Clothe

found
Az Receptor agonist in 1960 s
* .

* cause Vaso constrictive effects .

of ADHD , PTSD
• Reseed tin
symptoms
can use in opiate , Nicotine and alcohol

withdrawal .

g calaetious
-

→
ABSORPTION
-

*
Nearly 1004 absorption and bioavailability
- Plasma peak level after I -
shows of . - the

lnetial dose

→ clone desire
'
will cross BBB and placenta
a 20 -

404 .
ei protein bound .

in breast melt
→ clonidene I present
 Metabolism and elimination :

Yz life -
18 -

24 how

Meantyz -
12 hours .

RE TORS Aeron
.

e
A -

ADRENERGIC RECEPTORS -
5 SUBTYPES .

Li , Az , Bi ,
132 , 133

A
1- £2 .

I I
PRESENT PRESENT BOTH

PERE PH C- CENTRALLY e
RALLY
PERIPHERALLY .
 Az RECEPTOR

O O O

AZA AB 42C .

t d
d
LOCUS CERUEEUS
THALAMUS HIPPOCAMPUS
AMYGDALA

HIPPOCAMPUS OLFACTORY
SYSTEM '

HYPOTHALAMUS .

STRIATUM
C- CORTEX .