Beruflich Dokumente
Kultur Dokumente
Development and
1986 IFN treatment era 2011 approval of DAAs 2017
<0.75%
0.75–2.9% HCV infection can be associated
>2.9% MECHANISMS with extrahepatic manifestations.
Worldwide prevalence varies considerably, The balance between HCV interplay between the innate important driver of fibrogenesis,
with the highest prevalence in countries with clearance (the resolution and adaptive immune systems, characterized by the activation HC V
past or present history of iatrogenic infections. of acute infection) and but the precise mechanisms of hepatic stellate cells into
Some African and Asian countries have a persistent infection (chronic remain incompletely understood. myofibroblasts, which produce
prevalence of >5% in the adult population. HCV infection) depends on an Local liver inflammation is an excess extracellular matrix.
Written by Liesbet Lieben; designed by Laura Marshall Article number: 17007; doi:10.1038/nrdp.2017.7; published online 2 Mar 2017
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