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Conceptual Framework: Pathophysiology of the Disease

Process

Predisposing Factors Etiologic Factor Signs and Symptoms

• Increasing age, √ Headache


genetic, diet, stress,
√ Light headedness
left ventricular
hypertrophy, √ Dizziness
hypertension, aortic
Genetic factor, increasing
regurgitation, √ Chest pain
age, high intake of fatty
incompetent mitral and/or salty foods, stress √ Dyspnea
valve
√ Fatigue
Accumulation of fats in
Increase in peripheral the vessel walls √ Weight loss
resistance

Plaque formation
(atherosclerosis)

Loss of elasticity in
arteries
Atrial stenosis
Increase systolic blood
pressure
Thrombus
formation
Isolated systolic
hypertension Platelet
aggregation
Increase left atrium
volume and pressure Activation of
platelet
Left atrial dilatation
Consolidation

Left atrial hypertrophy


Vasoconstriction
Left ventricular filling
Thicken mitral valve
leaflet Coagulation
Blood ejected in the aorta
Incomplete valve closure
Small infarcts occur
Systemic circulation
Some blood regurgitate
to left atrium