PHILIPPINE COLLEGE OF HEALTH SCIENCES
College of Pharmacy
PHARMACOLOGY 1
NAME:
CHAPTER TITLE:
INSTRUCTION: Please answer the following items based on Basic and Clinical Pharmacology by Bertam Katzung
DRUG NAME BRAND NAME MECHANISM OF ACTION
LITHIUM • suppresses inositol signaling
and inhibits glycogen synthase
kinase-3 (GSK-3), a
multifunctional protein kinase
Carbamazepine Tegretol is a sodium channel blocker. It
binds preferentially to voltage-
gated sodium channels in their
inactive conformation, which
prevents repetitive and
sustained firing of
an action potential
Lamotrigine Lamictal alters Na + , K + , and Ca 2+
conductance, membrane
potentials, and the
concentrations of amino acids
prolongation of—the inactivated
state of the Na + channel
Valproic acid Depakene potent inhibitor of histone
deacetylase and through this
mechanism changes the
transcription of many genes.
promethazine Phenergan a phenothiazine derivative with
very weak dopamine receptor
antagonism, that also blocks
H1 receptors.
Triflupromazine Vesprin binds to the dopamine D1
and dopamine D2
receptors inhibition  in
SCORE:
DATE:
THERAPEUTIC USE
Bipolar affective disorder—
prophylactic use can
prevent mood swings
between mania and
depression
acute mania and for
prophylaxis in depressive
phase
acute mania and for
prophylaxis in depressive
phase
Valproic acid is increasingly
used as first choice in acute
mania
anti-emetic and sedative
effects.
ffective phrenotropic  A Feeling Of
agent in many acute and
chronic psychotic cases
ADVERSE DRUG REACTION
Tremor, edema, hypothyroidism,
renal dysfunction, dysrhythmias
diplopia and ataxia
Hematotoxicity and induction of P450
drug metabolism
nausea, dizziness, and headache
rash
possible weight gain, alopecia
tremor, liver dysfunction, inhibition
of drug metabolism
Extrapyramidal symptoms
Disorientation
Euphoria
Restlessness With Inability To
Sit Still.
 PHILIPPINE COLLEGE OF HEALTH SCIENCES
College of Pharmacy
PHARMACOLOGY 1
the chemoreceptor  Blurred Vision.
trigger zone (CTZ) and  Extrapyramidal Disease,
vomiting centre.  A Type Of Movement Disorder.

melperone Buronil  antagonist activity at D2 For the treatment of Extrapyramidal Disease

dopaminergic and 5HT2A
serotonergic receptors
resembles clozapine
Molindone Moban blocks postsynaptic
dopaminergic receptors
(D2) in the nucleus
accumbens, striatum,
and ventral tegmental
area; decreasing
dopamine activity
zotepine Losizopilon  Zotepine is an atypical
Lodopin  antipsychotic that is an
Setous  antagonist at central dopamine
(D1 and D2) receptors. It also
binds to serotonin, adrenergic
(α1), and histamine (H1)
receptors, and inhibits
noradrenaline reuptake.
Zuclopenthixol Clopixol & Acuphase antagonism of D1 and D2
dopamine
receptors. Zuclopenthixol also
has high affinity for alpha1-
adrenergic and 5-HT2
receptors produces neuroleptic
activity
Flupenthixol Depixol and Fluanxol Powerful both D1 and D2
dopamine receptors antagonist
blocks postsynaptic dopamine
receptors in the CNS.and
alpha-adrenergic receptor
schizophrenia, sleep, gastrointestinal disturbance
disorders, agitation and
mentally confused states 
Indicated for the  dizziness.
management of  drowsiness.
schizophrenia  depression.
 restlessness.
antimanic agent in somnolence and weight gain
patients with acute
bipolar mania.
And schizoprenia
Management of NEUROLEPTIC MALIGNANT
schizophrenia SYNDROME
treatment of acute  THROMBOEMBOLISM
psychotic episodes ardive dyskinesia, weakness
used for the long-term In preggy: shaking, muscle
treatment of stiffness and/or weakness,
schizophrenia sleepiness, agitation, breathing
problems and difficulty in feeding.
 PHILIPPINE COLLEGE OF HEALTH SCIENCES
College of Pharmacy
PHARMACOLOGY 1
antagonist
Perphenazine Trilafon d opamine antagonist with
antiemetic
blocks postsynaptic dopamine
2(D2) receptors in the
mesolimbic and medullary
chemoreceptor trigger zone
(CTZ), thereby preventing the
excess of dopamine in the
brain.
Pimozide Orap selectively inhibits type 2
dopaminergic receptors in the
central nervous system (CNS),
thereby decreasing dopamine
neurotransmission and
reducing the occurrence of
motor and vocal tics and
delusions of parasitosis. In
addition, this agent
antagonizes alpha-adrenergic
and 5-HT2 receptors
Prochlorperazine Compazine  
dopamine blockade in
the chemoreceptor
trigger zone of the brain.
Asenapine () Saphris combination of antagonist
activity at D2 and 5-HT2A
receptors
Fluphenazine decanoate Prolixin blocking postsynaptic
dopamine D2 receptors in the
limbic, cortical system and
basal ganglia.
Haloperidol ester Haldol Decanoate competitively blocks
Anti emesis slow heart rate, weak pulse, weak
or shallow breathing; fever, 
And tx for
schizophrenia.
reduce uncontrolled 1) electrocardiographic
movements (motor tics) abnormalities,
or outbursts of 2) severe extrapyramidal reactions,
words/sounds (vocal tics) 3) hypotension,
caused by Tourette 4) a comatose state with respiratory
syndrome.  depression.
Tx for severe N & V Drowsiness, dizziness,
amenorrhea, blurred vision, skin
reactions and hypotension
jaundice
treatment of somnolence, dizziness,
schizophrenia in adults, dysgeusia, oral
as well as the treatment hypoesthesia, nausea, increased
of acute manic or mixed appetite, fatigue, and increased
episodes of bipolar weight.
his medication is a long- Drowsines
acting form Dizziness
of fluphenazine that is sweating, dry mouth
used to treat certain
mental/mood problems
(chronic schizophren
 treatment of extrapyramidal movement
 PHILIPPINE COLLEGE OF HEALTH SCIENCES
College of Pharmacy
PHARMACOLOGY 1
postsynaptic dopamine schizophrenia, tics in disorders, especially
receptors in the mesolimbic Tourette syndrome, parkinsonism, acute dyskinesias,
dopaminergic system and and akathisia
increases turnover of brain
dopamine
Loxapine Loxitane blocking dopamine at Anti emetic dizziness, drowsiness, faintness
postsynaptic receptor sites in vomiting dry mouth
the brain.
Paliperidone Invega) antagonist and thus interferes schizoaffective disorder  drowsiness;
with neurotransmitter as monotherapy and an
communication in the brain. It adjunct to mood  nausea and vomiting
blocks dopamine type 2, stabilizers
serotonin type 2, and alpha 2
adrenergic receptors,
acetophenazine Acetophenazine blocks reatment of disorganized lurred vision, a dry mouth, tremors
postsynaptic mesolimbic and psychotic thinking. or uncontrollable shaking,
dopaminergic D1 and D2 depression
receptors in the brain;
depresses the release of
hypothalamic and hypophyseal
hormones 
Amisulpride Solian binds selectively to dopamine treat symptoms of  drowsiness.
D2, D3 receptors in the limbic schizophrenia and
system,  hallucination
 weight gain.
 dizziness.

Trifluoperazine blocking central dopamine antipsychotic and Drowsiness, dizziness fatigue

receptors antiemetic activities weakness
Geodon combination of dopamine type used to
Ziprasidone () 2 (D2) and serotonin type 2 treat schizophrenia and
(5HT2) antagonism. the manic symptoms of
bipolar disorder (manic
depression) in adults and
children 
Lithium carbonate,) Eskalith
 PHILIPPINE COLLEGE OF HEALTH SCIENCES
College of Pharmacy
PHARMACOLOGY 1
Topiramate ( Topamax) blocks voltage-dependent
sodium and calcium channels.
It also inhibits the excitatory
glutamate pathway while
enhancing the inhibitory effect
of GABA.
used alone or with other
medications to prevent
and control seizures
(epilepsy). This
medication is also used to
prevent migraine
headaches and decrease
how often you get
them. Topiramate will not
treat a migraine
headache once it occurs.