debitore esecutato "/>

The bulk of the urine-recovered dye must have been taken up into the horny layer of the
pores and skin after which slowly released into the circulation. A cumulative 4-day absorption
assuming cm 2 of scalp was given as zero.
According to the outcomes obtained, Daphnia magna is probably the most sensitive
organism, and resorcinol may be categorised as acutely poisonous solely to Daphnia.
However, this value is questionable to be used as a restrict worth in risk evaluation that is the
best focus examined on this examine , and the NOEC could possibly be considerably larger
than acknowledged within the study. In the environment, resorcinol is rapidly degraded half-
life about 2 h by reaction with photochemically produced hydroxyl radicals. Under aerobic
circumstances, resorcinol proved to be readily biodegradable in a take a look at performed
according to OECD TG C, and it is more likely to be biodegraded beneath anaerobic
circumstances.

No resorcinol-associated macroscopic findings, organ weight, or opposed microscopic target

organ results had been noticed within the F zero and F 1 parental animals. The F zero and F
1 females continued to receive the resorcinol throughout mating, gestation, and lactation and
through the day of euthanasia for study design, see Appendix 7. There have been no F zero
and F 1 parental resorcinol-associated deaths or medical findings in the course of the weekly
detailed bodily examinations. In controls and the high-dose group, a qualitative
histopathological evaluation of the brain forebrain, midbrain, and hindbrain was additionally
carried out for the aforementioned animals RTF, There had been no opposed results
concerning reproductive efficiency, mortality, and physique or organ weights.

Animals that died showed hyperaemia and distension of stomach and intestine, while there
were no gross lesions at necropsy in survivors Flickinger, In one other examine with CFY
rats. Most of the studies are of adequate quality and acceptable for danger characterization
purposes.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied
Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the
uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of
resorcinol in and concluded that there are no epidemiological knowledge relevant to the
carcinogenicity of resorcinol in people and that the proof of its carcinogenicity in animals is
insufficient; thus, resorcinol is not classifiable as to its carcinogenicity to humans. JECFA
assessed the hazards from the usage of resorcinol as a meals flavouring agent and
concluded that this use is of no security concern. Overall, the research aren't enough for a
statistical extrapolation method based on the EU Technical Guidance Document EC, a.

The third study, performed in , included of lively staff.

Assuming a physique weight of 64 kg IPCS, gives an exposure estimate of 0.
Most of the studies are of enough quality and acceptable for risk characterization functions.
Resorcinol is thought to form covalent bonds with haem Sessler et al.
Although thyroid effects are a significant end-level in each human case-studies and animal
studies, there is a lack of consistency within the leads to the animal studies.
Two long-term research with Swiss mice or NZW rabbits, where the animals have been
treated with 0.
The weight of evidence means that rodents are more sensitive to thyroid effects than
people.

In in vitro human pores and skin studies, resorcinol was evaluated from a representative hair
dye formulation that contained zero. However, it must be considered that acned skin could
also be broken due either to scratching or to the blemishes themselves.
There are variations in thyroid physiology between people and animals. The weight of
evidence means that rodents are more delicate to thyroid effects than people.

In each species, there were no antagonistic effects on ultimate mean physique weights,
haematology, or medical chemistry parameters, and no chemical-associated gross or
microscopic lesions were noticed. In one other study, rats were uncovered to zero or 0. No
thyroid hormone measurements have been performed.
The microscopic examination of the thyroid gave minimal changes follicular hyperplasia ,
which were statistically not significant between controls and individual dose teams RTF, In
vitro research have been performed to assess the consequences of resorcinol on thyroid
operate. In excessive-dose teams, a lower in body weight and decreased survival have been
famous. Owing to concern about the thyroid results of resorcinol, which have been proven in
human studies to happen at excessive doses, this finish-point particularly has been the point
of focus in several studies. In most of the older studies, the results of resorcinol publicity on
the thyroid gland are conflicting. It has been instructed that thyroid results appear to be
depending on an administration route that enables for continued systemic exposure e.

There were no revealed animal research displaying thyroidal results with a dose—response
relationship that could possibly be used for a tolerable intake. In the frame of a full life cycle
toxicity test OECD TG , Lima noticed no opposed effects after forty eight h of publicity at the
highest concentration tested, zero. Furthermore, Cronin et al. The fish and pond snails have
been placed immediately into the aquaria, while the remaining five species have been
segregated in several baskets and suspended within the aquaria. The solely investigation
into this finish-point is that from the dose vary-finding research reported in sections 8.
One factor growing potential toxic results is the application of resorcinol to injured pores and
skin Cassano et al. Surviving F 0 parental and F 1 following choice rats underwent complete
gross necropsy following the breeding interval seven F zero males per group , following
completion of weaning of F 1 pups F zero females , following scheduled necropsy of F zero
females remaining seven F 0 males per group , on PND 28 F 1 uncovered pups , or on PND
30 or 70 F 1 pups chosen for behavioural testing.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company,
Signs of intoxication included salivation, tremors, and convulsions, and treated pores and
skin areas showed slight erythema and extreme dryness. Mean data for three donors and 16
replicates indicate a plateau in receptor fluid concentration between 24 and forty eight h, as
reflected by cumulative absorption values of 1. A steady-state permeability coefficient. For
male albino rats strain not given;.