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This trend has not gone unnoticed by consumer healthcare companies. Products for bone and joint health rank in the top five types of health supplements purchased in the United
States, the United Kingdom, China, and other countries based on their market shares.2 Likewise, people are increasingly concerned about environmental health and the negative effects
of synthetic drugs and other chemicals. One in four consumers in the United States say they would be persuaded to purchase a supplement that is naturally-derived.3
Cyplexinol®, an all-natural complex of stem cell-activating proteins specifically known as bone morphogenetic proteins (BMPs), and various growth factors, is the perfect ingredient for
consumers’ bone and joint health needs. BMPs are the signals which build bone tissue, renew joint cartilage, and support regeneration in many other parts of the body. Best of all,
Cyplexinol’s® efficacy for increasing bone mineral density and improving joint function has been clinically tested - a trait many health-conscious consumers look for in health
supplements.4,5
Novel ingredients are driving this market growth. Traditional products, such as calcium supplements, have actually seen declining sales over the past decade.6 Part of this trend has to
do with newer research that has emerged. Health-conscious consumers are excited by ingredients that have shown promise clinically, but are increasingly wary of products which have
received unfavorable results.
Joint function is not just a concern for the elderly. Pain, inflammation, and stiffness in joints along with acute joint injuries affect active young adults, including athletes and fitness
trainees. Joint health is a major part of sports nutrition, and interest in natural products that improve joint strength and flexibility has steadily increased.6
Calcium
• 38% of the bone supplement market in 2017
• Sales have been declining for over a decade
• Supplements help slow bone mineral density loss, but have recently been linked to some health conditions like colorectal polyps
Glucosamine/Chondroitin
• 33% of the joint supplement market and 2% of the bone supplement market in 2017
• Shows some clinical effectiveness in select groups with joint pain
• Sales have declined over the past decade
Collagen
• Strong, elastic protein which is a major component of bone and joint tissue
Vitamin D
• 19% of the bone supplement market in 2017
• Deficiency is common, and can lead to brittle bones and other health disorders
• Sales grew 5.6% from 2016 to 2017
Magnesium
• 14% of the bone supplement market in 2017
• Important component of bone mineral and some enzymes
• Sales grew 8.9% from 2016 to 2017
Hyaluronic acid (hyaluronan)
• A glycosaminoglycan (GAG) which is a component of cartilage
• Acts as a lubricant for joints
• Estimated CAGR of 5.2% from now until at least 20239
Turmeric
• A natural product with potent anti-inflammatory properties
• 7% of the joint supplement market in 2017
• Sales grew 17.1% from 2016 to 2017
Fish oil
• Major source of omega-3 fatty acids
• 7% of the joint supplement market in 2017
• Sales have slowly increased since 2015
Gelatin
• Animal-derived collagen
• Sales grew 11.9% from 2016 to 2017
5-Loxin
• Patented joint supplement derived from Boswellia serrata extract
• Still fairly novel but initial studies indicate it is effective in improving joint pain and flexibility in osteoarthritis10,11
Cyplexinol® is the first over-the-counter dietary ingredient to improve bone and joint health by providing the signaling protein molecules required for activating stem cells. It consists of
a complex of bone proteins, with bone morphogenetic proteins (BMPs) and other growth factors bound to and contained within a network of collagen fibers. Derived entirely from
natural sources, it can be taken orally without harmful side effects. Clinical studies support that taking Cyplexinol® daily can improve bone mineral density in people with bone loss, as
well as improving joint comfort and functionality.4,5,12
Osteoarthritis: Cartilage regeneration by chondrocytes likewise is controlled by signals from BMPs and other molecules. People with osteoarthritis tend to have lower levels of BMPs in
the synovial tissues (joint membranes) of arthritic joints.29 Some genetic variations in BMP genes have been associated with a higher risk of developing osteoarthritis as well.30
Cyplexinol® addresses bone and joint health issues at the root of the problem by boosting the first step of bone synthesis. Several case studies have reported that daily supplementa-
tion with Cyplexinol® can reverse bone mineral density loss and improve DEXA scores, with impact seen as quickly as eight months. Additionally, no complications have been reported
from taking Cyplexinol®.5,35
In clinical trials, subjects reported the following with daily supplementation of Cyplexinol®, in as fast as 7 days:4,36,37
• Reduced joint pain frequency
• Reduced joint stiffness
• Improved joint flexibility
• Improved overall quality of life in people with osteoarthritis
• No side effects
2-BETA COXATENE: THE OSTEOINDUCTIVE ACTIVITY OF CYPLEXINOL® WITH GREATER IMMUNE SIGNALING SUPPORT
Products that support healthy inflammation signaling and balance have been a major health trend in recent years. Consumers have increasingly looked to these products to help improve
joint function. It is estimated that the global immune support market will be worth $106.1 billion by the year 2020. And the biologics segment is projected to be one of the most
lucrative, as health concerns about long-term use of NSAIDs and corticosteroids have been raised.38
2-Beta Coxatene consists of low-dose, concentrated Cyplexinol® blended with a 65% concentrate of Boswellia serrata, a plant known for its potent anti-inflammatory effects. This
combination makes it a superior option for encouraging balanced immune signaling and has an osteoinductive effective.
Cyplexinol®
• The only osteoinductive natural ingredient
• Supports bone tissue growth
• Supports greater bone mineral density
• Supports joint tissue formation
• Improves joint function
2-Beta Coxatene
• Provides a multiple pathway approach to balance inflammation signaling for rapid joint comfort
• Supports healthy cartilage tissue – is osteoinductive
• Supports bone tissue growth – is osteoinductive
• Supports healthy GI mucosal tissue
The flexible utility of Cyplexinol® makes it easy to include in any supplement formulation.
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