ANNEXURE-A

SYLLABUS
Section-A (30 Questions)
General Study Common for all Subjects
1. General awareness about India and State of Punjab with particular reference to
Geography and History of India and Punjab, Constitution of India and Salient
features of Indian Economy.
2. Current event of National and International importance.
3. Basic Concepts of Ecology, Environment and Science and Technology.
 LECTURER - PHARMACY
Section-B: (70 Questions)

1. Handling of prescription; Pharmaceutical calculations: posology, calculation of doses

for infants, adults and elderly patients; enlarging and reducing recipes percentage
solutions, alligation, alcohol dilution, proof spirit, isotonic solutions, displacement
value etc.
2. Preformulation studies; Rheology: concepts of rheology, applications of rheology in
pharmaceuticals
3. Tablet production and coating systems; Processing of parenteral and related sterile
products; Capsules and microencapsulation
4. Nanoparticles, solid lipid nanoparticles (SLNs): method of preparation,
characterization, evaluation and pharmaceutical applications.
5. Controlled release drug delivery; Subdermal implantable systems; Transdermal
therapeutic systems; Novel ocular drug delivery systems; Nasal drug delivery systems;
Pulmonary drug delivery systems
6. Bioavailability and bioequivalence testing, significance of terminology, conduct of
bioavailability trials.
7. Stability testing: stress testing of drug substances, stability testing protocols, shelf life
determination, ICH guidelines.
8. Infrared Spectroscopy; Ultraviolet Spectroscopy; Fluorimetric Analysis ; Nuclear
Magnetic Resonance Spectroscopy; Mass Spectrometry; Electron Spin Resonance
Spectroscopy; X-Ray Spectroscopy
9. Chromatography: general principles, classification, normal and reversed phase, bonded
phase, separation mechanisms. Paper chromatography, TLC, HPTLC, HPLC, GC, ion-
exchange chromatography
10. Various types of bioassays, advantages and limitations of bioassays, radioimmunoassay,
ELISA, PCR and their applications in medicine
11. Recombinant DNA technology: types of genetic recombination, genetic transformation,
transduction, plasmids and their biological significance, conjugation, transposons, various
cloning vectors including plasmids and bacteriophages, host for cloning vectors, expression
vectors, practical applications of genetic recombination.
12. Monoclonal antibodies: production of monoclonal antibodies, diagnostic therapeutic and
analytical applications.
13. Important techniques in establishing identity, purity and quality of plant drugs:
organoleptic methods, solubility, specific gravity, optical rotation, specific rotation,
refractive index, melting point, swelling index, foaming index and bitterness value.
Moisture content, ash values, extractive values including volatile oil, qualitative chemical
tests. Quantitative chemical tests: acid value, iodine value, saponification value, ester
value, unsaponifiable matter and acetyl value. Microscopic: general microscopy,
histochemistry. Quantitative microscopy: lycopodium spore method, palisade ratio,
stomatal number, stomatal index, veinislet number and veinlet termination number
14. Transgenic animals and their applications in drug discovery
15. Pharmacokinetics: significance of plasma drug concentration measurement. Compartment
model- definition and scope. Pharmacokinetics of drug absorption - zero order and first
 order absorption rate constant. Volume of distribution and distribution coefficient.
Compartment kinetics- one compartment and two compartment models. Determination of
pharmacokinetic parameters from plasma and urine data after drug administration by
intravascular and oral route. Clearance concept, mechanism of renal clearance, clearance
ratio, determination of renal clearance. Extraction ratio, hepatic clearance, biliary
excretion, extra-hepatic circulation. Non-linear pharmacokinetics.
16. Fundamentals of general pharmacology: dosage forms and routes of administration,
mechanism of action, combined effect of drugs, factors modifying drug action, tolerance
and dependence; Pharmacogenetics; Principles of basic and clinical pharmacokinetics,
absorption, distribution, metabolism and excretion of drugs; Adverse drug reactions;
Discovery and development of new drugs; Bioavailability and bioequivalence studies
17. Clinical trial design (placebo, multicentre clinical trials, randomization, blinding) and
different phases of clinical trials
18. Chemistry of cell membrane receptors: drug receptor interaction, G-protein coupled
receptors, ion channel linked receptors, ligand gated ion channels (LGICs). Ligand-
receptors theories: clarks occupancy theory, rate theory, induced fit theory,
macromolecular perturbation theory and activation aggregation theory
19. Stereochemistry: nomenclature, isomerism, stereoisomerism, conformational and
configurational isomerism, optical activity, specification of configuration, reactions
involving stereoisomers, chirality, conformations.
20. Methods of drug design: lead, discovery of lead, lead optimization, objective of lead
optimization, pharmacophoric identification and analog approach of drug designing.
Various approaches in QSAR
21. Synthetic strategies: protection and deprotection of various groups; Polymorphism in drug
discovery; Polymers: monomers and polymers, addition polymers, stereochemistry of
polymers, copolymers of two or more monomers, condensation polymers, applications
22. Intellectual property and international trade, concept behind WTO (World Trade
Organization), WIPO (World Intellectual Property Organization), GATT (General
Agreement on Tariff and Trade), TRIPs (Trade Related Intellectual Property
Rights),TRIMS (Trade Related Investment Measures) and GATS (General Agreement on
Trades in Services), status in India and other developing countries
23. Pharmaceutical Ethic: Pharmacy Act; Drugs and Cosmetics Act; Medicinal and Toilet
Preparations (Excise Duties) Act; Narcotic Drugs and Psychotropic Substances Act,
Drugs Price Control Order, Prevention of Cruelty to Animals Act, Minimum Wages Act,
Patents Act