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Contents
5 How to live longer and healthier
1 8 S E C R E T S T O S TAY YO U N G
DISCL AIMER
6 The impact of genes on aging
9 Oxidation process of the body
This is not medical advice and should not be
10 Oxidation and free radicals
taken as such. I merely share my own opinion and
12 The importance of keeping your heart strong
experience of what has worked for me.
14 Research into stem cells and the projections
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CONTENTS
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5 18 SECRETS TO STAY YOUNG
How
to live
1 8 S E C R E T S T O S TAY YO U N G
any problems
with aging healthier
Making just a few changes in your daily life-
style can help you live longer and healthier.
A recent study showed that just four bad habits:
smoking, drinking too much alcohol, not enough ex-
ercise, and not eating enough fruits and vegetables,
can affect how old people become – in some cases it
can be a difference of twelve years!
impact
damaged cells:
Aging is
THEORY:
of genes
that become shorter. These were first found by
Russian theorist Alexei Olovkinov. Every time a
Cellular clock theory: Since a lot of human cells cell reproduces, the chromosome or genetic ma-
do not continue to reproduce unlimitedly, this terial loses a little bit of the protective cap. This
theory says that aging is the consequence of cells happens until a cell can no longer divide.
on aging
that have reach their programmed reproductive
Oxidative (free radicals) stress: The theory
limit. In other words, after a while we’re just out of
behind this is that free radicals – the toxic
cells, sort of like with a rechargeable battery.
by-products of cell metabolism and/or oxidation –
Neuro-endocrine theory: Changing hormone are responsible for damage to DNA and therefore
levels determine how much we age. According a cause of cell death. Even though are cells are
to this hypothesis, menopause is an example of fairly good at adapting, as time goes by the cu-
age-related hormonal changes, which results mulative damage is too much. Mitochondria are
in aging (less oestrogen, higher susceptibility to the engines of the metabolism and we think they
conditions such as osteoporosis). play a central role because of the free radicals
When people feel like they’re getting “old”, for
they produce. This theory was first proposed in
most people this has to do with visible changes. Weaker immune system: We have less of specif-
the fifties and led to the conviction that the con-
People think of grey hair or skin that doesn’t look ic cells that strengthen our immune system and
sumption of antioxidants could possibly counter
as smooth as it used to. they function less well as we age. This makes our
this process.
bodies more vulnerable for life threatening dis-
eases like cancer. Genome error: caused by environmental toxins
These, however, are just the external signs of a or spontaneous mutations. This leads to damage
series of biological processes that cause “aging” in our DNA that cannot be repaired at a cellular
in our cells and the bodily system. Even though level. This can lead to cell death and organ mal-
getting older is one of the few experiences that all function, which can speed up the aging process.
people have in common, we actually don’t know
that much about it. It is one of the least under-
stood processes. There are many a theory, though,
on why time influences our personal biology
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9 18 SECRETS TO STAY YOUNG
Oxidation
which changes you can expect:
in your
body Cardiovascular system – The heart muscle become
thicker and the blood vessels become more rigid, which
process of
leads to less oxygen coming into the brain and the body.
Lung capacity can decrease with no less than 40 percent
when someone gets older.
What you can do: Enough exercise can improve heart and
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the body
lung capacity at any age.
Brain and nervous system – The nerve cell loses its struc-
ture, together with several functions of individual nerve
cells. Full-grown nerve cells can still be reproduced, but
how much this could be exactly has not yet been estab-
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lished. The most serious decrease of our mental function Oxidation is a process in which
is caused by diseases like Alzheimer’s or dementia, not oxygen, in combination with
the normal aging process. another substance, produces oxide.
Every second we breathe in oxygen,
it goes into our bodies and the
What you can do: Scientists have only just started study- oxidation process takes place. The
ing how good the brain is at adapting. You can try and human body transforms a small
improve your memory and other brain functions by doing amount of the oxygen into free rad-
puzzles and learning new skills (like dancing or playing a icals. These are essential to fight off
musical instrument). diseases.
However, too many free radicals and
the wrong type of free radicals can
Bones and joints – bone density decreases around
be disastrous for our bodies. This
the age of 35 for most people, this goes even faster for
risk increases significantly when the
post-menopausal women.
air we breathe is filled with pollution
from vehicles, factories, and all that
good stuff.
What you can do: Exercising with weights, like power
training, in addition to walking and running, has been Nowadays people are more and
shown to help maintain bone density. more aware of healthy nutrition.
Certain types of food are seen as
harmful and some foods are accept-
Muscles – Between the ages of 30 and 70 our muscle ed as being good for our bodies.
mass decreases with more than 20 percent for men and However, foods that can counter the
women if they do not get enough (and regular) exercise. oxidation process in our bodies are
really good for our general health.
What you can do: The same regular exercise that slows
down the loss of bone density will help maintain muscle
mass.
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Oxidation
and free
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radicals
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Blood pressure
The importance
Our blood pressure is a part of our general health that should be checked
and regulated regularly. High blood pressure or hypertension can be influ-
enced by our body weight, especially if you have a BMI score of 30 or higher.
This score is classified as “obesity”. Excess fat increases the amount of work our
of keeping
heart needs to do to pump blood around in our body. The harder the heart has to
work, the more pressure on the walls of our blood vessels. Lowering body weight,
even 5 to 10 percent, can decrease blood pressure and increase the heart’s health.
Cholesterol level
your heart
Control over the cholesterol level also has an important part to play in the health of
the heart, it decreases risks of cardiovascular disorders, heart attacks and strokes. The
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two main types of cholesterol are low-density lipoprotein – LDL, also known as “bad”
cholesterol – and highdensity lipoprotein – HDL, also known as “good” cholesterol. We
find LDL-cholesterol in food that has a lot of saturated fats, especially animal protein.
Blood circulation
blood pressure
Taking good care of our hearts also has an effect on the blood circulation. Good circu-
lation is necessary to transport oxygen and nutrients to the many different cells in your
body. Without good circulation, tissue will start to die, which can lead to amputations
or even death, dependant on which tissue is not receiving enough oxygen. High blood
pressure, cholesterol plaque and other cardiovascular diseases can all have an influence
/ cholesterol
on our body and on how efficiently it can transport blood.
under control
sure you exercise for at least 30 minutes, five days a week. In a heart-healthy diet, most
of the calories come from vegetables, fruit and foods full of fibre like legumes and whole
grains. In addition to these foods you should eat (in moderation) lean protein, mostly fish,
but also low-fat dairy products, nuts and seeds.
Research into
divide so quickly can help to come up with better treatments and possibly a solution
for cancer. Stem cells from embryos can replicate or reproduce themselves, even after
many months and even more than a year after they create millions of other stem cells.
By studying these cells, scientist hope to figure out which qualities cause this long-term
self-renewal and which factors usually regulate cell proliferation. When scientists can
the projections
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The human body contains stem cells, stem cells are a specific type of cell that has certain
characteristics. Stem cells can divide and renew for a long time. They are non-specific
cells that canz adapt and turn into special type of cell, such as red blood cells, brain cells
or muscle cells.
Because of the discovery of stem cells and their remarkable qualities, research into stem
cells started. However, the research requires scientists to use a source that has lots of
stem cells – embryos. This lead to a debate about the ethics of the research. Despite its
controversial methodology, there are many benefits to stem cell research.
Insight into the development of cells Stem cells are the predecessors of all the other
cells in the body. Embryos in the blastocyst stage that takes place roughly three to five
days after fertilisation, contains around 100 stem cells. When the embryo develops, these
stem cells become different specialised cells within the body. Studying how the stem
cells develop to specialised cells that then develop into organs could help scientists
New medical treatments
understand the steps of the process. Then they could see clearly when possible errors
arise. • One of the most promising benefits of stem cell research is still the advancement
and creation of medical treatments. By learning how stem cells develop, researchers can
Better understanding of genetic diseases Hereditary diseases, also known as genetic
think of new treatments to activate this development or stop it. Stem cells offer a renew-
diseases, means that certain problems are passed on from a parent to a child due to a
able source of cells that could potentially replace sick cells. This means stem cells have
defect in a chromosome - a strand of deoxyribonucleic acid (DNA) that carries the genes.
the potential to help ease diseases like Parkinson’s, amyotrophic lateral sclerosis, spinal
Genes, the basic units of genetics, contain all the information for human qualities, like the
cord injuries, burn wounds, heart disease, diabetes and arthritis.
colour of someone’s eyes. Scientists study stem cells to find out where the errors take place;
that might lead to chromosome deficiencies or damaged genes. When scientists learn
where and how diseases arise, they can find a way to try and prevent or cure the disease.
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Anti-stress
•
management
Recent It is true that stress can be good for us sometimes, it can motivate us to take
action and gives us the capability to save our lives and those of others in extreme
situations. However, in our contemporary Western society we are constantly
under stress. This is caused byworking days that are too long, the fear that you
developments
could lose your job soon, technological changes, financial pressure and a large
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gives you extra energy. A little bit of stress is normal and even useful. Stress can
• In January 2011 researchers from the Tottori University in Japan help you when you need to work extra hard or react extra fast. When you are
successfully made pacemaker cells using embryotic stem cells of mice. constantly stressed, however, this is bad for our bodies.
This can lead to breakthroughs in the treatment of arrhythmia and could decrease the
need for electronic pace makers in human patients. Stress is linked to headaches, stomach problems, back pains and trouble
sleeping. It can weaken our immune system which makes it more difficult to
• In November 2010 research into embryotic stem cell based treatment was approved.
fight off potential diseases. When someone has health issues, stress can make
This therapy should help in the treatment of hereditary diseases that cause blindness in
the situation worse. It can cause someone to be moody, tense or even depressed.
young people.
Relationships can suffer and people don’t do well at work or in school.
• In October 2010, 12 years after the human embryotic stem cells were isolated for the
first time, a therapy that was directly derived from such cells was tested for the first
time.
What can you do against stress?
• In August 2010, according to an article in the Daily Telegraph, scientists made syn-
thetic blood using stem cells. This could help victims of big disasters when blood banks
The good news is that you can learn ways to control stress. You can do the follow-
can’t handle the demand. The scientists say their eventual goal is created the rare blood
ing things:
type O-negative. This blood type can be given to any patient but is only produced by 7%
of the population. • Find out what causes stress in your life
• In January 2010 researchers at Stanford proved that transplanted neurons, grown • Find ways to decrease the amount of stress
from embryotic stem cells, were capable of making good brain connections in newly
• Learn healthy way to release stress or decrease the harmful effects
born mice. This discovery that shows stem cells can be turned into specific brain cells
can lead to new treatments for problems with the nervous system such as Amyotrophic
Lateral Sclerosis and for spinal cord injuries. How do you measure stress?
We all know that stress really isn’t good for us. Sometime it is clear where
stress comes from and other times we have no idea what the actual issue is. It
is important to figure out what causes your stress. Keeping a stress diary can
help with this, write down every time something happens that makes you feel
stressed. Keeping a stress journal can help you figure out what causes stress and
how much stress you feel. When you know what’s causing it, you can start taking
steps to reduce stress or to manage it better.
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Effect of
For a lot of people stress is a fact of life. For many of them it might not be possible to
eliminate stress completely, but there are plenty of ways to at least reduce stress. You
can try some of these ideas to find out if it helps:
• Handle your time better and more effectively: you will get more done with less
aging
stress if you follow a clear schedule. Think about which things are most important, and
do those first.
• Handle it better: that sounds simple, but look at how you deal with stress. Be honest
1 8 S E C R E T S T O S TAY YO U N G
about what works and what doesn’t work. Think about the things you can do better to
deal with stress.
on your
• Take good care of yourself. Make sure you get enough rest. Make sure you eat
healthy. Quit smoking and limit the amount of alcohol you drink.
• Try new ways of thinking: if you notice that you are starting to worry about some-
thing but you cannot change it, try and stop the thought. Work on letting go of things
immune
you cannot change. Learn to say “no” so you don’t always have unexpected work to do.
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What we eat and drink is fuel for our bodies. When our bodies get good food we feel
system
energetic, alert, we sleep better and we’ll live longer. If our body constantly receives
things like Big Macs, cake or fries, then your cholesterol will be too high, you will be
overweight, feel sluggish and slow and probably die years earlier than we thought.
Healthy eating habits only require a little bit of effort. The only thing you need to
do is read information about healthy food and actually take something from it.
You probably already know that fruit and vegetables are important, but also learn what The thymus, one of the important organs of the immune system,
the healthiest versions of that are (for example broccoli). is where certain immune cells (Tlymphocytes or T-cells) grow. The
thymus starts shrinking after puberty. When a person is middle
aged, then the thymus is only about 15% of its maximum size.
Eat less processed food, like white bread, white pasta, white rice and less sugar is healthy Some T-cells will kill certain disease particles immediately.
too. It is not always easy to buy food that is not processed (nearly everything in the
While other T-cells help parts of the immune system that are spe-
supermarket has been made unhealthy in one way or another). Take a few minutes
cialised in attacking different types of infections. Although the
every Sunday morning to plan the meals for the week. If you are working with a
number of T-cells does not decrease as we grow older, the function
budget, look at advertisements and buy what’s on sale (as long as it’s healthy, of
of the T-cell decreases. That is why parts of our immune system
course). The idea is that if you plan out the whole week, you stay away from temptation.
weaken.
More on stress?
http://www.optimalegezondheid.com/mini-stress-cursus-101-inleiding/
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Effects of changes
What can you
do to help
The immune system loses the ability to fight infections when we grow older.
This heightens the risk of diseases and can make vaccinations less effective. Flu
vaccinations or other vaccinations won’t work as well anymore and do not protect
for as long as expected. The immune system cannot track and correct cell defects
as well anymore, which results in an increase of cancer associated with aging.
prevent cancer
When someone ages, the immune system also seems to be less tolerant in relation
to the body’s own cells. Sometimes this leads to an auto-immune deficiency – normal
tissue is seen as foreign tissue, and immune cells attack certain organs or tissues.
Aging also influences healing of infections and wounds.
An infection is an immune response when the Aging also influences healing of infections
and wounds. An infection is an immune response when the immune system thinks there
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is a problem. It sends more cells to the problem. This causes swelling, pain, redness, heat Are you worried about preventing cancer? It is possible to stay ahead of cancer as well
and irritation. Inflammation is often a sign of infection, but can also be the result of an as possible through little changes in your daily life, from eating a healthy diet to having
auto immune deficiency. regular cancer screenings.
Many old people age slower. This can be a direct effect of changes in the immune system
or it can be the consequence of other issues such as diabetes and arteriosclerosis, which
You have probably heard contradictory messages about cancer prevention. Sometimes a
lead to less blood supply to certain parts of the body, for example the lower legs.
specific cancer prevention tip is recommended in research or the news and then it is
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• Limit the amount of fat – eat lighter and healthier by choosing foods that are less rich
in fat, especially the ones that originate from animal sources. Fatty diets are usually high Detect it early on
in calories and can increase the chance of overweight or obesity – who in turn increase
Regular self-checks and professional screening for different types of cancer – like
the risk of cancer.
skin, colon, prostate, cervical or breast cancer – increase the likelihood of detecting
• If you choose to drink alcohol, only do this in moderation. The risk of different forms of cancer. When you catch it early on, the treatment is more likely to be successful.
cancer, including breast cancer, lung, kidney and liver cancer increases with the amount Take cancer prevention into your own hands today. The reward will last you a lifetime.
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of alcohol you drink and how often you drink.Ensure a healthy weight and plenty of
exercise
A healthy weight can reduce the risk of different types of cancer, like breast cancer,
prostate cancer, lung cancer, colon cancer and kidney cancer. Exercise is important too.
Besides helping you regulate your weight, exercise itself can reduce the risk of breast
cancer and colon cancer.
• Avoid afternoon sun. Stay out of the sun between 10 am and 4 pm; that is when the
sun rays are at their strongest.
• Stay in the shade. When you are outside, stay in the shade as much as possible.
Sunglasses and a large hat can help too.
• Cover exposed areas. Wear densely woven, loose-fitting clothing that covers as much
of your skin as possible. Choose light or dark colours that reflect more UV radiation.
• Try not to save on sunscreen. Use plenty of sunscreen when you are outside and put it
one more than once a day.
• Avoid sunbeds. These are just as harmful, if not more harmful, than natural sun light.
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Important to
keep your brain
active
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Many of us are afraid to lose our mental capacities when we grow older. We can keep
aging brains active to keep them younger longer. Food, physical and social activities all
play a role in keeping our brain active. Brain games and activities will stimulate our brains
and help aging brains stay more active.
• Stay optimistic. How you look at your day every day will decide how you feel the rest
of the day. You can choose to only look at the positives in life. The day will go a lot better
when you have a better mind set and it will improve our sense of wellbeing.
• Treat any signs of depression. It is a common cause of decreasing cognition in older
adults. See a doctor, take medication as prescribed and avoid taking things such as
sleeping pills and alcohol.
• Sign up as a volunteer or join a group, do something that makes you feel useful. Be
socially active and make sure you are in contact with others.
· Start with something new to challenge your brain. Take up a new hobby, learn a new
language or write a book. Go on the internet to see what interests you, maybe something
like genealogy or figuring out your family history.
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influence
Lack of sleep influences our cognitive functioning, our emotional health and our phys-
ical health. The immune system needs sleep to keep out diseases. Sleep disorders like
insomnia and sleep apnea can lead to fatigue, irritability, depression, forgetfulness, stress,
obesity and high blood pressure.
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Insomnia
The hormone theory of aging claims that the most important factors of aging in our
Insomnia is a general inability to fall asleep or stay asleep. Lack of exercise, not enough
bodies comes from the endocrine system. The complex endocrine system of our bodies
water, stress, fear, medicine and caffeine are common causes of insomnia. Insomnia is
regulates the hormones that in turn regulate different bodily processes. When we age,
often a symptom and not a cause. Different circumstances can lead to insomnia. About
these systems become less efficient. This leads to changes in our bodies, like with women
30-50% of people have suffered from insomnia and 10% has chronic insomnia. Since
during menopause. According to the hormone theory these changes will eventually lead
sleeping is an important part of staying healthy, we will have a look at how you can almost
to the effects of aging.
guarantee a good night’s rest.
• Unwind before bed. Instead of watching TV, try to read a book or do a few deep
There is scientific proof for this. Researchers have removed pituitary gland in mice. This
• breathing exercises.
gland regulates the majority of our endocrine system. Researches gave the mice all hor-
• Take a warm bath before bed: the warm water will help you relax and higher body mones that are currently known to be replacements for people that do not have pitu-
temperature will help you fall asleep. itary glands. The researchers concluded that the pituitary gland also produces another,
unknown hormone that has a negative effect on the aging process.
• Go to bed at the same time each night. It will give your body a constant sleeping
rhythm. Try to go to bed at the same time every night and get up at the same time every
morning.
The facts
• Avoid liquids just before bed. Fluid intake increases the chance of waking up during
Hormonal changes are an important part of aging. Whether they actually regulate the
the night.
speed at which we age or whether they are a result of other changes in the body is still
• Avoid sugar before bed. High blood sugar can lead to insomnia. A snack with lots of
protein a few hours before bed can help very well, however. unknown. It is unlikely that the hormone replacement in people will increase the life span.
• Exercise regularly: Exercise is one of the best treatments for insomnia. Some doctors prescribe human growth hormone (HGH), but there is no research that
• Avoid alcohol before bed: Although it might help, because it knocks you out, alcohol concludes that this could be the answer to the problem.
prevents you from getting deep, recovering sleep.
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Conclusion and
recommenda-
tions
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For most people this is a lot of information, and fairly intimidating to take in all at once.
If you want to become older and live healthier, then in essence it can be boiled down to
two sentences:
• Make sure you live healthy (exercise, little stress)
• Make sure you eat healthy
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Best of luck,
Adriaan