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[ clinical commentary ]

JOEL E. BIALOSKY, PT, PhD1,2  •  JASON M. BENECIUK, PT, PhD1,2  •  MARK D. BISHOP, PT, PhD1  •  ROGELIO A. CORONADO, PT, PhD3
CHARLES W. PENZA, DC, PhD1  •  COREY B. SIMON, PT, PhD4,5  •  STEVEN Z. GEORGE, PT, PhD5

Unraveling the Mechanisms of Manual


Therapy: Modeling an Approach
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M
anual therapy (MT) interventions are a preferred treatment these 2 prerequisites are met, patients can
for both health care professionals from a variety of be matched to an appropriate treatment,
disciplines14,36,77,82 and patients with musculoskeletal pain allowing for the targeted application
of a specific intervention of known
conditions.2,12,53,70 Despite the popularity of MT, systematic
mechanisms to patients with presentations
reviews only find small to modest effect sizes43,73 or fail to recommend amenable to these mechanisms.15,45
these interventions.39,68 In fact, individual clinical practice guidelines Mechanistic-based treatment approaches
for low back pain include differing recommendations for the use of for MT necessitate identification of the key
spinal manipulation, indicating Mechanistic-based approaches mechanisms through which MT works;
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

conflicting research support.60 Such to treating individuals presenting however, the current understanding of
findings are not dissimilar to those for with musculoskeletal pain conditions these mechanisms is lacking, requiring
other interventions for pain and are represent a rational targeted approach additional and more optimally designed
attributed to substantial individual for personalizing treatment.26,32,45 studies to answer this important question.
variability in treatment response. 32 There are 2 prerequisites needed to
Subsequently, the clinical decision- properly implement this approach: The Need for a Model
making process that guides the use first, a mechanism contributing to a of the Mechanisms of MT
of MT may be best directed at the clinical population or subpopulation The mechanistic approach to MT is
individual patient on the provider level, (ie, a homogeneous subgroup) must be complicated by the complex nature of
Journal of Orthopaedic & Sports Physical Therapy®

rather than using a “one-size-fits-all” identified; second, the biological effects of MT interventions. While drug effects are
approach.32 a treatment should be established. When often attributed to a specific and well-
defined active ingredient, the mechanisms
UUSYNOPSIS: Manual therapy interventions are the patient, the provider, and the environment in underlying complex interventions, such as
popular among individual health care providers which the intervention occurs. Therefore, a model those used for MT, are multifaceted and
and their patients; however, systematic reviews to guide both study design and the interpreta- comprise specific and nonspecific factors
do not strongly support their effectiveness. tion of findings is necessary. We have previously related to the intervention, the patient, the
Small treatment effect sizes of manual therapy
proposed a model suggesting that the mechanical provider, and the environment in which
interventions may result from a “one-size-fits-
all” approach to treatment. Mechanistic-based
force from a manual therapy intervention results the intervention is provided. Subsequently,
treatment approaches to manual therapy offer in systemic neurophysiological responses leading a single, well-defined mechanism of an
an intriguing alternative for identifying patients to pain inhibition. In this clinical commentary, we MT intervention is unlikely, and resulting
likely to respond to manual therapy. However, the provide a narrative appraisal of the model and outcomes are probably related to varying
current lack of knowledge of the mechanisms recommendations to advance the study of manual inherent elements and contextual
through which manual therapy interventions therapy mechanisms. J Orthop Sports Phys Ther factors.13,25,74 We believe that research
inhibit pain limits such an approach. The nature of 2018;48(1):8-18. doi:10.2519/jospt.2018.7476 focusing on individual mechanisms
manual therapy interventions further confounds
such an approach, as the related mechanisms are UUKEY WORDS: manipulation, mobilization, in isolation will always fall short of
likely a complex interaction of factors related to neurophysiology, pain, theory providing meaningful insight, because
MT is a complex intervention involving

1
Department of Physical Therapy, University of Florida, Gainesville, FL. 2Brooks-PHHP Research Collaboration, Jacksonville, FL. 3Department of Physical Therapy and Department of
Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX. 4Doctor of Physical Therapy Program, Duke University, Durham, NC. 5Duke Clinical Research
Institute and Department of Orthopaedic Surgery, Duke University, Durham, NC. Drs Bialosky and Bishop were supported by National Center for Complementary and Integrative Health
grant R01 AT006334 from the National Institutes of Health. The authors certify that they have no affiliations with or financial involvement in any organization or entity with a direct financial
interest in the subject matter or materials discussed in the article. Address correspondence to Dr Joel E. Bialosky, Department of Physical Therapy, University of Florida, Box 100154,
University of Florida Health Science Center, Gainesville, FL 32610-0154. E-mail: bialosky@phhp.ufl.edu t Copyright ©2018 Journal of Orthopaedic & Sports Physical Therapy®

8 | january 2018 | volume 48 | number 1 | journal of orthopaedic & sports physical therapy


multiple interactions of complementary and not intended to emphasize any tic literature within the context of our
mechanisms. As with other complex single or specific approach. The model model, as well as highlight key areas for
interventions, MT providers and was designed to comprehensively account advancing this area of research. For the
researchers benefit from a theoretical for the interacting mechanisms behind a model to continue to be relevant, specific
model to both guide the design and assist complex MT intervention. Importantly, issues related to its future application
in interpreting the results of mechanistic the model allows researchers (1) to are considered. Importantly, this com-
studies. consider and account for competing mentary is not intended to be a system-
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We published a model to begin to mechanisms when designing studies (ie, atic review or complete appraisal of the
account for the multiple pain inhibitory mechanisms related to biomechanical original model. Rather, the commentary
mechanisms of MT.6 The model postulates effects, peripherally mediated effects, highlights areas that we believe are im-
that the mechanical stimulus from an MT spinal cord–mediated effects, and portant considerations for progressing
intervention results in neurophysiological supraspinally mediated effects), and clinical and research perspectives.
responses within the peripheral and (2) to acknowledge the potential for
central nervous systems responsible for alternative plausible explanations to their Advancing the Understanding Through
pain inhibition (FIGURE 1). Importantly, findings should the study not account for Appropriate Study Design
the model is applicable to different competing mechanisms. Mechanistic studies of MT are often per-
MT approaches (ie, joint mobilization, This clinical commentary will address formed in humans, which, unlike animal
massage, neurodynamic interventions) the current state of the MT mechanis- models, prohibit direct observation of the
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

Imaging
Nonspecific responses
• Placebo/expectation
• Psychological measures
Pain modulatory - Fear
circuitry - Catastrophizing
Pain Pain-related • ACC - Kinesiophobia
brain circuitry • Amygdala
• PAG
Endocrine response
Journal of Orthopaedic & Sports Physical Therapy®

• RVM
Rating
• B-endorphins
• Opioid response
Imaging
Autonomic response
• Skin temperature
• Skin conduction
• Cortisol levels
• Heart rate
Mechanical stimulus

Tissue Peripheral nervous system Spinal cord Neuromuscular responses


• Motoneuron pool
• Afferent discharge
• Muscle activity
Decrease spasm
Increase range of motion
Hypoalgesia
Inflammatory mediators • Temporal summation
• Selective blocking of
neurotransmitters

Imaging

FIGURE 1. Comprehensive model of the mechanisms of manual therapy. The model suggests that a transient, mechanical stimulus to the tissue produces a chain of
neurophysiological effects. Solid arrows denote a direct mediating effect. Broken arrows denote an associative relationship, which may include an association between
a construct and its measure. Bold boxes indicate the measurement of a construct. Abbreviations: ACC, anterior cingulate cortex; PAG, periaqueductal gray; RVM, rostral
ventromedial medulla. Reprinted from Bialosky et al,6 with permission from Elsevier. ©2009 Elsevier.

journal of orthopaedic & sports physical therapy | volume 48 | number 1 | january 2018 | 9


[ clinical commentary ]
nervous system. Our model based the as- temporal precedence with an outcome. since the model was originally published,
sessment of nervous system responses to For example, spinal stiffness and lumbar and, in fact, more recent studies continue
MT in humans on associated responses multifidus recruitment were assessed at to refute a specific biomechanical mech-
serving as behavioral correlates (ie, proxy baseline and immediately following a anism. The clinical examination process
measures) of underlying mechanisms. spinal manipulative therapy intervention for determining biomechanical dysfunc-
For example, changes in skin blood flow over 2 sessions, and then a week follow- tion continues to be unreliable,97 relates
represent an indirect correlate of the ing the second session, in participants poorly to clinical outcomes,85 and dem-
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sympathetic nervous system responses with low back pain.38 Improvements in onstrates a poor association with reli-
to MT,104 while changes in the flexor the Oswestry Disability Index were me- able and accurate mechanical measures61
withdrawal reflex may represent a spinal diated by improved lumbar multifidus as well as with magnetic resonance
cord–mediated response to MT.24 Nu- recruitment and decreases in stiffness.38 imaging.63
merous studies have provided evidence of Moderators are variables measured prior Specific to clinical outcomes, signifi-
immediate neurophysiological responses to treatment that interact with a specific cant within-group improvements are ob-
following MT; however, while serving intervention and influence an outcome of served in response to MT interventions;
as proof-of-concept work for more com- interest often identified in a randomized however, between-group differences are
plex designs, single pre/post randomized clinical trial.62,76 For example, secondary not observed, confirming similar re-
controlled trials are not designed to de- analysis of the UK BEAM trial found sponses to techniques of varying mechan-
termine the individual or combined in- that, although several baseline factors ical parameters.19,55,100 Furthermore, the
fluential factors of clinical improvement. predicted overall outcome, none were clinical outcomes of MT interventions,
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

Future studies must establish a link be- predictive of response to a specific treat- whether based on clinical presentation
tween these associated responses and ment (ie, spinal manipulation, exercise, or random allocation, are similar.31,59 Col-
clinical symptoms, as well as establish or spinal manipulation followed by exer- lectively, this body of literature continues
covariance of improvements between as- cise), with only trends identified for the to support our initial assertion against an
sociated responses and clinical outcomes. role of positive treatment expectations isolated and specific mechanical mecha-
Evaluating these multifactorial relation- for those receiving combined treatment.93 nism accounting for clinical outcomes in
ships requires complex study designs Identifying treatment-effect moderators response to complex MT interventions.6
that are not always feasible to conduct in provides information to establish “for Despite this evidence to the contrary,
clinical settings. Cook18 has highlighted whom and under what conditions” treat- the clinical approach to MT based on a
Journal of Orthopaedic & Sports Physical Therapy®

the limitations of reliance on immediate ment is effective.76 theorized specific biomechanical mecha-
assessment of either mechanistic or clini- nism persists.1,29,30,42,95 We believe that
cal outcomes, including similar findings Advancing the Understanding this perpetuation of dated modes of ac-
in response to numerous interventions of the Mechanical Force tion for MT is both unsubstantiated and
and the failure to relate these to long- Clinical use of MT is traditionally driven counterproductive.
term clinical outcomes. One strategy to by the assumption of a peripherally act-
address these concerns and to advance ing, mechanical mechanism,10,33,52 for ex- Advancing the Understanding
this line of research in future studies is to ample, the application of a specific MT of MT-Related Pain Inhibition
attempt to distinguish these immediate technique applied to a perceived dys- Our model was designed to account
associated responses as treatment me- functional vertebral segment identified for the mechanism of MT on pain
diators and moderators. Mediators are through passive movement assessment inhibition.6 Psychophysical testing,
variables measured during the course or imaging. Our model acknowledges a such as the application of standardized
of treatment to evaluate for change and mechanical force as an inherent element noxious thermal or mechanical forces,
subsequent impact on outcome.62,76 Me- of any MT intervention and directs stud- allows for the study of mechanisms
diators have been described as process ies to account for mechanical force as a related to changes in pain processing.
variables that implicate possible mecha- potential contributing mechanism. Based Systematic reviews support a transient
nisms by which an intervention may be on the literature at the time, the model pain inhibitory effect of MT21,40,69 on
effective, especially when these variables theorized that clinical outcomes were re- psychophysical measures, occurring
represent a plausible construct that the lated to corresponding neurophysiologi- both locally and remotely. Higher pain
treatment is intended to modify. Potential cal responses and occurred independent sensitivity, as determined by a lower pain
mediators of change establish how or why of the specific mechanical parameters of threshold at the site of injury or pain, may
treatment effects occur and should be the force. Little has changed to support a reflect local sensitization in the peripheral
identified a priori and measured before, mechanism related to the specific biome- (reduced receptor threshold) or central
during, and after treatment to establish chanical parameters of the interventions nervous system (specific somatosensory

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regions), while higher pain sensitivity at shown that temporal summation of transcutaneous electrical nerve stimu-
sites distant from the site of injury may heat pain is reduced immediately after lation has incorporated paradigms that
reflect more general sensitization of the the application of spinal manipulative determine differential pain-relieving
central nervous system. Changes in pain therapy, and that these reductions effects on movement-evoked pain.83,94
sensitivity are observed in response to are greater than those following Movement-evoked pain lessens following
MT both at the site of application and exercise or carefully constructed sham an MT intervention,4,56,57 which suggests
at distal sites, indicating the presence interventions. 7-9,11 Improved pain that future investigation should differ-
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of a central mediating effect.22,64,81 The modulatory capacity, as observed through entiate these findings from spontaneous
approach of such studies is often limited changes in conditioned pain modulation, pain, in terms of the magnitude of re-
to assessment of static measures of has been found to correspond to sponse as well as the relationship to clini-
mechanical and thermal pain thresholds, joint mobilization to the knee in cal outcomes of importance to patients.
providing little insight into individual participants with knee osteoarthritis.23
pain modulation capacity. Subsequently, favorable changes in Advancing the Understanding of
Psychophysical testing protocols pain modulatory capacity represent a Supraspinally Mediated Mechanisms
allow for the assessment of in vivo pain potential biological effect of MT, possibly Previous mechanistic models of MT
modulatory capacities and profiling informing mechanistic-based treatment incorporating nervous system responses
of individuals based on response approaches. Such approaches have been took a “reflexive” route, meaning that
to nociceptive input. For example, undertaken in drug trials. For example, neurological responses to MT were
conditioned pain modulation is duloxetine, a drug that enhances limited to physiologic or autonomic
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

characterized by a reduction of pain descending inhibition of pain, is more outputs.75 Our model acknowledged
sensitivity at one site in response effective in individuals who demonstrate such processes but advanced the pathway
to nociceptive input at another site diminished conditioned pain into regions of the nervous system not
and reflects descending inhibition of modulation.103 Furthermore, ketamine, typically considered as having a “direct”
pain through the spino-bulbar-spinal which inhibits temporal summation, is response to MT. The timing of this focus
loop, representing a pain inhibitory more effective for individuals presenting was vital, because when the model was
process. 78,101 Temporal summation, with heightened temporal summation.46 first proposed, limited evidence from
characterized by an increase in pain A similar approach has not been human and animal research supported
sensitivity in response to repeated adequately considered in the field of MT, the assumption of MT altering sensory
Journal of Orthopaedic & Sports Physical Therapy®

noxious stimulation, represents increased necessitating further study and a future processing in supraspinal structures.48,65,84
dorsal horn excitability27,47 and reflects a direction of studies of pain inhibition in The understanding of supraspinally
pain facilitatory process.45,102 Dynamic response to MT. mediated mechanisms of MT has pro-
psychophysical testing allows for profiling Movement-evoked pain offers an gressed greatly since the model was
of individuals. For example, those with alternative pain modulatory measure originally published, including studies
augmented temporal summation or that should be considered in future of MT-associated measures of cortical
inefficient conditioned pain modulation mechanistic-focused MT studies. Move- function through somatosensory-evoked
are considered at risk for developing ment-evoked pain often has a greater as- potentials,48,49 as well as neuroimaging
a pain condition, experiencing greater sociation with physical function decline advances through positron emission
pain severity when a pain condition and decreased quality of life than does tomography72 and functional magnetic
develops, and progressing from acute resting/spontaneous pain.87,89 For exam- resonance imaging (fMRI). Findings
pain to chronic pain.102 Conversely, those ple, pain in response to a repeated lifting from these approaches have significantly
with blunted temporal summation or task accounted for significant and unique advanced the understanding of MT-
augmented conditioned pain modulation variance in disability beyond a measure related changes in cortical function. For
may be less likely to develop a pain of spontaneous pain in participants with example, fMRI has been used to study the
condition, experience less pain severity whiplash-associated disorder.66 Differ- effects of MT in several complementary
when a pain condition develops, and ences in magnitude and influence of pain ways. First, fMRI has been used to inves-
be less likely to progress from acute types suggest that different mechanisms tigate cortical responses during MT. For
to chronic pain.102 Subsequently, pain and MT effects may also differ between example, during the posterior-to-anterior
modulatory profiles may be useful in spontaneous and movement-evoked mechanical force produced by MT, acti-
identifying more homogeneous groups pain. Considering movement-evoked vation is observed in medial parts of the
of patients. pain may better characterize the pain- postcentral gyrus (S1) bilaterally, the sec-
Pain modulatory capacities are relieving properties of interventions pro- ondary somatosensory cortex (S2), poste-
responsive to MT. For example, we have viding episodic relief. The literature on rior parts of the insular cortex, different

journal of orthopaedic & sports physical therapy | volume 48 | number 1 | january 2018 | 11


[ clinical commentary ]
Zone 1 Zone 2 Zone 3

Provider

Mechanical
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stimulus

Pain modulatory Pain-related Clinical


circuitry brain circuitry Pain inhibition
Context outcomes
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

Tissue Peripheral nervous system Spinal cord

Patient

FIGURE 2. Updated comprehensive model of the mechanisms of manual therapy. The model suggests that a transient, mechanical stimulus to the tissue produces a chain
of neurophysiological effects. Zone 1 represents the mechanical stimulus from the provider to the tissue, as well as the interaction between the patient and provider. Zone 2
Journal of Orthopaedic & Sports Physical Therapy®

represents potential nervous system responses to the mechanical stimulus, as well as the patient-provider interaction. Zone 3 represents the potential outcomes.

parts of the cingulate cortex, and the cer- ing of nociception before and after MT. results of this study suggest that MT al-
ebellum.67 Second, fMRI has been used to Healthy volunteers, who completed an ters cortical interactions within nocicep-
assess how MT alters the central nervous exercise-injury protocol to induce low tive processing networks at rest, such that
system responses to a noxious stimulus. back pain, underwent resting-state fMRI. subsequent stimuli are received within
For example, healthy volunteers under- They were then randomized into 1 of 3 the cortex in an altered state. Future
went fMRI scanning while receiving nox- MT interventions: spinal thrust manipu- studies should attempt to further clarify
ious stimuli applied to the cuticle of the lation, spinal nonthrust mobilization, or how MT disrupts maladaptive cortical
index finger. Participants then received therapeutic touch, and then underwent patterns and functional connectivity as-
a supine thrust manipulation directed a second resting-state fMRI. Following sociated with chronic pain.
to the mid thoracic spine and were im- MT, there was a reduction in experimen-
mediately returned to the scanner for re- tally induced low back pain, with no dif- Limitations
imaging with a second delivery of noxious ferences observed between types of MT. Methodological approaches to
stimuli. The thrust joint manipulation Common to all MT interventions, the measurement are one of the primary
was associated with hypoalgesia, as well coupling of cortical activity decreased be- limitations to the study of MT
as a significant reduction in activity in the tween sensory discriminant and affective mechanisms, as many techniques
sensory-motor cortices S1, S2, anterior regions (primary somatosensory cortex described in the model to evaluate
cingulate cortex, cerebellum, and insular and posterior insular cortex), while in- nervous system processing are not
cortices, with reduction of cortical activ- creases were observed between affective direct or are isolated measures of
ity correlated to decreased pain percep- regions (posterior cingulate and anterior nervous system activity. The model is
tion.86 Third, resting-state fMRI assessed insular cortices) and affective and de- based on associated neurophysiological
the coupling of cortical activity between scending pain modulatory regions (insu- responses and not direct observation of
brain regions involved in the process- lar cortex and periaqueductal gray).41 The nervous system activity. Subsequently,

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have been associated with clinical out-
• Equipoise comes. For example, a study comparing
• Expectation Provider the use of spinal thrust manipulation to
• Pain beliefs
• Clinical experience nonthrust mobilization for participants
Mechanical stimulus with low back pain observed no group-
• Soft tissue biased dependent differences in pain, disability,
• Nerve biased
total visits, days in care, or rate of recov-
• Joint biased
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ery; however, a significant association was


observed between the treating therapist’s
lack of equipoise (ie, preference for thrust
versus nonthrust mobilization) and sub-
Context sequent outcomes.19 Moreover, provider
expectations can also influence patient
outcomes. For example, baseline physician
expectations are predictive of changes in
pain and physical function in response to
acupuncture in individuals with chronic
pain99 and in return to work following an
• Stiffness
acute episode of low back pain.58 Further-
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

Tissue • Muscle tone


• Preference • Range of motion more, pain relief in response to a placebo
• Expectation intervention was significantly greater for
• Pain beliefs Patient
• Pain-associated distress
a group of individuals following third mo-
• Prior experience lar surgery when the provider was aware
of the chance of administering an active
FIGURE 3. Zone 1 of the model, encompassing the interaction between the provider and patient, as well as the medication, as compared to when the
mechanical stimulus to the targeted tissue. Solid arrows denote a direct mediating effect. Broken arrows denote provider knew that no active drug would
an association between a construct and its measure. Bold boxes provide examples of measurable constructs for be administered.44 Collectively, provider
consideration. preference and expectations have strong
Journal of Orthopaedic & Sports Physical Therapy®

potential to influence MT outcomes;


the observed responses are suggestive replacement for determining clinically therefore, we have revised the model to
of specific nervous system activity effective interventions. account for both the potential role of pro-
(generally based on findings from animal vider characteristics in the mechanical
studies); however, these assumptions are Advancing the Model force, as well as the potential influence on
not directly confirmable in humans, as We have modified the model since its ini- patient-reported outcomes through a su-
conducting such studies would introduce tial development to represent some of the praspinally mediated effect.
valid ethical concerns. The model key changes in understanding MT mecha- Finally, the model was designed to
considers associated neurophysiological nisms. For simplicity, we present the re- account for the mechanisms of MT in pain
responses and attempts to provide vised model in its entirety (FIGURE 2) and inhibition. However, complete reliance
direct relationships to clinical outcomes. by individual zones, with zone 1 (FIGURE on this aspect of MT may result in limited
Importantly, neurophysiological 3) representing the provider, mechanical conclusions and failure to acknowledge
responses to MT are beneficial in force, and targeted tissue; zone 2 (FIGURE overall clinical effectiveness, which is
furthering our understanding of why 4) representing patient nervous system yet another multifactorial construct.
MT is effective; however, the gold responses; and zone 3 (FIGURE 5) repre- More recently, reliance on the sensory
standard for determining whether senting clinical outcomes. The personal aspect of pain as a primary outcome
MT is effective is patient self-report.80 attributes of the MT provider (ie, the clini- has been discouraged in the case of
The model can be used to guide and cian) comprise one element omitted from chronic pain conditions.90 Core outcome
account for nervous system responses the original model. Clinical equipoise is domains for pain have been suggested,
to MT as a plausible explanation for the lack of a preference for an interven- including factors such as physical
observed clinical outcomes; however, tion. Equipoise is desirable in clinical function, emotional function, sleep, and
neurophysiological responses must be trials to avoid bias20; however, a lack of satisfaction with treatment.91,92 Patients
linked to patient self-report outcomes equipoise may be desirable in practice, as seeking physical therapy care attach
and should not be interpreted as a provider preferences for an intervention importance to improvement in constructs

journal of orthopaedic & sports physical therapy | volume 48 | number 1 | january 2018 | 13


[ clinical commentary ]
domains that are valued from a patient
• Somatosensory-evoked • Somatosensory-evoked perspective.
potentials potentials
• Imaging • Imaging
– Positron emission – Positron emission CONCLUSION
tomography tomography

T
– Functional magnetic – Functional magnetic he implementation of effective
resonance imaging resonance imaging
• Conditioned pain MT depends on many factors, in-
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modulation cluding a thorough understanding


of the underlying multifactorial mecha-
nisms through which these interventions
exert their effectiveness. Determin-
ing the mechanisms of MT would both
Pain modulatory Pain-related strengthen the best available research
circuitry brain circuitry and enhance clinical practice through
a personalized treatment approach,
perhaps resulting in better agreement
between clinical judgment, patient pref-
• Autonomic response erences, and the available literature. Clin-
– Skin temperature
ical prediction rules are one approach to
Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.

– Skin conduction
– Cortisol levels stratification initially embraced by MT
– Heart rate providers and researchers. Many clini-
Peripheral nervous system Spinal cord • Neuromuscular cal prediction rules purported to identify
responses
– Motoneuron pool key signs and symptoms suggestive of pa-
– Afferent discharge tients with musculoskeletal pain who are
– Muscle activity likely to benefit from MT.3,16,28,34,37,54,71,79,96
• Temporal summation Despite the initial enthusiasm, the meth-
• Cytokines odology of these approaches has been
• Neuropeptides
questioned and cautious interpretation
Journal of Orthopaedic & Sports Physical Therapy®

• Nerve growth factor


recommended, as initial results may rep-
resent spurious findings or a generally fa-
FIGURE 4. Zone 2 of the model, encompassing the nervous system response of the patient to receiving a manual
vorable prognosis rather than one specific
therapy intervention. Solid arrows denote a direct mediating effect. Broken arrows denote an association between
a construct and its measure. Bold boxes provide examples of measurable associated responses suggestive of a to the effects of MT.5,51,88 Furthermore,
direct nervous system response. derivation studies require validation,
and the vast majority of derived clinical
prediction rules lack additional study or
• Movement-evoked pain
Pain inhibition Clinical outcomes
have failed attempted validation stud-
• Resting pain
• Emotional distress ies.17,35,50 While a noble effort, the current
• Fatigue state of clinical prediction rules suggests
• Interference that this approach may not be optimal for
• Satisfaction
• Decreased pain sensitivity identifying MT responders. Subsequent-
• Enhanced pain inhibition ly, a different approach is necessary, and
• Decreased pain facilitation
mechanistic-based approaches may pro-
vide a more robust method.
FIGURE 5. Zone 3 of the model, encompassing the outcomes of the model for which related mechanisms of
Study of the mechanisms of MT is
manual therapy may account. Solid arrows denote a direct mediating effect. Broken arrows denote an association
between a construct and its measure. Bold boxes provide examples of measurable constructs for consideration. made difficult by the complex nature of
these interventions, resulting in the in-
beyond the sensory aspect of pain,105 and domains are not mechanistic, precluding teraction of multiple complementary
MT is effective in altering outcomes a similar approach to study; and (2) pain mechanisms. We have published a model
beyond the sensory aspect of pain.53,98 We inhibition is an important precursor to that served as the basis for studies to
believe that a continued emphasis of the the other domains. However, mechanistic further our understanding of aspects of
model of the mechanisms of MT in pain studies should be designed to link MT- modulation of pain sensitivity, as well as
inhibition is warranted, because (1) other related pain inhibition to core outcome to guide studies of supraspinal effects of

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MT. Recent work suggests limitations to comprehensive model. Man Ther. 2009;14:531- a general cervical range of motion exercise:
the original model that can be improved 538. https://doi.org/10.1016/j.math.2008.09.001 multi-center randomized clinical trial. Phys Ther.
by the inclusion of provider factors, the 7. B
 ialosky JE, Bishop MD, Price DD, Robinson ME, 2010;90:1239-1250. https://doi.org/10.2522/
Vincent KR, George SZ. A randomized sham- ptj.20100123
inclusion of movement-evoked pain, and
controlled trial of a neurodynamic technique 18. Cook C. Immediate effects from manual therapy:
linking findings to a broader spectrum in the treatment of carpal tunnel syndrome. J much ado about nothing? J Man Manip Ther.
of pain-related outcome domains. Mov- Orthop Sports Phys Ther. 2009;39:709-723. 2011;19:3-4. https://doi.org/10.1179/10669811
ing forward, we believe that the tradi- https://doi.org/10.2519/jospt.2009.3117 0X12804993427009
8. B
 ialosky JE, Bishop MD, Robinson ME, 19. Cook C, Learman K, Showalter C, Kabbaz V,
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tional emphasis on solely biomechanical


Zeppieri G, Jr., George SZ. Spinal manipulative O’Halloran B. Early use of thrust manipulation
mechanisms of MT is misguided in focus therapy has an immediate effect on thermal versus non-thrust manipulation: a randomized
and limited in scope. Subsequent efforts pain sensitivity in people with low back pain: clinical trial. Man Ther. 2013;18:191-198. https://
should focus on a broader understanding a randomized controlled trial. Phys Ther. doi.org/10.1016/j.math.2012.08.005
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18 | january 2018 | volume 48 | number 1 | journal of orthopaedic & sports physical therapy

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