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PATHOPHYSIOLOGY

DEFINITION:

Diabetes Mellitus is a group of metabolic disease condition characterized by


elevated level of glucose in the blood resulting from defects in insulin secretions, insulin
action or both.

PREDISPOSING FACTOR:

 Genetic Predisposition
 Autoimmune disorder
PRECIPITATING FACTOR:

 Sedentary lifestyle
 Obesity
 Age
 Voracious eating
 Corticosteroids drugs
DIABETES MELLITUS

Impaired Insulin Increased basal hepatic glucose GI absorption of glucose


secretion production

Impaired transport and Increased and rapid build


metabolization of up of glucose in the
glucose into cell for S & SX: blood stream
energy  Polyuria
 Glycosuria
Increased blood viscosity

S & SX:
 Polydipsia Increased BP
Hypertension related to
 Polyphagia
increased stroke volume
Weight lost
Increased breakdown of fats

Blood vessel wall


thicken, scleroses, &
Increased free fatty acids in occluded by plaque that
the circulation adheres to the vessel

OBSTRUCTION IN BLOOD
FLOW

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