DRUG STUDY

DRUG DRUG ACTION INDICATION CONTRAINDICATIONS ADVERSE DRUG NURSING

NAME / DOSAGE EFFECTS INTERACTIONS CONSIDERATIONS

Generic Inhibits cell wall synthesis ♦ 500 mg IV Contraindicated in patients CV: Aminoglycosides: ♦ Before giving dug,
Name: promoting osmotic q8o ANST(-) hypersensitive to drug or phlebitis, May cause ask patient if she is
cefuroxime instability usually other cephalosporin. thrombophle synergistic activity allergic to penicillin or
bactericidal bitis against some cephalosporin. Obtain
Use cautiously in patients organisms. May specimen for culture
Brand Name: hypersensitive to penicillin GI: diarrhea, increase and sensitivity tests
Kefox because of possibility of anorexia, nephrotoxicity. before giving first
cross-sensitivity with other vomiting Monitor patient’s dose. Absorption of
beta lactam antibiotics renal function oral drug is induced.
Therapeutic Hematologic: closely.
Class: hemolytic
Cephalosporin anemia,
thrombocyto
penia,
transient
neutropenia,
eosinophilia

Generic Inhibits bacterial cell wall ♦300 mg IV Hypersensitivity to ♦ Nausea Drug to drug ◙ Tell patient that
Name: synthesis by binding to q6o ANST(-) ampicillin, any component ♦ Vomiting - Increased ampicillin medication may cause
Ampicillin one or more of the of the formulation, or other ♦ Loss of effect with nausea or vomiting
penicillin penicillins appetite probenecid (small, frequent meals,
- Increased risk of
binding proteins (PBPs); ♦ Diarrhea frequent
rash with allopurinol
Brand name: which in turn inhibits the ♦ Abdominal - Increased bleeding
mouth care, sucking
Unasyn final transpeptidation step pain effect lozenges, or chewing
of peptidoglycan synthesis ♦ Rash with heparin, oral gum may help); or
in bacterial cell walls, thus ♦ Itching anticoagulants diarrhea (buttermilk,
Classification: inhibiting cell wall ♦ Headache - Decreased effect boiled milk, or yogurt
Antibiotic biosynthesis. Bacteria ♦ Confusion with tetracyclines, may help).
(penicillins) eventually lyse due to ♦ Dizziness chloramphenicol
ongoing activity of cell - Decreased efficacy ◙ Instruct client to
wall of hormonal maintain adequate
autolytic enzymes contraceptives, hydration (2-3 L/day
atenolol with
(autolysins and murein of fluids) unless
ampicillin
hydrolases) while cell wall instructed to restrict
assembly is arrested. fluid intake.
Generic •Binds with opiate ♦10 mg SIVP •Contraindicated in patients •CNS: CNS depressants, •Reassess patient’s
Name: receptors in the CNS, q4o x 8 dose hypersensitive to drug Sedation, including level of pain at least
Nalbuphine altering perception of and dizziness, barbiturate 15 and 30 minutes
HCL emotional response to pain •Use cautiously in patients vertigo, anesthetics. after parenteral
with history of drug abuse headache, Increased administration
and in those with emotional agitation, respiratory and
Brand name: instability, head injury, confusion, CNS depression. •Nalbuphine acts as an
Nubain increased ICP, impaired crying, opioid antagonist and
ventilation, MI depression, Incompatibility may cause withdrawal
accompanied by N/V, dysphoria, Nafcillin, syndrome. For patients
Classification: upcoming biliary surgery, euphoria, ketorolac. who have received
Opioid agonist- and hepatic or renal disease faintness, long-term opioids,
antagonist floating Laboratory Test give 25% of the usual
analgesic feeling, Interactions dose initially. Watch
hallucination May interfere with for signs of
s, heaviness enzymatic methods withdrawal.
feeling, for detection of
hostility, opioids, depending •Alert: Drug causes
nervousness, on the specificity of respiratory depression,
numbness, test. which at 10mg is
restlessness, equal to respiratory
seizures, depression produced
tingling, by 10 mg of morphine
unreality,
unusual •Monitor circulatory
dreams and respiratory status,
bladder and bowel
•CV: function. If
Bradycardia, respirations are
hypertension, shallow or rate is
hypotension, below 12
tachycardia breaths/minute,
withhold dose and
•EENT: notify prescriber
Blurred
vision, dry •Constipation is often
mouth severe with
maintenance therapy.
•GI: Nausea, Make sure stool
vomiting, softener or other
biliary tract laxative is ordered.
spasms, •Psychological and
constipation physical dependence
cramps, may occur with
dyspepsia prolonged use.

•GU: Urinary
urgency

•Respiratory:
Respiratory
depression,
asthma,
dyspnea,
pulmonary
edema

•Skin:
Burning,
clamminess,
diaphoresis,
pruritis,
urticaria