Beruflich Dokumente
Kultur Dokumente
Zulham Yamamoto
18 Maret 2019
Tujuan pembelajaran:
Setelah mengikuti perkuliahan ini, mahasiswa
diharapkan mampu untuk:
a. Mampu membandingkan struktur
mikroskopis kelenjar eksokrin dan
endokrin,
b. Mampu menjelaskan unsur sistem
endokrin,
c. Mampu menjelaskan struktur mikroskopis
kelenjar-kelenjar endokrin: (1) hipofisis, (2)
pineal, (3) tiroid, (4) paratiroid, dan (5)
supra renal, termasuk struktur yang
membentuknya (misalnya kapiler, folikel,
dan koloid), nama dan ciri sel yang
mensekresikan hormon, dan ciri khas
struktur kelenjar.
d. Mampu menyebutkan peran fisiologis
setiap kelenjar/sel endokrin sebagai
penghasil hormon tertentu.
1.
Subtopics
Endocrine system and cell to cell
communication
2. Endocrine system components
3. Endocrine glands Vs. Exocrine
glands
– Glands development
– Glands
• Exocrine
• Endocrine
4. Endocrine glands
1. hypophysis
2. pineal
3. thyroid
Referensi:
4. parathyroid 1. Gartner LP. Color textbook of histology.
5. Suprarenal 2nd ed. 2001
6. Pancreas (dibahas dalam blok 2. Kus I. Light and electron microscopic
digestive system)
examination of pineal glands in rats
7. Liver (dibahas dalam blok digestive
system) exposed to constant light and constant
darkness. 2004
3. Al-Hussain SM. The pinealocytes of the
human pineal gland: a light and electron
microscopic study. 2006
1. Endocrine System and
Cell to Cell Communication
A neuron has a long fiber that delivers
its neurotransmitter.
Cell Communications
• Necessary for integration of cell activities
• Mechanisms
– gap junctions
• pores in cell membrane allow signaling chemicals to move
from cell to cell; Example- cardiomyocytes
– Neurotransmitters
• released from neurons to travel across gap to 2nd cell;
Examples– Acetyl choline in neuromuscular junction
– Paracrine (local hormones)
• secreted into tissue fluids to affect nearby cells
– Hormones
• chemical messengers that travel in the bloodstream . . .
(receptors)
Hormone
delivery
Synapse
(Neurosecretion)
O'Riordan et al., 2nd ed, page 5
Endocrine cells secrete a hormone
into the bloodstream.
(capillary)
2. Endocrine System Components
• Endocrine system
– endocrine organs/glands (thyroid, pineal, etc.)
– hormone producing cells in organs (brain (hypothalamus),
liver, kidney, respiratory tract and gastrointestinal tract)
• Endocrine glands/cells
– produce hormones
• Hormone
– chemical messenger secreted into bloodstream,
stimulates response in another tissue or organ;
– Composition/class: (1) protein/peptide, (2) amino-acid
derivatives, (3) steroid and fatty acid dericatives – lipid droplets
• Target cells
– have receptors for a specific hormone
3. Endocrine vs. Exocrine Glands
• Exocrine glands
– ducts carry secretion to a surface or organ cavity
– extracellular effects (food digestion)
– Example: saliva, sweat, pancreas, liver
• Endocrine glands
– no ducts;
– intracellular effects, alter target cell
metabolism
– Example: hypophysis, pineal, thyroid, parathyroid,
adrenal glands, pancreas, liver
Exocrine Glands
Endocrine Glands
Capillary
Basophil
Anterior
pituitary
Electron
Micrograph
Larry Kahn
Endocrine Glands (Zona fasciculata), Electron Micrograph
SER
Endothelium
Capillary lumen
17-16
Posterior
Anterior
Hypothalamus
• Shaped like a flattened funnel, forms floor and walls of third ventricle.
• Regulates primitive functions from water balance, sex drive, . . .
• Regulate many functions carried out by pituitary gland
Anterior Posterior
Pineal
Hypothalamic Nuclei
(b) Hypothalamus
Posterior Anterior
Anterior/Posterior Pituitary Circulation
Blood flow to pituitary gland is via a portal circulation the hypophyseal portal
system. Arterial flow is via superior and inferior hypophyseal artery into
capillary beds in series.
Pituitary gland
Adenohypophysis
Pars tuberalis
Pars intermedia
Pars distalis
Neurohypophysis
Median eminence
Infindibular stalk
Pars nervosa
Adenohypophysis
• Regions:
Using HE:
– Pars distalis
• Acidophils:
– Pars intermedia • Orange to red granules
– Pars tuberalis • Basophils:
• Histology structure pars distalis • Blue granules
– Connective tissue: fibrous capsule, • Chromophobs are degranulated
reticular fibers around large sinuoidal chromophils
capillary • Folliculostellate cells: supporting or
– Blood vessel: fenestrated endothel communication of cell function
– Parenchymal cells
• Chromophils
– Acidophils, using EM/IHC:
» Somatotroph: increase cellular
metabolic rates
» mammotroph: prolactin
– Basophils, using EM/IHC:
» Corticotroph: ACTH and lipotropic
hormone
» Thyrotroph: TSH
» Gonadotroph: FSH and LH
• Chromophob
• Folliculostellate cells
Endocrine Glands
Capillary
Basophil