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VI [BIOM]

BIOLOGICAL MODELING AND SIMULATIONS


Time : 3 Hrs. Theory : 100 Marks Term Work : 25 Marks Oral : 25 Marks
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Steps in Modeling, Purpose of Modeling, lumped parameter models, distributed parameter
models, compartmental modeling, modeling of circulatory system, regulation of cardiac output
and respiratory system.
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Biophysics tools, Nernst Equation, Donnan Equilibrium, Active Transport (Pump) GHK equation,
Action Potential, Voltage Clamp, Channel Characteristics, Hodgkin- Huxley Conductance
Equations, Simulation of action potential, Electrical Equivalent model of a biological membrane,
impulse propagation- core conductor model, cable equations.
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Modeling of skeletal muscle, mono and polysynaptic reflexes, stretch reflex, reciprocal
innervations, two control mechanism, Golgi tendon, experimental validation, Parkinson¶s
syndrome.
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Four eye movements, quantitative eye movement models, validity criteria.
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Thermoregulatory mechanisms, model of thermoregulatory system, controller model, validation
and application.
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Behavior of the immune system, linearized model of the immune response.
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BIOMEDICAL INSTRUMENTATION - II
Time : 3 Hrs. Theory : 100 Marks Term Work : 25 Marks Practical and Oral : 25 Marks
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Nerve, Muscle, Pacemaker and Cardiac muscle
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Typical medical recording system and general design consideration. Sources of noise in low
level recording circuits. ECG, EMG, EEG, EOG, ERG. Phonocardiography. Measurement of
skin resistance.
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Measurement of Heart Rate, Pulse rate, Blood pressure, Temperature and Respiration rate,
Apnea Detector.
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Cardiac Arrhythmias. Ambulatory monitoring instruments.
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Cardiotocograph, Methods of monitoring of Foetal Heart rate and labour activity, Foetal scalp
PH measurement, Incubator and infant warmer.
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BIOSTATISTICS
Time : 3 Hrs. Theory : 100 Marks Term Work : 25 Marks
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Basic Concepts, Measurement and Measurement scales, The simple Random Sample, Ordered
Array, frequency distribution, Measures of Central tendency, measures of dispersion, Variance
and Standard deviation.
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Basic Probability concepts, Elementary properties of Probability, Bionomial Disribution, Poisson
Distribution, Continuous Probability distributions, Normal distribution with applications.
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Confidence interval for a population mean, Confidence interval estimates for Population
parameters, and various other confidence intervals, t-distribution, applicability to samples from
normal distributions, Determination of sample size for estimating means and for estimating
proportions, Confidence interval for the Variance of a normally distributed population.
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Purpose of Analysis of variance, Linear Mathematical model for analysis of variance, The
completely randomized design, Randomized Complete Block diagram, Repeated measures
design, The factorial experiment. Two-factor Experiments with Replication.
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Curve fitting, Regression and Correlation Model, Sample regression equation, using regression
equation, Correlation coefficient, Multiple Linear regression model, Multiple Linear Correlation
model, Obtaining Multiple Linear regression equation, evaluating Multiple Linear regression
equation, Regression analysis-Qualitative independent variables, Variable selection procedures.
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Statistical decisions, Stastitical Hypothesis, Null Hypothesis, Type I and Type II errors, level of
significance, One Tailed and Two Tailed tests, Relationship between Estimation theory and
Hypothesis testing. Yates¶ Correction for Continuity.
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Mathematical properties of chi-square distribution, Tests of goodness-of-fit, tests of
independence, tests of homogeneity, The fisher exact test.
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The sign test, the Wilcoxon signed-rank test for location, The median test, The spearman rank
correlation coefficient, Non Parametric Regression Analysis, Classification (differential,
diagnosis) : sequential clinical trials, and other applications.
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DIGITAL SIGNAL PROCESSING FOR BIOMEDICAL APPLICATIONS
Time : 3 Hrs. Theory : 100 Marks Term Work : 25 Marks
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Review of Discrete time signals and systems.
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Review of Z transform, Analysis of LTI systems in Z domain.
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DTFS definitions from orthogonal complex exponentials, CTFS and DTFS and Properties of
DTFS, Power Density Spectrum, DTFT and Properties of DTFT, Energy Density Spectrum.
Relationship between DTFT and Z transform.
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DTFT, DFT and DFT properties, Block convolution using DFT by Overlap-add and Overlap-save
methods, Fast Fourier transform (FFT).
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System Transfer function, System realizations using direct, cascade, parallel and Lattice forms.
System Analysis : Impulse response, zero input and zero state response Signal generation.
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Design of FIR filters, Design of IIR filters from analog filters, frequency transformations, Design
of digital filters based on least squares method digital filters from analogue filters, Properties of
FIR digital filters, Design of FIR filters using windows, Comparison of IIR and FIR filters, and
Linear phase filters. Application of Filters on Biomedical Signals like ECG, EEG, EMG,
Receiver, Advantages, Disadvantages.
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Need for Special Architecture, Difference between DSP Processor and microprocessor, general
DSP Processor.

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MEDICAL IMAGING - I
Time : 3 Hrs. Theory : 100 Marks Term Work : 25 Marks Oral : 25 Marks
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Introduction, Production and Characteristics of Ultrasound, Display System : A-mode, B-mode
and M-mode display and applications, Ultrasound transducers and instrumentation, Real-Time
Ultrasound, Continuous wave and Pulsed wave Doppler Ultrasound systems, Color flow
imaging, applications, Ultrasound contrast agents and applications.
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Properties of X-rays, Production of X-rays, X-ray interaction with Matter. Total Radiographic
System : X-ray tubes, Rating of X-ray tubes. X-ray generators, X-ray Image and Beam Limiting
Devices, Controls, X-ray Film development technique.
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MICROCONTROLLERS AND EMBEDDED SYSTEMS
Time : 3 Hrs. Theory : 100 Marks Term Work : 25 Marks Oral : 25 Marks
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Introduction to Single chip microcontrollers of Intel MCS 51 family. Comparison of
microprocessor and microcontroller, architecture and pin functions of 8051 Single chip
microcontroller, C.P.U. timing and machine cycles, internal memory organization, Program
counter and stack, input/output ports, counters and timers, serial data input and output
Interrupts. Connection of external memory. Power saving modes. Interfacing of 8051 with
EPROM.
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Instruction set addressing modes, immediate, registers, direct and indirect data movement and
Exchange instructions, push and pop up-codes, arithmetic and logic instructions, bit level
Operations, jump and call instructions, input/output port programming, programming timers
Asynchronous serial data communication, timer and hardware interrupt service routines.
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External memory and memory address decoding, memory mapped I/O, time delay subroutine
look up table implementation, interfacing matrix keyboard and seven segment displays through
scanning and interrupt driven programs, interfacing ADC and DAC. Interfacing of LCD display.
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Introduction to Embedded Systems, Examples of embedded system, their characteristics and
their typical hardware components, Software Embedded into a system embedded software
architecture, Processor and Memory organization Structural Units in a processor, Processor
Selection for an embedded system, Memory Devices, Memory selection for an embedded
system, Allocation of Memory to program segments and blocks and memory map of a system,
Direct Memory access, Interfacing processor, memories and I/O devices.
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I/O devices, Timer and counting devices, Serial Communication using the µ12C¶, µCAN¶ and
Advanced I/O Buses between the networked multiple Devices, host system or computer parallel
communication between the networked I/O Multiple Devices using the PCI, PCI-X and
advanced buses.
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Device drivers, Parallel port device drivers in a system, serial port device Drivers in a system,
device drivers for internal programmable timing devices, Interrupt servicing (handling)
mechanism, Deadline and Interrupt Latency.4.
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