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This randomized clinical trial compared the efficacy and safety of ibuprofen versus morphine for postsurgical analgesia in 91 children undergoing tonsillectomy. The children were randomized to receive acetaminophen with either 0.2-0.5 mg/kg of oral morphine or 10 mg/kg of oral ibuprofen. The results showed that ibuprofen provided safe and effective analgesia with fewer side effects compared to morphine. The study concluded that ibuprofen should be considered over morphine for postsurgical pain management in children after tonsillectomy due to safety concerns with morphine use.
This randomized clinical trial compared the efficacy and safety of ibuprofen versus morphine for postsurgical analgesia in 91 children undergoing tonsillectomy. The children were randomized to receive acetaminophen with either 0.2-0.5 mg/kg of oral morphine or 10 mg/kg of oral ibuprofen. The results showed that ibuprofen provided safe and effective analgesia with fewer side effects compared to morphine. The study concluded that ibuprofen should be considered over morphine for postsurgical pain management in children after tonsillectomy due to safety concerns with morphine use.
This randomized clinical trial compared the efficacy and safety of ibuprofen versus morphine for postsurgical analgesia in 91 children undergoing tonsillectomy. The children were randomized to receive acetaminophen with either 0.2-0.5 mg/kg of oral morphine or 10 mg/kg of oral ibuprofen. The results showed that ibuprofen provided safe and effective analgesia with fewer side effects compared to morphine. The study concluded that ibuprofen should be considered over morphine for postsurgical pain management in children after tonsillectomy due to safety concerns with morphine use.
• Treatment: Is ibuprofen a safer and more efficacious postsurgical analgesic agent rather
than morphine for post-tonsillectomy?
PATIENT/ INTERVENTION COMPARISON OUTCOME
FOCUS POPULATION This prospective Acetaminophen with Acetaminophen with Ibuprofen in randomized clinical 0.2-0.5 mg/kg oral 0.2-0.5 mg/kg oral combination with trial recruited children ibuprofen. morphine. acetaminophen who had sleep provides safe and disordered effective breathing who were analgesia in children scheduled for undergoing tonsillectomy +/2 tonsillectomy. Post- adenoid removal. A tonsillectomy total of 91 children morphine use should were consented to be participate in the limited, as it may be study. Children were unsafe in certain randomized to receive children. acetaminophen with either 0.2–0.5 mg/kg oral morphine or 10 mg/kg of oral ibuprofen.
Critical Review with Summary of the Literature
Sleep disordered breathing (SDB) is characterized by a disruption in ventilation and
breathing patterns during sleep. In children, SDB is often caused by hypertrophy of the tonsils and/or adenoids and is commonly managed by tonsillectomy. Until recently, codeine was commonly prescribed for postoperative pain management in many North American centers. The Federal Drug Administration issued a Drug Safety communication advising practitioners that codeine use in certain children could lead to rare but life-threatening respiratory failure and death. In conclusion, this study demonstrates that 68% of the children who received ibuprofen after the surgery showed improvement rather than those 86% children who did not during the first postoperative night. The study revealed that the standard dosage range of morphine analgesia increases the risk of oxygen desaturation comparing to ibuprofen. REFFERENCES Kelly, L. et al, (2015), Morphine or Ibuprofen for post-tonsillectomy analgesia: A randomized trial, retrieved from https://pediatrics.aappublications.org/content/pediatrics/135/2/307.full.pdf
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