Beruflich Dokumente
Kultur Dokumente
importance, the presence of diffusely enlarged thyroid pain, in which the autoimmune
disorder of the immune system creates antibodies that damage the thyroid gland. And the
release of hormones that cause hyperactivity of the gland is called hyperthyroidism, the latter
produces inflammation that prevents the thyroid gland from producing enough hormones
called hypothyroidism, a combination of factors including hereditary factors, sex and age,
could determine the probability of that if you suffer from this disorder referring to (Ross DS,
Burch HB, Cooper DS, et al. 2016 American Thyroid Association Guidelines for Diagnosis
and Management of Hyperthyroidism and Other Causes of Thyroid. 2016), the diagnosed
criterion is thyroiditis that occurs in the thyroid gland, which is an organ that produces
hormones that play an important role in metabolism and the function is that the follicular
cells and the thyroid gland are produced, stored and released in the blood thyroid hormones,
also known as T3 ´´triiodothyronine´ ´ and T4 ´´tiroxina´´, very similar to each other and
Some of your thyroiditis symptoms may be fatigue, heat intolerance, cold feeling, or
excessive sweating. This disease is frequently diagnosed today, they are not usually difficult,
if they alter people's lifestyle and cause concern. Both aesthetic and general health problems
can be distressing, however, a patient with adequate information about their disease can
adequately manage their disease without major consequences for their body, whose proper
diagnosis and treatment can prevent the devastating and irreversible effects, the Pathological
anatomy according to Edward C. Kendall (Nobel laureate years later for his discovery of
the follicles by multinucleated giant cells, with the formation of granulomas and presence of
applied, that is, the use of the discipline that allows computer tools to be applied to the study
and management of biological data, where various areas of knowledge interact, such as
computing, statistics and chemistry, which collects the storage, organization, analysis,
bioinformatics, the thyroglobulin protein will be examined to also analyze the structure of
thyroiditis, in addition a chemical reaction will be identified and what deficiencies within the
human body.
Materials and methods
The revelation of the complete sequence of the human genome allows knowing the
between people for the development of diseases and the disease to be treated is thyroiditis,
This project is going to be carried out, which can be defined as the understanding of
how genetic variants according to (National Institute for Human Genome Research, NHGRI),
that is, with the support of miles of research that they have done, by
capture, organize, analyze, and distribute biological information for the purpose of answering
Using some applications, we are going to delve into the disease and analyze the structure of
thyroiditis and while it is true that there are miles of proteins that can be found in an organism
and in the thyroid there is thyroglobulin produced by thyroid cells. . Where the activity of the
thyroid hormone T4 or thyroxine depends on the very intense form of body temperature, the
states of lethargy of hibernating mammals, we can refer to the materials as the development
and implementation of tools that affect access, use and management. of various types of
information, which will be used by the ncbi platform, uniprot to use them as the source of
information, and molecular viewers such as pymol to analyze the structure to see a detail of
its compound, both the thyroid hormone protein and thyroiditis disease to know how it affects
this part of the body. Where would be the simulation of artificial life systems, which includes
platforms such as NCBI, which is the one that completes the function of being an important
source of molecular biology information and we also offer some bioinformatics tools for the
analysis of DNA sequences. , RNA and proteins, BLAST being one of the most used.
Another of these platforms is Uniprot, this is that database of free access to protein sequence
and functional information, many entries that are derived from genome sequencing projects.
It is the thyroid-specific protein, the main component of the colloid, which constitutes 75% of
the proteins. Thyroglobulin incorporates, for which it requires the enzyme thyroid peroxidase
and H2O2. Thyroid hormones T4 and T3 are formed within thyroglobulin after a coupling
process between its precursors. The thyroid protein in which it is located is called
Thyroglobulin in which from the ncbi which can be said to be T4 as a scientific name could
be found where (Jacobs D.S., Demott W.R. Grady H. et al., Laboratory Test Handbook, Edit
´´660.000 D ´´s synthesized and secreted specifically by the thyroid follicular tissue.
Quantitatively it represents the most important protein of this gland. It is used as a matrix for
the synthesis of thyroid hormones and provides a storage of thyroid hormones in the follicular
conditions.
Results:
tissue, to say how much is the molecular weight of this protein, it is wanted to clarify that,
Kilodalton is a unit of molecular mass equivalent to 1,000 daltons, where the molecular
weight would be 69 KDa, and to say how many amino acids the protein has, I have to say that
an amino acid is an organic molecule with an amino group (-NH2 ) and a carboxyl group
(-COOH), these are the basis of proteins, in which the function is the optimal transport of
nutrients and the optimization of the storage of all nutrients, and this protein is composed of
610 amino acids, a component The main colloid, which constitutes 75% of the proteins,
thyroglobulin incorporates I-, for which it requires the enzyme thyroid peroxidase and H2O2.
Thyroid hormones T4 and T3 are formed within thyroglobulin after a coupling process
between their precursors MIT (monoiodotyrosine) and DIT (diiod tyrosine). The
thyroglobulin (TG) gene is organized into 48 exons, that is, the portion of the gene that
studies identify susceptibility loci for multiple common infections), identified and
characterized new mutations in the TG gene, reported eight patients from seven families not
related to goiter, hypothyroidism and low serum TG levels. Molecular analyzes revealed
and c.7093T> C [p.W2346R], and four previously reported mutations: c.378C> A [p.Y107
*], c.886C> T [p.R277 *], c.1351C> T [p.R432 *] and c.7007G> A [p. R2317Q]. (National
With this it can be deduced that the genetic heterogeneity of the TG defects and the
The applications with which they can interact are diverse in the biological part, and the
molecular vializers are diverse, in this investigation the pymol application was used, which
allowed us to see the molecule and in this case we visualized the thyroglobulin protein, where
this protein comes from the thyroid gland and characteristics were shown, that is, the analysis
process was carried out, since the amino acids and the weight of the thyroglobulin protein
were examined. The result of the study allowed an analysis of the protein and a greater
knowledge of thyroid disease in the thyroid gland, the same access to the multiple
bioinformatics allowed to summarize the information in a faster and more efficient way to
carry out the research, this topic is important in what is the development of biology, that is,
an advance in every sense, through these tools You can strengthen the understanding of new
issues or problems that are taking place.To finish I want to say that the natural process that
the body has when it gets sick is great in all the structure that divides, where we believe that it
is little, but it is not true, in conclusion of the thyroid, it is that the gland is important since it
is capable of secreting and producing and storing two hormones, thyroxine and
thiodothyroidine.
Bibliography
➢ Coscia, F., Taler-Vercic, A., Chang, V.T., Sinn, L., O'Reilly, F.J., Izore, T., Renko,
M., Berger, I., Rappsilber, J., Turk, D., Lowe, J. (2020) Nature 578: 627-630
➢ Endocr Rev. 2016 Feb;37(1):2-36. doi: 10.1210/er.2015-1090. Epub 2015 Nov 23.
➢ Siffo, Sofía; Adrover, Ezequiela; Citterio, Cintia Eliana; Miras, Mirta Beatriz; Balbi,
Viviana A.; Chiesa, Ana Elena; Weill, Jacques; Sobrero, Gabriela; González,
Rogelio; Rivolta, Carina Marcela; Targovnik, Hector Manuel (2017) Conicet digital