Item: Pynocare Folder (PHYTOTHERAPY RESEARCH; Japanese Study)

Detailing Guidelines:

Page 1

Doctor, presenting for the first time, study on Proanthocyanidin the major
active constituent of French Pine bark extract, the chief ingredient in
PYNOCARE, in the Treatment of Chloasma.

Study was also published in PHYTOTHERAPY RESEARCH, an indexed

International Journal.

(Please note, from page 1, you are supposed to go to page 3, on which

the study abstract is shown.)

Page 3

Doctor, this was long term i.e. 1 year, open design clinical trial to investigate
the effect of orally administered Proanthocyanidin, on Chloasma.

12 non-pregnant, Japanese women aged between 34 to 58 years with

Chloasma were enrolled for 6 months and 11 of these12, for another 5
months.

Clinical observation, L* value or Lightening, Melanin index, and Size

measurements of Chloasma were performed.

The first 6 months of Proanthocyanidin rich extract intake, improved

Chloasma in 83% i.e.10 of the 12 women , and following 5 months of intake
improved Chloasma in i.e. 54%, 6 of the 11 women.

L* values also increased after Proanthocyanidin rich extract intake -

57.8 at the start vs. 59.3 at 6 months and 58.7 at the end of study.

Melanin-index significantly decreased after 6 months & also decreased at the

end of study.

The beneficial effect of Proanthocyanidin rich extract was maximally

achieved after 6 months.

The later intake of Proanthocyanidin rich extract for 5 months, may prevent
Chloasma from becoming worse, prior to the summer season.

To conclude- the Oral administration of Proanthocyanidin rich extract

effectively reduced the Hyperpigmentation of women with Chloasma, and is
Safe.

(Please go back to page 2 after completing page 3)

Page 2:

Doctor, Pynocare with its innovative formula, MSCC Complex Actisome is

fortified with 100% natural ingredients.

French maritime pine park extract in Pynocare is several times more

potent than vitamin E & vitamin C in protecting against UV rays.

D.Salina extract having the richest source of natural beta carotene and other
carotenoids provides systemic photoprotection and also prevents UV-induced
erythema formation.

Vitamin C & E derived from natural sources inhibit the acute UV-damages
such as erythema, sunburn and tanning as well as UV photoaging and skin
cancer.

Page 4:

Doctor, there are three more Clinical studies which were conducted on
Pynocare already shared with you. First, study done by Spin Control, France
on Thai patients, Second, a Published double blind study conducted by
HUKM, Malaysia on Malaysian patients and most recently another double
blind, placebo controlled study among Filipino women as published in the
International Journal of Dermatology, July 2009.

Doctor, Please recommend 100% natural supplement PYNOCARE in

common Acquired Hypermelanosis like Melasma, Photomelanosis & Post-
inflammatory Hyperpigmentation.

Doctor, Pynocare, Helps Treat Acquired Hypermelanosis at it’s Root.

Pynocare comes with no chemicals, no preservatives, no side effects, proven
efficacy & comes in a tamper proof 5 layered packing.

Recommended dose is 1-2 capsules twice daily after meals for minimum 12
weeks.