates fasting glycemia and nonenteral glucose clearance in mice. Endocrinology 141,
3703-3709 (2000).
148. Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF,Egan JM. Insulinotropic
glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet
size in mouse pancreas. Diabetes 49, 741-748 (2000).
149. Kieffer TJ, Habener JF. The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol
Endocrinol Metab 278, E1-E14 (2000).
150. Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr Rev 20, 876-913 (1999).
151. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C,Habener JF. Leptin suppression of
insulin secretion and gene expression in human pancreatic islets: implications for the development of
adipogenic diabetes mellitus. J Clin Endocrinol Metab 84, 670-676 (1999).

152. Seufert J, Kieffer TJ, Habener JF. Leptin inhibits insulin gene transcription and reverses
hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci U S A 96, 674-679 (1999).
153. Yip RG, Boylan MO, Kieffer TJ, Wolfe MM. Functional GIP receptors are present on adipocytes.
Endocrinology 139, 4004-4007 (1998).
154. McLean E, Mayer I, Kieffer TJ, Donaldson EM, Souza LM. Growth and metamorphosis in tadpoles of
RANA pretiosa pretiosa, treated with recombinant porcine growth hormone, prolactin, somatostatin
(SRIF) and anti-SRIF. Ribarstvo 56, 43-54 (1998).
155. Kieffer TJ, Heller RS, Leech CA, Holz GG,Habener JF. Leptin suppression of insulin secretion by the
activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 46, 1087-1093 (1997).
156. Heller RS, Kieffer TJ, Habener JF. Insulinotropic glucagon-like peptide I receptor expression in
glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes 46, 785-791 (1997).
157. Tseng CC, Kieffer TJ, Jarboe LA, Usdin TB,Wolfe MM. Postprandial stimulation of insulin release by
glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent
insulinotropic polypeptide receptor antagonist in the rat. J Clin Invest 98, 2440-2445 (1996).
158. Pederson RA, Kieffer TJ, Pauly R, Kofod H, Kwong J,McIntosh CH. The enteroinsular axis in dipeptidyl
peptidase IV-negative rats. Metabolism 45, 1335-1341 (1996).
159. Kieffer TJ, Heller RS, Unson CG, Weir GC,Habener JF. Distribution of glucagon receptors on
hormone-specific endocrine cells of rat pancreatic islets. Endocrinology 137, 5119-5125 (1996).
160. Schieldrop PJ, Gelling RW, Elliot R, Hewitt J, Kieffer TJ, McIntosh CH,Pederson RA. Isolation of a
murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and
quantification of glucose-induced increases in GIP mRNA. Biochim Biophys Acta 1308, 111-113 (1996).
161. Kieffer TJ, Heller RS,Habener JF. Leptin receptors expressed on pancreatic beta-cells. Biochem
Biophys Res Commun 224, 522-527 (1996).
162. Heller RS, Kieffer TJ, Habener JF. Point mutations in the first and third intracellular loops of the
glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun 223, 624-
632 (1996).
163. Morrow GW, Kieffer TJ, McIntosh CH, MacGillivray RT, Brown JC, St Pierre S,Pederson RA. The
insulinotropic region of gastric inhibitory polypeptide; fragment analysis suggests the bioactive site lies
between residues 19 and 30. Can J Physiol Pharmacol 74, 65-72 (1996).
164. Kieffer TJ, Huang Z, McIntosh CH, Buchan AM, Brown JC,Pederson RA. Gastric inhibitory polypeptide
release from a tumor-derived cell line. Am J Physiol 269, E316-322 (1995).
165. Kieffer TJ, McIntosh CH,Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide
and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136,
3585-3596 (1995).
166. Mayer I, McLean E, Kieffer TJ, Souza LM,Donaldson EM. Antisomatostatin-induced growth
acceleration in chinook salmon (Oncorhynchus tshawytscha). Fish Physiol Biochem 13, 295-300
(1994).
167. Kieffer TJ, Buchan AM, Barker H, Brown JC,Pederson RA. Release of gastric inhibitory polypeptide
from cultured canine endocrine cells. Am J Physiol 267, E489-496 (1994).
168. Kieffer TJ, Schieldrop PJ, McLean E, Donaldson EM,Brown JC. A radioimmunoassay for oncorhynchid
growth hormone targeted to the physiological range. Can J Physiol Pharmacol 72, 1155-1161 (1994).
169. Kieffer TJ, Verchere CB, Fell CD, Huang Z, Brown JC,Pedersen RA. Glucose-dependent insulinotropic
polypeptide stimulated insulin release from a tumor-derived beta-cell line (beta TC3). Can J Physiol
Pharmacol 71, 917-922 (1993).
Book Chapters
1. White MG, Ellis CE, Kieffer TJ. Regenerative Medicine for Diabetes. Oxford Textbook of Endocrinology
and Diabetes (in press)
2. Gage BK, Wideman RD, and Kieffer T.J. Generating Pancreatic Endocrine Cells From Pluripotent Stem
Cells. In: Islets of Langerhans, edited by Md. Shahidul Islam. Springer-Verlag Berlin Heidelberg 2013
3. Bruin JE and Kieffer TJ. Differentiation of human embryonic stem cells into pancreatic endocrine cells.
Hayat MA (ed) Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury.
Springer 2012

4. Cheung AT, Hsu EC, Calos M, and Kieffer TJ. A Gut reaction to stem cell therapy for diabetes. In:
Burrill Stem Cell Report: Progress and Prospects, edited by Herold E. 2007, p. 94-102.
5. Wideman RD and Kieffer TJ. Metabolic actions of the glucagon-like peptides. In: Nutrients and Cell
Signaling, edited by Zempleni J and Dakshinamurti K. New York NY Marcel Dekker, Inc., 2005, p. 565-
585.
6. Habener JF and Kieffer TJ. Glucagon and glucagon-like peptides. In: Joslin's Diabetes Mellitus (14 ed.),
edited by Kahn RC, Weir GC, King GL, Moses AC, Smith RJ and Jacobson AM. Philadelphia, PA:
Lippincott Williams & Wilkins, 2005, p. 179-193.
7. Cheung AT and Kieffer TJ. Gene therapy for metabolic disease. In: Diabetes Mellitus: A Fundamental
and Clinical Text (3 ed.), edited by LeRoith D, Taylor SI and Olefsky M. Philadelphia, PA: Lippincott
Williams & Wilkins, 2004, p. 747-762.
8. Kieffer TJ. Glucose-dependent insulinotropic polypeptide (GIP): Role in energy homeostasis. In:
Encyclopedia of Hormones & Related Cell Regulators, edited by Greeley GH. New York, NY: Academic
Press, 2003, p. 150-157.
9. Kieffer TJ, Hussain MA, and Habener JF. Glucagon and glucagon-like peptide production and
degradation. In: Handbook of Physiology, Section 7: The Endocrine System, edited by Jefferson LS and
Cherrington AD. New York, NY: Oxford University Press, 2001, p. 197-265.
10. Wolfe MM, Boylan MO, Kieffer TJ, and Tseng CC. Glucose-dependent insulinotropic polypeptide (GIP):
Incretin vs. enterogastrone. In: Gastrointestinal Endocrinology, edited by Conn MP and Greeley GH.
Totowa, NJ: Humana Press, 1999, p. 439-446.

Patents (not updated)
1. US 7,335,646 B2, Kieffer et al., Compositions and Methods for Regulated Protein Expression
in Gut GRANTED
2. US 09/804,409 Kieffer and Cheung, Compositions and Methods for Regulated Protein
Expression in Gut GRANTED
3. PCT IB01/00722, Kieffer and Cheung, Compositions and Methods for Regulated Protein
3. Euro 01923894.8, Kieffer and Cheung, Compositions and Methods for Regulated Protein
4. Can 2,403,205, Kieffer and Cheung, Compositions and Methods for Regulated Protein
Expression in Gut PENDING
5. Japan 2001-567312, Kieffer and Cheung, Compositions and Methods for Regulated Protein
6. China 01818129.5, Kieffer and Cheung, Compositions and Methods for Regulated Protein
7. NZ 521199, Kieffer and Cheung, Compositions and Methods for Regulated Protein Expression
in Gut GRANTED
8. Aus 50575/01, Kieffer and Cheung, Compositions and Methods for Regulated Protein

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The University of British Columbia

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CIHR Pancreatic Islet Generation $1,230,000 2002 2007 D J Hill, L Rosenberg, M

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Research Update: Cell JDRF Research Update Winnipeg MB JDRF Nov 8,

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Cell-Based Insulin Ray Gall Memorial Edmonton, AB University of Nov 14,

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Glucose-Dependent Invited Seminar Osaka, Japan Kansai Electric Apr 18,

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Engineering Cells for Invited Seminar Sydney, Garvan Feb 6,

Using Model Systems to 15th ANZ Zebrafish Sydney, Annual Feb 3,

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Cell Therapy for Invited Presentation Toronto, ON Donnelly Sept 6,

Insulin Replacement by Departmental Seminar Vancouver BC Department of Sept 22,

Diabetes: Causes, CIHR Café Scientifique Vancouver, BC CIHR Jan 26,

Eliminating the needle for Pharmaceutical Sciences Vancouver, BC University of Dec 2,

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Laboratory of Molecular JDRF Calgary Chapter Calgary, AB JDRF Nov 3,

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Gastro-Intestinal 47th International Paris, France Apr,

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