ARYAKUL COLLEGE OF PHARMACY & RESEARCH

NATKUR, P.O.: CHANDRAWAL

ARYAKUL COLLEGE ROAD, ADJACENT TO CRPF BASE CAMP
LUCKNOW – 226002, UTTAR PRADESH (INDIA).

SUB: BIOPHARMACEUTICS & PHARMACOKINETICS (SUB CODE: BP604T)

Multiple choice questions- Unit-1

1. Pharmacokinetics is:
a. The study of biological and therapeutic effects of drugs
b. The study of absorption, distribution, metabolism and excretion of drugs
c. The study of mechanisms of drug action
d. The study of methods of new drug development

2. What does “pharmacodynamics” exclude?

a. Localization of drug action
b. Mechanisms of drug action
c. Excretion of substances
d. Interaction of substances

3. The main mechanism of most drugs absorption in GI tract is:

a. Active transport (carrier-mediated diffusion)
b. Filtration (aqueous diffusion)
c. Endocytosis and exocytosis
d. Passive diffusion (lipid diffusion)

4. What kind of substances cannot permeate membranes by passive diffusion?

a. Lipid-soluble
b. Non-ionized substances
c. Hydrophobic substances
d. Hydrophilic substances

5. A hydrophilic medicinal agent has the following property:

a. Low ability to penetrate through the cell membrane lipids
b. Penetrate through membranes by means of endocytosis
c. Easy permeation through the blood-brain barrier
d. High reabsorption in renal tubules

6. Pick out the appropriate alimentary route of administration when passage of drugs through liver
is minimized:
a. Oral
b. Transdermal
c. Rectal
d. Intraduodenal

Biopharmaceutics BP604T MCQs Unit 1 1

7. Which route of drug administration is most likely to lead to the first-pass effect?
a. Sublingual
b. Oral
c. Intravenous
d. Intramuscular

8. Biological barriers include all except:

a. Renal tubules
b. Cell membranes
c. Capillary walls
d. Placenta

9. What is the reason of complicated penetration of some drugs through brain-blood barrier?
a. High lipid solubility of a drug
b. Meningitis
c. Absence of pores in the brain capillary endothelium
d. High endocytosis degree in a brain capillary

10. The term “biotransformation” includes the following:

a. Accumulation of substances in a fat tissue
b. Binding of substances with plasma proteins
c. Accumulation of substances in a tissue
d. Process of physicochemical and biochemical alteration of a drug in the body

11. Biotransformation of the drugs is to render them:

a. Less ionized
b. More pharmacologically active
c. More lipid soluble
d. Less lipid soluble

12. Tick the drug type for which microsomal oxidation is the most prominent:
a. Lipid soluble
b. Water soluble
c. Low molecular weight
d. High molecular weight

13. Pick out the right statement:

a. Microsomal oxidation always results in inactivation of a compound
b. Microsomal oxidation results in a decrease of compound toxicity
c. Microsomal oxidation results in an increase of ionization and water solubility of a drug
d. Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion
from the organism is facilitated

Biopharmaceutics BP604T MCQs Unit 1 2

14. Metabolic transformation (phase 1) is:
a. Acetylation and methylation of substances
b. Transformation of substances due to oxidation, reduction or hydrolysis
c. Glucuronide formation
d. Binding to plasma proteins

15. Conjugation is:

a. Process of drug reduction by special enzymes
b. Process of drug oxidation by special oxidases
c. Coupling of a drug with an endogenous substrate
d. Solubilization in lipids

16. Which of the following processes proceeds in the second phase of biotransformation?
a. Acetylation
b. Reduction
c. Oxidation
d. Hydrolysis

17. Half life (t ½) is the time required to:

a. Change the amount of a drug in plasma by half during elimination
b. Metabolize a half of an introduced drug into the active metabolite
c. Absorb a half of an introduced drug
d. Bind a half of an introduced drug to plasma proteins

18. Half life (t ½) does not depend on:

a. Biotransformation
b. Time of drug absorption
c. Concentration of a drug in plasma
d. Rate of drug elimination

19. The rate of diffusion of drug across biological membrane is

a. Directly proportional to the concentration gradients
b. Dependant on route of administration
c. Indirectly proportional to membrane thickness
d. None of the above

20. Aqueous filled pores present in cell membrane responsible for absorption of
a. water insoluble molecules
b. water soluble molecules
c. both a and b
d. None of the above

Biopharmaceutics BP604T MCQs Unit 1 3

21. Passive diffusion is expressed by
a. Fick's first law of diffusion
b. Fick's second law of diffusion
c. First order kinetics
d. zero order kinetics

22. Noyes and Whitney equation is used to describe

a. Absorption
b. Dissolution
c. Distribution
d. Disintegration

23. ___________ is used to study gastric emptying.

a. Barium sulphate
b. Aluminum sulphate
c. Calcium sulphate
d. Aluminum hydroxide

24. The rate of drug transport across a cell membrane by lipid diffusion depends on all of the
following EXCEPT.
a. Surface area of absorption
b. Lipid partition coefficient
c. Density of transporters
d. Concentration gradient

25. According to pH partition theory, a weakly acidic drug will most likely be absorbed from the
stomach because the drug which exist primarily in the
a. un-ionised, more lipid soluble form
b. ionised, more water soluble form
c. form of weak acid and more soluble in acid media
d. ionic form of the drug which facilitates diffusion

26. Which tissue has the greatest capacity to biotransform drugs?

a. Kidney
b. Liver
c. Lung
d. Skin

27. Which form of drug shows rapid dissolution rate?

a. Crystalline
b. Amorphous
c. Hydrate
d. None of the above
Biopharmaceutics BP604T MCQs Unit 1 4
28. Protein binding of drugs helps to maintain _____ for absorption of drugs.
a. non sink condition
b. sink condition
c. none of the above

29. When the solvent in association with the drug is water, the solvate is known as
a. Anhydrate
b. Amorphous
c. Hydrate
d. none of the above

30. Which of the following is carrier mediated transport system?

a. passive diffusion
b. active transport
c. pore transport
d. none of the above

31. As per BCS system, class I drugs come under:

a. high solubility high permeability
b. low solubility high permeability
c. high solubility low permeability
d. low solubility low permeability

32. Dissolution test apparatus no. 1 as per IP is:

a. Paddle
b. Basket
c. Rotating basket
d. Rotating cylinder

33. Very weak bases having pKa < 5:

a. are ionized in the entire pH range of GIT
b. shows absorption which is pH dependent
c. are unionized at all pH values
d. none of the above

34. Based on Henderson-Hasselbalch equation, at what pH value a weak acid would be 99.9%
ionized?
a. At pH equivalent to pka – 3
b. At pH equivalent to pka + 3
c. At pH equivalent to pka - 1
d. At pH equivalent to pka + 1
Biopharmaceutics BP604T MCQs Unit 1 5
35. Micronized form of drug absorbed fast because
a. surface area increased
b. viscosity increased
c. angle of distribution increased
d. none of the above

36. Which of the following drug diffuses readily into the brain?
a. Penicillin
b. Thiopental
c. Dopamine
d. all of the above

37. Oil soluble vitamins absorbed by ________ .

a. pore transport
b. passive diffusion
c. carrier mediated transport
d. endocytosis

38. ____ types of drugs are absorbed by pore transport mechanism.

a. Macromolecules
b. Ionic drugs
c. Drugs with molecular weight 100-400
d. Water soluble drugs of molecular weight less than 100

39. ACE inhibitor Enalapril is absorbed via ____ carrier system.

a. Pyrimidine
b. L-amino acid
c. Small peptide
d. none of the above

40. Absorption of Griseofulvin and Spironolactone is _______.

a. diffusion rate limited
b. dissolution rate limited
c. permeation rate limited
d. none of the above

41. Which of the following strategies are widely used to improve or promote transport of drug to
brain?
a. Use of DMSO
b. Use of Mannitol
c. Prodrug approach
d. All of the above

Biopharmaceutics BP604T MCQs Unit 1 6

42. In carrier mediated transport energy is derived from _____
a. Hydrolysis of ATP
b. Protein metabolism
c. concentration gradient
d. All of the above

Biopharmaceutics BP604T MCQs Unit 1 7