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Advanced Acridinium Ester (AE) Technology Done Right.

AE-based assays from Siemens Healthcare—so you get it right the first time, every time.

Siemens expertise in Advanced AE Technology enables consistent and continuous development of new and innovative
assays which deliver what is of utmost importance to you; precision, accuracy, and performance for improved patient care.
Siemens Advanced AE Technology is flexible and versatile, allowing assay design to be tailored precisely to the diagnostic
requirements of numerous disease states, delivering an extensive, high quality immunoassay menu.
 AE Technology Advantages
Siemens provides a bank of over 40 active and pending molecule patents from which
to choose when designing an assay to provide optimal performance.
AE technology in combination with other assay design features adds greater robustness
by providing:
• Better low end sensitivity • Enhanced reagent stability • Smaller sample volume
• Increased precision • Faster throughput • Longer reagent shelf life

Acridinium Ester Technolgy (AE) Evolution

Molecule Full name of variant Assay(s) Assay performance enhancement Patient/laboratory benefit
DMAE Dimethyl (AE) First automated IA assays Sensitivity, precision, throughput, reagent stability, Comprehensive disease state testing
reagent shelf life
NSP DMAE N-sulfopropal (AE) HIV 1/0/2 Improved sensitivity Earlier detection, earlier treatment
HE GAE Hexa ethylene glycol AE TSH-3 Ultra Decreased sample size, improved low end precision Improved management of thyroid disease
HQYAE High quantum yield AE Troponin I Ultra 10-fold increase in precision Advanced diagnosis of acute
myocardial infarction
5-fold increase in sensitivity vs. prior release Improved stratification for patients
with acute coronary syndrome
ZAE Zwitterionic AE HBsAg II Improved diagnostic sensitivity Improved detection of HBsAg mutants
Vitamin D Improved diagnostic sensitivity, faster TAT (18 min) Aligns with recent research linking
Vitamin D to multiple disease states
ISOZAE NSP-isopropoxy Under patent review Double light output of ZAE for advanced For new and innovative assay
DMAE-A-NHS sensitivity assays developments
References: Local Contact Information
Natrajan A, Jiang Q. Meeting Evolving Clinical Demands for Assay Performance: Advances in Acridinium Ester Technology
on the ADVIA Centaur Systems. Siemens Healthcare Diagnostics 2012;11. Siemens Healthcare
Laboratory Diagnostics
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Order No. A91DX-CAI-160402-GC1-4A00 | 04-2016 | © Siemens Healthcare Diagnostics Inc., 2016 siemens.com/healthcare