PERHITUNGAN BAHAN

- Setiap tablet mengandung 300 mg Irbesrtan

- Bobot tiap tablet 500 mg

- Jumlah tablet 100 tablet dan 2000 tablet

Perhitungan untuk satu tablet

- Fase dalam = 80% x 500 mg = 400 mg

1. Irbesartan = 300 mg

2. PVP 3 %

PVP = 3/100 x 500 mg = 15 mg

3. Amilum 10 %

Amilum = 10/100 x 500 mg = 5 mg

4. Laktosa

Laktosa = 400 mg – (300 mg + 15 mg + 5 mg)

Perhitungan fase luar 20%

5. Primogel 3 %

Primogel = 3/100 x 500 mg = 15 mg

6. Avicel PH 102 15 %

Avicel = 15/100 x 500 mg = 75 mg

7. Mg. Stearat 1 %

Mg. Stearat = 1/100 x 500 mg = 5 mg

8. Talk 1 %

Talk = 1/100 x 500 mg = 5 mg

Perhitungan untuk 100 tablet

1) Irbesartan = 300 mg x 100 tablet

= 30000 mg = 30 gram
2) PVP = 15 mg x 100 tablet

= 1500 mg = 1,5 gram

3) Amilum = 5 mg x 100 tablet

= 500 mg = 0,5 gram

4) Laktosa = 80 mg x 100 tablet

= 8000 mg = 8 gram

5) Primogel = 15 mg x 100 tablet

= 1500 = 1,5 gram

6) Avicel = 75 mg x 100 tablet

= 7500 mg = 7,5 gram

7) Mg. Stearat = 5 mg x 100 tablet

= 500 mg = 0,5 gram

8) Talk = 5 mg x 100 tablet

= 500 mg = 0,5 gram

Perhitungan untuk 2000 tablet

1) Irbesartan = 300 mg x 2000 tablet

= 600000 mg = 600 gram

2) PVP = 15 mg x 2000 tablet

= 30000 mg = 30 gram

3) Amilum = 5 mg x 2000 tablet

= 10000 mg = 10 gram

4) Laktosa = 80 mg x 2000 tablet

= 160000 mg = 160 gram

5) Primogel = 15 mg x 2000 tablet

= 30000 mg = 30 gram
6) Avicel = 75 mg x 2000 tablet

= 150000 = 150 gram

7) Mg.Stearat = 5 mg x 2000 tablet

= 10000 mg = 10 gram

8) Talk = 5 mg x 2000 tablet

= 10000 mg = 10 gram