Curriculum Vitae

Prof. Francesco Ria

Biographic Information

Birth: Rome (Italy) Dec 22nd, 1961

Marital Status: Married, with Loredana Ingrosso.
One daughter, Dominique.
Citizenship: Italian
Home Address: Roma, Via L. da Pietrasanta, 18, 00154
Work Address: Istituto di Patologia Generale, Universita’ Cattolica del S. Cuore
School of Medicine
L.go F. Vito, 1,
00168 Roma

Academic degree

Institution City Year Degree

Catholic University Rome (I) 1986 MD
Catholic University Rome (I) 1990 PhD in Oncology
Catholic University Rome (I) 1992 Specialist in Oncology

Professional activity

Position Name and address of employer From To

Post Massachussets Institute of Technology – M L. Gefter 1988 1989
Doctoral Cambridge (MA) USA
Fellow
MIUCA Catholic University - Rome 1991 1994
Visiting Roche Milano Ricerche – L. Adorini H.S. Raffaele - Milano 1993 2000
Scientist
Researcher Catholic University - Rome 1994 2004
Visiting La Jolla Institue for Allergy and Immunology – E.E. Sercarz 2000 2001
Scientist San Diego (CA) USA
Associate Immunopathology – School of Medicine - 2004 To date
Professor Catholic University - Rome

Teaching Activity

Università Cattolica del S. Cuore; School of Medicine: Immunology and Immunopathology.

Università Cattolica del S. Cuore; School of Medicine & Surgery: Immunology and
Immunopathology.
Università Cattolica del S. Cuore: School of Biotechnology: Cellular and Molecular Immunology.
Università Cattolica del S. Cuore: Undergraduate School for Laboratory Technicians: Immunology.

I serve(d) teaching hours to several Specialization Schools and to PhD courses in Oncology,
Biochemistry, Cardiology and Experimental Medicine.
Clinical Experience and Duties
I serve as MD in the Laboratory for Clinical Immunology of the Policlinico A. Gemelli, since 1991.
The laboratory runs approximately 200 000 tests/year in the fields of systemic and organ-specific
autoimmune diseases, allergies, monoclonal gammapathies and HLA typing.
Additional information: scientific activity, prizes, etc.

Scientific activities:
• Role of Antigen presenting cells from lymph node and CNS in vivo and in vitro
• Regulation of Th1/Th2 polarization
• Naked DNA vaccination in adult and in uterus
• Identification and recruitment of T cells ex vivo
• Role of bacteria in human and experimental autoimmunity

1990 – Prize “Luigi Califano”, first classified for Basic Research Section

Member of the American Association for Immunology (AAI).

Member of the Italian Society for Immunology, Clinical Immunology and Allergology (SIICA)
Member of the Steering Committee of the Italian Association for Neuroimmunology (AINI)
Member of the Italian Society of Clinical Immunology and Allergology (SIIAC)

Academic Editor for PLOS One; Referee for several international scientific journals.
Acted as a referee for: FP6 of the EU; the Italian foundation for Multiple Sclerosis (FISM); Italian
Ministry for University (MIUR); the Spanish Ministry for Research; French Foundation for
Multiple Sclerosis (ARSEP).

Funds obtained as Principal Investigator (PI) or Head of Operative Unit (HOU).

• “Epitopi minori nella immunoterapia adiuvante del cancro”- Italian Association for Cancer
Research (AIRC) 1990-1991 (PI)
• “Studio della risposta immune fetale verso protein ricombinanti espresso in vivo mediante
trasferimento genico diretto nel muscolo fetale” – National Research Council (CNR) 1996 (HOU)
• “Stimolazione di risposte linfocitarie di tipo Th1 e Th2 da parte di astrociti e microglia e effetti
della polarizzazione della risposta linfocitaria sullo stato funzionale delle cellule gliali” – Italian
National Health Institute (ISS) 1998-2001 (PI).
• “Definition and regulation of T cells specific for self-antigens of the CNS”- NMSS Research
Project 03/2002-03/2005 (PI)
• Analysis of the role of Myelin-specific CD8+ cells in RR-EAE by TCR centred studies – FISM
Pilot Project 2003-2004 (PI)
• Transgenic models in complex diseases (Preparation of transgenic mice carrying the PLP-
specific Beta chain(s) characteristic of public CD4+ cells). FIRB MIUR – 2004-2006 (HOU)
• Analysis of the shift in TCR repertoire usage during immune response to Her-2/neu in BALB/c
and BALB/neuT mice – PRIN MIUR 2005-2006 (HOU)
• Molecular mechanisms for transfer of information from environment to T cells in the
pathogenesis of EAE - FISM Pilot Project 2009-2010 (PI)
• Determinants of virus-specific immune control in viral HIV co-infections. PRIN MIUR 2010-
2011. (HOU)
• Latent Tuberculosis and development of a model for post-exposure vaccination. PRIN MIUR
2010-2012. (HOU)
• Molecular mechanisms for transfer of information from environment to encephalitogenic T
cells in the pathogenesis of EAE. Role of TLR2 - FISM Project 2011-2012 (PI)
• Immunoscope analysis of T cell responses to MBP85-99 in Multiple Sclerosis.(2011-2013)
Don Carlo Gnocchi Fundation. (HOU)
• “Janus-faced” liposomes as therapeutic tools to mediate a T suppressor phenotype in Multiple
Sclerosis. FISM Project 2017-2019 (PI) (300.000 E)
Seminars held at the following Institutions:

16 June 1989 Istituto di Biologia Cellulare “L. Califano” Napoli.

29 June 1989 Laboratorio di Biologia Cellulare, CNR Roma.
8 December 1989 Boston Biomedical Research Institute, Boston (USA).
11 April 1990 Istituto Ricerche Immunobiologiche Siena, Siena.
16 July 1995 Robarths Research Institute, Univ. Western Ontario, London (Ontario-
Canada).
19 July 1995 Samuel Lunenfeld Research Institute of the Mount Sinai Hospital,
Toronto (Ontario-Canada).
13 May 1996 Istituto Dermopatico dell’Immacolata, Roma.
22 July 1996 Istituto Ricerche Immunobiologiche Siena, Siena.
27 September1996 Basel Institute for Immunology, Basilea (CH).
14 February 2003 Università di Torino 2, Orbassano (TO)
29 October2003 Keryos – Milano
14 Jamuary Scuola di Specializzazione in Reumatologia – Università Cattolica –
Roma
18 December 2007 Istituto Nazionale per le Malattie Infettive “Lazzaro Spallanzani”- Roma
3 June 2008 Università Campus Biomedico - Roma
7 June 2009 Bernhard Nocht Institute for Tropical Medicine – Hamburg (D)
15 Octber2009 INSERM U563 Institute Claude de Preval - Toulouse (F)
29 April 2010 Seconda Università di Napoli
11 November 2011 University of Nottingham (UK)

Invited Speaker:

Biomarkers in Rheumatology (Rome, 2010)

European Charcot Foundation Symposium (Fiuggi 2010)
Biomarkers in Rheumatology – 2nd GISEA International Meeting (Rome, 2011)
Biomarkers in Rheumatic Diseases – 7th GISEA International Meeting (Rome 2016)
List of publications

1. Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced
inflammatory response. Di Simone N, Di Nicuolo F, Marana R, Castellani R, Ria F, Veglia M,
Scambia G, Surbek D, Barnea E, Mueller M. PLoS One. 2017 Jul 12;12(7):e0180642. doi:
10.1371/journal.pone.0180642.
2. Low reliability of anti-KIR4.183-120 peptide auto-antibodies in multiple sclerosis patients.
Marino M, Frisullo G, Di Sante G, Samengo DM, Provenzano C, Mirabella M, Pani G, Ria F,
Bartoccioni E. Mult Scler. 2017 May 1:1352458517711275. doi: 10.1177/1352458517711275.
[Epub ahead of print]
3. Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and
Pathogenesis. Camassa S, Palucci I, Iantomasi R, Cubeddu T, Minerva M, De Maio F, Jouny S,
Petruccioli E, Goletti D, Ria F, Sali M, Sanguinetti M, Manganelli R, Rocca S, Brodin P,
Delogu G. Front Cell Infect Microbiol. 2017; 7:137. doi: 10.3389/fcimb.2017.00137.
eCollection 2017.
4. PIF* promotes brain re-myelination locally while regulating systemic inflammation- clinically
relevant multiple sclerosis M.smegmatis model. Migliara G, Mueller M, Piermattei A, Brodie C,
Paidas MJ, Barnea ER, Ria F. Oncotarget. 2017; 8(13):21834-21851. doi:
10.18632/oncotarget.15662.
5. Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium
Tuberculosis and Modulates Autoimmune Encephalomyelitis. Piermattei A, Migliara G, Di
Sante G, Foti M, Hayrabedyan SB, Papagna A, Geloso MC, Corbi M, Valentini M, Sgambato
A, Delogu G, Constantin G, Ria F. Front Immunol. 2016 7:191. doi:
10.3389/fimmu.2016.00191. eCollection 2016.
6. PE_PGRS33 Contributes to Mycobacterium tuberculosis Entry in Macrophages through
Interaction with TLR2. Palucci I, Camassa S, Cascioferro A, Sali M, Anoosheh S, Zumbo A,
Minerva M, Iantomasi R, De Maio F, Di Sante G, Ria F, Sanguinetti M, Palù G, Brennan MJ,
Manganelli R, Delogu G. PLoS One. 2016 Mar 15;11(3):e0150800. doi:
10.1371/journal.pone.0150800. eCollection 2016.
7. Is Citrullination Required for the Presence of Restricted Clonotypes Reacting With Type II
Collagen? Comment on the Article by Chemin et al. Di Sante G, Tolusso B, Ria F, Laura
Fedele A, Gremese E, Ferraccioli G. Arthritis Rheumatol. 2016 Aug;68(8):2052-3. doi:
10.1002/art.39661.
8. Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory
Rheumatoid Arthritis. Di Sante G, Tolusso B, Fedele AL, Gremese E, Alivernini S, Nicolò C,
Ria F, Ferraccioli G. EBioMedicine. 2015 Nov 17;2(12):2037-45. doi:
10.1016/j.ebiom.2015.11.019. eCollection 2015 Dec.
9. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to
adult. Barnea ER, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas MJ. Pharmacol
Ther. 2015 Dec;156:10-25. doi: 10.1016/j.pharmthera.2015.10.008. Epub 2015 Nov 3.

10. Human IgG Antinuclear Antibodies Induce Pregnancy Loss in Mice by Increasing Immune
Complex Deposition in Placental Tissue: In Vivo Study. Veglia M, D'Ippolito S, Marana R, Di
Nicuolo F, Castellani R, Bruno V, Fiorelli A, Ria F, Maulucci G, De Spirito M, Migliara G,
Scambia G, Di Simone N. Am J Reprod Immunol. 2015 Dec;74(6):542-52. doi:
10.1111/aji.12429. Epub 2015 Sep 21.
11. Antitumor immunization of mothers delays tumor development in cancer-prone offspring.
Barutello G, Curcio C, Spadaro M, Arigoni M, Trovato R, Bolli E, Zheng Y, Ria F, Quaglino E,
Iezzi M, Riccardo F, Holmgren L, Forni G, Cavallo F. Oncoimmunology. 2015 Feb
3;4(5):e1005500. eCollection 2015 May.
12. Immunomodulation by gut microbiota: role of Toll-like receptor expressed by T cells. Valentini
M, Piermattei A, Di Sante G, Migliara G, Delogu G, Ria F. J Immunol Res. 2014;2014:586939.
doi: 10.1155/2014/586939. Epub 2014 Jul 24. Review.
13. T cell repertoire in DQ5-positive MuSK-positive myasthenia gravis patients. Marino M, Maiuri
MT, Di Sante G, Scuderi F, La Carpia F, Trakas N, Provenzano C, Zisimopoulou P, Ria F,
Tzartos SJ, Evoli A, Bartoccioni E. J Autoimmun. 2014 Aug;52:113-21. doi:
10.1016/j.jaut.2013.12.007. Epub 2014 Jan 4.
14. Functional dissection of protein domains involved in the immunomodulatory properties of
PE_PGRS33 of Mycobacterium tuberculosis. Zumbo A, Palucci I, Cascioferro A, Sali M,
Ventura M, D'Alfonso P, Iantomasi R, Di Sante G, Ria F, Sanguinetti M, Fadda G, Manganelli
R, Delogu G. Pathog Dis. 2013 Dec;69(3):232-9. doi: 10.1111/2049-632X.12096. Epub 2013
Oct 7.
15. Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in
children: a case-control study. Chiaretti A, Pulitanò S, Conti G, Barone G, Buonsenso D, Manni
L, Capozzi D, Ria F, Riccardi R. Int J Infect Dis. 2013 Dec;17(12):e1186-93. doi:
10.1016/j.ijid.2013.07.006. Epub 2013 Sep 12.
16. Porphyromonas gingivalis and the pathogenesis of rheumatoid arthritis: analysis of various
compartments including the synovial tissue. Totaro MC, Cattani P, Ria F, Tolusso B, Gremese
E, Fedele AL, D'Onghia S, Marchetti S, Di Sante G, Canestri S, Ferraccioli G. Arthritis Res
Ther 2013 Jun 18;15(3):R66. doi: 10.1186/ar4243.
17. C. Nicolò, G. Di Sante, A. Procoli, G. Migliara, A. Piermattei, M. Valentini, G. Delogu, A.
Cittadini, G. Constantin, F. Ria (2013): M tuberculosis in the adjuvant modulates time of
appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2.
PLoS One 8: e55819. doi: 10.1371/journal.pone.0055819.
18. A. De Gaetano, A. Matone, A. Agnes, P. Palumbo, F. Ria, S. Magalini (2012): Modeling
rejection immunity . Theor Biol Med Model. 9:18. doi: 10.1186/1742-4682-9-18
19. S. Borrello, C. Nicolo’, G. Delogu, F. Pandolfi and F. Ria (2011): TLR2: a crossroads between
infections and Autoimmunity? Int J Immunopath Ph 24: 549-556.
20. C. Nicolò, G. Di Sante, G. Migliara, M. G. Valentini, A. Piermattei, G. Delogu and F. Ria
(2011): Intracellular bacteria can cause EAE in SJL mice or modify self-specific T cell
repertoire. J Neurol Sci 311: 103-106.
21. S. Soldini, I. Palucci, A. Zumbo, M. Sali, F. Ria, R. Manganelli, G. Fadda and G. Delogu
(2011): PPE_MPTR genes are differentially expressed by Mycobacterium tuberculosis in vivo.
Tuberculosis [e-published sept 2] 91: 563-568.
22. F. Pandolfi, R. Cianci, F. Casciano, D. Pagliari, T. De Pasquale, R. Landolfi, G. Di Sante, J.T.
Kurnick and F. Ria (2011): Skewed T-cell receptor repertoire: more than a marker of
malignancy, a tool to dissect the immunopathology of inflammatory diseases. J Biol Regul
Homeost Agents 25:153-161.
23. M. Sali, G. Di Sante, A. Cascioferro, A. Zumbo, C. Nicolò, V. Donà, S. Rocca, F. Ria, G. Palù,
G. Fadda, R. Manganelli and G. Delogu (2010): Surface expression of MPT64 as a fusion with
the PE domain of PE_PGRS33 enhances BCG protective activity against Mycobacterium
tuberculosis in mice. Infect Immun: 78: 5202-5213.
24. M. C. De Rosa, B. Giardina, C. Bianchi, C. Carelli Alinovi, D. Pirolli, G. Ferraccioli, M. De
Santis, G. Di Sante, and F. Ria (2010): Modeling the Ternary Complex TCR-V -/CollagenII
(261-273)/HLA-DR4 Associated with Rheumatoid Arthritis. PloSOne: 5: e11550
25. C. Ticconi, F. Rotondi, M. Veglia, A. Pietropolli, S. Bernardini, F. Ria, A. Caruso and N. Di
Simone: Antinuclear antibodies in women with recurrent pregnancy loss. (2010) Am J Repr
Immunol 64:384-392.
26. T.R. Smith, I. Maricic, F. Ria, S. Schneider, V. Kumar (2010): CD8 + Dendritic cells prime
TCR-peptide-reactive regulatory CD4+FOXP3- T cells. Eur J Immunol. 40: 1906-1915.
27. S. Rolla, F. Ria, S. Occhipinti, G. Di Sante, M. Iezzi, M. Spadaro, C. Nicolò, E. Ambrosino,
I.Fiore Merighi, P. Musiani, G. Forni and F. Cavallo (2010): Erbb2 DNA vaccine combined
with Treg cell deletion enhances antibody response and reveals latent low-avidity T cells.
Potential and limits of its therapeutic efficacy. J Immunol 184: 6124-6132.
28. C. Nicolò, M. Sali, G. Di Sante, M. C. Geloso, E. Signori, R. Penitente, S. Unyial, M. Rinaldi,
V. M. Fazio, B. M. C. Chan, G. Delogu and F. Ria (2010): Mycobacterium smegmatis
expressing a chimeric protein MPT64-PLP139-151 reorganizes the PLP-specific T cell
repertoire favouring a CD8-mediated response and induces R-EAE. J Immunol. 184:222-235.
29. F. Ria, R. Penitente, M. De Santis, C. Nicolò, M. Orsini, D. Arzani, A. Fattorossi, A. Battaglia,
G.F. Ferraccioli: Collagen-specific T cell repertoire in blood and synovial fluid varies with
disease activity in Early Rheumatoid Arthritis. Arth. Res. Ther. (2008) 10:R135.
30. R.Penitente, C. Nicolo, P.Van den Elzen, G.Di Sante, C. Agrati, F.Aloisi, Eli E.Sercarz and
F.Ria: Administration of PLP 139-151 primes T cells distinct from those spontaneously
response to this antigen. J Immunol. (2008) 180, 6611-6622.
31. S. Rolla, C. Nicolo’, S. Malinarich, M. Orsini, G. Forni, F. Cavallo and F. Ria: Distinct and
non-overlapping T-cell receptor repertoires expanded by DNA vaccination in wild-type and
Her-2 transgenic BALB/c mice. J Immunol (2006) 177: 7626-33.
32. Columba-Cabesaz S., Griguoli M., Roisicarelli B, Magliozzi R., Ria F., Serafini B., Aloisi F.
Suppression of established experimental autoimmune encephalomyelitis and formation of
meningeal lymphoid follicles by lymphotoxin beta receptor-Ig fusion protein. J
Neuroimmunol. (2006) 179:76-86.
33. C. Nicolò, G. Di Sante, M. Orsini, S. Rolla, S. Columba-Cabezas, V. Romano Spica, G.
Ricciardi, B.M. C. Chan and F. Ria: Mycobacterium Tuberculosis in the adjuvant modulates the
balance of Th immune response to self-antigen of the CNS without influencing a “core”
repertoire of specific T cells. Int Immunol. 18 (2006): 363-74.
34. F. Ria, A. Gallard, C. Raja-Gabaglia, J.C. Guery, E.E. Sercarz and L. Adorini: Selection of
similar T-cell reportoires but induction of distinct T-cell responses by native and modified
antigen J. Immunol. 172 (2004), 3447-3453.
35. V.M. Fazio, F. Ria, E. Franco et al: Perinatal immunization, long term responsiveness and
safety of in utero anti hepatitis-B DNA vaccination. Gene Ther. (2004) 544-551.
36. F. Ria, P. van den Elzen, L.T. Madakamutil, J.E. Miller, e. Maverakis and E.E. Sercarz:
Molecular characterization of the T cell repertoire using immunoscope analysis and its possible
implementation in clinical practice. Curr. Mol. Med. 1 (2001), 297-304.
37. M. Rinaldi, F. Ria, P. Parrella, E. Signori, A. Serra, S.A. Ciafrè, I. Vespignani, M. Lazzari,
M.G. Farace, G. Saglio, V.M. Fazio: Antibodies elicited by naked DNA vaccination against the
complementary-determining region 3 hypervariable region of immunoglobulin heavy chain
idiotypic determinants of B-lymphoproliferative disorders specifically react with patients' tumor
cells. Cancer Res. 61 (2001), 1555-1562.
38. F. Ria, M. Landriscina, F. Remiddi, R. Rosselli, M. Iacoangeli, M. Scerrati, G. Pani, S. Borrello
and T. Galeotti: The level of manganese superoxide dismutase content is an independent
prognostic factor for glioblastoma. Biological mechanisms and clinical implications. Br J
Cancer. 84 (2001), 529-534.
39. F. Aloisi, F. Ria and L. Adorini: Regulation of T cell responses by CNS antigen-presenting
cells: different roles for microglia and astrocytes Immunol. Today. 21 (2000), 141-147.
40. F. Aloisi, F. Ria, S. C. Cabezas, H Hess, G. Penna and L. Adorini: Relative efficiency of
microglia, astrocytes, dendritic cells and B cells in T cell priming and Th1/Th2 cell
restimulation. Eur. J. Immunol. 29 (1999), 2705-2714.
41. F. Ria, G. Penna and L. Adorini: Th1 induce and Th2 cells inhibit antigen-dependent IL-12
secretion by dendritic cells. Eur. J. Immunol. 28 (1998), 2003-2016.
42. S. A. Ciafrè, M. Rinaldi, I. Vespignani, P. Parrella, D. Seripa, E. Signori, F. Ria, M. G. Farace
and V. M. Fazio: A plasmid family containing two different expression cassettes suitable for
immuno-modulation and genetic immunization. Plasmid 40 (1998), 84-89.
43. F. Aloisi, F. Ria, G. Penna and L. Adorini: Microglia are more efficient than astrocytes in
antigen processing and Th1 but not Th2 cell activation. J. Immunol. 160 (1998), 4671-4680.
44. J. C. Guèry, F. Ria, F. Galbiati and L. Adorini: Normal B cells fail to secrete IL-12. Eur. J.
Immunol. 27 (1997), 1632-1639.
45. L. Adorini, J. C. Guèry, F. Ria and F. Galbiati: B cells present antigen to CD4+ cells but fail to
produce IL-12: selective APC for Th2 development? Ann. N. Y. Acad. Sci. 485 (1997), 401-
411.
46. J.C. Guery, F. Ria and L.Adorini: Antigen presentation and Il-12 production by dendritic cells
in vivo. Adv. Exp. Med. Biol. 417 (1997), 317-321.
47. L. Adorini, F. Aloisi, F. Galbiati, S. Gregori, F. Ria and S. Trembleau: Targeting IL-12, the key
cytokine driving Th1-mediated autoimmune diseases. Chem. Immunol. 68 (1997) 175-197.
48. J. C. Guèry, F. Ria, F. Galbiati, S. Smiroldo and L. Adorini: The mode of protein administration
determines preferential antigen presentation by dendritic cells or B cells. Intern. Immunol., 9
(1997), 9-15.
49. Landriscina, F. Remiddi, F. Ria, B. Palazzotti, M. E. de Leo, R. Rosselli, M. Iacoangeli, M.
Scerrati, and T. Galeotti: The level of MnSOD is directly correlated with grading in brain
tumours of neuroepithelial origin. Bri. J. Cancer 47 (1996), 1810-1819.
50. J. C. Guèry, F. Ria and L. Adorini: Dendritic cells but not B cell present antigenic complexes to
class II restricted T cells after administration of proteins in adjuvant. J. Exp. Med. 143 (1996),
751-758.
51. M. Piastra, A. Stabile, G. Fioravanti, M. Castagnola, G. B. Pani, and F. Ria: Cord blood
mononuclear cell responsiveness to -lactoglobulin: T cell activity in “atopy prone” and “non-
atopy prone” newborns. Intern. Arch. Allergy Immunol. 104 (1994), 358-365.
52. G. B. Pani, M. Piastra and F. Ria: Failure of non-Dominant self epitope to induce tolerance:
Implications for autoimmune diseases. Immunol. Invest. 23 (1994), 337-346.
53. F. Ria, M. Landriscina, F. Remiddi and T. Galeotti : Monoclonal antibody recognize human,
mouse and rat MnSOD in Western blot and immunostaining. Biochem. Mol. Biol. Int. 33
(1994), 107-115.
54. F. Ria, M. Landriscina, and T. Galeotti: Preparation of a monoclonal antibody against rat
MnSOD, using a COOH-terminal peptide. Biochem. Biophys. Res. Co. 195 (1993), 697-703.
55. F. Ria, B. M. C. Chan, M. T. Scherer, J. A. Smith and M. L. Gefter: Immunological activity of
covalently linked T cell epitopes. Nature 343 (1990), 381-383.
56. M. L. Gefter, D. L. Perkins, F. Ria, S. Roy and M. T. Scherer: Regulatory effects of T cell
epitopes. UCLA Symposia on Molecular Biology, New Series, 113 (1990), 47-51.
57. M. T. Scherer, B. M. C. Chan, F. Ria, D. L. Perkins J. A. Smith and M. L. Gefter: Control of
cellular and humoral immune responses by peptides containing T cell epitopes. CSH Symp.
Quant. Biol. LIV (1989), 497-504.
58. G. Flamini, F. Ria, E. Pizzigallo and S. Gignina: Chromatographic and electrophoretic studies
of immune-complexes in non-A, non-B hepatitis. J. Chromatogr. B, 426 (1988), 55-64.
59. G. Flamini, F. Ria and F. Scuderi: Size-exclusion high performance liquid chromatography of
immune-complexes isolated from patients with acute leukaemia. Preliminary observations. J.
Chromatogr. B, 421 (1987), 434-436.