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2.

0 Stream Table
STREAM
NO. 1 2 3 4 5 6 7 8 9 10 11 12

Mixer M-101 Heat Exchanger E-101 Counter-current Plug Cooler E-102 Liquid-liquid
Valve V-101 Valve V-102 Valve V-103 Centrifugal Pump
Outlet / Outlet / Flow Outlet / Separator
DESCRIPTI Outlet / Outlet / Reactor R-101 Outlet Liquid-liquid
Feed Feed Feed Outlet / Mixer Centrifugal Pump P-101 Outlet / Heat Counter-current Plug V-101 Outlet /
ON Mixer Mixer / Separator

Exchanger E-101
M-101 Inlet M-101 Inlet M-101 Inlet P-101 Inlet Flow Reactor R-101 Inlet Cooler E-102 Inlet V-101 Inlet Mixer M-101 Inlet
Inlet

HF ✔ - - ✔ - - ✔ ✔ ✔ ✔ ✔ -

Ac2O - ✔ - - ✔ - ✔ ✔ ✔ ✔ ✔ -

IBB - - ✔ - - ✔ ✔ ✔ ✔ ✔ ✔ ✔

IBAP - - - - - - - - - ✔ ✔ -

AcOH - - - - - - - - - ✔ ✔ -

AcF - - - - - - - - - ✔ ✔ -

Pd / Raney
- - - - - - - - - - - -
Ni

H2 - - - - - - - - - - - -

IBEP - - - - - - - - - - - -

H2O - - - - - - - - - - - -

IBEB - - - - - - - - - - - -

CO - - - - - - - - - - - -

PdCl2 - - - - - - - - - - - -

Polar
- - - - - - - - - - - -
Solvent

Ibuprofen - - - - - - - - - - - -

Temperature °C 25 25 25 25 25 25 25 25 80 80 75 75
Pressure atm 1 1 1 1 1 1 1 1 1 1 1 1
13 14 15 16 17 18 19 20 21 22 23 24
Liquid-liquid Distillation Heat Exchanger Valve V-104
Stripper S-101 Stripper S-101 Distillation T-101 Distillation T-102 Heat Exchanger Distillation T-102
Separator T-101 E-104 Outlet /
Outlet / Outlet /
V-101 Outlet / Outlet / Mixer Outlet Outlet / Heat E-103 Outlet / Outlet / Heat Outlet / Plug Flow Feed Feed Plug Flow
Distillation Distillation
Column T-101 Column T-102 Exchanger E-103 Mixer M-101 Exchanger E-104 Reactor R-102
Stripper S-101 Inlet M-101 Inlet Reactor R-102 Inlet
Inlet Inlet Inlet Inlet Inlet Inlet
✔ ✔ - - - - - - - - - -
✔ - ✔ - ✔ ✔ ✔ - - - - -
- - - - - - - - - - - -
✔ - ✔ - ✔ - - ✔ ✔ - - -
✔ - ✔ ✔ - - - - - - - -
✔ - ✔ ✔ - - - - - - - -
- - - - - - - - - ✔ - ✔
- - - - - - - - - - ✔ -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -

75 75 25 25 25 25 25 25 30 25 25 30
1 1 1 1 1 1 1 1 6.90846 1 1 6.90846
25 26 27 28 29 30 31 32 33 34 35 36
Flash Flash Column Catalyst Filter Heat Exchanger Heat Exchanger Distillation Distillation
Valve V-105 Plug Flow Reactor Heat Exchanger Catalyst FIlter Heater E-108
Column T-103 F-101 E-106 E-107 Column Column
Outlet / Plug R-102 Outlet / E-105 Outlet / Outlet / Outlet /
T-103 Outlet Outlet / Catalyst Outlet / Heat Outlet / Plug Flow F-101 Outlet / Heat T-104 Outlet T-104 Outlet /
Flow Heat Flash Distillation Trickle-bed
Reactor R-102 Exchanger E-105 Column T-103 FIlter F-101 Exchanger E-106 Reactor R-102 Exchanger E-107 Column T-104 Heater E-108 Reactor R-103
Inlet Inlet Inlet Inlet Inlet Inlet Inlet Inlet Inlet Inlet
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- ✔ ✔ - ✔ - - ✔ ✔ - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- ✔ ✔ - ✔ ✔ ✔ - - - - -
✔ ✔ ✔ ✔ - - - - - - - -
- ✔ ✔ - ✔ - - ✔ ✔ - ✔ ✔
- - - - - - - - - ✔ - -
- - - - - - - - - ✔ - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -

25 30 37 37 37 37 30 37 25 25 25 120
1 6.90846 1 1 1 1 6.90846 1 1 1 1 53.2939
37 38 39 40 41 42 43 44 45 46 47 48
Compressor Flash Heat Exchanger Liquid-liquid Heat Exchanger
Valve V-106 Valve V-107 Trickle-bed Reactor Flash Column Heat Exchanger
P-101 Column E-108 Separator E-109
Outlet / Outlet / T-105 Outlet / E-109 Outlet /
Feed Feed R-103 Outlet / Outlet / Flash T-105 Outlet / Heat V-106 Oulet / Heat Outlet / Trickle-bed
Trickle-bed Trickle-bed Outlet Liquid-liquid Cooling
Reactor R-103 Reactor R-103 Compressor P-101 Column T-105 Exchanger E-108 Separator T-106 Exchanger E-109 Crystallizer CC-101
Reactor R-103 Inlet
Inlet Inlet Inlet Inlet Inlet Inlet Inlet Inlet
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -
- - - - - - - - - - - -

- - - - - - - - - - - -
- - - - - - - - - - - -
- - ✔ - ✔ ✔ - ✔ ✔ - - ✔
- - - - - - - - - - - -
- - - - - - - - - - - -
✔ - ✔ - ✔ ✔ ✔ - - - - -
- ✔ - ✔ ✔ ✔ - ✔ ✔ ✔ ✔ -
- - - - - - - - - - - -
- - - - - - - - - - - -

25 25 120 120 120 117 117 117 77 77 120 77


1 1 53.2939 53.2939 53.2939 1 1 1 1 1 53.2939 1
49 50 51 52 53 54 55 56 57

Cooling Crystallizer Cooling Crystallizer Centrifugal Pump Heat Exchanger Solvent Recovery Solvent Recovery Cooling Crystallizer Dryer

CC-101 Outlet / Solvent CC-101 Outlet / Centrifugal P-102 Outlet / Heat E-110 Outlet / Cooling Unit R-104 Outlet Unit R-104 Outlet Feed CC-101 Outlet / D-101
Recovery Unit R-104 Inlet Pump P-102 Inlet Exchanger E-110 Inlet Crystallizer CC-101 Inlet Dryer D-101 Inlet Outlet

- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
✔ ✔ ✔ ✔ - ✔ - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
- - - - - - - - -
✔ ✔ ✔ ✔ ✔ - ✔ - -
- - - - - - - ✔ ✔

25 25 25 25 25 25 25 25 25
1 1 1 1 1 1 1 1 1
Equipment table

Tag Number Equipment

V-101 Valve

V-102 Valve

V-103 Valve

M-101 Mixer

P-101 Centrifugal Pump

E-101 Heat Exchanger

R-101 Counter-current Plug Flow Reactor

E-102 Cooler

V-101 Liquid-liquid Separator

S-101 Stripper

T-101 Distillation Column

T-102 Distillation Column

E-103 Heat Exchanger

E-104 Heat Exchanger

V-104 Valve

V-105 Valve

R-102 Plug Flow Reactor

E-105 Heat Exchanger

T-103 Flash Column

F-101 Catalyst Filter


E-106 Heat Exchanger

E-107 Heat Exchanger

T-104 Distillation Column

E-108 Heater

V-106 Valve

V-107 Valve

R-103 Trickle-bed reactor

C-101 Compressor

T-105 Flash Column

E-108 Heat Exchanger

T-106 Liquid-liquid Separator

E-109 Heat Exchanger

CC-101 Cooling Crystallizer

P-102 Centrifugal Pump

E-110 Heat Exchanger

R-104 Solvent recovery unit

D-101 Dryer