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Pathology
1. Lepromin test is strongly positive in - Tuberculoid leprosy
2. Lish nodules seen in - Neurofibromatosis
3. Chromosomal abnormalities can be diagnosed by - FISH/G banding/PCR
4. Immediate post traumatic massive blood loss leads to - Reticulocytosis
5. Platelets are stored in - Room temperature
6. MC type of Esophageal Ca overall - Adenocarcinoma
7. MC type of oesophageal Ca in India - Squamous cell Ca
8. Chronic gastric reflux - Barrett’s esophagus - Adenocarcinoma
9. Acute inflammation pain is mediated by - Bradykinin
10. Richest source of Histamine - Mast cells
11. Richest source of serotonin - Platelets
12. Cytokine responsible for inflammation is - Interleukin-1
13. First response to hemorrhage is - Tachycardia
14. Most affecting cell in case of HIV is - CD4 T cells
15. MC neoplastic disease in AIDS - Kaposi sarcoma
16. MC lung carcinoma in smoker - Squamous cell Ca
17. MC lung Ca in non smokers & Females - Adenocarcinoma
18. MC type of Emphysema – Centri acinar - occurs in upper lobe
19. Most specific antibody in SLE is - Anti double stranded DNA antibody
20. Anti smith Ab/anti nuclear Ab/anti ds DNA Ab seen in - SLE
21. Phagocytosis enhanced by coating the surface of antigen is called - Opsonisation
22. Which is not Vitamin K dependent factor - Factor VIII
23. MC site for liquefactive necrosis - Brain
24. MC organ affected by fatty change – Liver
25. MC cause of fatty change is - Alcoholism
26. MC organ to be affected by hypoxia - Heart
Pathology

27. Reye’s syndrome is associated in - Salicylate poisoning

28. Perl’s stain-Prussian blue reaction is used to demonstrate is - Hemosiderin
29. Mccalum’s patch is seen in - Left atrium
30. MC tumour in children heart - Rhabdomyosarcoma
31. MC congenital cardiac malformation - VSD
32. Least common cardiac congenital malformation - ASD
33. DOC to relieve pain in MI - Morphine
34. MC organism of lobar pneumonia - Streptococcus pneumonia

Pathology
Davinci Medical Academy
35. MC site of metastasis of Ca lung is – Liver
36. Small cell carcinoma - Oat cell carcinoma
37. Tumor of lung best prognosis - Squamous cell carcinoma
38. Commonest cancer in which metastasis is seen in brain - Lung Ca
39. Metastasis to the heart commonly in - bronchogenic Ca
40. Metastasis of small cell carcinoma lung - Liver
41. Commonest site of metastasis - liver
42. Bony metastasis is not seen in - Testis Ca
43. Small cell cancer commonly metastases to - Liver
44. Metastasis to heart are mostly from - Breast
45. In smokers Ca lung is - small cell Ca
46. Small cell carcinoma - Oat cell carcinoma
47. MC cause of fatty change is - Alcoholism
48. MC organ to be affected by hypoxia - Heart
49. Tumor of lung best prognosis - Squamous cell carcinoma
50. Mc callum’s patch is seen in - rheumatic fever/left atrium
51. Papillary necrosis is seen -DM/analgesic nephropathy/sicklecell anemia/Ac. Pyelo-
nephritis
52. Micronodular cirrhosis is seen in - alcoholic cirrhosis
53. Pathological change of liver cells in acute viral hepatitis - ballooning degeneration
54. Typhoid ulcer is - peyer’spatch/longitudinal/may perforate/stricture is rare
55. Direct coomb’s is +ve in hemolytic anemia due to - paroxysmal cold hemoglobin-
uria
56. Russel bodies-multiple myeloma/intracellular accumulation of protein
57. Glomerulosclerosis is a feature of - DM/HTN
58. Characteristic pathologic features in malignant HTN - fibrinoid necrosis
59. Type of Ca breast occuring b/l - lobular Ca
60. Giant cell foreign body - Tb syphilis/leprosy/60-100 nuclei
61. MC type of salivary neoplasm - mixed cell parotid neoplasm
62. Bone tumor arises from epiphysis - osteoclastoma
Pathology

63. Bone tumor arises from metaphysis - osteogenic sarcoma

64. Bone tumor which is hormone dependent - fibrous dysplasia
65. Microscopic pic. of seminoma testis-sheet of lymphocytes in homogenous back-
ground
66. Amyloid is best identified by - green perfringens viewed by polarising microscopy
67. Amyloidosis most commonly affects - Liver
68. secondary amyloidosis is seen with - TB/leprosy/RA/osteomyelitis
69. Amyloid stroma is seen in - medullary Ca thyroid

Pathology
 70. Syphilitic aneurysm mostly involves - arch of aorta
71. True blood cells are - RBC
72. Commonest type of Hodgkin’s lymphoma - nodular sclerosis
73. Type of Hodgkin’s lymphoma with best prognosis - lymphocytic predominant
74. Auer rods are seen in - AML-M1 & M3
75. Philadelphia chromosome is - translocation from chromosome 22 to 9/seen in CML
76. Commonest type of bronchogenic carcinoma - Adenocarcinoma
77. Gandy gamma bodies are seen in - sickle cell anemia
78. Transudative ascites is seen in - nephrotic syndrome / CCF
79. Commonest type of nephrotic syndrome in children - Minimal change disease
80. Nephrotic syndrome is caused by - malaria/penicillamine/syphilis
81. AFP is increased in-IUD/polycystic kidney disease/congenital nephrotic syndrome
82. Nephrotic syndrome - massive proteinuria/hypoalbnemia/hypercholesterolemia
83. Commonest site of TB of intestine - Illeum
84. Granulomatous disease - TB/leprosy/sarcoid
85. Characteristic feature of amoebic ulcer - flask shaped
86. Gall stones in hemolytic anemia are - Pigment
87. A person is labelled as hepatitis carrier if HbsAg is +ve after - 6 months
88. Disseminated intravascular coagulation causes - snakebite/malaria/polycythemia
89. Villous atrophy is seen in - celiac disease, giardiasis, tropical sprue
90. Test for thalassemia trait - HbA2

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91. Chronic constrictive pericarditis usually due to - TB/empyema
92. Lung abscess is common following - staphylococcal pneumonia
93. Precancerous lesions in GIT - ulcerative colitis/pigmentary cirrhosis/polyposis
coli/villous adenomas
94. Commonest variety of Ca stomach - Adenocarcinoma
95. Platelet function can be assessed by - clotting time
96. Good pasture’s syndrome is characterized by - necrotizing hemorrhagic interstitial
pneumonitis
97. Lipoma becomes malignant commonly at which site - retro-peritoneal
98. Commonest Ca in elderly male - Ca prostate
99. Fat necrosis is common in - breast/omentum/retroperitoneal fat
100. Piece meal necrosis is seen in - chronic active hepatitis
101. Pheochromocytoma arises from-adrenal medulla/extra adrenal site/sympathetic
chain
102. Renal papillary necrosis is seen in - DM/analgesic abuse/sickle cell anemia
103. Commonest cause of renal papillary necrosis - analgesic nephropathy
104. Unconjugated hyper bilirubinemia is seen in - gilberts
105. Carcinogens - asbestos/alkylating agents/benzene
106. Transitional cell Ca caused by - napthylamine/smoking/bilharziasis
107. Pseudo polyps are seen in - ulcerative colitis
108. Radiation can cause - acute leukemia/papillary Ca thyroid
109. Worm causing myocarditis - Trichinella
110. Malaria affects - brain -liver-spleen
111. MC complication of infective endocarditis - thromboembolism
112. Diabetic gangrene is due to - atherosclerosis
113. Urine findings in SLE - proteinuria
114. Hypersensitivity angitis is seen in - Henoch scholein purpura
115. Liquefactive necrosis occurs in - Brain
116. Mallory hyaline found in-alcoholic cirhosis,indian childhood cirrhosis/wilson’sdis-
ease
Pathology

117. Epithelium in the ureter is - Transitional

118. Commonest complication of TB meningitis - cerebral infarction
119. Labile cells - bone marrow cells/epidermal cells/living cells small intestine
120. Antiglomerular antibodies are present in - good pasture syndrome
121. Commonest cause of cerebral infarction - Embolism
122. Atherosclerosis commonly affects - left anterior descending artery
123. Eosinophilia is a feature of - Aspergillosis
124. Splenectomy is useful in - spherocytosis

Pathology
 125. G6PD deficiency is inherited as - X-linked recessive
126. Predominant cell after 72 hrs of MI - Macrophages
Pathology
127. Kwashiorkor - fatty liver/edema/bitot’s spot
128. Addison’s disease - Hypoglycemia
129. Features of chronic alcoholic liver disease - fatty liver
130. Features of rheumatic heart disease - valvular involvement
131. Destruction of fat in acute pancreatitis is due to - lipase & trypsin
132. Alpha 1 antitrypsin deficiency occurs in - Emphysema
133. Cloudy swelling is due to - accumulation of water intracellularly
134. Hallmark of atherosclerosis histologically is - deposition of fat in intima
135. Chronic SDH is caused by - rupture of bridging veins
136. In thrombasthenia there is a defect in - platelet aggregation
137. Intracellular calcification begin in the - Mitochondria
138. MC islet tumor is - insulinoma
139. Rickets is due to - decreased absorption of calcium
140. Type of pericarditis in TB - Constrictive
141. MCC of aortic aneurysm - Trauma
142. Mallory hyaline bodies seen - alcoholic cirrhosis/1ry biliary cirrhosis/indian child-
hood cirrhosis
143. Late feature of multiple myeloma - renal failure
144. Locally malignant tumor - chordoma

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145. Preservative used for storing blood for transfusion is - CPD-A
146. Pancreas secretes - elastase, ribonuclease, colipase & not aminopeptidase
147. Commonest cause of intra cerebral bleed is - HTN
148. Liquefactive necrosis is common in- brain
149. Phagocytosis of TB bacillus does not occur because of - cord factor
150. Tree bark like calcification in chest x-ray is seen in - syphilitic aneurysm
151. Blood stored in CPD-A is - 35 days
152. Gastric ulcer is caused due to - decreased mucosal resistance
153. Raised serum ferritin is seen in - leukemia/CRF/RA
154. Auto immune hemolytic anemia is seen in - CLL
155. Most diagnostic test for SLE - antibodies against DNA
156. High dose radiotherapy causes pancreatic - Acinar defeciency
157. Polyarteritis nodosa is preceded by a history of - Bronchial asthma
158. Mesothelioma is - mostly malignant
159. Plasma cells are increased in - RA
160. Massive proteinuria is most likely to occur in - constrictive pericarditis
161. Cords of billroth in the liver are - Sinuses
162. Commonest variety of acute inflammation is - catarrhal inflammation
163. Soft granuloma is typically found in - Tuberculosis
164. Confirmation of myelofibrosis is by – Bone marrow biopsy
165. Large giant cells are found in - neonatal hepatitis
166. Greater risk of carcinoma of stomach is associated with - intestinal metaplasia
167. Common primary tumors of heart - Myxoma
168. Thyroglossal cyst may occasionally give rise to - Papillary Ca
169. Adenomyomas of gall bladder are always located in - Fundus
170. Primary tumors of veins are commonest in - Inf.vena cava
171. Dangerous complication in the 2nd week of massive MI - Rupture of the heart
172. Tylectomy literally means - Excision of a lump
173. Tuberous xanthomas in tendons are caused by - hypercholesterolemia
Pathology

174. Congo-red with amyloid produces - brilliant pink color

175. B/L contracted scarred kidney is seen in - chronic pyelonephritis
176. Hemodialysis associated amyloid is deposited in - Knee joint
177. Commonest histological type of Ca testis - seminoma
178. Red infarction is seen in - small intestine
179. Cells most sensitive to hypoxia are - Neurons
180. Chediak higashi syndrome is due to - defective phagocytosis
181. Soft granuloma is typically found in - Tuberculosis

Pathology
 182. Largest number of bone marrow cells are - meta myelocytes
183. Syphilis affects most commonly - ascending aorta
184. Marker for ovarian tumors - CA-125
185. Flame cells are seen in - osteosarcoma
186. Calcification in necrotic tissue called - dystrophic calcification
187. Phagocytic cells are - macrophages
188. Aschoff cells are - neutrophills
189. MC germ cell tumor - Teratoma
190. Glucose is indispensable source of energy for - erythrocytes
191. Hyperglycemia of 2 weeks old best IOC - glycosylated hemoglobin
192. MC tumor due to radiation arises from - Breast
193. Earliest response to iron therapy is - reticulocytes
194. Single plaque with satellite lesions is - Lepromatous leprosy
195. Bronchogenic cysts occur commonly in - carina
196. In brain phagocytosis is done by - Microglia
197. Sequestered lobe of lung is commonly supplied by - descending aorta
198. Lines of zahn is seen in - coralline thrombus
199. Pale infarct is not seen in - lung
200. Pale infarct is seen in - heart/spleen/liver
201. Damage to nervous tissue is repaired by - neuroglia
202. MC structural red cell defect without Hb abnormality - spherocytosis

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203. Flea bitten kidney is seen in - malignant HTN/PAN/infective endocarditis
204. Increased ESR is seen in - Multiple myeloma
205. MC site of MI - Anterior wall left ventricle
206. Gall stone formation is predisposed by - low lecithin to low cholesterol ratio
207. DIC is seen in - Ca pancreas/Leukemia/Snakebite
208. Predisposed to develop osteosarcoma - Paget’s disease of bone
209. Commonest route of infection in acute pyogenic abscess of liver - hematogenous
210. MC type of cell death due to sudden occlusion of blood supply - coagulation ne-
crosis
211. Acanthosis nigricans can occurs due to - keratinization of epidermal cells
212. Glanzmann’s disease is - congenital defect of platelets
213. Apple jelly nodule in nasal septum is seen in - Lupus vulgaris
214. Lacunar cells are found in which type of hodgkins - Nodular sclerosis
215. Grossly pigmented liver is seen in - Dubin jhonson syndrome
216. Lipid cast are seen in - Nephrotic syndrome
217. Cryoprecipitate is rich in factor - 8
218. Gingival biopsy is useful in diagnosis of - amyloidosis
219. Coagulative necrosis is seen in - Gangrene
220. Infective endocarditis in drug abuse commonly affects - Tricuspid valve
221. Chronic ITP is due to - antibody production against platelets
222. CEA (carcino embryonic antigen) is elevated in - alcoholic cirrhosis/Ca-colon/ul-
cerative colitis
223. Diagnostic feature of rheumatic heart disease in heart - Aschoff nodules in
myocardium
224. Severe MS is associated with - right ventricular hypertrophy
225. Most diagnostic special stain for Amyloid - congo-red in polarized light
226. B/l hilar lymphadenopathy wthi non caseous granuloma is suggestive of - sar-
coidosis
227. Hyaline in hyaline membrane disease is - Fibrin
228. Commonest malformation in a baby born to diabetic mother - congenital heart
disease
Pathology

229. Salt loosing nephropathy is - Intestinal nephritis

230. Medullary Ca of thyroid is associated with increase in - Calcitonin
231. First feature seen in iron deficiency anemia - low ferritin
232. Cause of renal damage in - septicemia - Acute tubular necrosis
233. Proximal convoluted tubule will be injured by - Arsenic
234. Epitheloid cell is a modified - Macrophage
235. Asbestosis is usually related to - Mesothelioma
236. Marker for vascular tumour - Keratin
Pathology
 237. Faeco-orally transmitted - Hepatitis A
238. Mycosis fungoides affects - T-cells
Pathology
239. Mucin producing glands seen in - esophagus/cervix/duodenum
240. AIDS involves - T-helper cells
241. MCC of aneurysm - Atherosclerosis
242. Serum marker of rickets - alkaline phosphatase
243. Philadelphia chromosome is an example of - balanced translocation
244. Plasma alkaline phosphatase is highest in - biliary cirrhosis
245. Concentric hypertrophy is caused by - malignant HTN
246. Initial site of intra cellular calcification - mitochondria
247. Laminin is present in - basement membrane
248. Hairy cell leukemia affects - B cells
249. Myxoma is seen in - left atrium
250. Myotonic dystrophy is inherited in chromosomes - 19
251. Lewy bodies are seen in - Parkinsonism
252. Howell jolly bodies are seen after - Splenectomy
253. AFP is increased in - endodermal sinus tumor
254. Clara cells are seen in - bronchioles
255. Glioma of optic nerve is usually - pilocytic
256. ANCA is pathognomonic of -wegner’s granulomatosis
257. ANCA is sensitive & specific for the diagnosis of - idiopathic crescentic nephritis
258. Interstitial nephritis is caused by - Methicillin
259. Increased osmotic fragility is seen in - hereditary elliptocytosis

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260. Decrease in osmotic fragility causes hemolysis in - alpha &beta thalasemia
261. Characteristic of SLE of kidney - wire loop lesion
262. Neurofibromatosis is associated with - pheochromocytoma
263. Pautriers microabscess is seen in - mycosis fungoides
264. H.pylori causes - chronic atrophic gastritis/gastric/duodenal ulcer/lymphoma
265. Heart failure cells are seen in - Lungs
266. Mast cells release interleukin - 2
267. Bronchiectasis means - inflammation/dilatation/cavitation
268. Aneurysms in polyarteritis nodosa usually spares - Periphery
269. Phagocytosis is not done by - Histiocytes
270. Following splenectomy which cell increase earliest - Neutrophills
271. Blood smear is best seen at pH of - 6.8
272. Causes for precocious puberty-craniopharyngioma/head injury
273. Fragile X syndrome - large testes/large head/large ear
274. Nuchal fold thickness is used to diagnose - Down’s syndrome
275. Commonest fungal infection in neutropenia - Candida
276. Condition associated with obesity - hypothyroidism/insulinoma/cushing’s syn-
drome
277. Erosive arthritis occurs in - OA/Gout/psoariatic arthritis
278. Osteoporosis is caused by - Heparin/hypoparathyroidism/RA
279. Feulgen reaction detects - DNA
280. Tam horse fall protein is produced in - Kidney
281. Size of micro filter used in blood transfusions sets - 170 micrometers
282. Schiller-duval bodies is seen in - endodermal sinus tumour
283. Jumping gene - Transposon
284. Bradykinin is a cleavage product of - kininogen
285. Kaposi sarcoma arise from - vascular tissue
286. Kaposi sarcoma is caused by - HHV-8
287. Lesion in wernicke’s encephalopathy occurs in - mamillary bodies
Pathology

288. Marker for malignant melanoma - S100

289. Highest chance of transmission after needle stick injury is for - Hepatitis C
290. MC sarcoma in person receiving immunosuppressive treatment - kaposi sarcoma
291. Most sensitive &specific investigation for Ca breast - mammography
292. Early granulation tissue in acute MI is seen within - 1week
293. Colorectal carcinoma is associated with - low fiber & high fat intake
294. Reid’s index is used in diagnosis of - chronic bronchitis
295. Giant cells in measles are called as - warthin finkeldey cells

Pathology
 296. Prostatic growth in BPH is due to - dihydrotestosterone
297. Best stain to demonstrate sideroblast in bone marrow - perls stain
298. Most imp.function of epithelioid cells in tuberculosis - phagocytosis
299. ESR is zero in - Afibrinogenemia
300. Commonest infantile testicular tumor - Yolk sac tumour
301. Yellowish exudates at multiple sites seen in colonoscopy indicates - Crohn’s dis-
ease
302. Sago spleen is seen in - Amyloidosis
303. Atheromatous changes of blood vessels affect early in - Kidney
304. Biphasic pattern on histology is seen in which tumor - synovial cell sarcoma
305. Most abundant glycoprotein present in basement membrane - Laminin
306. Choristoma is - Normal tissue in abnormal site
307. Virchow’s triad includes - endothelial injury/stasis of blood flow/hypercoagulabili-
ty
308. Virchow’s triad seen in - DVT/peripheral vascular disease
309. Chromosome defect in cystic fibrosis - chromosome 7
310. Myasthenia gravis antibodies are present against - nicotinic receptor proteins
311. Downey cell is seen in - infectious mononucleosis
312. Mucinous cystadenoma of the ovary arises from - surface colonic epithelium
313. Podocytes are seen in - bowman’s capsule
314. Diascopy is used in diagnosis of - hemangioma/lupus vulgaris/sarcoidosis
315. Amyloidosis of kidney is seen in-ulcerative colitis/suppurative lung disease/Han-
sen dis
316. Mesentric tumors are - usually cystic
317. GI stromal malignancy arise from - smooth muscle

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318. Sure sign of malignancy - Metastasis
319. Route of infection in tubercular pyelonephritis - hematogenous
320. Schistiocytes are - Broken RBC
321. Which occurs 1st in wound healing - Neutrophils line in the wound edge
322. Drug induced lupus can be identified by - anti-histone antibodies
323. Renal artery stenosis may occur in - atherosclerosis/fibromuscular dysplasia/
polyarteritis nodosa
324. Brain tumor highly vascularized in nature - Glioblastoma
325. Wear & tear pigment in the body refers to – Lipochrome
326. Ca dependant cell adhesion molecule is – Cadherin
327. BCL 2 protein is located in – Mitochondria
328. Pyrogen Prostaglandins – PGE2
329. CD marker of basophil- CD13
330. Marker for seminoma testis- HCG

Pathology

Pathology
 MCQ’s
1. The epitheloid cell and multinucleated B. T cells
gaint cells of granulomatous inflammation C. Plasma cells
are derived from: D. Basophils
A. Basophils Ans. B
B. Eosinophils
C. CD4 T lymphocytes 5. In primary tuberculosis, all of the following
D. Monocytes-macrophages may be seen except:
Ans. D A. Cavitation
B. Caseation
2. The following host tissue responses can be C. Calcification
seen in acute infection, except: D. Langerhan giant cell
A. Exudation Ans. A
B. Vasodilation
C. Margination 6. A mylocardial infarct showing early granu-
D. Granuloma formation lation tissue has most likely occurred:
Ans. D A. Less than 1 hours
B. Within 24 hours
3. The following feature is common to both cy- C. Within 1 week
totoxic T cells and NK cells: D. Within 1 month
A. Synthesize antibody Ans. D
B. Require antibodies to be present for
action 7. A 10 year old boy, died of acute rheumatic
C. Effective against virus infected cells fever. All the following can be expected at
D. Recognize antigen in association with autopsy except:
HLA class II markers A. Ashoff nodules
Ans. C B. Rupture of chordae tendinae
C. McCallum patch
4. In the intra-epithelial region of the mucosa D. Fibrinous pericarditis
of intestine the predominant cell popula- Ans. B
tion is that of: 8. All of the following are seen in asbestosis
A. B cell except:

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 A. Diffuse alveolar damage 14. Disease or infarction of neurological tissue
B. Calcified pleural plaques causes it to be replaced by:
C. A. Fluid
Diffuse pulmonary interstitial fibrosis
D. Mesotheliomas B. Neuroglia
Ans. A C. Proliferation of adjacent nerve cells
D. Blood vessel
9. Macrophages containing large quantities of Ans. B
undigested and partial digested bacteria in
intestine are seen in: 15. Flat small vegetations in the cusps of both
A. Whipple’s disease tricuspid and mitral valves are seen in:
B. Amyloidosis A. Viral myocarditis
C. Immunoproliferative small instetinal B. Libmann Sach’s endocarditis
disease C. Rheumatic carditis
D. Vibrio cholerae infection D. Infective endocarditis
Ans. A Ans. B

10. The histological features of celiac disease 16. A married middle aged female gives history
include all of the following, except: of repeated abortions for the past 5 years.
A. Crypt hyperplasia The given below is conceptions prenatal
B. Increase in thickness of the mucosa karyogram. This karyogram suggests the
C. Increase in intraepithelial lymphocytes following:
D. Increase in inflammatory cells in A. Klinfelter’s syndrome
lamina propria B. Turner’s syndrome
Ans. B C. Down’s syndrome
D. Patau’s syndrome
11. In a chronic alcoholic all the following may Ans. C
be seen in the liver except:
A. Fatty degeneration 17. An increased incidence of cholangiocarci-
B. Chronic hepatitis noma is seen in all of the following, except:
C. Granuloma formation A. Hydatid cyst of liver
D. Cholestatic hepatitis B. Polycystic disease of liver
Ans. C C. Sclerosing cholangitis
D. Liver flukes
12. Crescent formation is characteristic of the Ans. A
following glomerular disease: 18. Strong correlation with colorectal cancer is
A. Minimal change disease seen in:
B. Rapidly progressive A. Peutz-Jeghers polyp
glomerulonephritis B. Familial polyposis coli
C. Focal and segmental C. Juvenile polyposis
glomerulosclerosis D. Hyperplastic polyp
D. Rapidly non prgressive Ans. B
glomerulonephritis
Ans. B 19. Which of the following is the most common
location of hypertensive hemorrhage?
13. Necrotizing papillitis may be seen in all of A. Pons.
the following conditions except: B. Thalamus.
A. Sickle cell disease C. Putamen/external capsule.
B. Tuberculous pyelonephritis D. Subcortical white matter.
C. Diabetes mellitus Ans. C
D. Analgesic nephropathy
Ans. B 20. A 63-year old man presented with massive
splenomegaly, lymphadenopathy and a to-

Pathology
 tal leucocyte count of 17000 per mm3. The B. Superoxide dismutase
flowcytometry showed CD19 positive, CD5 C. MAO
positive, CD23 negative, monoclonal B-cells D. Hydroxylase
with bright kappa positivity comprising Ans. B
80% of the peripheral blood lymphoid cells.
The most likely diagnosis is: 26. Autoimmune haemolytic anemia is seen in:
A. Mantle cell lymphoma. A. ALL
B. Splenic lymphoma with villous B. AML
lymphocytes. C. CLL
C. Follicular lymphoma. D. CML
D. Hairy cell leukemia. Ans. C
Ans. A
27. All of following are correct about thrombox-
21. The HLA class III region genes are import- ane A2 except:
ant elements in: A. Low dose aspirin inhibits its synthesis
A. Transplant rejection phenomenon. B. Causes vasoconstriction in blood
B. Governing susceptibility to vessels
autoimmune diseases. C. Causes broncoconstriction
C. Immune surveillance. D. Secreted by WBC
D. Antigen presentation and elimination. Ans. D
Ans. C
28. Which of the following complications is
22. All the statements about lactoferrin are likely to result after several units of blood
true, except: have been transfused:
A. It is present in secondary granules of A. Metabolic alkalosis
neutrophil. B. Metabolic acidosis
B. It is present in exocrine secretions of C. Respiratory alkalosis
body. D. Respiratory acidosis
C. It has great affinity for iron. Ans. A
D. It transports iron for erythropoiesis.
Ans. D 29. The mother has sickle cell disease and fa-
ther is normal. Chances of children having
23. Which of the following procedures are used sickle cell disease and sickle cell trait re-
as routine technique for karyotyping using spectively are:
light microscopy? A. 0 and 100%
A. C-banding B. 25 and 25%
B. G- banding C. 50 and 50%
C. Q-banding D. 10 and 50%
D. Brd V-banding Ans. A
Ans. B
30. Father has a blood group B, mother has AB;
24. Restriction fragment length polymorphism children are not likely to have the following
is used for: blood group:
A. Analysis of chromosome structure. A. O
B. DNA estimation. B. A
C. Synthesis of nucleic acid. C. B
D. Detecting proteins in a cell. D. AB
Ans. A Ans. A

25. Enzyme that protects the brain from free 31. Protein involved in intercellular connec-
radical injury is: tions is:
A. Myeloperoxidase A. Connexin

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 B. Integrin Ans. C
C. Adhesin
D. None of the above 38. Pulmonary surfactant is secreted by:
Ans. A A. Type I pneumoncytes.
B. Type II pneumocytes.
32. An example of a tumour suppressor gene is: C. Clara cells.
A. Myc. D. Bronchila epithelial cells.
B. Fos. Ans. B
C. Ras.
D. Rb. 39. Which one of the following conditions com-
Ans. D monly predisposes to colonic carcinoma?
A. Ulcerative colitis.
33. The following is not a feature of malignant B. Crohn’s disease.
transformation by cultured cells: C. Diverticular disease.
A. Increased cell density. D. Ischaemic colitis.
B. Increased requirement for growth Ans. A
factors.
C. Alterations of cytoskeletal structures. 40. Fibrinoid necrosis may be observed in all of
D. Loss of anchorage. the following except:
Ans. B A. Malignant hypertension.
B. Polyarteritis nodosa.
34. A simple bacterial test for mutagenic car- C. Diabetic glomerulosclerosis.
cinogens is: D. Aschoff’s nodule.
A. Ames test. Ans. C
B. Redox test.
C. Bacteriophage. 41. All of the following statements are true re-
D. Gene splicing. garding reversible cell injury, except:
Ans. A A. Formation of amorphous densities in
the mitochondrial matrix.
35. The classification proposed by the Interna- B. Diminished generation of adenosine
tional Lymphoma Study Group for non-Hod- triphosphate (ATP)
gkin’s lymphoma is known as: C. Formation of blebs in the plasma
A. Kiel classification. membrane.
B. REAL classification. D. Detachment of ribosomes from the
C. WHO classification. granular endoplasmic reticulum.
D. Rappaport classification. Ans. A
Ans. B
42. Which of the following statements pertain-
36. All of the following features are seen in the ing to leukemia is correct?
viral pneumonia except: A. Blasts of acute myeloid leukemia are
A. Presence of interstitial inflammation. typically sudan black negative.
B. Predominance of alveolar exudates. B. Blasts of acute lymphoblastic leukemia
C. Bronchiolitis. are typically myeloperoxidase positive.
D. Multinucleate giant cells in the C. Low leucocyte alkaline phosphatase
bronchiolar wall. score is characteristically seen in blastic
Ans. B phase of chronic myeloid leukemia.
D. Tartarate resistant acid phosphatase
37. Aschoff’s nodules are seen in: positivity is typically seen in hairy cell
A. Subacute bacterial endocarditis. leukemiA.
B. Libman-Sacks endocarditis. Ans. D
C. Rheumatic carditis.
D. Non-bacterial thrombotic endocarditis. 43. In which of the following conditions bilater-

Pathology
 al contracted kidneys are characteristically 47. Which type of amyloidosis is caused by mu-
seen? tation of the transthyretin protein?
A. Amyloidosis. A. Familial Mediterranean fever.
B. Diabetes mellitus. B. Familial amyloidotic polyneuropathy.
C. Rapidly progressive (crescentic) C. Dialysis associated amyloidosis.
glomerulonephritis. D. Prion protein associated amyloidosis.
D. Benign nephrosclerosis. Ans. B
Ans. D
48. In familial Mediterranean fever, the gene
44. All of the following vascular changes are ob- encoding the following protein undergoes
served in acute inflammation, except: mutation:
A. Vasodilation. A. Pyrin.
B. Stasis of blood. B. Perforin.
C. Increased vascular permeability. C. Atrial natriuretic factor.
D. Decreased hydrostatic pressure. D. Immunoglobulin light chain.
Ans. D Ans. A

45. The subtype of Hodgkin’s disease, which is 49. Which of the following statements is not
histogenetically distinct from all the other true?
subtypes, is: A. Patinets with IgD myeloma may present
A. Lymphocyte predominant. with no evident M-spike on serum
B. Nodular sclerosis. electrophoresis.
C. Mixed cellularity. B. A diagnosis of plasma cell leukemia can
D. Lymphocyte depleted. be made if circulating peripheral blood
Ans. A plasmablasts comprise 14% of
peripheral blood white cells in a
46. In apoptosis, Apaf-1 is activated by release patient with 109/L.´ 109/L and
of which of the following substances from platelet count of 88 ´white blood cell
the mitochondria? count of 11
A. Bcl-2 C. In smoldering myeloma plasma cells
B. Bax. constitute 10-30% of total bone marrow
C. Bcl-XL cellularity.
D. Cytochrome C. D. In a patient with multiple myeloma, a
Ans. D monoclonal light chain may be detected
in both serum and urine.

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 Ans. B
50. In-situ DNA nick end labeling can quanti-
tate:
A. Fraction of cells in apoptotic pathways.
B. Fraction of cells in S phase.
C. p53 gene product.
D. bcr/abl gene.
Ans. A
51. Which one of the following stains is specific with a nodular pattern.
for amyloid?
A. Periodic acid Schiff (PAS)
B. Alzerian red.
C. Congo red.
D. Von-Kossa.
Ans. C
54. Which one of the following is not a feature
52. Which one of the following diseases charac-
teristically causes fatty change in liver?
A. Hepatitis B virus infection.
B. Wilson’s disease.
C. Hepatitis C virus infection.
D. Chronic alcoholism.
Ans. D
53. A 48-year-old woman was admitted with
a history of weakness for two months. On
examination, cervical lymph nodes were
found enlared and spleen was palpable
2 cm below the costal margin. Her hemo-
globin was 10.5 g/dl, platelet count 237 x
109/L and total leukocyte count 40 x 109/L,
which included 80% mature lymphoid cells
with coarse clumped chromatin. Bone mar-
row revealed a nodular lymphoid infiltrate.
The peripheral blood lumphoid cells were
positive for CD19, CD5, CD20 and CD23 and
were negative for CD79B and FMC-7. The
histopathological examination of the lymph
node in this patient will most likely exhibit
effeacement of lymph node architecture by:
A. A pseudofollicular pattern with
proliferation centers.
B. A monomorphic lymphoid proliferation
C. A predominantly follicular pattern.
D. A diffuse proliferation of medium to
large lymphoid cells with high mitotic
rate.
Ans. D
of liver histology in non cirrhotic portal fi-
brosis (NCPF).
A. Fibrosis in and around the portal tracts.
B. Thrombosis of the medium and small
portal vein branches.
C. Non specific inflammatory cell
infiltrates in the portal tracts.
D. Bridging fibrosis.
Ans. D
Pathology
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