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1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Solvent, Chemical production
In compliance with the conditions described in the annex to this safety
data sheet.
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Page 1 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled
H370 Causes damage to organs (Eyes).
Precautionary statements
Prevention
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No
smoking.
P233 Keep container tightly closed.
P280 Wear protective gloves/ protective clothing.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Storage
P403 + P235 Store in a well-ventilated place. Keep cool.
Signal word
Danger
Hazard statements
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled
H370 Causes damage to organs (Eyes).
Precautionary statements
P280 Wear protective gloves/ protective clothing.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308 + P311 IF exposed or concerned: Call a POISON CENTER or doctor/ physician.
Index-No. 603-001-00-X
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 2 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
For the full text of the H-Statements mentioned in this Section, see Section 16.
Hazardous components (1999/45/EC)
Chemical Name (Concentration)
CAS-No. Classification
methanol (<= 100 % )
67-56-1 F, Highly flammable; R11
T, Toxic; R23/24/25-39/23/24/25
For the full text of the R-phrases mentioned in this Section, see Section 16.
3.2 Mixture
not applicable
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, Drowsiness, Dizziness, narcosis, agitation, spasms, inebriation, Nausea,
Vomiting, Headache, blindness, Impairment of vision, Coma
Drying-out effect resulting in rough and chapped skin.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
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Page 3 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 4 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 5 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Engineering measures
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Page 6 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
Colour colourless
Odour characteristic
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Page 7 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
pH No information available.
Flash point 10 °C
Method: c.c.
1.9
Reference substance: n-butyl acetate
Water solubility at 20 °C
soluble
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 8 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
absorption
Symptoms: Nausea, Vomiting
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Page 9 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
absorption
Skin irritation
Drying-out effect resulting in rough and chapped skin.
Eye irritation
Irritations of mucous membranes
Sensitisation
Sensitisation test: guinea pig
Result: negative
(IUCLID)
Germ cell mutagenicity
Genotoxicity in vivo
Mutagenicity (mammal cell test): micronucleus.
Result: negative
(IUCLID)
Genotoxicity in vitro
Ames test
Result: negative
(IUCLID)
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
CMR effects
Carcinogenicity:
Did not show carcinogenic effects in animal experiments.
Mutagenicity:
Based on available data the classification criteria are not met.
Teratogenicity:
Based on available data the classification criteria are not met.
Reproductive toxicity:
Based on available data the classification criteria are not met.
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 10 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
12.1 Toxicity
Toxicity to fish
LC50 Lepomis macrochirus (Bluegill sunfish): 15,400 mg/l; 96 h (in soft water) (ECOTOX
Database)
Toxicity to daphnia and other aquatic invertebrates
EC5 E.sulcatum: > 10,000 mg/l; 72 h (Lit.)
EC50 Daphnia magna (Water flea): > 10,000 mg/l; 48 h (IUCLID)
Toxicity to algae
EC50 Pseudokirchneriella subcapitata (green algae): ca. 22,000 mg/l; 96 h (External MSDS)
IC5 Scenedesmus quadricauda (Green algae): 8,000 mg/l; 8 d (IUCLID)
Toxicity to bacteria
EC5 Pseudomonas fluorescens: 6,600 mg/l; 16 h (IUCLID)
Toxicity to fish (Chronic toxicity)
NOEC Oryzias latipes (Orange-red killifish): 7,900 mg/l; 200 h
(External MSDS)
12.2 Persistence and degradability
Biodegradability
99 %; 30 d
OECD Test Guideline 301D
Readily biodegradable.
Biochemical Oxygen Demand (BOD)
600 - 1,120 mg/g (5 d)
(IUCLID)
Chemical Oxygen Demand (COD)
1,420 mg/g
(IUCLID)
Theoretical oxygen demand (ThOD)
1,500 mg/g
(Lit.)
Ratio BOD/ThBOD
BOD5 76 %
Closed Bottle test
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -0.77
(experimental)
(Lit.) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Surface tension
22.6 mN/m
at 20 °C
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 11 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Stability in water
2.2 yr
reaction with hydroxyl radicals (IUCLID)
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
Substances of very high concern (SVHC) This product does not contain substances
of very high concern according to
Regulation (EC) No 1907/2006 (REACH),
Article 57 above the respective regulatory
concentration limit of ≥ 0.1 % (w/w).
National legislation
Storage class 3
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 13 of 18
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 14 of 18
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Sectors of end-use
SU 3 Industrial uses: Uses of substances as such or in preparations at industrial sites
SU9 Manufacture of fine chemicals
SU 10 Formulation [mixing] of preparations and/ or re-packaging (excluding alloys)
Chemical product category
PC21 Laboratory chemicals
Process categories
PROC1 Use in closed process, no likelihood of exposure
PROC2 Use in closed, continuous process with occasional controlled exposure
PROC3 Use in closed batch process (synthesis or formulation)
PROC4 Use in batch and other process (synthesis) where opportunity for exposure arises
PROC5 Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/ or significant contact)
PROC8a Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at non-dedicated facilities
PROC8b Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at dedicated facilities
PROC9 Transfer of substance or preparation into small containers (dedicated filling line, including
weighing)
PROC10 Roller application or brushing
PROC15 Use as laboratory reagent
Environmental Release Categories
ERC1 Manufacture of substances
ERC2 Formulation of preparations
ERC4 Industrial use of processing aids in processes and products, not becoming part of articles
ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)
ERC6b Industrial use of reactive processing aids
2.1 Contributing scenario controlling worker exposure for: PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a,
PROC8b, PROC9, PROC10, PROC15
Product characteristics
Concentration of the Substance in Covers the percentage of the substance in the product up to
Mixture/Article 100 %.
Physical Form (at time of use) High volatile liquid
Workers
CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method
2.1 PROC1 <1 ECETOC TRA
2.1 PROC2 <1 ECETOC TRA
2.1 PROC3 <1 ECETOC TRA
2.1 PROC4 <1 ECETOC TRA
2.1 PROC5 <1 ECETOC TRA
2.1 PROC8a <1 ECETOC TRA
2.1 PROC8b <1 ECETOC TRA
2.1 PROC9 <1 ECETOC TRA
2.1 PROC10 <1 ECETOC TRA
2.1 PROC15 <1 ECETOC TRA
4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure
Scenario
Please refer to the following documents: ECHA Guidance on information requirements and chemical
safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;
ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure
Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH
Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC
Guidance Specific Environmental Release Categories (SPERCs).
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 16 of 18
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Sectors of end-use
SU 22 Professional uses: Public domain (administration, education, entertainment, services,
craftsmen)
Chemical product category
PC21 Laboratory chemicals
Process categories
PROC15 Use as laboratory reagent
Environmental Release Categories
ERC2 Formulation of preparations
ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)
ERC6b Industrial use of reactive processing aids
Product characteristics
Concentration of the Substance in Covers the percentage of the substance in the product up to
Mixture/Article 100 %.
Physical Form (at time of use) High volatile liquid
Workers
CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method
2.1 PROC15 <1 ECETOC TRA
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 17 of 18
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure
Scenario
Please refer to the following documents: ECHA Guidance on information requirements and chemical
safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;
ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure
Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH
Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC
Guidance Specific Environmental Release Categories (SPERCs).
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
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