Tissue factor It is required for carboxylation of glutamate

Which of the following initiates in vivo coagulation residues of some coagulation factors
by activation of factor VII? Which of the following characterizes vitamin K?

Plasmin activator Its activity is enhanced by heparin therapy

Thrombomodulin It is required for carboxylation of glutamate

residues of some coagulation factors
Protein C
It is required for biological activity of fibrinolysis
Tissue factor
Sodium citrate It is made by the endothelial cells
The anticoagulant of choice for most routine XII, XI, IX, VIII, X, V, II, I
coagulation studies is: Which of the following clotting factors are measured
by the APTT test?
Ethylenediaminetetraacetic acid (EDTA)
XII, VII, X, V, II, I
Sodium citrate
II, VII, IX, X
Heparin
XII, XI, IX, VIII, X, V, II, I
Sodium oxalate
1:9 VII, X, V, II, I
Which ratio of anticoagulant-to-blood is correct for PT and APTT
coagulation procedures? Which coagulation test(s) would be abnormal in a
vitamin K-deficient patient?
1:5
PT and APTT
1:10
Fibrinogen level
1:4
Thrombin time
1:9
PT and APTT PT only
Which test would be abnormal in a patient with It standardizes PT results
factor X deficiency? Which of the following is correct regarding the
international normalized ratio (INR)?
PT and APTT
It standardizes PT results
PT only
It is used to monitor heparin therapy
APTT only
It standardizes APTT results
Thrombin time
Factor XIII It uses the International Sensitivity Ratio (ISR)
Which clotting factor is not measured by PT and Reject the sample and request a new sample
APTT tests? A standard 4.5-mL blue-top tube filled with 3.0 mL
of blood was submitted to the laboratory for PT and
Factor XIII APTT tests. The sample is from a patient
undergoing surgery the following morning for a
Factor VIII tonsillectomy. Which of the following is the
necessary course of action by the technologist?
Factor V
Report the PT result
Factor IX
Report the APTT result

Run both tests in duplicate and report the average
result
Reject the sample and request a new sample
Increased platelet aggregation and clotting
Thrombotic thrombocytopenic purpura (TTP) is
characterized by:
Increased platelet aggregation and clotting
Thrombocytosis
Prolonged PT
Prolonged APTT
Hypersplenism
Thrombocytopenia may be associated with:
levels
Bleeding time
Thrombocytopenia and giant platelets
Bernard-Soulier syndrome is associated with:
Thrombocytopenia and giant platelets
Decreased factor VIII assay
Decreased bleeding time
Abnormal platelet aggregation to ADP
Normal platelet aggregation to ristocetin; decreased
aggregation to collagen, ADP, and epinephrine
Which set of platelet responses would be most
likely associated with Glanzmann's
thrombasthenia?

Hypersplenism Normal platelet aggregation to ADP and ristocetin;

decreased aggregation to collagen
Increased proliferation of pluripotential stem cells
Normal platelet aggregation to collagen; decreased
Acute blood loss aggregation to ADP and ristocetin

Postsplenectomy Normal platelet aggregation to ADP; decreased

Cyclo-oxygenase aggregation to collagen and ristocetin
Aspirin prevents platelet aggregation by inhibiting
the action of which enzyme? Normal platelet aggregation to ristocetin; decreased
aggregation to collagen, ADP, and epinephrine
Thromboxane A2 synthetase Spontaneous remission within a few weeks
Which of the following is a characteristic of acute
Cyclo-oxygenase immune thrombocytopenic purpura?

Prostacyclin sythetase Insidious onset

Phospholipase Spontaneous remission within a few weeks

Glycoprotein Ib
Normal platelet adhesion depends upon: Predominantly seen in adults

Glycoprotein Ib Nonimmune platelet destruction

APTT is normal in TTP but prolonged in DIC
Fibrinogen TTP differs from DIC in that:

Calcium Schistocytes are not present in TTP but are present

Glycoprotein IIb, IIIa complex
Platelet count
Which of the following test results is normal in a
patient with classic von Willebrand's disease?
in DIC
PT is prolonged in TTP but decreased in DIC
APTT is normal in TTP but prolonged in DIC

Activated partial thromboplastin time Platelet count is decreased in TTP but normal in
DIC
Platelet count Escherichia coli 0157:H7
Hemolytic uremic syndrome (HUS) is associated
Factor VIII:C and von Willebrand's factor (VWF) with:
Fever, thrombocytosis, anemia, and renal failure XI

Escherichia coli 0157:H7 VIII

Leukocytosis and thrombocytosis X

IX
Fever, granulocytosis, and thrombocytosis A prolonged APTT is corrected with factor VIII-
Platelet granules deficient plasma but not with factor IX-deficient
Storage pool deficiencies are defects of: plasma. Which factor is deficient?

Platelet production VIII

Platelet adhesion X

Platelet aggregation IX

Platelet granules V
Autoimmune disease Mild to severe bleeding episodes
Which of the following is correct regarding acquired Which of the following is a characteristic of classic
thrombotic thrombocytopenic purpura? hemophilia A?

Decreased VWF Mild to severe bleeding episodes

Decreased platelet aggregation Prolonged PT

Decreased platelet adhesion Autosomal recessive inheritence

Autoimmune disease Prolonged bleeding time

Prostacyclin DIC
Which of the following prevents platelet Refer to the following results:
aggregation? PT = prolonged
APTT = prolonged
Thromboxane B2 Platelet count = decreased
Which disorder may be indicated?
Antithrombin
von Willebrand's disease
Thromboxane A2
Factor VIII deficiency
Prostacyclin
Factor X Factor IX deficiency
The APTT is sensitive to a deficiency of which
clotting factor? DIC
Increased risk of thrombosis
Factor X Factor XII deficiency is associated with:

Calcium Epistaxis

PF3 Bleeding episodes

Factor VII Increased risk of thrombosis

X
Which factor deficiency is associated with a Decreased risk of thrombosis
prolonged PT and APTT? Hemophilia A
The following results were obtained on a patient:
IX normal platelet count and function, normal PT, and
prolonged APTT. Which of the following disorders
is most consistent with these results? Dysfibrinogenemia

Bernard-Soulier syndrome Lupus anticoagulant

Factor XIII deficiency
von Willebrand's disease Normal PT and APTT results in a patient with a
poor wound healing may be associated with:
Glanzmann's thrombasthenia
Factor XIII deficiency
Hemophilia A
Hypofibrinogenemia Factor VII deficiency
The following laboratory results were obtained from
a 40-year-old woman: PT = 20 sec; APTT = 50 sec; Factor VIII deficiency
thrombin time = 18 sec. What is the most probable
diagnosis? Factor XII deficiency
Hemarthrosis
Factor VIII deficiency One of the complications associated with a severe
Hemophilia A is:
Factor VII deficiency
Immune-mediated thrombocytopenia
Hypofibrinogenemia
Hemarthrosis
Factor X deficiency
von Willebrand's disease Mucous membrance bleeding
Refer to the following results:
PT = normal Mild bleeding during surgery
APTT = prolonged Type 1
Bleeding time = increased The most common subtype of classic von
Platelet count = normal Willebrand's disease is:
Platelet aggregation to ristocetin = abnormal
Which of the following disorders may be indicated? Type 1

Factor IX deficiency Type 2A

Factor VIII deficiency Type 2B

DIC Type 3
V
von Willebrand's disease A prolonged APTT and PT are corrected when
Prolonged APTT, normal PT mixed with normal plasma. Which factor is most
Which results are associated with hemophilia A? likely deficient?

Prolonged APTT, normal PT VIII

Prolonged PT, and APTT XI

Prolonged PT, normal APTT IX

Normal PT and APTT V

Severe liver disease Thrombin time
Which of the following is associated with multiple Which laboratory test is affected by heparin
factor deficiencies? therapy?

Severe liver disease Fibrinogen assay

An inherited disorder of coagulation Protein C assay

 Prothrombin time
Thrombin time
Platelet morphology
Protein S assay Deactivation of factor Va
PT, APTT, TT Factor V Leiden promotes thrombosis by
A 50-year-old man has been on heparin for the past preventing:
7 days. Which combination of the tests is expected
to be abnormal? Activation of protein S

APTT, TT only Activation of protein C

PT and APTT only Activation of factor V

APTT, TT, fibrinogen assay Deactivation of factor Va

Hemophilia A
PT, APTT, TT Which of the following is the most prevalent
APTT inherited bleeding disorder?
What test is used to monitor hepatin therapy?
Factor XII deficiency
INR
Hemophilia B
PT
Factor VII deficiency
APTT
Hemophilia A
TT thrombocytes
INR Which of the following peripheral blood cells is
What test is commonly used to monitor warfarin involved in hemostasis?
therapy?
thrombocytes
APTT
lymphocytes
TT
erythrocytes
Ecarin time
granulocytes
INR Factor VII
Va and VIIIa Which factor is used only in the extrinsic
What clotting factors (cofactors) are inhibited by coagulation pathway?
protein S?
Factor V
VIII and IX
Factor VIII
V and X
Factor II
Va and VIIIa
Factor VII
VIII and X Vitamin K synthesis
Bleeding time Long-term antibiotic therapy is a cause of bleeding
Which of the following tests is most likely to be because it disrupts:
abnormal in patients taking aspirin?
Vitamin K synthesis
Platelet count
Platelet aggregation
Bleeding time
Contact activation
Fibrinolytic activity Prevention of thrombotic events
Inhibits thrombin
Heparin: Coagulation inhibition
aPTT
Inhibits PF3 Which of the following assays will be abnormal with
hemophilia A?
Inhibits thrombin
blood vessel function
Complexes with protein C
aPTT
Degrades antithrombin
Factor Assays PT
Which of the following is the most useful in
differentiating hemophilia A from hemophilia B? Platelet count
1.Chediak-Higashi Syndrome
Patient's history Patients have alvinism and giant granules in
neutrophils with impaired platelet release
A familial pattern of inheritance
1.Chediak-Higashi Syndrome
Factor assays
2.Gray platelet Syndrome
Activated partial thromboplastin time
X and II 3.Thrombocytopenia with absent radii (TAR)
Which factors are part of the common coagulation 3.Thrombocytopenia with absent radii (TAR)
pathway? Rare disorder of skeletal system where patients
have no radial bones
X and XII
1.Chediak-Higashi Syndrome
X and II
2.Gray platelet Syndrome
X and XIII
3.Thrombocytopenia with absent radii (TAR)
VII and X 2.Gray platelet Syndrome
30% Platelets lack alpha granules and are larger and
Clotting factors must be present at a minimum of gray or blue-gray in color.
which percentage for hemostasis to be achieved?
1.Chediak-Higashi Syndrome
Question options:
2.Gray platelet Syndrome
20%
3.Thrombocytopenia with absent radii (TAR)
Occurs 5 to 14 days after heparin therapy
50% Heparin-induced thrombocytopenia (HIT) usually:

Occurs as a result of protein C deficiency

75%
Occurs 5 to 14 days after heparin therapy

30% Will show an increase in platelets

Fibrin breakdown
The primary role of plasmin is: Occurs only in males
XIII
Platelet aggregation Which factor is not measured by the PT or aPTT
test?
Fibrin breakdown
XIII
aPTT
XII
PT
X fibrinolysis
Clot removal is accomplished by which of the
VII following systems?
Deep vein thrombosis
D-dimers may be elevated in which of the following: anticoagulation

Glanzmann's thrombasthenia hemostasis

Sickle cells disease fibrinolysis

Deep vein thrombosis thrombosis

Factor-deficient plasma
Bernard-Soulier syndrome Factor assays measure the percentage of activity of
Cardiovascular disease a given factor by mixing the patient's plasma with:
All of the following may lead to deficiencies of
clotting factors except: Adsorbed plasma

Autoimmune disease Factor-specific plasma

Cardiovascular disease Normal plasma

Renal disease Factor-deficient plasma

It is associated with postpartum women, previous
Liver disease viral infections or gastric carcinomas
adhesion of platelets In thrombotic thrombocytopenic purpura, which of
An essential requirement for adequate primary the following statements is the most accurate?
hemostasis is:
The organ most affected is the kidney.
presence of vitamin K
It is associated with postpartum women, previous
retraction of the clot viral infections or gastric carcinomas

formation of a thrombus More males are affected than females.

adhesion of platelets It is associated with E. coli O157:H7

The platelet plug is formed. Bernard-Soulier syndrome
Primary hemostasis refers to the process by which: The presence of thrombocytopenia and giant
platelets on the peripheral smeal of a patient is
platelets are destroyed characteristic of:

The platelet plug is formed. Bernard-Soulier syndrome

A cross-linked fibrinolytic system Hemophilia A

Fibrin degradation products are generated Glanzmann's thrombasthenia

aPTT
Which of the following is the most accurate Classic von Willebrand's disease
coagulation test used to monitor heparin therapy? ITP
The disease in which platelets are destroyed by
platelet count antibodies is:

bleeding time ITP

TIP Glanzmann's thrombasthenia

von Willibrand's disease Gray platelet syndrome

DIC Bernard-Soulier syndrome

Normal platelet aggregation Factor XIII
Which platelet response(s) is usually associated Which factor is also known as fibrin stabilizing
with hemophilia A? factor?

Normal platelet aggregation thrombin

Defective ADP release; normal response to ADP prekallekrein

Absent aggregation to epinephrine, ADP, and Factor XIII

collagen
Factor IV
Decreased amount of ADP in platelets interaction of clotting factor
Deep muscle hemorrhages Which of the following is NOT part of primary
All of the following are associated with platelet hemostasis?
disorders except:
platelet aggregation
Abnormal platelet morphology
interaction of clotting factor
Epistaxis and menorrhagia
platelet adhesion
Deep muscle hemorrhages
vasoconstriction
Thrombocytopenia 1.Factor I
VIII fibrinogen
If the aPTT is polonged but the PT is normal, which
of the following factors is most likely deficient? 1.Factor I

VIII 2.Factor II

X 3.Factor III

VII 4.Factor IV

II 5.Factor V
Greater than 450 x 109/L
Thrombocytosis is defined as a platelet count that 6.Factor VII
is:
7.Factor VIII
Less than 450 x w109/L 3.Factor III
thromboplastin
Greater than 600 x 109/L
1.Factor I
Less than 300 x 109/L
2.Factor II
Greater than 450 x 109/L
Gray platelet syndrome 3.Factor III
A platlet release defect in which there is a severe
lack of alpha granules in platelets is known as: 4.Factor IV

Chediak-Higashi syndrome 5.Factor V

6.Factor VII 2.Factor II

7.Factor VIII 3.Factor III

5.Factor V
labile factor 4.Factor IV

1.Factor I 5.Factor V

2.Factor II 6.Factor VII

3.Factor III 7.Factor VIII

7.Factor VIII
4.Factor IV antihemophilic factor

5.Factor V 1.Factor I

6.Factor VII 2.Factor II

7.Factor VIII 3.Factor III

6.Factor VII
proconvertin or stabile factor 4.Factor IV

1.Factor I 5.Factor V

2.Factor II 6.Factor VII

3.Factor III 7.Factor VIII

a gragment of the cytoplasm of a megakaryocyte
4.Factor IV Which of the following is true about platelets?

5.Factor V production is controlled by erythropoietin

6.Factor VII normal count is about 50 x 109/L

7.Factor VIII are made n the spleen

4.Factor IV
calcium a gragment of the cytoplasm of a megakaryocyte
von Willebrand's disease and Bernard-Soulier
1.Factor I Which of the following are platelet adhesion
disorders?
2.Factor II
von Willebrand's diease and Glanzmann's
3.Factor III thrombasthenia

4.Factor IV Glanzmann's thrombasthenia and congenital

fibrinogenemia
5.Factor V
von Willebrand's disease and Bernard-Soulier
6.Factor VII
Glanzmann's thrombasthenia and Hermansky-
7.Factor VIII Pudlak syndrome
2.Factor II Inherited - sex linked recessive
prothrombin Hemophilia A and B are:

1.Factor I Acquired coagulation defect

 The organ most affected is the spleen.
Inherited - autosomal dominant
Platelets are permanently impaired
Inherited - sex linked recessive
The toxin responsible for this syndrome is produced
Inherited - autosomal recessive by E. coli O157:H7
platelet defect
Nosebleeds and gum bleeding are usually Impaired neurological function is one of the primary
manifestations of which type of coagulation symptoms
disorder? 9:1
Which of the following ratios of blood to
thrombosis anticoagulant is acceptable for most coagulation
procedures?
clotting factor disorder of factor XII
1:9
vascular disorder
5:1
platelet defect
Bernard-Soulier syndrome 9:1
A coagulation disorder commonly associated with
umbilicus bleeding and post-circumcision bleeding 1:4
is known as: Calcium ions
Platelet aggregation is dependent on the presence
Idiopathic thrombocytopenic purpura of:

Glanzmann's thrombasthenia Calcium ions

von Willebrand's disease Potassium

Bernard-Soulier syndrome Sodium citrate

converts fibrinogen to fibin
Which of the following is one of the key roles of Magnesium
thrombin with respect to fibrinogen? Female carrier
A man with hemophilia A and an unaffected female
activates factor V and VIII can produce a:

converts fibrinogen to fibin Female with hemophilia A

releases fibrin split products Female carrier

changes fibrinogen to prothrombin Male carrier

Factor XIII
Which of the clotting factors is not a protease? Male with hemophilia A
Spleen
Factor IX Which organ is responsible for sheltering 20% of
the total platelet volume in the circulation?
Factor VII
Kidney
Factor XIII
Liver
Factor II
The toxin responsible for this syndrome is produced Spleen
by E. coli O157:H7
In hemolytic uremic syndrome (HUS), which of the Adrenal gland
following statements is the most accurate? Fibrinogen
The main substrate of the coagulation system is: GP Ib

Collagen GP IIb/IIIa

Calcium vWF

ADP cadmium
Ca2+ and thromboplastin
Fibrinogen In the prothrombin test, the patient's citrated
Petechiae plasma is combined with:
A decreased platelet count is most often anticipated
when a patient demonstrates: Phospholipids

Thrombosis Ca2+ and actin

Petechiae Thromboplastin only

Hemarthrosis Ca2+ and thromboplastin

Fibrinogen
Glossitis The substrate upon which the coagulation cascade
II, VII, IX, and X is centered is:
The prothrombin group of factors consists of
factors: Vitamin K

III, VIII, IX, and X Fibrinogen

II, VII, IX, and X Thrombin

XI, XII, prekallikrein, and HMWK Fibrin

Hemophilia B
I, V, VIII, and XIII Christmas disease is another name for:
Fitzgerald factor
Which factor is involved in contact activation? Factor VII deficiency

Fibrinogen Hemophilia B

Factor II Hemophilia A

Fitzgerald factor von Willebrand's disease

Vasoconstriction
Factor X The first response of a cut vessel is:
Factor V
Which factor is measured by both the PT and the Activation of the intrinsic pathway
aPTT?
Platelet aggregation
Factor XIII
Vasoconstriction
Factor V
Vasodilation
Factor VIII 7 to 10 days
The average lifespan of a platelet in a normal adult
Factor IX is:
GP IIb/IIIa
Platelet aggregation cannot occur if __________ is 7 to 10 days
absent.
18 to 21 days
 Sickle cell disease
1 to 5 days
TTP
5 to 7 days
Bone marrow Polycythemia vera (PCV)
Platelets are synthesized in the:
Acute leukemia
Liver Sodium citrate
The anticoagulant of choice for routine coagulation
Bone marrow procedure is:

Lymph glands Sodium citrate

Spleen Sodium oxalate

Adhesion, aggregation, release, stabilization
There are four phases in regards to platelet
function. The correct order of occurrence from the
beginning to end is:
Adhesion, release, aggregation, stabilization
Adhesion, aggregation, release, stabilization
Aggregation, adhesion, stabilization, release
Release, aggregation, adhesion, stabilization
Factor VIII
The only clotting factor not synthesized exclusively
by the liver is:
Sodium fluoride
Heparin
Neonatal alloimmune thrombocytopenia
Several days after birth, a baby boy develops the
following symptoms, petechiae, purpura, and skin
hemorrhage. The platelet count is 18,000. The
most likely explanation is:
Drug-induced thrombocytopenia
Neonatal alloimmune thrombocytopenia
Secondary thrombocytopenia

Factor IX Neonatal DIC

Platelet count
Factor VII Which of the following test results is normal in a
patient with classic von Willebrand's disease?
Factor VIII
Platelet count
Factor V
Factor X deficiency Factor VIII and vWF levels
The following laboratory results have been obtained
for a 40-year-old woman: PT=20 seconds Bleeding time
(reference range is 11 to 15 seconds), aPTT=50
seconds (reference range is 22 to 40 seconds), and Activated partial thromboplastin time
thrombin time=18 seconds (reference range is 11 to fibrinolysis, plasmin
15 seconds). What factor deficiency is most likely? The process of fibrin degradation is called
______________ and is controlled by the enzyme
Factor X deficiency ____________.

Factor VIII deficiency fibrinolysis, protease

Factor VII deficiency fibrinolysis, plasmin

Factor XIII deficiency fibrination, plasmin

Polycythemia vera (PCV)
Which of the following conditions may result in fibrination, protease
primary thrombocytosis? Activating thromboplastin
All of the following are functions of thrombin except:
Activating factors V and VIII
Activating thromboplastin
WBC (X109/L) = 4.5, RBC (X1012/L) = 6.7, Hgb
(g/dL) = 16.7, Hct(%) = 48.2, MCV (Fl) = 89, MCH
(pg) = 29.2, MCHC (%) = 35.2, RDW (%) = 13.4, Plt
(X109/L) = 253

Simulating platelets to product PGI2 WBC only

Initiating the platelet release reaction WBC and RBC

10 to 15 seconds
The reference range for a thrombin time is: Hgb and Hct

10 to 15 seconds RBC only

Platelets, Hgb and Hct
40 to 60 seconds If the following results are for a 75 year old female
patient, which are out of range LOW?
100 to 120 seconds
WBC (X109/L) = 9.5, RBC (X1012/L) = 5.7, Hgb
20 to 40 seconds (g/dL) = 10.7, Hct(%) = 28.2, MCV (Fl) = 89, MCH
Fibrin degradation (pg) = 29.2, MCHC (%) = 35.2, RDW (%) = 13.4, Plt
The D-dimer test measures: (X109/L) = 53

Fibrinogen deposition RBC only

Fibrin deposition Platelets, Hgb and Hct

Fibrinogen degradation RBC, Hct and MCV

Fibrin degradation RBC and Hgb

200 to 400 mg/dL WBC and RBC
The reference range for fibrinogen is: If the following results are for a 50 year old male
patient, which are out of range HIGH?
600 to 750 mg/dL
WBC (X109/L) = 11.5, RBC (X1012/L) = 6.7, Hgb
200 to 400 mg/dL (g/dL) = 16.7, Hct(%) = 48.2

100 to 200 mg/dL Hgb and Hct

400 to 600 mg/dL RBC and Hgb

RBC and Hgb
If the following results are for a 10 year old male RBC only
patient, which are out of range HIGH?
WBC and RBC
WBC (X109/L) = 4.5, RBC (X1012/L) = 6.7, Hgb RBC, Hct and Hgb
(g/dL) = 16.7, Hct(%) = 48.2 If the following results are for a 25 year old female
patient, which are out of range LOW?
RBC and Hgb
WBC (X109/L) = 9.5, RBC (X1012/L) = 3.7, Hgb
Hgb and Hct (g/dL) = 10.7, Hct(%) = 28.2, MCV (Fl) = 89, MCH
(pg) = 29.2, MCHC (%) = 35.2, RDW (%) = 13.4, Plt
WBC and RBC (X109/L) = 253

RBC only RBC only

WBC only
If the following results are for a 62 year old male Platelets, Hgb and Hct
patient, which are out of range LOW?
RBC and Hgb Plasmin

RBC, Hct and Hgb Tissue-type plasminogen activator (tPA)

high
The patient's thrombin time is 20 seconds. Is this Thrombin
high, low, or normal? Inactivates factors XII, XI, and IX in the presence of
antithrombin
high The anticoagulant known as heparin:

low Chelates calcium

my head hurts and I can no longer answer Inactivates factors XII, XI, and IX in the presence of
questions antithrombin

normal Degrades antithrombin activity

high
The patient's prothrombin time is 14 seconds. Is Inhibits PF3 activity
this high, low, or normal? Prevents activation of factor X by VIIa
Tissue factor pathway inhibitor (TFPI):
high
Prevents activation of factor X by VIIa
low
Activates the common pathway
my head hurts and I can no longer answer
questions Inhibits fibrinolysis

normal Inhibits the kallikrein proteins

yes Factors I, V, VII, XIII
The patient's APTT time is 35 seconds. Is this The fibrinogen group of coagulation factors include:
normal?
Factors XI and XII
I have no idea
Factos II, VII, IX, X
no
Factors III, VIII, IX, X
my head hurts and I can no longer answer
questions Factors I, V, VII, XIII
Plasminogen activator system
yes Fibrinolysis is controlled by the:
Thromboxane A2
The vasoconstrictor substance released from the Thrombin feedback activation system
platelets at the site of injury is:
Feedback inhibition system
Thrombin
Intrinsic system
Thromboxane A2
Plasminogen activator system
Adenosine diphosphate All of the above
Therapeutic thrombolytic agents include:
Prostacyclin
Thrombin tPA
Which of the following is not a component of the
fibrinolytic system? Streptokinase

Urokinase Urokinase
All of the above Thrombocytopenia with absent radii
Epistaxis Alpha granule defect
A decreased platelet count is most often anticipated Which defect characterizes Gray's syndrome?
when a patient demonstrates:
Coagulation defect
Genitourinary bleeding
Platelet adhesion defect
Rectal bleeding
Dense granule defect
Severe hemorrhage
Alpha granule defect
Epistaxis GP IIb/IIIa, GP Ib/IX
Aspirin The autoantibody generated in ITP is directed
Which of the following causes irreeversible against:
inactivation of platelets?
Collagen
Vitamin K
GP IIb/IIIa, GP Ib/IX
Aspirin
vWF
Heparin
Fibrinopeptides A and B
Coumadin Factor assays
Hermansky-Pudlak syndrome Which of the following is the most useful in
A platelet release defect in which there is a severe differentiating hemophilia A from hemophilia B?
deficiency of dense granules in platelets is known
as: Factor assays

Bernard-Soulier syndrome Activated partial thromboplastin time

Chediak-Higashi syndrome A familial pattern of inheritance

Hermansky-Pudlak syndrome Patient's history

Administration of prothrombin complex concentrate
Wiskott-Aldrich syndrome Treatment of patients with factor II, VII, or X
Ristocetin co-factor activity deficiency consists of:
The single best predictive assay for von Willebrand
factor is: Administration of whole blood

Ristocetin co-factor activity Administration of cryoprecipitate

aPTT Administration of FFP

Bleeding time Administration of prothrombin complex concentrate

Factor XIII deficiency
Platelet count Keloid scar formation is most commonly associated
Chronic idiopathic thrombocytopenic purpura with:
Which of the following is an autoimmune
thrombocytopenic disorder process? Factor IX deficiency

von Willebrand's disease Factor XII deficiency

Hemolytic uremic syndrome Factor XIII deficiency

Chronic idiopathic thrombocytopenic purpura Factor VIII deficiency

Factor V
Factor V Leiden is a genetic mutation of:

The prothrombin molecule

Factov V

Hemophilia A

Factor IV
Factor VIII deficient plasma
When performing a factor VIII activity assay, a
patient's plasma is mixed with:

Plasma with a high concentration of factor VIII

Normal patient's plasma

Normal control plasma

Factor VIII deficient plasma

Fresh frozen plasma
The most suitable product for treatment of factor
VIII deficiency is:

Factor VIII concentrate

Factor V Leiden

Fresh frozen plasma`

Prothrombin complex concentrate

Prolonged APTT, normal PT
Which results are associated with a Factor IX
Deficiency?

Normal PT and APTT

Prolonged PT, normal APTT

Prolonged PT, and APTT

Prolonged APTT, normal PT

Megakaryocyte
Identify the large blue cell in this bone marrow
smear.

Reed Sternberg cell

Nucleated red cell

Megakaryocyte

Myeloblast