NAME: AQUITANIA, Mary Christelle G.

SCORE:______________

SECTION: 3E – Medical Technology DATE: _______________

BB LECTURE SEATWORK
OTHER BLOOD GROUP SYSTEM

ANTIGEN ANTIBODY
BLOOD GROUP ISBT # GENE ASSIGNMENT
SYMBOL BIOCHEMISTRY PHENOTYPE SYMBOL Ig TYPE Clinical Significance

HDN
M+ N- IgM HEMOLYTIC
Glysophorin M- N+ Anti-M DISEASE OF THE
NEWBORN
M A M+ N+ Anti-N
HTR
Chromosome N [M, N] IgG HEMOLYTIC
MNSs 002
4q28q31 S Glycophorin S+ s- Anti-S TRANSFUSION
REACTION
s B S- s+ Anti-U
[S, s] S+ s+ REJECTED
S- s- U TRANSPLANTED
KIDNEY
Lua
Lub
Lu(a+b+) Anti-
Lu3
Lu(a+b-) Lua Mild HDN,
Lutheran 005 Chromosome 19q Lu4 Glycoprotein IgG
Lu(a-b+) Anti- most likely rare
Lu5
Lu(a-b-) Lub
Lu6
Lu7
Codominant
antigen

Located on Anti-
Di(a+b+)
anion Dia
Di(a+b-)
exchange Anti-
Dia Di(a-b+)
protein of Dib Mild HDN
Dib
Diego 010 Chromosome 17q AE-1 IgG Moderate➙Sev
Wra
(erythrocyte Anti- ere HTR
Wrb Rare:
band) Wra
Wr(a+)
Anti-
Wr(b+)
Resistant to Wrb
all enzyme
and chemical
treatment
Located on
acetylcholines
terase
(AchE),
involved Anti-
Yt(a+b+)
Yta enzyme in Yta
Cartwright 011 Chromosome 7q Yt(a+b-) IgG HTR
Ytb neurotransmi Anti-
Yt(a-b+)
ssion Ytb

Sensitive to
Pronase &
DTT 0.2M
Xg 012 Chromosome Xp Xga XG transcript XgaXg Anti- IgG Not implicated
detected n XgXg Xga in HDN/HTR
erythrocyte
and
nonerythroid
tissues (heart,
placenta,
skeletal
muscle,
trachea,
prostate,
thyroid,
 spinal cord)
Antitetical
relationship
of antigen
[Sca, Scb]

Shown to be Sc: 1, 2
expressed by Sc: -1, 2
Sc1 RBC Sc: 1, -2 Anti- Not implicated
Sc2 adhesion Sc1 in HTR
Scianna 013 Chromosome 1p IgG
Sc3 protein Sc: 1, 2, Anti-
Rd ERMAP Rd+ Sc2 Mild HDN
Sc: 1, -2,
Resistant to Rd+
all enzyme
and chemical
treatment

Inherited as
codominant
allele

Antitetical
relationship
of antigen

Null
phenotype
demonstrate
PNH III
Doa absence of Do(a+b+)
Anti- PAROXYSMAL
Dob DO antigens Do(a+b-) NOCTURNAL
Doa
Dombrock 014 Chromosome 12p Gya due to all Do(a-b+) IgG HEMAGLOBINURIA
Anti-
Hy residing on a
Dob HDN
Joa glycosylphosp Gy(a+)
hatidylinosito
l. This is a
part of the
mono-ADP-
ribosyltransfe
rease family

Sensitive to
Trypsin
Pronase
DTT 0.2M
Mild HDN only
(Anti-Coa,
Located on
Anti-Cob)
the integral
transmembra
Anti- SevereHDN
ne protein,
Co(a+b+) Coa Mild HTR
Coa Aquaporin-1
Co(a+b-) Anti- (Anti-Co3)
Colton 015 Chromosome 7p Cob (AQP1) IgG
Co(a-b+) Cob
Co3
Co(a-b-) Anti- Co(a-b-):
Resistant to
Co3 Myeloid
all enzyme
leukemia,
and chemical
Preleukemic
treatment
dysmyelopoieti
c syndromes
Chido/Rogers 017 Chromosome 6p Ch1 Located on Chido: Anti- IgG Not implicated
Ch2 C4 CH/RG: Ch1 in HDN
Ch3 complement 1,2,3 Anti-
Rg1 component CH/RG: Ch2 HTR
Rg2 1,-2,3 Anti-
 CH/RG:
1,2,-3
Poorly CH/RG:
expressed on -1,-2,-3
cord cells CH/RG:
-1,2,-3 Ch3
Sensitive to CH/RG:
FICIN 1,-2,-3 Anti-
WH
PAPAIN Rg1
Chymotrypsi Rodger: Anti-
n CH/RG: Rg2
Trypsin 11,12
Pronase CH/RG:
Cloroquine 11,-12
CH/RG:
-11,12
Glycophorin GE: 2,3,4
C (GPC)
YUS TYPE
Ge2 and/or
GE: -2,3,4 Anti-
Ge3 Glycophorin Rare HDN
Ge2
Ge4 D (GPD) (variable)
GERBICH Anti-
Gerbich 020 Chromosome 2q Wb IgG
TYPE Ge3
Lsa Sensitive to Acute➙Delaye
GE: -2,-3,4 Anti-
Ana FICIN d HTR
Ge4
Dha PAPAIN LEACH
Trypsin GE:
-2,-3-,4
Anti-
Cra
Anti-
Tca
Anti-
Cra Dra
Tca Anti-
Dra Glycoprotein Esa
Esa Anti-
Not implicated
IFC Resistant to Cr(a+) IFC
in HDN
Cromer 021 Chromosome 1q UMC FICIN Cr(a-) Anti- IgG
WES b PAPAIN UMC
Mild HTR
Trypsin Anti-
Tcb Cloroquine WES b
Tcc
WES a Anti-
Tcb
Anti-
Tcc
Anti-
WES a
Knops 022 Chromosome 1q Kna Glycoprotein Kn(a+b+) Anti- IgG Not implicated
Knb Kn(a+b-) Kna in HDN/HTR
McCa Resistant to Kn(a-b+) Anti-
SI1 FICIN Knb Autoimmune
SI2 PAPAIN disease:
SI3 Cloroquine Sytemic lupus
Yka Weakened by erythromatosus
TRYPSIN Chronic cold
Chymotrysin agglutinin
DTT 0.2M disease

Poorly
expressed on
cord cells

Depressed in
 patients with
autoimmune
disease and
Lu(a-b-)
phenotype
Glycoprotein
Antigen
carried on
CD44

Poorly
Not implicated
expressed on Anti-
In(a+b+) in HDN
Ina cord cells Ina
Indian 023 Chromosome 6p In(a+b-) IgG
Inb Anti-
In(a-b+) HTR
Depressed in Inb
patients with
Lu(a-b-)
phenotype

Resistant to
Cloroquine
Resides on
SEMAPHOR
IN CDw108
Not implicated
(GPI-linked
in HDN/HTR
John Milton protein) Anti-
026 Chromosome 15q JMH JMH IgG
Hagen JHM
Absence of JMH
Sensitive to
Ag: PNH III
all enzyme
and chemical
treatment
Bga
(HLA-
Directed
B7)
towards Rare HTR
Bgb Bga
human Anti-
Bg Chromosome Xp (HLA- Bgb IgG
leukocyte Bg Not implicated
B17) Bgc
antigens in HDN
Bgc
(HLA)
(HLA-
A28)
Found more
than 90% in
Resides at
terminal RBCs, several
trisaccharide tissue types
structure, [e.g. stomach,
GalNAcβ1- Sid(a+) colon, kidney,
Sda 4(NeuAcα2- Anti- IgM
SID (Sda) Chromosome 17 Sid(a-) oocytes], and
(SID) 3)Galβ, Sda IgG
body fluids [e.g.
carried on
saliva, breast
glycoproteins
milk, serum, and
and
urine with the
glycolipids
greatest
concentration]
Jk(a+b+) Anti-
Chromosome Jka Jk(a+b-) Jka Mild HDN
Kidd 009 Glycoprotein IgG
18q12 Jkb Jk(a-b+) Anti- HTR
Jk(a-b-) Jkb
Duffy 008 Chromosome Fya Glycoprotein Fy(a+b+) Anti- IgG HDN
1q22-23 Fyb Fy(a+b-) Fya Acute HTR
Fy(a-b+) Anti-
Fy(a-b-) Fyb
Anti-
Fy3
Anti-
Fy4
 Anti-
Fy5
Anti-
Fy6
K
k K+ k+
Kpa K+ k-
Kpb K- k+
Jsa
Chromosome Jsb Kp(a+b+) Severe HTR
Kell 006 Glycoprotein Anti-K IgM
7q33 K11 Kp(a+b-) Severe HDN
K14 Kp(a-b+)
K24
K17 McLeod
Kpc
Ko
Glycoprotein PCH
PAROXYSMAL
P Anti-P COLD
P Formed by HEMAGLOBINURIA
P1 Anti-P1
P 003 Chromosome 22q P1 the action of IgM UTI
Pk Anti-
Pk glycosyl Parasitic
p (P null) Pk
transferase, infection
like ABH Ag Early abortion
Hemolytic
Glycoprotein anemia
Hodkin’s
Branched and disease
linear I
I Anti-I IM
Chromosome carbohydrate
I 027 IgM INFECTIOUS
6p24 structure that i MONONUCLEOSIS
i Anti-i
are formed by Alcoholic
the action of cirrhosis
glycosyl Myeloid
transferase leukemia
Reticulosis