Beruflich Dokumente
Kultur Dokumente
(synaptic transmission)
Dr. Isabel Hwang
Dendrites
Axon Synaptic
Cell Myelin
body (speeds signal terminals
突觸末梢
transmission)
Synaptic transmission
突觸傳遞
Neurons communicate at synapses
Synapses are
junctions where
signals are
transmitted
between
9 two neurons
9 or between
neurons and
effector cells
Synaptic transmission
Synapses are interaction points 交互作用點
within the nervous system
Dendrites
Myelin
sheath
Receiving
cell body
Axon
Types of synapse
Electrical synapses
9 Electrical signals pass between cells
Chemical synapses
9 Sending (presynaptic) cell secretes a chemical signal,
a neurotransmitter
9 The neurotransmitter crosses the synaptic cleft
9 The neurotransmitter binds to a receptor on the
surface of the receiving (postsynaptic) cell
Electrical Synapse 電突觸
Not as common as chemical synapse
Gap junctions 縫隙連接 connect presynaptic membranes
with postsynaptic membranes
Gap junctions have pores that allow ions to flow between
the two cells
Very efficient propagation of action potentials
9 Formed by
connexin proteins
9 Found in smooth
and cardiac
muscles, brain, and
glial cells 神經膠質
細胞 (to sustain
neurons)
Chemical synapses make complex
information processing possible
Some neurotransmitters
1. Excite the receiving cell
2. Inhibit the receiving cell’s activity by
decreasing its ability to develop action
potentials
Sending neuron 1
Action
Vesicles potential
Axon of arrives
sending Synaptic
neuron terminal
Synapse
2
3
Vesicle fuses
with plasma Neurotransmitter
membrane is released into
synaptic cleft
Synaptic
cleft
Receiving 4
neuron
Receiving Neurotransmitter
neuron Neurotransmitter binds to receptor
Ion channels molecules
Ions
Myelin
sheath
Receiving
cell body
Axon
Synaptic
terminals
Amount of NT released depends upon frequency of APs
Acetylcholine (Ach) 乙醯膽鹼
Most widely used neurotransmitter
9 used in brain and autonomic nervous system
9 used at all neuromuscular junctions
Ligand-Gated
Channels
Excitatory
PostSynaptic
Potential