SRI RAMACHANDRA MEDICAL COLLEGE AND RESEARCH INSTITUTE

(DEEMED TO BE UNIVERSITY)
PORUR, CHENNAI – 600116

DEPARTMENT OF NEPHROLOGY
SRI RAMACHANDRA COLLEGE OF ALLIED HEALTH SCIENCES
PROJECT TITLE
“ASSESSMENT OF COGNITIVE IMPAIRMENT IN MAINTENANCE
HEMODIALYSIS PATIENTS USING THE MONTREAL COGNITIVE
ASSESSMENT TEST”
SUBMITTED TO
INSTITUTIONAL ETHICS COMMITTEE
SRI RAMACHANDRA MEDICAL COLLEGE AND RESEARCH INSTITUTE
(DEEMED TO BE UNIVERSITY)
PORUR, CHENNAI – 600116
PRINCIPAL INVESTIGATOR:
MUTHAMIZH.M
MSc RENAL SCIENCE AND DIALYSIS TECHNOLOGY
DEPARTMENT OF NEPHROLOGY,
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH
(DEEMED TO BE UNIVERSITY)
PORUR, CHENNAI-116
GUIDE:
Dr. E.RAM PRASAD. M.D., D.M. (NEPHROLOGY).
PROFESSOR,
DEPARTMENT OF NEPHROLOGY,
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH
(DEEMED TO BE UNIVERSITY)
PORUR, CHENNAI-116
CO GUIDE:
Mrs. MEETHA S MSc (RS & DT)
ASSISTANT PROFESSOR,
DIVISION OF RENAL SCIENCE AND DIALYSIS TECHNOLOGY
FACULTY OF ALLIED HEALTH SCIENCE
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH
(DEEMED TO BE UNIVERSITY)
PORUR, CHENNAI-116
1
 INSTITUTIONAL ETHICS COMMITTEE
SRI RAMACHANDRA COLLEGE AND RESEARCH INSTITUTE
(DEEMED TO BE UNIVERSITY)
Initial Review Submission Form for M.Sc Research Proposal

1. Title of the proposal

“ASSESSMENT OF COGNITIVE
IMPAIRMENT IN MAINTENANCE
HEMODIALYSIS PATIENTS USING THE
MONTREAL COGNITIVE ASSESSMENT
TEST”

2. Name of the Investigator MUTHAMIZH M

MSc RENAL SCIENCE AND DIALYSIS
TECHNOLOGY

3. Name of the Guide DR.E.RAM PRASAD M.D., D.M (NEPHRO)

PROFESSOR
DEPARTMENT OF NEPHROLOGY
4. Name of the Co-Guide Mrs. MEETHA S MSc (RS & DT)
ASSISTANT PROFESSOR
DIVISION OF RENAL SCIENCE AND
DIALYSIS TECHNOLOGY
FACULTY OF ALLIED HEALTH SCIENCE

5. Name of the HOD DR.M. JAYAKUMAR,MD, DM(NEPHRO)

PROFESSOR AND HEAD
DEPARTMENT OF NEPHROLOGY

6. Forwarding letter from the Guide Appendix-1

and H.O.D

7. Consent from the other -

Department, if applicable

8. Mention ethical issues to be No issues

addressed in your study

9. Protocol Enclosed in the Appendix-3

10. Consent form Appendix-2

2
11. Covering letter from the guide with Enclosed
the checklist attached
12. All relevant enclosures like Enclosed in Appendix 4
proformae, case report forms,
questionnaires, follow up cards etc.

13. CV of the PI and guide Enclosed in Appendix 7

14. Checklist of the guide and students Enclosed

while forwarding the application to
the IEC

3
 APPENDIX

1. Forwarding letter from the head of the departments.

2. Consents from HOD.
3. Protocol of the proposed research.
4. Performa & Abbreviations.
5. Informed consent form in English.
6. Informed consent form in Tamil.
7. Curriculum vitae of all the investigators.

4
 Appendix-1
Forwarding Letter
19.12.2019
From
Muthamizh M
MSc Renal Science and Dialysis Technology
Batch-2018-2019,
Sri Ramachandra Institute of Higher Education and Research,
Deemed to be University,
Porur, Chennai-116

To
The Chairman,
The Institutional Ethics Committee,
Sri Ramachandra Institute of Higher Education and Research,
Deemed to be University,
Porur, Chennai-116,

Through proper channel

Respected sir,
I here with submit my research proposal titled “ASSESSMENT OF COGNITIVE
IMPAIRMENT IN MAINTENANCE HEMODIALYSIS PATIENTS USING THE
MONTREAL COGNITIVE ASSESSMENT TEST” for institutional ethics committee
approval. Kindly consider my research proposal and do the needful.
Thanking you,

Yours sincerely,
MUTHAMIZH M

5
 Appendix-2

TO WHOMSOEVER IT MAY CONCERN

I, Dr. E.RAM PRASAD.M.D., D.M.(NEPHROLOGY), Department of Nephrology, Sri

Ramachandra Institute of Higher Education and Research, do hereby give my consent for
MUTHAMIZH M MSc RENAL SCIENCE AND DIALYSIS TECHNOLOGY (2018-2019),
Sri Ramachandra Institute of Higher Education and Research to conduct her research project,
titled “ASSESSMENT OF COGNITIVE IMPAIRMENT IN MAINTENANCE
HEMODIALYSIS PATIENTS USING THE MONTREAL COGNITIVE
ASSESSMENT TEST” in our department.

This letter of consent being issue on...................................

Signature of guide

6
 Appendix-3

Protocol of the proposed research

1. Title of the research project:
“ASSESSMENT OF COGNITIVE IMPAIRMENT IN MAINTENANCE
HEMODIALYSIS PATIENTS USING THE MONTREAL COGNITIVE
ASSESSMENT TEST”
2. Aim:
The aim of the study is to assess the cognitive impairment in maintenance hemodialysis
patients by using the Montreal Cognitive Assessment Test.
Objective:
To evaluate and assess the cognitive impairment in maintenanace hemodialysis patients
who were on hemodialysis more than three months by using Montreal Cognitive
Assessment Test.
3. Materials and Methodology:
Sample Area: The study will be conducted at the Department of Nephrology Sri
Ramachandra Institute of Higher Education and Research, Porur, Chennai.
Sample Size: 150 patients (α 0.05 and β 80)
Type of the study: Prospective Observational study
Period of the study: 6months
Inclusion criteria:
 Age 18 – 65 years
 Dialysis vintage of at least 3 months
 ESRD patients on maintenance hemodialysis
 Patients who were willing to give informed consent
Exclusion criteria:
 Peritoneal Dialysis Patients
 Acute Kidney Injury Patients
 Newly Initiated on Hemodialysis

4. Study Methodology:
Patients will be included in this study after obtaining informed consent and based on
their inclusion and exclusion criteria. Patients were grouped based on their age, vintage of
hemodialysis, co-morbid conditions. Then the cognitive status of each patient will be
analyzed by using Montreal Cognitive Assessment Test (MoCA).The obtained data will
be analyzed statistically by using SPSS software analysis.

7
5. Need of the study
Cognitive Impairment is when a person has trouble remembering, learning new things,
concentrating or making decisions that affect their everyday life.
End Stage Renal Disease is associated with an increased risk of cognitive impairment in
patients undergoing maintenance hemodialysis.
This study will be helpful in detecting the cognitive impairment of patients on
maintenance hemodialysis by using Montreal Cognitive Assessment Test (MoCA).
The MoCA test is short screening which covers the patient’s attention, concentration,
memory, orientation, language, visuoconstructional skills, conceptual thinking,
calculation and executive function.
Advantages:
 More sensitive than Mini Mental State Examination (MMSE).
 Easily approachable and non-invasive screening tool
 Early detection of cognitive impairment helps in prevention of depression in
maintenance hemodialysis patients.
 Early detection of cognitive impairment will reduce the treatment time with
cognitive stimulation therapy.

6. Statistical analysis:
The results of the study will be analyzed using SPSS software. The data will be
expressed in percentage, mean & standard deviation.P value <0.05 will be considered
Statistically significant.

8
 Appendix-4

PROFORMA

Age:

Gender:

Date of birth:

Height:

Weight:

BMI

DIALYSIS DETAILS:

Dialysis Vintage:

Frequency of dialysis:

Access:

Kt /V:

Ultrafiltration:

9
MONTREALCONGNITIVE ASSESSMENT (MOCA) Name:
Education: D.O.B:
Sex: Date:

10
11
 Appendix-5

INFORMED CONSENT

Title of the study:

“ASSESSMENT OF COGNITIVE IMPAIRMENT IN MAINTENANCE
HEMODIALYSIS PATIENTS USING THE MONTREAL COGNITIVE
ASSESSMENT TEST”

Principle investigator:
Muthamizh.M
MSc Renal Science and Dialysis Technology
Batch-2018-2019,
Sri Ramachandra Institute of Higher Education and Research,
Deemed to be University,
Porur, Chennai-116

Brief description of the study process:

This study is aimed to assess the cognitive impairment of patients on maintenance hemodialysis.
Patients were grouped based on their age, vintage of hemodialysis, co-morbid conditions. By
using Montreal Cognitive Assessment Test which is a screening tool scores ranges between 0 and
30. A score 26 or over is considered to be normal, score < 26 indicates the presence of cognitive
impairment.
Possible risk of the participants: There is no risk involved in this study
Cost and payment to the participant: There is no cost involved and no payment will be
made to patient
Confidentiality: Information obtained in this study will be kept confidential. Your name will
not be used in reporting of information in publications or conference presentations.
Participant’s right to withdraw from the study: You have the right to refuse to participate
in this study, the right to withdraw from the study and the right to have your data destroyed at
any point during or after the study, without penalty.

12
 Appendix-6

VOLUNTARY CONSENT BY THE PARTICIPANT:

PARTICIATION IN THIS STUDY IS COMPLETELY VOLUNTARY, AND YOUR
CONSENT IS REQUIRED BEFORE YOU CAN PARTICIPATE IN THIS STUDY.
I have read this consent form (or it has been read to me) and I fully understand the contents of
this document and voluntarily consent to participate in this study. All of my questions
concerning this study have been answered. If I have any questions in the future about this
study they will answered by the investigator listed above. I understand that this consent ends
at the conclusion of this study.

Student Investigator – from SRMC Supervisor – from SRMC

MUTHAMIZH.M Dr.E.RAM PRASAD. M.D., D.M.
MSc Renal Science and Dialysis Technology (NEPHROLOGY).
Department of Nephrology Sri PROFESSOR,
Ramachandra Institute of Higher Education Department of Nephrology
and Research, Porur, Chennai 600 116 Sri Ramachandra Institute of Higher
Email:muthamizhhene@gmail.com Education and Research, Porur,
Phone: 9092133946 Chennai 600 116

By signing this form, I agree to participate in this study. A copy of this form has been given
to me.
Date:

Name:

Patient’s signature:

Thumb impression:

Witness name:

Witness signature:

13
 CERTIFICATION OF INFORMED CONSENT

I certify that I have explained the nature and purpose of this study to the above name
individual, and I have discussed the potential benefits of this study participation. The
questions the individual had about this study have been answered, and we will always be
available to address future questions.

BENEFITS:

 Early detection of cognitive impairment helps in prevention of depression in

maintenance hemodialysis patients.
 Early detection of cognitive impairment will reduce the treatment time with
cognitive stimulation therapy.

Date of consent:

Signature of person obtaining:

Name:

Signature

14
 இைணப் -5

ெதரியப் ப த் தப் ப ம் அ ம
ஆய் த்தைலப் :
மான் ட்ரியல் அ வாற் றல் ம ப் ட் ேசாதைனையப்
பயன் ப த் பராமரிப் ேமாைடயா ஸ் ேநாயாளிகளில்
அ வாற் றல் ைறபாட்ைட ம ப் ெசய் தல்

க் ய ேசாதைனயாளர்:
த்த ழ் .
ராமச்சந் ரா உயர்கல் நி வனம் மற் ம் ஆராய் ச்
ேபா ர், ெசன் ைன 116.

ஆய் பணிைய பற் ய ளக் கம் :

இந்த ஆய் பராமரிப் ேமாைடயா ல் ேநாயாளிகளின்
அ வாற் றல் ைறபாட்ைட ம ப் வைத ேநாக் கமாகக்
ெகாண் ள் ள . ேநாயாளிகள் தங் கள் வய , ேமாைடயா ன்
ண்ேடஜ் , இைண ேநா ற் ற நிைலைமகள் ஆ யவற் ன்
அ ப் பைட ல் வாக இ ந்தனர். ஸ் ரீனிங் க
ம ப் ெபண்களான மாண்ட்ரல ீ ் அ வாற் றல் ம ப் ட்
ேசாதைனையப் பயன் ப த் வதன் லம் ம ப் ெபண்கள் 0 தல் 30
வைர இ க் ம் . ஒ ம ப் ெபண் 26 அல் ல அதற் ேமற் பட்ட
சாதாரணமாகக் க தப் ப ற , ம ப் ெபண் <26 அ வாற் றல்
ைறபா இ ப் பைதக் க் ற .

பங் ேகற் பாளர்க க் சாத் யமான ஆபத் :

இந்த ஆய் ல் எந்த ஆபத் ம் இல் ைல

ெசல மற் ம் பங் கட்டணம் :

இந்த ஆய் ல் ஈ ப பவர்க க் எந்த ஒ கட்டண ம்
இல் ைல

இரக யத்தன்ைம:
இந்த ஆய் ல் இ ந் ெபறப்பட்ட தகவல் கள் கண் ப் பாக
ரக யமாக ைவக்கப் ப ம் . பங் ேகற் பாளர்களின் ெபயர்
ெவளி கேளா அல் ல மாநாட் ல் ளக்கக்காட் களிேளா
தகவல் கள் பயன் ப த்தப் படமாட்டா .

பங் ேகற் பாளரின் ஆய் ல் இ ந் ல வதற் கான உரிைம:

இந்த ஆய் ல் பங் ேகற் க ம க்க உங் க க் உரிைம உண் ,
ஆய் ல் இ ந் ல வதற் கான உரிைம மற் ம் ஆய் ன் ேபா
அல் ல அதற் ப் ற எந்த ேநரத் ம் அபராதம் இன் உங் கள்
தரைவ அ க்க உரிைம உண் .

15
 இைணப் -6

பங் ேகற் பாளர்களின் சம் மதம் :

இந்த ஆய் ல் பங் ெப ெவார் ற் ம் தன் னார்வம் ெகாண் ம்

மற் ம் இந்த ஆய் ல் பங் ேகற் க ன் னதாகேவ அ ம

அளிக் ேறன் .
இந்த ஆய் பற் ய என் எல் லாேகள் க க் ம் ப லளிக்கப் பட்ட .
ேழபட் ய டப்பட் ள் ள இந்த ேசாதைனயாளர் லம் இந்த ஆய்
பற் எ ர்காலத் ல் நான் ெகாண்ட எந்த ேகள் க க் ம்
ப லளிப் பார்.
இந்த ஆய் ன் ல் என் ஒப் தல் ற என்
ரிந் ெகாண்ேடன் .

ேசாதைனயாளர் வரங் கள் ெதாடர் :

ெபயர்: த்த ழ் .

ெமாைபல் : 9092133946
இந்த ப வத்ைத ைகெய த் ட் ,

நான் இந்த ஆய் ல் பங் ேகற் க ஒப் க்ெகாள் ேறன் .

இந்த ப வத் ன் ஒ நகல் எனக் வழங் கப் பட்ட .

ேத
ெபயர்

ைகெய த்

பங் ேகற் பவர்

சாட்

16
 சான் தழ்

ஒப் தல் ப வம்

ேமேல ப் டப்பட் ள் ள நபரிடம் இந்த ஆய் ன் தன் ைம மற் ம்
ேநாக் கத்ைத ளக் ட்ேடன் என் சான் றளிக் ேறன் . இந்த
ஆய் ல் பங் ேகற் பதனால் ைடக்கக் ய நன் ைமகைளப் பற் ம்
கலந் ைரயா இ க் ேறன் . இந் த ஆய் ைவக் த் இவ க்
இ ந்த சந்ேதகங் கள் நிவர்த் ெசய் யப் பட்டன. ேம ம் ,
வ ங் காலத் ல் எழக் ய ேகள் க க் ப லளிக்கதயாராக
இ ப் ேபாம் .

நன்ைமகள் :

 அ வாற் றல் ைறபாட்ைட ன் ட் ேய கண்ட வ

பராமரிப் ேமாைடயா ஸ் ேநாயாளிகளில்
மனச்ேசார்ைவத் த க்க உத ற .
 அ வாற் றல் ைறபாட்ைட ன் ட் ேய கண்ட வ
அ வாற் றல் ண் தல் ச்ைச டன் ச்ைச ன்
ேநரத்ைதக் ைறக் ம்

ேத :
ஒப் தல் ெப பவரின் ைகெயாப் பம்

ெபயர்:

ேம பா ைவயாளாி ைகெயா ப

ெபய :

17
 CURRICULUM VITAE OF GUIDE

Name: Dr. E.RAM PRASAD. M.D., D.M. (Nephrology).

Age: 41 years
Sex: Male
Date of birth: 17-05-1978
Marital status: Married
Permanent Address : NO-15, MAHALAKSMI NAGAR 2ND CROSS
STREET, 1ST LAYOUT ADAMBAKKAM CHENNAI .
PIN -600088
Phone: 044-43559635
Mobile: 9894120150
-
EMail: ramprasadnephro@gmail.com

QUALIFICATION
M.B.B.S = 1995- 2000, SRI RAMACHANDRA MEDICAL COLLEGE.
SRI RAMACHANDRA UNIVERSITY
M.D (GENERAL MEDICINE) = 2002- 2005, RAJAH MUTHIAH MEDICAL
COLLEGE
ANNAMALAI UNIVERSITY.
D.M. (NEPHROLOGY) = 2008 -2011 SRI RAMACHANDRA MEDICAL
-COLLEGE,
SRI RAMACHANDRA UNIVERSITY.

WORK EXPERIENCE

SEP 2005 –MARCH 2007 - (1 YEAR &6MONTH) –Worked as Assistant Professor in

Dept. of
Medicine in Sree Balaji Medical College Chennai.
APRIL 2007 –JULY 2008(1year & 4 months) - Worked as Assistant Professor in
Department of Medicine in Sri Ramachandra Medical College Chennai.

4, September 2011 – May 2019 -Working as Associate Professor in Dept of Nephrology in

Sri Ramachandra Medical College Chennai.

May 2019 -till date- Professor in Nephrology in Sri Ramachandra Medical College Chennai.

18
EXPERIENCE

Fluent in procedures in Nephrology like double lumen catheter insertion, renal biopsy, perm
Catheter insertion &bed side CAPD Catheter insertion
Well trained in all dialysis procedures HD, IPD, CAPD, CRRT, plasmapheresis,
hemoperfusionand HDF
Experienced in renal transplantation, personally involved in more than 200 renal Transplants.
Trained in emergency advanced cardiac life support.

RESERCH WORK
Dissertation on ENOS polymorphism in ADPKD and its disease modifier effect
Dissertation on clinical profile of pulmonary tuberculosis in retro positive pt.
Inflammation and its association with arterial stiffness and abdominal aortic
calcification in chronic kidney disease patients, GATE Project, Sri Ramachandra
University., Co- Investigator.

CURRENT RESERCH WORK

Study Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter

Study to Demonstrate the Effects of Sotagliflozin on Cardiovascular and Renal Events in
Patients with Type 2 Diabetes, Cardiovascular Risk Factors and Moderately Impaired Renal
Function
IEC NO: IEC/18/APR/140/12
Study Number /Name: EFC14875 / The SCORED Trial

CONFERENCE

Presented a paper on a case of rare post-transplant fungal infection in a national conference

Indian Society on Nephrology, Southern chapter. 2010.
Trained in bed side CAPD catheter insertion at PDSCIENTIA March 2012, Bengaluru.
ED1 POLYMORPHISM IN ADPKD - Oral paper presented in Indian society of nephrology
southern Chapter ,2015 ,Calicut. BEST PAPER - SECOND PRICE.
SPOUSAL TRANSPLANT SINGLE CENTRE EXPERIENCE - presented in Indian society
of nephrology southern chapter ,2015 ,Calicut.
FUNGAL INFECTION IN RENAL TRANSPLANTATION - presented in EUROPEAN
RENAL ASSOCIATION –EDTA CONFERENCE IN, VIENNA AUSTRIA 2016.
SLEEP DISORDERS IN MHD PATIENTS-presented in EUROPEAN RENAL
ASSOCIATION –EDTA CONFERENCE IN, COPENHAGEN,DENMARK 2018.

19
AUTHOR IN TEXT BOOK

NAME: MANUAL OF HYPERTENSION.

CHAPTER: 31. Pharmacogenomics in the Management of Hypertension, MAY 2016,
JAYPEE PUBLICATION

PUBLICATION

1. Role of the endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism
on the progression of autosomal dominant polycystic kidney disease:
ElumalaiRamprasad, Periasamy S, Ramanathan G, Lakkakula B.J Renal Inj Prev.
2014; 3(3): 69-73.

2. Role of renin angiotensinaldosterone system gene polymorphisms and

Hypertension induced end stage renal disease in ADPKD
Gnanasambandan Ramanathan1, Ramprasad, Elumalai2, Soundararajan
Periyasamy2 and Bhaskar V.K.S. Lakkakula1*
Iranian Journal of Kidney Diseases | Volume 8 | Number 4 | July 2014

3. Renal Contraction Therapy by Transcatheter Arterial Embolization for ADPKD

- A Modality to Augment CAPD? K. B. Mahesh Kumar, E. Ram
Prasad, Santhosh Joseph, S. Prabha,P.Soundararajan Volume 26, Issue 2, August
2014 -Indian Journal of Peritoneal Dialysis. Case Report

4. Endothelin 1 gene is not a major modifier of chronic kidney disease advancement

among the autosomal dominant polycystic kidney disease patients
Shiva Nagendra Reddy Annapareddy1, Ramprasad Elumalai1*, Bhaskar V.K.S.
Lakkakula2,3, Gnanasambandan Ramanathan2, Soundararajan Periyasamy1
J Nephropharmacol. 2016; 5(1): 13–18.

5. Pathways, perspectives and pursuits in polycystic kidney disease

L. V. K. S. Bhaskar1*, Ramprasad Elumalai2, Soundararajan Periasamy2
J Nephropharmacol. 2016; 5(1): 41–48.

20
6. Angiotensinogen gene polymorphisms and progression of chronic kidney disease
in ADPKD patients
Ramanathan Gnanasambandan1, Ramprasad Elumalai2,Periyasamy
Soundararajan2
Bhaskar V. K. S. Lakkakula1,3
ClinExpNephrol DOI 10.1007/s10157-015-1183-2

7.TRPC6 gene promoter polymorphisms in steroid resistant nephrotic syndrome

children
KempanahalliBasappa Mahesh Kumar1, Senguttuvan Prabha1, Elumalai Ramprasad1,
Lakkakula VKS Bhaskar2,3*, Periasamy Soundararajan1
J Nephropharmacol. 2015; 4(2): 52–56.
8. Effect of chronic kidney disease on circulating ghrelin concentrations
MANIKANTAN SEKAR (1), RAMPRASAD ELUMALAI (1), MAHESH KUMAR
KEMPANAHALLI BASAPPA (1), BHASKAR V.K.S. LAKKAKULA (2),
SOUNDARARAJAN
PERIASAMY (1)*
Annals of R.S.C.B., Vol. XIX, Issue 2, 2015, pp. 41 – 46
9. Curvularialunata, a rare fungal peritonitis in continuous ambulatory peritoneal
dialysis (CAPD); a rare case report
Haritha Subramanyam1, Ramprasad Elumalai1*, AnupmaJyoti Kindo2,
Soundararajan Periasamy1J Nephropharmacol. 2016; 5(1): 61–62. A CASE REPORT,

10.Renin gene rs1464816 polymorphism contributes to chronic kidney disease

progression in ADPKD
Gnanasambandan Ramanathan1, Ramprasad Elumalai2, Soundararajan Periyasamy2
andBhaskar V. K. S. Lakkakula1,3
Journal of Biomedical Science (2016) 23:1
DOI 10.1186/s12929-015-0217-0
11. Aldosterone synthase gene is not a major susceptibility gene for progression
of chronic kidney disease in ADPKD patients.
Gnanasambandan Ramanathan1, Ramprasad Elumalai2, Soundararajan
Periyasamy2 And Bhaskar V.K.S. Lakkakula1,3*
Saudi Journal of Kidney Diseases and Transplantation 2016
12. ECE1 gene variant shows tendency toward chronic kidney disease advancement
among autosomal polycystic kidney disease patients
Shiva Nagendra Reddy Annapareddya,VinuutnaSravaniKumbakonamb, Ramprasad
Elumalaia,GnanasambandanRamanathanc, SoundararajanPeriyasamya,
21
 Bhaskar V.K.S. Lakkakula
Hong Kong Journal of Nephrology (2016) 18, 20e25

13. Role of CYP2E1 (PstI/RsaI) gene polymorphisms on the tacrolimus drug toxicity of
kidney transplantations among South Indians
Gnanasambandan Ramanathan1*, Priya Sethumadavan1, Ramprasad Elumalai2,
Solomon Franklin Durairaj Paul3
ImmunopatholPersa. 2016;2(2):e20

14. Correlation of Serum Hepcidin Levels with Inflammation and Iron Status in
Patients withEsrdKalidindiRajaKarthik, ChandruT ,. Ram Prasad EVarun Kumar B
,Soudararajan P
INDIAN JOURNAL OF RESEARCH
Volume : 5 | Issue : 8 | August 2016

15. Influence of angiotensin converting enzyme (ACE) gene rs4362

polymorphism on the progression of kidney failure in patients
with autosomal dominant polycystic kidney disease (ADPKD)
GnanasambandanRamanathan, Santu Ghosh1, Ramprasad Elumalai2, Soundararajan
Periyasamy2 &Bhaskar V.K.S. Lakkakula
Indian J Med Res 143, June 2016, pp 748-755
DOI:10.4103/0971-5916.191992

16. Aldosterone Synthase Gene is Not a Major Susceptibility Gene for

Progression of Chronic Kidney Disease in Patients with Autosomal
Dominant Polycystic Kidney Disease
Gnanasambandan Ramanathan1, Ramprasad Elumalai2, Soundararajan Periyasamy2,
Bhaskar V. K. S. Lakkakula1,
Saudi J Kidney DisTranspl 2017;28(3):552-557
17.Assessment of Abdominal Aortic Calcification in PredialysisChronicKidney Disease
and Maintenance Hemodialysis Patients
Jagadeswaran Dhakshinamoorthy1, Ram Prasad Elumalai1, Bhawana Dev2, A. J.
Hemamalini.3,P. M. Venkata Sai2, Soundararajan Periasamy1Saudi J Kidney Disease
Transplant 2017;28(6):1338-1348

18. PPARG genotypes are not a major modifiers of chronic kidney disease progression
Am-ong the diabetic nephropathy patientsMookambika R. Velayuthan1,2, Ramprasad
Elumalai1, SoundararajanJ Renal Endocrinol2018;4:e12.

22
19. Fungal peritonitis in continuous ambulatory peritoneal dialysis patients; a study
From- South of IndiaRenukaprasadYelahanka Suryanarayana1, Indhumathi
Elumalai2, Gnanasambandan Ramanathan3, Ramprasad Elumalai1*, Jayakumar
Matcha1ImmunopatholPersa. 2018;4(2):e15

20. Renal transplant in elderly: a viableOption?

RamprasadElumalai
INDIAN JOURNAL OF RESEARCH Volume-7 | Issue-3 | March-2018

21.Association between end-stage diabetic nephropathy and MTHFR(C677T and

A1298C) gene polymorphismsNephrology(2018)

22. Insulin receptor gene polymorphisms modify the progression of kidney failure in
diabetic nephropathy patientsMookambika R. Velayuthan1,2, Ramprasad Elumalai1,
Soundararajan Periyasamy1, Bhaskar V.K.S. Lakkakula3,4J PrevEpidemiol.
2017;2(1):e06

23
 CURRICULUM VITAE CO-GUIDE

S.MEETHA
Mobile : 9994493228 E-mail: meethasenthilnathan@gmail.com
No: 1/512, Plotno: 42 2nd Main Road, AGS colony sabari Nagar extension
Mugalivakkam- Chennai -600 125

EDUCATIONAL QUALIFICATION:

 M.Sc.Renal Sciences and Dialysis Technology at Sri Ramachandra University,

Chennai (2012)
(First class and Topper)

 B.Sc. Allied Health Sciences (specialization in Renal Dialysis Technology) at

Sri Ramachandra Medical College and Research Institute, Chennai (2009)

PROFESSIONAL EXPERIENCE:

4 years of Teaching experience and 2 years of clinical experience

S.NO EMPLOYER DESIGNATION FROM TO

1 Sri Ramachandra Assistant Professor October 2019 Till Date
University Division of Renal Sciences
and Dialysis Technology
Faculty of AHS
2 Chettinad Hospital Lecturer in Renal Science December 2014 February 2017
and Research and Dialysis Technology
Institute, Padur
3 Chettinad Hospital Clinical Instructor Renal December 2012 November
and Research Science and Dialysis 2014
Institute, Padur Technology
4 Sri Ramachandra Junior Technologist Dialysis July 2009 July 2010
University Technology
5 Sri Ramachandra Dialysis Internee June 2008 May 2009
University

24
AWARDS:

 “Special capacity” for renal dialysis technology by National Curricula Review

Committee by Public health foundation of India, September 2014.

 “Best oral paper presentation award” for the paper “Assessment of

Arterio venous fistula using color Doppler ultrasound” in CARE at
Sri Ramachandra University, Chennai, 2013 – third prize

 “Excellence award” in written exam conducted by Society for dialysis technology

and paramedics conference at Madras Medical Mission,Chennai, 2012 –Fourth prize

COMMITTEE MEMBER:

 National Curricula Review Committee by September 2014

The Ministry of Health and Family Welfare.
National Initiative for Allied Health Sciences (NIAHS)
Public Health Foundation of India (PHFI) ISID Campus
Institutional Area,VasantKunjNew Delhi 110070,
Government of India.

 Society for dialysis technology and paramedics, MMM hospital, Chennai 2012

 Life time member in “Allied Health professional association”

PROJECTS:

 In under graduation “Relation between Intradialytic weight gain and

Nutritional Marker in hemodialysis patients”April 2009

 In post-graduation “Assessment of Arterio venous fistula using Doppler

Ultrasound in maintenance Hemodialysis Patients” June 2012

PAPERS PRESENTED IN CONFERENCES:

 Assessment of Arterio venous fistula using Doppler Ultrasound in maintenance

Hemodialysis Patients in CARE 2013

 Double Filtration Plasmapheresisin continuing dialysis educationProgram 2012at

Sri Ramachandra university

 Relation Between Intradialytic Weigh Gain And Nutritionalmarkers In

Hemodialysis Patients in Indian Society of Nephrology 2011

25
POSTER PRESENTATIONS

 “Relation Between Intradialytic Weigh Gain and Nutritional Markers In

Hemodialysis Patients”in Indian society of nephrology (Southern chapter) conference,
held at Pondicherry in February 2010.

PUBLICATIONS

 Assessment of Level of Depression in Maintenance Hemodialysis patient in a

Tertiary care Centre, Jagadeswaran D, Padma J,Meetha.s, IndhumathiE,Georgi
Abraham, Soundararajan P
Indian Journal of Nephrology, Volume 17, Issue 3, Pg 128, July 2007(Abstract)

CONFERENCE ATTENDED

 9th Annual Conference of Society of Dialysis Technology held at MMM Hospital

Chennai June 2015
 National Curricula Review Committee by at Amrita Institute of Medical Sciences,
cochin, Kerala in September 2014
 8th Annual Conference of Society of Dialysis Technology held at MMM Hospital
Chennai May 2014
 Continuing Allied Health research Education, CARE 2013 CME held at Sri
Ramachandra Medical College and research institute, Chennai, September 2013
 7th Annual Conference of Society of Dialysis Technology held at MMM Hospital
Chennai June 2012
 Continuing dialysis education program held at Sri Ramachandra University,
Chennai April 2012.
 Indian Society Of Nephrology – southern chapter 32nd annual conference held at
Chennai, February 2012.
 6th Annual conference of Society for Dialysis Technologists and Para medicals,
Chennai May 2011
 International Society of Nephrology and peritoneal dialysis society of India
(PDSICON 2011) 14th annual conference, the madras medical mission hospital,
Chennai, October 2011.
 Chennai science festival by Chennai science city and Department of higher
education Government of Tamil Nadu, February 2011.
 Peritoneal Dialysis Society of India held at St. John ’s medical college hospital,
Bangalore, September 2010.

26
 Indian Academy of Nephrology and Indian Medical Association (IMA) held at
Sri Ramachandra University, Chennai, and April 2009.
 National seminar on kidney and cadaver transplant update and transplant
coordination workshop held at Sri Ramachandra University, Chennai, and April
2008.
 Continuing Allied Health research Education, CARE 2007 CME held at Sri
Ramachandra Medical College and research institute, Chennai, and September 2007.
 Continuing Allied Health research Education, CARE 2006 CME held at Sri
Ramachandra Medical College and research institute, Chennai, and September 2006.

 Continuing Allied Health research Education, CARE 2005 CME held at Sri
Ramachandra Medical College and research institute, Chennai, and September 2005.
 Work shop on soft skills by Collage of Allied Health Science held at Sri
Ramachandra Medical College and research institute, Chennai, and August 2005.

27
 CURRICULAM VITAE

Name : MUTHAMIZH.M

Date of birth : 28.06.1997

Citizenship : Indian

Languages Known : Tamil, English (To Read, Write, Speak and Understand)

Permanent Address : AATHUMEDU VILL, JAMANAPUDHUR POST

TIRUPATTUR DIST 635652

Mobile Number : 9092133946

E-Mail Address : muthamizhhene@gmail.com

Educational Qualifications : BSc AHS Renal Dialysis Technology,

MSc Renal Science and Dialysis Technology Pursuing.

College : Chettinad Academy of Research and Education (B Sc),

Sri Ramachandra Institute of Higher Education and Research
(M Sc)

28
Checklist for the guides of students while forwarding the application to the IEC

1. Protocol is complete Yes/No

2. Objectives clearly defined Yes/No
3. Methodology is described in detail Yes/No
4. The proposed methods will answer the research question Yes/No
5. Statistical method for sample size estimation/analysis spelt Yes/No
Out

6. Informed consent Yes/No

Patient information sheet and informed consent forms are
attached (English and regional language)

7. If children <18 years consent from parent/guardian Yes/No

(Assent form from children 12-18 years)

8. Forwarding letter from the HOD and the guide Yes/No

9. Consent letter from other departments, if applicable Yes/No
10. Ethical issues addressed Yes/No
11. Relevant proforma / case record form attached Yes/No
12. Brief CV of the PI / Guideattached Yes/No
13. Brief CV of the Co-PI if applicableattached

Signature of the guide with date

29