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Complexometric Titration
An application method of
Inorganic Pharmaceutical Analysis
MY
chelate
h l t
Complexometric titration curve is plotted of pM versus
volume of titrant, by calculated from pM = - log [M+]
pH
H=8
pCa
ml of EDTA
50
COMPLEXOMETRIC TITRATION FEASIBILITY
Example
50 ml of M2+ metal ion solution of 0.01 M is titrated
with Na2EDTA solution of 0.01 M. Calculate Keff after
49.95 ml of Na2EDTA addition where pM changed
by 2 units when 2 drops (0.10 ml) of Na2EDTA titrant
addition.
Before the titration
titration, EDTA is 0.5
0 5 mmoles
At one drop before the Equivalent Point, EDTA will
be 0.4995
0 4995 mmoles
mmoles, and the excess of 0 0.0005
0005
mmoles of M2+(in total volume of 99.95 ml) is 5 x 10-
6 M or pM = 5.30.
5 30
But if ΔpM is 2.0 units the pM = 7.30 or [M2+]= 5 x
10-88 M,
M occurred d after
ft 50.05
50 05 mll off tit
titrantt addition.
dditi
CY = (0.05 x 0.01)/100.05 = 5 x 10-6 M.
[MY2-] = 0.5 mmoles/100 ml = 5 x 10-3 M.
hence
Keff = 5x10-3/(5x10-8)(5x10-6) = K = 2 x 10-3 M
4 Mg(OH)
g( )2
White 4
MgIn- precipitate
CaIn-
Red
red
2
2 Ca(OH)2
White precipitate
8 10 12 14 8 10 12
pH pH
Complexometric Curve of Mg-Calmagite
a H2In- = 8.1
1
8 IV
HIn2-
7 H2In-
blue
red
pKa
6
pMg Eq Pt =5,26
=5 26 End Pt =5,7
=5 7
5
4 I
3 MgIn-
red Mg(OH)2
2 Whit
White
precipitate
1
0
6 7 8 9 10 11 12 13
pH
BUFFER PROPERTIES OF METAL IONS
M + L ML
metal ion Ligand
g Complex
p
1.
1 Adjustment of pH (buffering)
2. Masking
3
3. Demasking
4. Separation
5
5. Extraction
6. Anionization
7
7. Kinetic Masking
8. Metal ion indicator reaction
1) Selectivity due to pH
Mixture of Bi3+ and Th4+ : Bi3+ is titrated in
acid solution (p
(pH=2)) using
g indicator Xyline
y
Orange + Methylthymol Blue
-O S N N
3
NO2
Eriochrome Black T
H3In
OH HO
-O S N N
3
CH3
Calmagite
H3In