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Cytogenetic Profile of Adult and Pediatric Acute Myeloid Leukemia in Oman: 10-
Year Data From a Tertiary Care University Referral Hospital

Article  in  American Journal of Clinical Pathology · October 2015

DOI: 10.1093/ajcp/144.suppl2.141

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11 authors, including:

Arwa Al-Riyami Shoaib AL Zadjali

Sultan Qaboos University Hospital and Oman Medical Speciality Board, Muscat, Oman Sultan Qaboos University
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Mohammed Al-Huneini Murtadha Al-Khabori

SQUH Sultan Qaboos University
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 Hematopathology

141

Id: SA169

Cytogenetic Profile of Adult and Pediatric Acute Myeloid Leukemia in Oman: 10-Year Data From a Tertiary
Care University Referral Hospital

Arwa Al Riyami, MD, FRCPC,1 Nooh Al Bakri,2 Humoud Al Salmi,2 Shoaib Al Zadjali, PhD,1 Mohammed Al
Huneini,1 Murtadha Al Khabori,1 Khalil Al Farsi,1 AbdulHakim Al Rawas, MD,1 Zakia Al Lamki,1 Yasser Wali,1
Salam Alkindi,2 1Sultan Qaboos University Hospital, 2Sultan Qaboos University

Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults. Diagnostic karyotype is
one of the most powerful independent prognostic indicators in AML, and the current World Health Organization
(WHO) classification of AML is heavily dependent on the underlying cytogenetic profile. Herein we aim at
reviewing the cytogenetic profile of adult and pediatric AML patients diagnosed in our institution. Laboratory and
medical records of all AML patients diagnosed in our institution between 2005 and 2015 were reviewed. Details
obtained included patients’ gender, age at time of diagnosis, karyotype, and molecular results at time of diagnosis. A

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total of 69 patients (53 adults and 16 pediatric patients) were diagnosed with AML. The cohort included 54% males
and 46% females, with a median age of 20 years (range 1-82 years). A majority of the patients were young adults
with an age range of 18-40 years, while pediatric patients less than 11 years of age represented a third of the cohort.
About 7% were elderly, aged more than 65 years. The most common genetic abnormality in the adults is normal
karyotype (51% of adults), while it accounted for 38% of pediatric cases. Recurrent cytogenetic abnormalities
accounted for one-third of adults, with the most common being t(15;17), while nonrecurrent cytogenetic
abnormalities were the most common in the pediatric cases (56%). Risk stratification of the cohort based on genetic
data revealed that most of the adults were stratified into good-risk profile based on karyotype, NPM, and FLT3
status, while 62% of the pediatric cases fell into the intermediate-risk group. In conclusion, AML in the Omani
population is most common among young adults. Normal-karyotype AML is the most common among adults but
good-risk profile predominates. However, intermediate-risk profile predominates among pediatric patients. Detailed
molecular and gene expression profile studies are needed for further prognostication based on the new emerging
data.

© American Society for Clinical Pathology Am J Clin Pathol 2015;144:A141

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