Nama : Nuril Frida Lestari

NIM : 30101507531

JUDUL JURNAL DAN EDISI TNOA Journal of Ophthalmic Science and

Research VOL 54 October – Desember 2019
JUDUL ARTIKEL Study of Meibomian Gland Dysfunction and
Hypercholesterolemia
LATAR BELAKANG Abnormality of the meibomian glands,
commonly characterized
by terminal duct obstruction and/or
qualitative/quantitative
changes in the glandular secretion. It
may result in alteration of the tear film,
symptoms of eye irritation, clinically
apparent inflammation, and ocular
surface disease.
Hypercholesterolemia (total
cholesterol >200 mg/dl) is an
important risk factor for
cerebrovascular disease, ischemic
heart disease, and peripheral vascular
disease
Recent studies indicate that patients
with moderate-to-severe MGD
have a high incidence of total blood
cholesterol than the general
population. Furthermore, the
young- and middle-aged patients with
MGD with no history of
hypercholesterolemia may have higher
blood cholesterol levels than the
general population
TUJUAN investigate the association between MGD
and hypercholesterolemia in young- and
middle-aged adults
aged 20–60 years.
METODOLOGI Desain : observational case–control study
Populasi sampel : Individuals aged 20 – 60
years
• Case group : Diagnosed with MGD
and no known hypercholesterolemia
(60)
• Control group : Without MGD and no
known hypercholesterolemia (60)
Waktu : Jan 2015 – Juni 2016
Tempat : rural tertiary hospital
HASIL 1. Cholesterol levels among different
age groups within cases and
controls in this study reveal higher
mean cholesterol level among the
individuals aged 51–60 years.
Increasing age correlates also with
increase in the total cholesterol
levels and MGD.
2. MGD grade 2 and above found
more frequently in patients with
hyper cholestherolemia, Since
MGD Grade 2 and above alone are
symptomatic, it may be stated that
symptomatic MGD is associated
with hypercholesterolemia as past
studies by William and Pinna
suggested.
3. Cholesterol esters are present in
patients with MGD and increased
cholesterol in the glandular
secretion might have a role in the
pathogenesi of MGD. Increase in
cholesterol con-centration in
meibum results in incre-ase in its
melting point, and viscosityThese
changes result in meibomian gland
plugging and development of
MGD.

KESIMPULAN Among young and middle aged adults

aged 20–60 years, individuals with
moderate MGD have a higher incidence of
hypercholesterolemia than the healthy
controls.
RANGKUMAN DAN HASIL 1. Pasien dengan MGD pada
PEMBELAJARAN kelompok usia 51 tahun memiliki
kadar kolesterol yang lebih tinggi
dibanding populasi kontrol
2. Peningkatan sekresi kolesterol
meningkatkan viskositas meibom
yang dapat mengakibatkan
sumbatan sehingga terbentuk MGD
3. MGD grade 2 atau MGD
simptomatik ditemukan pada
pasien dengan hiperkolesterolemia