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emtabUlIs

1- esckþIefþIm :famBl nigemtabUlIs :


2- KøIkUlIs
3- KøIkUEsnemtabUlIsnigkMNkKúøykUs
4- vdþsuIRTikGasuIt
5- kardwknaMeGLicRtugnigpUsVrIlkmµGuksuItkmµ
6- lIBItemtabUlIs
7- eGtaNulemtabUlIs
8- GamINUGasuItemtabUlIs
9- nuyekøGUTItemtabUlIs
10- karrMlay nigkarRsUbsmasFatuGahar
Heng Savoeun/2009 1
Heng Savoeun/2009 2
karrMlayGahar
Ù smasZatuGaharRtUv:ner[bcMedaysmµPaBGg´suImy¨agNa EdlvaGac
RtUv:nRsUbykenA~geBaHev[ntUc

Ù RbEvgéneBaHev[ntUcTaMgmUlCaGñkTTYlxusRtUvsMrab´dMeNIrkarRsUbenH

Ù mYyEpñkZMénsmasZatuGaharRtUv:nRsUbenA~g duodenum(30cm)
nig jejunum(120cm )

Heng Savoeun/2009 3
karrMlayGahar

Heng Savoeun/2009 4
karrMlayGahar

Ù karrMlayGahar KWrYmTaMgkarkat´bMEbkGaharedayemkanic nig


Gg´suIm RBmTaMgkarRsUbykplitplbMEbkpgEdr

Ù bnÞab´BIkarbMEbkGaharCatUc>edayemkanictamkarTMBarmk dMeNIr
karkat´edayGg´suIm k¾bnþtamry;karlayGaharCamYyGg´sm uI

Ù Gg´suImsMrab´rMlayGahar KWCa hydrolaseEdleRbImU¨elKulTwk

Heng Savoeun/2009 5
GuIRdUlIs nigkarRsUbyk
smasPaKGahar

Heng Savoeun/2009 6
kabUGuIRdat
ÙGg´suIm EdlTTYlxus
RtUv~gkarbMEbkenH
dUcCa amylo-1,6-α
glucosidase,
isomaltase, maltase,
lactasenig saccharase
zitenA~g mucosacell

Heng Savoeun/2009 7
karxVH disaccharidase naMeTArkCMgWrak
Ù karrMxanénkarrMlay nigkarRsUbykkabUGuIRdat RtUv:nRtLb´mk
rkkarbnæyskmµPaB rWk¾karxVHTaMgRsugén disaccharidase
Ù ebIsin disaccharide minRtUv:nrMlayenaH vak¾minRtUv:nRsUb
ykEdr ehIyvaZøak´eTA~geBaHev[nZM
Ù enATIenaHvabg,eGaymanCMgWrakGUsµÚ‘osmotic diarrhoe) ehIy
nigkarbeJ©jxül´edaysarel|Igén:k´etrI~geBaHev[n

ó karxVH lactase bNþaleGay lactose minRtUv:nbMEbk ehIyk¾


minRtUv:nRsUbyk rYcvabg,eGaymanCMgWrak eRBaHza ;
1- mUlehtusMBaZGUsµÚ enaH lactose rkSaTwkenA~geBaHev[n
2- :k´etrI~geBaHev[nbMElg lactose eTACasarZatuBul

Heng Savoeun/2009 8
RbB½n§dwkCBa¢ÚnyfaRbePT RtUv)an
TamTarsMrab;karRsUbykmU:NUsakarIt
Ù GuicsUsepSg> dUcCa KøúykUs RPuctUs nigkaLak´tUs RtUv:n
RsUbykedayel|}nxusKñaEdlmann&yza reb[bdwkCJ¢ÚnsMerceTA
edayeyagtamTMrg´mU¨elKul
ó D-glucose RtUv:nRsUbyk cMENkÉ L-glucose minRtUv:n
RsUbykeT
Ù kardwkCJ¢ÚnmU¨NUsakarItskmµ RbRBwtþeTAEt~gvtþmanrbs´
GuIyu¨gsUdüÚm
Ù mU¨NUsakarItEdlRtUvdwkCJ¢Ún nigGuIy¨ugsUdüÚm :npþMúKñaedaybeg,It
CakuMepøcCamYymU¨elKulGñkyYr‘carrier molecule’ enAEpñkxagRb
ehagrbs´ mucosacell

Heng Savoeun/2009 9
RbB½n§dwkCBa¢ÚnyfaRbePT RtUv)an
TamTarsMrab;karRsUbykmU:NUsakarIt
Ù edaysarkMhab´sUdüÚmenAkñúg mucosacell TabEdlCalTÆpl
énskmµPaBrbs´ Na+ / K+-ATPase EdlzitenAEpñkxagQam
enaHsUdüÚmk¾GachUrtambeNþayCMraleGLicRtUKImI‘electroche-
mical gradient) kat´tamPñascUleTAkñúg mucosacell
RBmTaMgykeTACamYynUvmU¨NUsakarIt EdlenAEk|renaH
Ù clnkarénkardwkCJ¢ÚnenH eZVIkarrhUtdl´za kMhab´sUdüÚmkñúg
ekasika RtUv:nrkSaeGayenATabtamry;karbUmsUdüÚm-kal´süÚm
EdlGaRs&ynwg ATP
Ù dMeNIrkarenHnwgminRbRBwtþeTAeT[teT ebIsinskmµPaBrbs´vaRtUv
:nbgÁak´edaysarZatubgÁak´ dUcCa ouabain(RbECgCamYy K+
edIm|Icab´ykkEnøgcgP©ab´’

Heng Savoeun/2009 10
clnkarénkarCBa¢ÚnKøúykUsskmµTI2
(second active glucose transport) enAkøúgeBaHevon

EpñkxagsrésQam ~gekasika mucosa GJ©aj RbehageBaHev[n

•Glucosetransportercg
P¢ab´KøúykUsnigsUdüÚmCa
kuMepøcenAxagRbehag eBaHev[n
•CMralkMhab´rvagsUdüÚm
~gRbehag nig~gekasika
naMeTArkzamBlesrI
sMrab´kardwkCJ¢ÚnKøúykUs
RcasCMralkMhab´

Heng Savoeun/2009 11
xøaj;
Ù xøaj´‘triacylglycerine, kUelesþru¨lk¾dUc vItamIn A, D, E nig K
Edlrlaykñúgxøaj´’ Edl:nTTYlykCamYyGahar RtUv:neZVI
eGayGacRsUbyk:nedaykarbMEbk k¾dUc emulgation enAkñúg
RbehageBaHev[n
Ù bnÞab´BIkarRsUbykeTAkñúg mucosacell mk mankarsMerceLIg
nUvkarsagsg´CazµIénxøaj´kñúgTMrg´mYysmRsbsMrab´kardwkCJ¢Ún

kñúgQam

Heng Savoeun/2009 12
triacylglycerine énGaharRtUvbMEbkeday lipase
énlMEBg
Ù karbMEbkxøaj´enAkñúgRbehageBaHev[nRtUv:nkatalIsedayGg´suIm
lipase eTACabMENkduM>
Ù karrMlay triacylglycerine beg,It:n β-monoacylglycerine nigGasuItxøaj´
Ù vtþmanénGasuItTwkRbmat´ sMrab´karbeg,It micelle KWsMxan´Nas´
sMrab´karRsUbykénkUelesþr¨ul nigvItamInrlaykñúgxøaj´
Ù micelle TaMgGs´ekItmaneLIgenAb¨HnwgGJ©ajén mucosacell Edl
kEnøgenaHRtUv:nERbZatu nigZatupSMepSg>én micelle RtUv:nRsUbykmþgmYy>

Heng Savoeun/2009 13
karRsUbykxøaj;

Heng Savoeun/2009 14
karsMeyaKeLIgvijén triacylglycerine k¾dUc
kardak;pþúMKñaén chylomicrone sMerceLIg
enAkñúg mucosal celle
Ù karRsUbykGasuItxøaj´ monoacylglycerine, kUelesþru¨l nig
vItamInrlaykñúgxøaj´cUleTAkñúg mucosal cell sMerceTAtamry;
karsayPaygay
1- β-monoacylglyceride Edl:nRsUbykmkBIRbehageBaHev[n
GacRtUvrgRbtikmµeGEsÞrkmµpÞal´CamYyGasuItxøaj´kñúgTMrg´skmµ ‘acyl-CoA’
2- sMrab´clnkareGEsÞrkmµeLIgvijkñúg mucosacell mankarsMeyaK
triacylglycerine ecjBI α-glycerophosphatenig acyl-CoA

Heng Savoeun/2009 15
karbMEbk nigkarsMeyaKén triacylglycerine
kñúgeBaHevon
lumen lymph path

Heng Savoeun/2009 16
CIvsMeyaK nigkarbeBa©jén chylomicrone kñúg
mucosal cell énEs,kGn§Wlrbs; duodenum
chylomicroneekIteLIgenA~g mucosacell én duodenum
Ù triacylglycerineEdl:nbMEbk~geBlRsUbyk sMercnUvkar
sMeyaKeLIgvijedaykarpþMúén cholesterol triacylglycerine nig
phosphoglyceride CamYy apolipoprotein AI, AII nig B48
Ù kEnøgénkarpþúMenHKW golgi-body én mucosacell
Ù ecjBI golgi-bodyKW chylomicroneRtUv:nrkSaTuk~g
secretegranular rYck¾RtUv:nbeJ©jeTA~g extracellular
room tamreb[b exocytosis
Ù enAkEnøgenaHvak¾:nRbmUlpþúMKñaenA~gpøÚvcUlén lymph rbs´eBaH
ev[n rYck¾eTAdl´ lymph vessel

Heng Savoeun/2009 17
CIvsMeyaK nigkarbeBa©jén chylomicrone kñúg mucosal
cell énEs,kGn§Wlrbs; duodenum

Heng Savoeun/2009 18
karrMlayRbUetGuIn
Ù karbMEbkRbUetGuInRbRBwtþeTACaeRcIndMNak´enA~gRkBH nig
eBaHev[ntUc edaysar«TÆiBlrbs´ proteinase nig peptidase
Ù ~gRkBH RbUetGuInTTYlnUvkarbMEbkCaelIkdMbUgeday pepsin
Ù vamancMnYnRbEhl10PaKryénsm¬&nÆbuibTIt RtUv:nkat´pþac´Edl
eZVIeGayRbUetGuIndac´Cakg´>

Ù bnÞab´mkenA~geBaHev[n trypsin nig chymotrypsink¾dUc


peptidase epSg>eT[tEdlmanenA~glMEBgnigrMGileBaHev[n
kat´pþac´rhUtdl´GamINUGasuIt nigbuibTItxøI>EdlGacRtUvRsUbeday
Es|kRsTab´esþIgéneBaHev[g ehIyenA~g mucosal cell k¾
mankat´pþac´buibTItxøITaMgenaHeTACaGamINUGasuItbnþeT[t

Heng Savoeun/2009 19
karrMlayRbUetGuIn nigkarRsUbykGamINUGasuIt nig
oligopeptide

Heng Savoeun/2009 20
PaBsauMGkmµ (passive immunity)
Ù cMeBaHmnusSeBjv&y Es|kRsTab´esþIgéneBaHev[nCaZmµta minGnujati
eGayRbUetGuInRCabqøgkat´:neT
Ù enHKWCakarkarBarxøÜnRbqaMgTl´nwgkarcUlénRbUetGuInxageRkA EdlGac
bg,eGaymankareqøIytbnUvRbB&nÆsuaM‘immune)
Ù cMeBaHTarkeTIbnwgekIt Es|kRsTab´esþIgéneBaHev[n ‘mucosal cell’
GacTajykRbUetGuIntamdMeNIr pinocytosis
Ù enAelImUldðanenH antibodyénmþayEdlmanvtþmanenA~gTwkedaH
dMbUgRtUv:ncMlgeTAeGayTark

ehtuenH stVeTIbnwgekItk¾mansarZatusauM‘immune substance)


EdlenA~g:øsµarbs´vaminTan´manenAeLIy
→ PaBsauMGkmµ‘passive immunity)

Heng Savoeun/2009 21
rYsxøaMgRbqaMgnwgRbUetGuIn

Ù karekIneLIgénkarRCabqøgkat´Es|kRsTab´esþIgéneBaHev[n GacbNþal
mkBICMgWmYycMnYn nigCamUlehtusMrab´

karrYsxøaMgRbqaMgnwgRbUetGuInGahar

Heng Savoeun/2009 22
oligopeptide
RtUvRsUbykedayRbB½n§dwknaMEdlGaRs½y H+

Ù GMBIclnkarénkarRsUbykGamINUGasuIt nigbuibTIt eKdwgza;

Õ vaRbRBwtþeTAtamry;dMeNIrkarskmµEdlmann&yza RcasCMralkMhab´

Õ mYyEpñkZMénRbUetGuInGahar minRtUv:nTTYlyk~gTMrg´CaGamINUGa
suItesrIeT BiessRtUv:nTTYlyk~gTMrgD´IbuibTIt nigRTIbuibTIt

ehIyk¾GacCa tetrapeptideEdreday mucosal cell


→ eRBaHeK:nrkeXIjza kMhab´rbs´DIbiubTIt nigRTIbuibTItenA~g
Rbehagén duodenumeKWBI5eTA10dgZMCagkMhab´rbs´GamINUGasuIt
esrI dUcenH el|}nRsUbDIbiubTIt nigRTIbuibTIt KW el]nCagel|}nRsUb
GamINUsuIt

Heng Savoeun/2009 23
clnkarénkarRsUbyk peptide
rW peptideantibiotic eday mucosacell
→ edayehtuenH eKGacyl´:nza buibTItEdlRtUv:nRsUb
ykRtUv:nkat´pþac´enAxag~gekasikaCaGamINUGasuItesrI
→ bnÞab´mkRtUv:nbeJ©jBIkEnøgenaH eTA~gEv¨nTVarezøIm

kardwkCJ¢Ún RbRBwtþeTA
R:sCMralkMhab´Ca
lk¡N; protonecotransport

Heng Savoeun/2009 24