7/5/2018 Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies: American Journal of Psychiatry: Vol 0, No 0

Sign In | Register | POL Subscriptions

PsychiatryOnline DSM Library Books Collections Journals News APA Guidelines Patient Education International CME My POL

Enter Search Term Anywhere Search

Advanced Search

Home Current Issue All Issues About Residents' Journal AJP in Advance Podcast CME Authors & Reviewers

Previous Article
Add to My POL Email Send to Citation Mgr
Ahead of Print
Next Article

Physical Activity and Incident Depression: A Meta-Analysis

of Prospective Cohort Studies

Felipe B. Schuch, Ph.D., Davy Vancampfort, Ph.D., Joseph Firth, Ph.D., Simon Rosenbaum, Ph.D., Related Articles:
Philip B. Ward, Ph.D., Edson S. Silva, B.Sc., Mats Hallgren, Ph.D., Antonio Ponce De Leon, Ph.D.,
Andrea L. Dunn, Ph.D., Andrea C. Deslandes, Ph.D., Marcelo P. Fleck, Ph.D., Andre F. Carvalho,
Ph.D., Brendon Stubbs, Ph.D. Association Between ADHD and Obesity:
A Systematic Review and Meta-Analysis.
https://doi.org/10.1176/appi.ajp.2018.17111194 Samuele Cortese et al., American Journal
of Psychiatry

Methylphenidate and risk of serious

Abstract
cardiovascular events in adults.
Hedi Schelleman et al., American Journal
Objective:
The authors examined the prospective relationship between physical activity and incident of Psychiatry
depression and explored potential moderators.
Comprehensive meta-analysis of excess
mortality in depression in the general
Method:
Prospective cohort studies evaluating incident depression were searched from database community versus patients with specific
inception through Oct. 18, 2017, on PubMed, PsycINFO, Embase, and SPORTDiscus. illnesses.
Demographic and clinical data, data on physical activity and depression assessments, and Pim Cuijpers et al., American Journal of
odds ratios, relative risks, and hazard ratios with 95% confidence intervals were extracted. Psychiatry
Random-effects meta-analyses were conducted, and the potential sources of heterogeneity
were explored. Methodological quality was assessed using the Newcastle-Ottawa Scale. Physical activity reduces risk of depression
at any age, finds study
Results:
Susan Mayor, The BMJ
A total of 49 unique prospective studies (N=266,939; median proportion of males across
studies, 47%) were followed up for 1,837,794 person-years. Compared with people with Increased Leisure-Time Physical Activity
low levels of physical activity, those with high levels had lower odds of developing
Reduces Cancer Risk
depression (adjusted odds ratio=0.83, 95% CI=0.79, 0.88; I2=0.00). Furthermore,
PracticeUpdate
physical activity had a protective effect against the emergence of depression in youths
(adjusted odds ratio=0.90, 95% CI=0.83, 0.98), in adults (adjusted odds ratio=0.78, 95% OP82 Long-lived parents and
CI=0.70, 0.87), and in elderly persons (adjusted odds ratio=0.79, 95% CI=0.72, 0.86).
cardiovascular outcomes: 8 year follow-up
Protective effects against depression were found across geographical regions, with
adjusted odds ratios ranging from 0.65 to 0.84 in Asia, Europe, North America, and in 189,000 UK Biobank participants
Oceania, and against increased incidence of positive screen for depressive symptoms A Murray et al., J Epidemiol Community
(adjusted odds ratio=0.84, 95% CI=0.79, 0.89) or major depression diagnosis (adjusted Health
odds ratio=0.86, 95% CI=0.75, 0.98). No moderators were identified. Results were
consistent for unadjusted odds ratios and for adjusted and unadjusted relative risks/hazard
ratios. Overall study quality was moderate to high (Newcastle-Ottawa Scale score, 6.3).
Although significant publication bias was found, adjusting for this did not change the Powered by
magnitude of the associations.

Conclusions:
Available evidence supports the notion that physical activity can confer protection against
the emergence of depression regardless of age and geographical region.

Keywords: Exercise, Physical Activity, Depression, Mood Disorders-Unipolar, Incidence

Your Access Options

Log In Purchase
If you have an individual subscription to $35.00
this content, or if you have purchased
this content through Pay Per Article Add to cart
within the past 24 hours, you can gain
access by logging in with your username
and password here:

Username:
Password:
Login

https://ajp.psychiatryonline.org/doi/pdfplus/10.1176/appi.ajp.2018.17111194 1/2