Crystallization:

Crsysatallizaion is the process of formation of solid crystals from

solution , melt or by deposition directly from a gas phase.

The widespread use of crystallization within industry is in part due to the

fact that crystallization acts as both a separation and purification step;
almost all chemical processes utilize at least one crystallization step (either
as key separation mechanism or final product engineering).

How does the crystallization process occur?

The crystallization process consists of two major events:

 Nucleation – Molecules gather together in clusters in a defined

manner. Clusters need to be stable under current experimental
conditions to reach the “critical cluster size” or they will redissolve. It
is this point in the crystallization process that defines the crystal
structure.

 Crystal Growth – Nuclei that have successfully achieved the “critical

cluster size” begin to increase in size. Crystal growth is a dynamic
process, with atoms precipitating from solution and becoming
redissolved. Supersaturation and supercooling are two of the most
common driving forces behind crystal formation.
Development of crystallization processes represents a complex and
challenging issue, requiring simultaneous control of various product
properties, including purity, crystal size and shape, and molecular level
solid structure. The control of the nucleation phase is difficult but is the key
to process control; crystallization chemists usually aim to achieve goals of
high purity and high yield by solely using controlled cooling crystallization
techniques.