Beruflich Dokumente
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Classic Examples
Hydrocarbon Stapled Peptides
O NH HN R4
Lactam Bridge Peptides
H
Peptide Type of Modification Properties
R2 N
R3 O
α - Conotoxin N- to C- terminus cyclization Increased stability in human plasma1 O
Hydrocarbon stapling Increased protease resistance
BID BH3 Head to tail/ end to side chain cyclization
using ring closing metathesis and serum stability2
I would like to thank Ian Flynn and Heidi Fazeli and for design and support. This technique is aimed at identifying the receptor-bound conformation of various biological
References: peptides by constraining specific segment of the peptide
and studying its effect on the biological
1. Clark et al. Proc Natl Acad Sci USA 2005, 102, 13767–13772. activity.
2. Walensky et. al., Science, 2004, 3, 1466-1470
3. Raymond et. al., Nature 2009, 462, 182-188.
4. Judice et. al., Proc. Natl. Acad. Sci. USA. 1997, 94, 13426-13430
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