MOA VLDL LDL HDL TAG OTHER HALF LIFE THERAPEUTIC ADR MAXIMAL CONTRAINDICATION

S EFFECTS
HMG COA REDUCTASE 1- 3 H ARTHEROSCLEROSIS INC. ALT LIVER DISEASE
INHIBITORS COMPETITIVE HTN MYOSITIS PREGNANCY
RISK FOR CHD
INHIBITORS OF 18 – 55 5- 15 7- 30 Pita – 12 H RHABDOMYOLYSIS 4 -6 WEEKS SERIOUS ILLNESS
DM
“-STATIN” HMG COA Ator – 14 H HETEROZYGOUS FAMILIAL INC. CK TRAUMA
INHIBITORS Rosu – 19H HYPERCHOLE MYOPATHY MAJOR SURGERY
STROKE LUPUS LIKE RASH
UP REGULATES LDL MITIGATE MANIFESTATIONS OF ANGIOEDEMA
RECEPTORS ALZHEIMER’S PERIPHERAL NEUROPATHY
MI
GI
INHIBITS THROMBOSIS

BILE ACID SEQUESTRANTS PREVENT REAB OF HETEROZYGOUS FAMILIAL UNPALATABILITY

Cholstyramine BILE ACIDS IN THE HYPERCHOLE GI
REMOVAL OF DIGITALIS
Colestipol GUT 15 – 30 3-5 1–1 HYPOPT 2 – 4 WEEKS
RELIEVE PRURITUS
Colessevelam IDL COMBINED HYPERLIPIDEMIA MALABSORPTION OF
UP REGULATES LDL IMPROVE GLUCOSE METAB FOLICA CID AND VIT K
RECEPTORS REDUCE CHD GALLSTONE FORMATION
DRY FLAKING SKIN
INC. TAG

FIBRATES 1.5 H MIXED DYSLIPIDEMIA / SKIN RASHES HEPATIC / RENAL

PPAR alpha DYSBETALIPOPROTEINEMIA GI FENO: 2 WKS DYSFUNCTION
HYPERTAG W/ VLDL PRED.
“- RATE” AGONIST 5 - 20 10-35 20 – 50 Clo- 12 H CHOLE GALLSTONES
HYPERTAG W/ VIRAL PROTEASE
Gemfibrozil Feno- 20 H INHIBITORS (Clofibrate) GEM: 3 – 4 WKS GALLBLADDER DSE
MIZED DYSLIPIDEMIA W/ MYOPATHY / RHABDO
HYPERURICEMIA INC. ALT
ARRHYTMIA
HYPOK
DEC WBC / HCT
NIACIN DEC. CATABOLISM INHIBIT THROMBUS FORMATION CUTANEOUS
OF APO A1 HETEROZYGOUS FAMILIAL VASODILATION
HYPERCHOLE
REDUCE VLDL 5 – 25 15-35 20-50 LP (a) ACANTHOSIS NGRICANS 3 – 5 WKS. SEVERE ACID AND PEPTIC
SEVERE MIZED LIPEMIA
SECCRETION COMBINED GI DSE.
INHIBITS CETP HYPERLIPOPROTEINEMIA IMPAIRED CHO TOLEANCE
INHIBIS IC LIPASE FAMILIAL BETA TACHYPHYLAXIS DM
CATABOLIZE APO DYSBETALIPOPROTEINEMIA HYPERURICEMIA
B100 HYPOTENSION GOUT
RED CELL MACROCYTOSIS
BIRTH DEFECTS IN PREGNANCY
ANIMALS
PLT. DEF.
INHIBITOR OF INTESTINAL BLOCKS STEROL PHYTOSTEROLEMIA MYOSITIS
AB TRANSPORTER 22 HOURS LOW INCIDECE OF HEPATIC
DYSFUNCTION
NPC1L1 IN 18–20 1-5 5 – 11 ACTIVE LIVER DSE
PRIMARY HYPERCHOLE
Ezetimide INTESTINE BRUSH
BORDER
OMEGA 3 FA PPAR alpha SAME AS NITRATES AND DIARRHEA
AGONIST FIBRATES EXCESSIVE BLEEDING
DEC. PLT. AGGREAGATION
APOB100
ANTI ARRHYTMIC AT HIGH DOSES
ANTAGONIST REDUCE MI AND SUDDEN
CARDIAC DEATH
PROBUCOL INHIBIT STEROL SIMILAR TO STATINS ARRHYTMIA
BIOSYNTHESIS
THIAZOLIINEDIONES
4 - 16 5-13 26- 2

CRUZ, LESLEE A. 2E || FEUNRMF