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HAVENER EYE INSTITUTE

THE OHIO STATE UNIVERSITY • DEPARTMENT OF OPHTHALMOLOGY

ANNUAL REPORT 2009-2010


Dear Friends and Colleagues,
During the past year, The Havener Eye Institute has relocated to our new
facility at The OSU Eye and Ear Institute, one-half mile south of our
previous location. With an outpatient surgical center in our new building, we
have experienced exponential growth in the past year while simultaneously
CONTENTS
RESEARCH FOCUSED ON THE FUTURE

OSU President, Dr. E. Gordon Gee


with some Ophthalmology residents
maintaining extremely high patient satisfaction ratings. and fellows
1 RESEARCH
The ophthalmology residency program is the key element of our educational
program. Due to all of the efforts of our dedicated faculty, over five percent of
the OSU medical students have selected ophthalmology as their career choice. 8 GIVING
Research efforts are expanding in the areas of ocular oncology, ocular
biomechanics, and cerebrospinal fluid physiology. The faculty of the 12 EDUCATION
Department have been very active in clinical trials involving age-related
macular degeneration, diabetic retinopathy, pseudotumor cerebri, glaucoma,
cataract surgery and corneal collagen crosslinking for keratoconus. 16 EYECARE
Our grateful patients, alumni, and friends have continued their generous
gifts to our department in terms of time, advice, and donations. These gifts 26 GRANTS
are absolutely essential to further the research and educational activities of
our Institute in these trying times. We depend on this generosity to create a
legacy to sustain both present and future endeavors. 28 PUBLICATIONS
There are many unknowns about the future of healthcare and our profession.
One thing, however, is certain: it is the quality of our staff, faculty, residents, 30 PRESENTATIONS
and fellows that will allow us to meet our goals despite the many challenges
that face us. We will continue to train excellent physician leaders and restore
sight and prevent blindness through personalized clinical care and research. 32 MISSIONS
Sincerely,

Thomas F. Mauger, MD
Director and Chairman
The Carl M. and Grace C. Baldwin Chair in Ophthalmology
The William H. Havener Eye Institute
The Department of Ophthalmology OSU PRESIDENT RAISES $41K FOR RESIDENT RESEARCH & EDUCATION
The Ohio State University
OSU President E. Gordon Gee stepped from Despite this high title, he was completely by former Buckeye and golf legend, Jack
his vehicle onto the beautiful lawn of the comfortable with talking and posing for Nicklaus. As difficult as the course was, ev-
Dr. Mauger with THOMAS MAUGER, MD OSU Scarlet Golf Course and was eagerly photos with as many participants as he eryone agreed that it was a perfect day with
OSU President, Dr. CHAIRMAN met by over 100 charity participants at the could. To community sponsors and area sunny skies and well-matched foursomes.
E. Gordon Gee Fifth Annual BuckEYE Golf Classic. The ophthalmologists, Dr. Gee extended more
ROBERT LAFOLLETTE, MBA charity outing, held this past June, had a lot than just a smile and firm handshake. He The BuckEYE Classic trophy was awarded
ADMINISTRATOR to live up to as the previous events had been also gave his deep appreciation for their to Drs. Doug Baker, Jack Dingle, and Tom
hosted by first-class special guests including support of education and research at the Dingle for scoring well under par, but the
Archie Griffin, Thad Matta, Jim Tressel, and OSU Havener Eye Institute. real winners were the OSU Ophthalmology
LAURA SLADOJE Clark Kellogg. The bar was set high, but resident physicians. The $41,000 raised
OUTREACH DIRECTOR Dr. Gee is no stranger to the limelight. After meeting Dr. Gee, the charity partici- will go to support resident education.
pants were treated to a drive clinic led by
CHRISTINA STETSON As president of one of the largest universi- World Long-Drive finalist and OSU Oph- “It was a success, but we could not have
ties in the country, with an annual budget thalmology resident, Dr. Landon Colling. done it without the help of our sponsors,
PROGRAM COORDINATOR greater than the state of Rhode Island, Dr. He showed them proper swing technique, especially Fifth Third Bank,” said Dr.
Gee is at home with national attention, but ways to maximize their efforts, and con- Alan Letson, Residency Program Director.
MICHAEL HOUGHTON maintains his hometown charm. His candor cluded with tips on health and fitness. “These are companies that are so invested in
COVER PHOTO and friendliness are well known, but it’s their communities that they step up to make
still hard to prepare for the genuine level The participants were grateful for the tips, a difference. Their generosity supports the
of interest that he has for people. It is no as they were definitely needed for the chal- education and research of tomorrow’s eye
OPHTHALMOLOGY OUTREACH wonder that he was recently named TIME lenging course ahead. OSU Scarlet Golf physicians.”
PHONE | (614) 293-8760 magazine’s No# 1 College President in the Course is one of the top collegiate courses
EMAIL | EYE@OSUMC.EDU country. in America and was recently redesigned

1
Researcher/Clinician Dr. Cebulla with Researcher Researcher Dr. Abdel-Rahman
FIFTEEN-YEAR
Dr. Boru, discussing genetic findings performing genetic analysis CANCER SURVIVOR
BERNIE MUDROCK
"When we heard the word choroidal mela-
noma, we just wanted to run away, but soon
we knew we were in the right place to combat
this cancer. How lucky we were to be treated
by doctors in the Havener Clinic.

We had a real sense of confidence that we


were being treated by doctors who were the
best in their field, and would do everything
they could to take care of us. Dr. Davidorf put
a radioactive patch over the tumor. Bernie did
not have to lose his eye. He still has valuable
peripheral vision, and he says he does not even
notice a deficit in his vision. He sees as well
with one eye as he did with two, and he does
not have to deal with a prosthetic eye.

OCULAR
Dr. Davidorf has been a doctor and a friend
of eye melanomas. Dr. Havener and Dr. herbs that are able to alter the growth of
for such a long time. He still sees Bernie once
Frank Batley, former head of Radiation cancer cells. It is their belief that these
a year. We have been so fortunate to have
Oncology, designed a radioactive eye ring, types of herbal medicines may be able to
been given all these years together since the
using brachytherapy (applying radiation control the spread of cancer with minimal

MELANOMA
diagnosis. For that, we thank Dr. Fred Davi-
directly to the cancer) to treat these tumors side effects to the patient.
dorf and the rest if the doctors and staff at the
without enucleation. OSU was one of the
Havener Clinic.
first hospitals in the U.S. to use brachy- The Ocular Oncology Division is also
therapy for ocular melanoma, which is studying three different aspects of the
We donate funds every year to help research
now the standard of care. genetics of ocular melanoma. First, they
for choroidal melanoma. We do this for two
are looking for markers that can identify
reasons. First, we hope to help other people
In 1980, Dr. Havener passed the manage- patients with an aggressive form of the
one day. We know this is not a common can-
ment of patients with ocular melanoma to disease. This will allow researchers to
TRANSLATING RESEARCH INTO TREATMENT Dr. Frederick Davidorf, who established
the Ocular Oncology Division. In 1985,
follow these patients more carefully, and
in the future select these patients for any
cer, and we want to be a part of trying to cure
it once and for all. Second, we are so grate-
ful for the wonderful care we received. We
The OSU Ocular Oncology Division potential systemic treatment. Secondly,
Many patients envision the sterile to the management of patients with ocular wanted to find a way to give back."
Mohamed Abdel-Rahman, MD, PhD participated in one of the National Eye they are pre-selecting patients whom
environment of the laboratory and wonder melanoma. Patients are evaluated by ocu- Institute’s largest clinical trial to date. they believe will better respond to newly -DORIS MUDROCK
Colleen Cebulla, MD, PhD how hours of looking through a microscope lar oncologists Drs. Frederick Davidorf and The Collaborative Ocular Melanoma discovered treatments, and also decrease
Elson Craig, MD relates to their care. The Ohio State Colleen Cebulla, medical oncologists Drs. Study (COMS) lasted over fifteen years the toxicity of the medication. Finally,
Medical Center’s answer can be found Thomas Olencki and Kari Kendra, radia- and succeeded in proving that radiation they are attempting to identify the genetic
Frederick Davidorf, MD at the new OSU Center for Clinical & tion oncologist Dr. Douglas Martin, and treatment was just as effective in curing markers that a small subset of patients
Kari Kendra, MD, PhD Translational Science (CCTS). The CCTS human cancer geneticists Drs. Mohamed eye cancer as enucleation. and their family members have inher-
is a Medical Center-wide effort to fast track Abdel-Rahman and Robert Pilarski. By ited, which predisposes them to ocular
Thomas Olencki, DO the breakthrough scientific findings from pairing our researchers with our clinicians In addition to radiation, chemotherapy is melanoma and other tumors. Recogniz-
the labs to the clinics so patients can benefit and consulting specialists from every field also used to combat most cancers. While ing these patients will help in the early
from OSU’s top-tier research institute. of oncology, the Havener Eye Institute is radiation is used to target and destroy can- management of not only the patient, but
able to offer patients a more thorough ap- cer cells, chemotherapy uses toxic com- of their at-risk family members.
The Havener Eye Institute is on the proach to cancer care. pounds which kill cells. Both methods
forefront of this initiative with its dynamic, have destructive side effects, and anyone The future of ocular melanoma care is in
interdisciplinary ocular melanoma team In the tradition of OSU’s medical pioneers, who has witnessed the ravages of chemo- today’s laboratories. From Dr. Mohamed
working together to end this disease. In the ocular oncologists at the Havener Eye therapy and radiation understand how dif- Abdel-Rahman, cancer geneticist, to Dr.
October 2009, the Havener Eye Institute Institute have always sought to improve ficult and traumatic these treatments can Colleen Cebulla, clinician and researcher,
was recognized as one of the leading diagnostic tools and treatments. Until the be. In an effort to discover a less harsh we are bringing the latest understanding
centers for the treatment of ocular late 1960s, patients diagnosed with ocular therapy, Dr. Mohamed Abdel-Rahman of disease processes from the laboratory
melanoma at the 1st Annual Ocular melanoma had no choice but to have their and his collaborators are currently study- and applying them to clinical situations.
Melanoma Scientific Working Group. eye enucleated (surgically removed). ing naturally occurring medicinal herbs With experienced faculty and fresh ideas,
Then, under the leadership of the late Wil- to control the growth of melanoma cells. the Havener Eye Institute is translating
The Havener Eye Institute has a long his- liam Havener, OSU Ophthalmology began They have found several very promising, basic science into better patient care, Bernie & Doris Mudrock
tory of using a multi-disciplinary approach the concept of “conservative management” highly efficient and relatively non-toxic every day.

2 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 3


There are many theories about why high IOP can lead to
Medication-laden nanobubbles glaucoma, but testing these theories can be difficult, as very Natural Trabecular
few trabecular meshwork tissue samples are donated for Meshwork
research. Artificial tissue had to be created for enough to
be available for study. Trabecular meshwork tissue is very
complex, and past methods of construction were limited to
less realistic two-dimensional models. This complicates
the data analysis and interpretation. Clearly, a model that
can more closely resemble natural trabecular meshwork
tissues was imperative.

By weaving tiny fibers that had been nanoengineered, the


trabecular meshwork’s complex natural shape can now be
replicated, making closer study possible. The end of this
terrible disease could be just around the corner.

“Nanotechnology gives us a new perspective for re-


search,” said Dr. Zhao. “As we shrink things down, we Artificial Trabecular
can see many rules that are different from the larger scale Meshwork
world. It’s like opening the door to a new frontier in
medicine.”

NANOBUBBLE DELIVERING DRUG


From potions to pills to injections, the medical community
has always tried to find better and faster ways of getting
medication to where it will do the most good. In 2010,

NANOTECHNOLOGY
Genentech, the world’s leading biotech company, ap-
proved an $80,000 grant of Lucentis®. Lucentis® is an
anti-VEGF medication that slows the growth of abnormal
blood vessels in the back of the eye (retina) for patients
with age-related macular degeneration (AMD). Drs. Rob-
erts, Sanders, Letson, and Xu (PI) are now developing a
more efficient drug delivery method for anti-VEGF medi-

TINY PARTICLES The 1966 Oscar award-winning film


Fantastic Voyage took us on a microscopic
NANOFIBERS COMBAT GLAUCOMA cation using microscopic particles known as nanobubbles. Dr. Zhao shows Dr. Xu a microscopic
sample of nanofiberous material
Intraocular injections of anti-VEGF medication have been
THAT MAY SAVE journey through the bloodstream. In the
film, physicians and scientists were min-
In a David and Goliath tale, the nanoparticle
is poised to take on a disease that the National used to combat AMD for many years, but despite their
success, still have many problems. The anti-VEGF medi-
YOUR SIGHT iaturized to save a patient’s life. Setting
Eye Institute calls the second leading cause of
blindness in the world. Using tiny nanofibers, cation quickly leaves the eye after injection, and since a
aside science fiction (and shrinking people), OSU researchers Dr. Zhao, the Principal In- high concentration is needed for proper treatment, more
scientists and physicians have always been vestigator (PI), along with Drs. Gryzbowski, injections are necessary. Each additional injection multi-
Roberts, and Weber are creating artificial tis- plies the risks of local and systemic adverse reactions.
fascinated with the idea of utilizing atomic
sues that will be used to study glaucoma. The new drug-loaded nanobubbles will allow medication
and subatomic particles for healthcare and to accumulate in the retina for a longer period of time, until
technology. Now, they are using nanotech- activated selectively using ultrasound. The nanobubbles
The eye, unlike most of the body, relies on
nology to do just that. fluid rather than bone to help maintain its are dyed a fluorescent yellow, which makes them visible to
shape. Much like a water balloon, it requires imaging and able to be guided and released when they are
Nanotechnology, the study of controlling the correct amount of fluid to function prop- in place. The biodegradable nanobubbles keep the medica-
erly. Because the eye is constantly produc- tion from disbursing before reaching the target area, reduc-
extremely small matter, deals with structures
ing fluid, it needs to drain fluid to maintain ing the number of injections needed.
sized between 1 and 1000 nanometers (one
the right amount of intraocular pressure, or
billionth of a meter). By comparison, a pressure within the eye. “What we are creating is a clinical platform,” said Dr. Xu.
nanometer is to a meter what a marble is to “Right now we are using it for AMD, but really it could
the earth. At The OSU Havener Eye Institute, Glaucoma affects 65 million people worldwide be used for delivering medication for all ophthalmic dis-
and is generally associated with high intraocu- eases. We are very excited by the possibilities.”
we are using some of the world’s smallest
lar pressure (IOP). The trabecular meshwork
particles to deliver much-needed medica- In short, nanotechnology allows for more research, more
is located in between the cornea (clear surface
tion to patients with AMD and to discover of the eye) and the iris (the colored portion answers, fewer injections, fewer adverse reactions, and
the mechanisms behind glaucoma, one of the of the eye). It is responsible for draining the better care for our patients�and that is no small thing.
world’s most common blinding diseases. intraocular fluid and maintaining proper IOP.

4 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 5


Dr. Christoforidis
performing wound
healing research

Cynthia Roberts, PhD


Division Director

Mohamed Abdel-Rahman, MD, PhD

RESEARCH
REPORT Dr. Zhao examines nanofibers
Deborah Grzybowski, PhD

EXPANDING
The Research Division spans all subspecial- has resulted in appointments in Ophthalmol- analysis of experimental and human retinal sustained delivery of anti-VEGF therapy via
TREATMENT ties of Ophthalmology, and includes not ogy for Dr. Jun Liu, who is experienced in detachments with proliferative vitreoretinopa- intravitreal injection of micro/nanoparticles
only the faculty, but also residents, graduate corneal and ocular biomechanics; Dr. Ronald thy (PVR) and potential for therapy. Dr. John with encapsulated drugs for use in treating age-
OPTIONS & students, and medical students. Xu, a specialist in sustained intravitreal drug Christoforidis, also from the Retina Division, related macular edema.
DIAGNOSTIC delivery via multifunctional micro/nano has been evaluating the effect of intravitreal Jun Liu, PhD
It has been an eventful year, full of promise. particles; and Dr. Yi Zhao, who is an expert anti-VEGF agents on the function of cutaneous Medical students are also given the opportunity
INSTRUMENTS In cooperation with faculty from the Cornea, in the field of micro/nanofabrication for wound healing. to develop a research project of their own, or
Retina, and Glaucoma Divisions, we have simulating 3-D ocular tissue structures. to be involved in an ongoing research project.
conducted research into many ocular condi- Many small research projects are supported During the past academic year, two medical
tions. These collaborations have resulted The Research Division exposes ophthal- by the Ohio Lions Eye Research Foundation, students received Dorothy M. Bennett and
in numerous publications and grant awards mology residents to the scientific research from which the Department receives an annual Clark L. Bennett Medical Research Scholar-
from the National Institute of Health, the process by involving them with a faculty endowment. A portion of the grant supports ships under the supervision of Dr. Grzybows-
Columbus Foundation, the Ohio Lions Eye mentor in either basic science or clinical basic research in the Ohio Lions Ophthalmic ki’s project titled, “Retinal capillary angiopathy
Research Foundation, as well as numerous studies. Many residents choose a project Research Laboratory located in the Tzagournis as a biomarker for diabetic systemic disease.”
industry awards. that spans all three years of their residency Medical Research Facility. The lab is directed One student, Benjamin Abramowitz, worked on Ron Xu, PhD
to allow adequate time for a fully developed by Dr. Grzybowski and is well equipped for cell a project titled “Swelling Analysis of Biome-
Three research faculty with primary ap- project. They are encouraged to attend the culture-related projects including performing chanical Properties in the Post-LASIK Cornea.”
pointments in Ophthalmology include Dr. Association for Research in Vision and real-time RT-PCR, ELISA assays, in addition to
Mohamed Abdel-Rahman, specializing in Ophthalmology (ARVO) annual meeting and IHC, PCR, Western blots, and others. Another For the past year, our dedicated research and
uveal melanoma and cancer genetics; Dr. present their research. Our ophthalmology portion of the grant provides additional support clinical faculty have tirelessly pursued new
Deborah Grzybowski, who has expertise research faculty also serve as advisors for to the Graduate Fellowship in Eye Research. methods for diagnosis and treatment. The
in ophthalmic cell culture and intracranial graduate students whose thesis or disserta- collaborations between our laboratories and
fluid dynamics; and Dr. Cynthia Roberts, an tion involves vision-related research. The Department’s Lions Fellow is Leilei patient care clinics are key to unlocking the
ophthalmic engineering specialist. Over the Zhang, MS, who plans to graduate with a PhD treatments of the future.
past few years, a stronger collaboration with Dr. Colleen Cebulla from the Retina Divi- in June of 2012. Leilei’s research program
the Department of Biomedical Engineering sion has been investigating the proteomic has focused on developing a new method for Cynthia Roberts, PhD Yi Zhao, PhD

6 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 7


GIVING MAKING A DIFFERENCE
Thom & Nancy Robinson in front
of our donor recognition wall
Dr. Weber oversees
a medical student
examining a patient

2010 BUCKEYE BENEFACTORS


THIS LIST RECOGNIZES DONATIONS MADE TO THE DEPARTMENT FROM JANUARY 1, 2010 TO DECEMBER 31, 2010

$10,000 - $49,000 Dr. James Moses Dr. Herbert Bean Dr. Rebecca Kuennen
Jerry Colp Dr. Karl Pappa Dr. A. Gary Bitonte Barbara Landolfi
Phyllis Havener Elizabeth Reese* John Bockoven Dr. Richard Lembach
Dr. Alan Rehmar Dr. John Burns Dr. Carrie Lembach
Drs. Thomas Mauger &
Dr. Carl Shin Dr. Kenneth Cahill Dr. Max & Jean Lerner
L. Carol Laxson
George & Tina Skestos Dr. John Christoforidis Paul Little
Peggy Roberts Laura & Doug Sladoje Dr. Jeffrey & Sue McAdoo

Dr. Landon Colling
Jacob & Zel Yessenow Gina Coman Kathryne McKinney
$5,000 to $9,999 Dennis Corbett Dr. Randy McLaughlin
Dr. C. Patrick Carroll Jill & Karl Milliron
$500 to $999 Albert Covelli
Dr. Henry & Suzanne Croci Dian Montgomery
John Alberini Dr. Elson Craig*

$1 MILLION PLANNED GIFT


Dr. David Lehmann Lora Moore
Dr. N. Douglas Baker Shannon Culp
John Marakas Skip Murray
Dr. Frederick Davidorf Dr. Elliot Davidoff
Mildred Glover Dr. Jack Dingle Fred & Cheryl Nicely
$2,500 to $4,999 Dr. Thomas Dingle Marlene O’Dair
Dr. Charles & Susan Hickey
Dr. David Adam Dr. Philip O’Donnell
Dr. Christopher Hogan Henry & Elaine DiSalvo
Thom and Pat Robinson are an extraordinary “It all started with a football ticket,” said Dr. Kapetansky has been a loyal and active Dr. Louis Bloomberg* Robert Olson
John Jeffries Catherine Fenderson
couple from Troy, Ohio that work tirelessly Pat. “The more you are here, the more in- alumnus and professor of the Department of Dr. Colleen Cebulla Karen Price
Steven Juenger Ruth Fisher
to better their community and the future of volved you get, the more questions that you Ophthalmology for decades. He has taught Drs. Jack & Candace Hendershot Trish Rebish
Laurence Karns Dr. Gloria Fleming
Ohio. Evidence of their volunteering and ask, the more people that you meet. The countless students and residents the nuances Dr. Steven & Stacy Katz Ann Roush
Dr. Alan & Susan Letson Deborah Lanam Dr. Carla Ford
philanthropic efforts can be seen all over next think you know, you’re thinking ‘Gee, of glaucoma diagnosis and management. Jill Salerno
William & Lynne Martin Dr. Charles Leone Jr. Margery Forry
The Ohio State University—in the newly this is a wonderful place. What can we do T. Dwain Sayre
Dr. Robert McKinlay Tim McNemar Dr. Jill Foster
renovated main library, in the new Veterinary to help?’” The Robinsons are outstanding volunteer Grier Schaffer
Dr. Garret & Christina Mouser Dr. William Penland Kelli Fox
Medicine academic building, in the numer- leaders, members of boards and commit- Robert & Helenor Smith
ous athletic scholarships, and in a generous Thom and Pat understand the value of medi- tees, extraordinary donors, and enthusiastic Dr. Jeffrey Oehler Richard Poffenbaugh Steve Gifford Morris Stamm
planned gift to OSU Havener Eye Institute. cine and the importance of sight. They have Buckeye fans. They have formed a great Dr. Dale & Bonnie Solze Paul Ritter Jr. Dr. Richard Golden Christina & Graham Stetson
seen dramatic changes in ophthalmology partnership that has served Ohio State with Dr. Mac Ronning Alicia Green Craig Stevens
Pat is president of the board of trustees for in their lifetime, and know that even more distinction in many capacities. $1,000 to $2,499 Michael Sauer Carolyn Greshemer Mike Steyer
the Paul G. Duke Foundation, which was amazing discoveries are just around the Larry & Frances Black Dr. Edward Schechter James & Tally Grossman Dr. Michael Stone
established by and named for her father, bend. Their commitment to that brighter fu- “I think that we learned a lot from my dad,” Dr. Mark Gersman Dr. Paul & Lesley Weber Dr. Deborah Grzybowski Dr. Amit Tandon
founder of the lawn services company ture was what led them to make the one mil- said Pat. “He was just a good person and Bruce & Bridgitt Evans Roy Whipple Lori Hall Dr. David Taylor
ChemLawn. Thom served two tours of lion dollar planned gift to ophthalmology. taught us how to be generous. I always feel Michael & Joyce Hallet Dr. John Wilding Ann Havener Donna Taylor
duty in the United States Marine Corps and that you should give back to your commu- Dr. Marilyn Huheey Audrey Henry Marlene Tope
served as an area sales manager for Dinner “We liked it here [at OSU],” said Thom. nity. There is no reason not to; it all comes Dr. Curtin Kelley $100 to $499 Virginia Hess Dr. Paul Treger
Bell Foods, Inc. until he retired in 1978. “We liked Dr. Kapetansky and he got us back. You do get that reward back for help- Drs. Frank & Carol Kollarits Dr. J. Geoffrey Allen Mary Katherine Hobbs Lionel & Sandra Waldman
involved. We like to make gifts that make a ing others. I only wish that I could live to Robert & Danette LaFollette Liz Allison John Hummel & Mary Jayne Fox James Weaner
Both serve on numerous volunteer boards big impact and affect a lot of people. That’s 200, so I could give more.” Dr. Robert Lembach Virginia Armstrong Dr. Gary & Nancy Katz Lisa Williamson
and committees, and are enthusiastic advo- our goal.” Dr. James & Antoinette Magnuson Dr. William Banks III Rhonda Lee Kitzler Dr. Jeffrey Wincko
cates of OSU. Dr. Carl Minning Jr. Dr. Thomas Bates Dr. Marilyn Kosier George Wintringer

*Indicates deceased
8 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 9
DR W. THOMAS MARTIN Dr. & Mrs. Mouser are the youngest Havener
Legacy members, a group formed to rec-
ognize those who have generously donated
$10,000 or more. Their names will be added
Thinking thirty years ahead is not some- thalmology. After graduating, he joined his to the list of distinguished donors that have
thing that many people do, but when Dr. father’s Massillon, Ohio comprehensive made a philanthropic impact on the Depart-
W. Thomas Martin first started his oph- ophthalmology practice. ment. Dr. Mouser understands the importance
thalmology practice he wanted to show his of a solid educational foundation and is grate-
appreciation for the fine training that he “Dad was a big-hearted doctor,” said Dr. ful for the training he received at the Havener
had received in the OSU Department of Martin's son John Martin, DDS. “He Eye Institute. He wanted to make sure that
Ophthalmology. would rather that his patients get what they the residents who came after him would have
needed than take a paycheck home. He the best equipment possible to aid them in
With that in mind, he purchased life insur- really cared about his patients.” their training.
ance policies for himself and his two chil-
dren and named OSU Ophthalmology as the Dr. Martin really cared about his education “We are very excited to welcome Dr. & Mrs.
beneficiaries. After 30 successful years in as well. In addition to the matured insurance Mouser into the Havener Legacy,” said Alan
practice, he is still happy with his decision. policies, he has made many monetary gifts to Letson, Residency Program Director. “He
OSU Ophthalmology, totaling over $40,000. was a fantastic resident and their donation
“I wanted to give because of my training,” validates our daily efforts to ensure our resi-
said Dr. Martin. “I trained with Dr. Haven- “It is so encouraging to see residents giving dency program provides the best ophthalmic
er, who was like a walking dictionary. You back,” said Dr. Alan Letson, Residency Pro- training possible.”
could be in surgery with him and ask him gram Director. “We are always striving to live
anything. He could answer ophthalmology up to the level of training that Dr. Havener
questions all day.” always gave. Gifts like this make it possible.” DR GARRET & CHRISTINA MOUSER Donations like the Mousers’ enable the De-
partment to support resident education and
research through the purchase of textbooks
The son of a Northern Ohio ophthal- Dr. Martin is enjoying his much-deserved Garret Mouser, MD completed his residency practice in Columbus with satellite offices and equipment.
mologist, Dr. Martin went to OSU Medical retirement in Norfolk, Virginia where he in 2007. Upon graduation, he joined James in Canal Winchester and Washington Court
School before being selected by OSU Oph- lives with his oldest son, John. Moses, MD, in a thriving ophthalmology House.

ALUMNI PAY FORWARD FROM PLANNED GIFTS TO PRESIDENT'S CLUB, ALUMNI SHOW APPRECIATION

PRESIDENT’S CLUB Through their generous contributions, Presi-

DR DALE & BONNIE SOLZE


OSU President E.
dent’s Club members make a lasting impact in
Gordon Gee
the lives of students, researchers, faculty, and
The President’s Club is a special circle of staff every day. From providing much-needed
friends who share a common passion for and scholarships for students, to creating funds for
Dale Solze, MD is a native Ohioan, born
pride in Ohio State. They make a meaningful new ground breaking global research initia-
and raised in Green Springs, Ohio. With difference at the university by providing lead- tives, President’s Club members are opening a
his wife Bonnie as his office RN, he ership support for academics, health sciences, world of opportunities for Buckeyes to attain
opened his private practice in Fremont and the arts at The Ohio State University. The academic excellence and positively affect their
and has served the northeastern Ohio vision of the President’s Club is to represent communities and the world.
community for over a quarter of a cen- the largest source of philanthropic support
tury. He and Bonnie have four children and volunteer leadership required for The Ophthalmology alumni have been making
and eight grandchildren. Ohio State University to be recognized among a visible difference through the President’s
the world’s truly great universities. Club from the beginning. All of your Presi-
He is an alumnnus of both The Ohio dent's Club donation can be directed to the
State University Medical School and the The President’s Club was founded in Ophthalmology fund of your choice.
Havener Eye Institute. As a dedicated 1963 to cultivate a culture of philan-
Buckeye, Dr. Solze is a member of the thropic leadership for The Ohio State President’s Club members are actively
OSU President’s Club, and actively sup- University. It establishes lifelong helping to define Ohio State as the nation’s
ports the OSU Havener Legacy. Recent relationships with alumni, friends, leading public land-grant university. Take
donations have allowed the Solzes to parents, faculty, staff, and students and your seat in the President’s Club and make a
reach higher levels of giving in the encourages active involvement in the life of donation to Ophthalmology today!
Havener Legacy. They were awarded the university. By eliciting significant finan-
an engraved Bulova mantel clock in cial support, each year the President’s Club For more information on the President’s Club,
recognition of their timeless dedication members aid in the realization of current and please contact Barbara Landolfi at (614) 293-
that inspires us all. emerging academic priorities. 8760 or email us at eye@osumc.edu.

10 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 11


EDUCATION TRAINING TOMORROW’S OPHTHALMOLOGISTS
POSTGRADUATE

RESIDENT RESEARCH
American Association for Pediatric Ophthalmology and Strabismus
(AAPOS) 2010 Annual Meeting - Orlando, FL

Two of our residents, Dr. Lena Chheda and Dr. Cate Olson, recently SYMPOSIUM 2010
presented at the AAPOS Annual Meeting. Dr. Chheda presented her
poster entitled “The Effect of Surgical Preparation Technique on
Bacterial Load of Surgical Needles and Suture Material Used During
Strabismus Surgery” (DL Rogers, M Marcon, DL Bremer, GL Rog-
ers, RP Golden). Dr. Olson was recognized as “Best in Show” for
her poster “Changes in Optic Nerve Sheath Diameter After Lumbar
Puncture in Children” (DL Rogers, RR Fellows, E de los Reyes).

Association for Research in Vision and Ophthalmology (ARVO)


2010 Annual Meeting - Ft. Lauderdale, FL

We also want to recognize all of the residents had papers that were
presented at the ARVO Annual Meeting, including Drs. Vishal Drs. Dupps, Reichel, and Harton
Verma, Rick Whitehead, Andrew Hendershot, and Cedric Pratt.
The 53rd Annual Postgraduate Symposium in
“Metastasis in Small Uveal Melanomas” V Verma, MH Abdel-Rah- Ophthalmology was held on March 5th, 2010
man, CM Cebulla, FH Davidorf. with over 150 participants in attendance. This
year’s course directors, Cynthia Roberts,
“Utility of the Convergence Insufficiency Symptom Survey in a PhD, and Paul Weber, MD, brought numerous
Tertiary Care Center” G Whitehead, DL Rogers, M McGregor, A accomplished and knowledgeable speakers
Serna. together to discuss Ocular Imaging, including
William Dupps Jr., MD, PhD (Cleveland
“Cataract Surgery Simulators in the Training of Ophthalmology Resi- Clinic), Paul Harton Jr., MD (Harbin Eye
dents” AJ Hendershot, AM Mahmoud, TF Mauger. Clinic), Elias Reichel, MD (Tufts University
School of Medicine), Andrea Sawchyn, MD
“The Effect of Intravitreal Pegaptanib, Bevacizumab and Ranibi- (Wills Eye Institute), Mitchell Weikert, MD,
Dr. Kukuyev, second-year resident, zumab on Blood Vessel Formation During Cutaneous Wound Healing MS (Baylor College of Medicine), Colleen
performing a pediatric eye exam in a Rabbit Model” JB Christoforidis, R Ricketts, S Bean, C Pratt, J Cebulla, MD, PhD (OSU), Jennifer Lewis,
Pierce, MB Wells, K La Perle. PhD (OSU), Thomas Mauger, MD (OSU).

NATIONWIDE CHILDREN’S HOSPITAL


Nationwide Children’s Hospital (NCH) has the various diseases that disrupt visual
been caring for sick and injured children development in children. Management
and adolescents for more than 110 years. of eye problems in children can include
As home to OSU’s Division of Pediatric using glasses, medications, and complex
Ophthalmology, NCH and OSU Havener eye surgeries, while keeping in mind their
Eye Institute have enjoyed a long-standing unique needs. As young children cannot
academic relationship built on a shared always communicate effectively, alterna-
commitment to excellence in learning, tive strategies must be employed to obtain
discovery, and collaboration. NCH medical a complete history from the patient.
staff and research scientists hold faculty
positions at OSU. NCH also serves as the “You have to be on your toes,” said Dr.
pediatric ophthalmology training site for Alla Kukuyev, a second-year resident.
our ophthalmology residents. “You have to be very flexible when you
examine kids. They have to feel at ease.
“There is a variety of patients,” said Dr. Ce-
dric Pratt, chief resident, “and a very broad
You can only expect them to sit still for so
long—you have to play little games to keep GRADUATING RESIDENTS
spectrum of conditions. You get exposed to them interested. It is a fun place to work.” We wish our graduating residents well as they embark on new ventures.
a completely different aspect of ophthalmol- Cedric Pratt, DO remains at the Havener Eye Institute to complete a two-
ogy that you never see in an adult clinic. Seven fellowship-trained pediatric oph- year retina fellowship. Wendy Smith, MD matched with the National In-
The Ohio State residency program provides thalmologists along with the support of stitute of Health for a uveitis fellowship. Rick Whitehead, MD has been
especially strong pediatric training that is subspecialists in cornea, retina, oculoplas- selected for a pediatric ophthalmology fellowship at Indiana University.
not found in most residencies.” tics, optometry, and neuro-ophthalmology Katie Baston, MD joined a comprehensive ophthalmology private prac-
supervise residents in the outpatient clinic tice in El Paso, TX. Landon Colling, MD has moved to Lynchburg, VA
Pediatric ophthalmology focuses on the and in the operating rooms at Nationwide to practice comprehensive ophthalmology in a private practice.
development of the visual system and Children's Hospital.

12 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 13


Back Row: Drs. Cloud, Davis, Verma, Buzzacco, Costin, Whitehead, Lawhon, Pratt, Colling DAVIDORF LECTURESHIP:
RENOUN GUEST SPEAKERS
Front Row: Drs. Wall, Tung, Smith, Olson, Vaccarella, Kukuyev, Baston, Chheda

Drs. Frederick Davidorf and James Augsburger

JAMES AUGSBURGER, MD
University of Cincinnati SANFrancisco
University of Cincinnati Chairman Dr. James Augsburger, was our AAO Alumni Reception
first lecturer for the new Davidorf Lectureship Series. Dr. Augs-
burger spoke about Genetic Prognostication of Metastasis in Uveal Each year the OSU Havener Eye Institute holds a special
Melanoma. “As a national expert in the field of ocular melanoma, reception in honor of the many excellent ophthalmologists

RESIDENTS
Dr Augsburger has an incredible breadth of knowledge,” said Sun- that hail us as their Alma Mater. This anticipated event
day Olatunji, MD, a first-year retina fellow. “His talk highlighted coincides with the American Academy of Ophthalmology
more than the new genetic classification techniques; he really (AAO) Annual Meeting, which brings together ophthal-
delved into the subject and what it could mean for patients with mologists from across the nation and around the world.
ocular cancer.”
The 2009 Alumni Reception found us in San Francisco,

FELLOWS
CA. A perfect day and a spectacular view from the top
FIRST-YEAR RESIDENT CLASS (2009-2012) of the Hotel Nikko greeted Havener alumni, faculty, and
Dominic Buzzacco, MD colleagues as we celebrated both our alumni and the OSU
Adam Cloud, MD Department of Ophthalmology’s 80th Anniversary.
Bryan Costin, MD
Irene Tung, MD "It gives us a chance to reconnect with our fellow alum-
Leah Vaccarella, MD Ashley San Filippo, MD received her medical degree from the ni," said Rebecca Kuennen, an OSU alum and new faculty
Palak Wall, MD Northeastern Ohio Universities Colleges of Medicine and phar- member. "It's an opportunity to gain a national perspective
macy in Rootstown, OH and her ophthalmology residency at the on our field and what to expect in the future."
SECOND-YEAR RESIDENT CLASS (2008-2011) University of Missouri in Kansas City, MS. Now that she has con- Drs. Michael Wells, Frederick
Lena Chheda, MD cluded her Glaucoma Fellowship here at the Havener Eye Institute, Davidorf, Daniel Martin, Alan
Aaron Davis, MD she has joined a private practice here in Columbus. Letson, and Colleen Cebulla
Alla Kukuyev, MD Dr. William Anninger, Dr. & Mrs. Conley Call,
William Lawhon, MD Andrew Hendershot, MD completed his Medical degree, ophthal- Dr. Kenneth Cahill, and Dr. Steven Meadows
Cate Olson, MD
Vishal Verma, MD
mology residency, and his cornea fellowship all at The Ohio State
University. Now, he plans to stay on at the Havener Eye Institute
DANIEL F. MARTIN, MD
as a faculty member in the Cornea Division. Cleveland Clinic
THIRD-YEAR RESIDENT CLASS (2007-2010)
Katie Baston, MD Sunday Olatunji, MD attended Chicago Medical School in Chi- Not long after the first Davidorf Lectureship Series, a second
Landon Colling, MD cago, IL where he received his medical doctorate. He completed speaker, Dr. Daniel Martin, was invited to speak about the CATT
Cedric Pratt, DO his ophthalmology residency at the Kresge Eye Institute in Detroit, Clinical Trial, a research project that is comparing the effective-
Wendy Smith, MD MI and is half-way through a two-year vitreoretinal fellowship at ness of Ranibizumab vs Bevacizumab, two Age-Related Macular
Rick Whitehead, MD the Havener Eye Institute. Degeneration (AMD) medications. A dynamic speaker, Dr. Martin
outlined the benefits of the study and the history of other clinical
MAKLEY-BATTLES TEACHING AWARD Michael Wells, MD is a Baylor College of Medicine graduate. He trials that had been its predecessors utilizing his extensive knowl-
C. Patick Carroll, MD completed his ophthalmology residency at the University of North edge of AMD. “Dan is a great speaker,” said OSU faculty member
Carolina - Chapel Hill. At the conclusion of his two-year Vitreo- Dr. Colleen Cebulla. “His work transcended politics and was criti-
EXCELLENCE IN EDUCATION AWARD retinal Fellowship here at the Havener Eye Institute, he decided to cal to create this important clinical trial for patients with macular
John Christoforidis, MD join our faculty. degeneration. We are proud to be a part of it.”

14 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 15


EYECARE PERSONALIZED CARE
Dr. David Castellano using the new
EMR system during a patient visit NEW FACULTY
ANDREW HENDERSHOT, MD
Anterior Segment
Dr. Hendershot is originally from Findlay,
OH. He studied biochemistry and pre-
medicine at Ohio Wesleyan University
before coming to Ohio State. He com-
pleted his Medical Doctorate, general sur-
gery internship, ophthalmology residency,
and corneal fellowship all at Ohio State.
“I have been at Ohio State so long, it just
feels like the right place to be,” said Hen-
dershot. “I will be helping patients with a
variety of corneal diseases and disorders
and giving back to the University that has
given me so much.”

ANDREA SAWCHYN, MD
Glaucoma
Dr. Sawchyn graduated summa cum
laude from the University of Notre Dame
with a BS in Science Preprofessional
Nurses' station at the new outpatient surgery center Studies. For both her medical degree
and ophthalmology residency she at-

OUTPATIENT SURGERY CENTER OPENS


tended The Ohio State University. She
ELECTRONIC RECORDS continued her training with a glaucoma
fellowship at Wills Eye Institute in Phila-
In August 2009, the first OSU Outpatient teamwork, and experienced management to In addition to our move to our new Eye and Ear Institute last delphia, PA. Dr. Sawchyn will add new
Surgery Center (OSC) opened at the OSU Eye coordinate an outstanding patient-centered year we also migrated onto Epic-based electronic medical diagnostic and therapeutic modalities to
& Ear Institute. The OSC is a state-of-the-art surgical experience. records (EMR). This is potentially a difficult and burdensome the division, as well as a passion to help
facility specializing in Ophthalmology, Otolar- transition for all physicians, but particularly for ophthalmolo- patients.
yngology, Plastic Surgery, and Hand surgeries. OSC employees are extremely proud of their gists due to our unique documentation and imaging needs.
work, their patients, and their involvement with
They provide an extensive array of subspecial- the center’s development. High staff retention Dr. Milisa Rizer, Medical Director of the EMR project, and
ized, complicated surgical procedures in the and equally high volume of employee referrals Thomas Bentley, IT director, provided tremendous support for MICHAEL WELLS, MD
convenience of an outpatient setting. There are are a testament to the staff’s pride and satisfac- this move along with our direct support team lead by Linda
six dedicated operating room suites available tion. The employees of the OSC bring to the Locke and Gail Cook. However, it was the dedication and Retina
at the OSC with world-renowned surgeons and organization a unique outpatient perspective. perseverance of the staff, residents, fellows, and faculty of the
highly trained staff to ensure that each patient They have merged inpatient and outpatient ex- Havener Eye Institute that lead to a relatively smooth transition. Dr. Wells hails from Texas where he
has the best surgical experience possible. periences to create a highly engaged team envi- graduated cum laude from Rice University
ronment with spectacular patient outcomes. Eyeroute by Topcon was installed to provide robust imaging with his degree in physics. He acquired
The OSC has been recognized for its consis- access within the EMR. The integrated medical record has his Medical Doctorate from Baylor
tently high Press Ganey patient satisfaction Patients have readily shared their approval of improved physician communication and patient safety. The College of Medicine and completed his in-
scores. They continue to be ranked in the the OSC. The OSC staff consistently receive Medical Center will be adopting Epic as its inpatient medical ternal medicine internship at University of
99th percentile when compared to similarly positive feedback through patient phone calls record in 2011. Nationwide Children’s Hospital has already Texas-Southwestern. He went to Univer-
size organizations. Their success can be sharing positive remarks, high monthly and transitioned to Epic and will soon complete installation at their sity of North Carolina - Chapel Hill for his
largely contributed to their ability to provide quarterly Press Ganey scores, and letters of ap- outpatient clinics, including ophthalmology. This will create ophthalmology residency, before coming
superior innovative care in a smaller, patient- preciation to OSUMC senior administration. a unique environment for the patients, staff, and doctors in to OSU Havener Eye Institute for his
focused environment within a conveniently Central Ohio. vitreoretinal fellowship. “Having trained
accessible facility. “Excellent care,” one patient commented on at so many different universities is a great
their Press Ganey survey. “Very professional This transition, while not without difficulties, will position experience,” said Wells, “I am looking
The entire surgical team has strongly in- staff. I have already made recommendations the Medical Center and the Havener Eye Institute to improve forward to sharing the sum of my eclectic education with my central
volved physician leadership, superior staff, to family & clients.” patient care, education, and research for the future. Ohio patients.”

16 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 17


The Glaucoma Division continued its storied thousands of patients. The findings from this

ANTERIOR
history of active participation in all three multi-centered clinical trial have resulted in
mission areas. To facilitate expanded efforts major research spin-offs that will further elu-
in all three areas we have added Andrea cidate the mechanisms of glaucoma damage
Sawchyn, MD to our faculty. Dr. Sawchyn and result in an even greater preservation of

SEGMENT
completed her residency here at OSU and fol- sight in the future. Several of these stud-
lowed by a glaucoma fellowship at Wills Eye ies, both clinical and laboratory, are being
Hospital in Philadelphia. performed here through collaboration of the
Rebecca Kuennen, MD Paul Weber, MD biomedical engineering faculty including Drs.
Division Director Division Director In the education arena, the division was Cynthia Roberts and Jun Liu.
heavily involved in the Department’s Annual
Postgraduate Symposium, “Ocular Imaging The division faculty also participated in a
– Front to Back and Beyond.” Division mem- trial utilizing new technology to identify
bers also actively participate in the education progression of optic nerve damage in glau-
of medical students, residents, fellows, prac- coma earlier than current methods, thereby
ticing physicians, patients, and the public. enhancing glaucoma management. This was
presented at ARVO, the largest ophthalmol-
Past generous contributions of state-of-the-art ogy research meeting in the country.
diagnostic equipment from grateful patients
Andrew Hendershot, MD Gloria Fleming, MD The clinical volume in the glaucoma division
like Jerry Colp have allowed us to stay at the
very forefront of patient care and research. is rapidly expanding. This past year we saw
a nearly 20% increase in patient visits, from
Closeup of a keratoprosthesis (artificial corneal transplant) 6,045 the previous year to 7,199 this past
In the research mission, we closed out 16
years of involvement in the NIH-NEI-funded year.
Ocular Hypertension Treatment Study. This
has proven to be one of the most impactful We are proud of our contributions in all mis-
The Anterior Segment Division continues The division mentored multiple resident and ophthalmic studies funded by the National sion areas for the Department, the Medical
to be actively involved with clinical care, fellow research projects this past year. Such Eye Institute. It has already had a major Center, the University and the community.
education, research, and service. Dr. Andrew projects included the use of a cataract surgery impact on the management of glaucoma
Hendershot recently joined as a new faculty simulator in resident training, comparison of Richard Lembach, MD Andrea Sawchyn, MD and will result in prevention of blindness in PAUL WEBER, MD
member after completing his cornea fellow- ultrasonographic measurements of corneal
ship in June 2010. Dr. Randy McLaughlin aggregate modulus in normal and post-LASIK
and Dr. Kelly Kingsbury continue to provide patients, measurement of corneal epithelial

GLAUCOMA
optometric care including comprehensive thickness in keratoconus using a Fourier do-
evaluations as well as routine and complex main anterior segment OCT, and use of confo-
contact lens services. cal microscopy in diagnosis of Acanthamoeba
and fungal keratitis.
Medical student, resident, and fellow education
continues to be a strong focus in the division The division also had abstracts presented at the
through staffing clinics and surgeries at The 2010 Association for Research in Vision and
Ohio State University Medical Center, Ohio Ophthalmology and Ocular Microbiology and Thomas Mauger, MD
State University Eye and Ear Institute, Colum- Immunology Group meetings. The division Chairman
bus Veterans Administration Outpatient Clinic, is currently conducting clinical trials with
and Nationwide Children’s Hospital. The divi- nepafenac 0.3% in the prevention and treat-
sion staffed over 500 cataract surgeries at the ment of ocular inflammation and pain after
Columbus VA with the residents last year. cataract surgery. The division along with Dr.
Cynthia Roberts will soon be starting a clinical
During the past year, the division had over research trial studying the safety and effective-
16,000 patient office visits and performed ness of the VEGA UV-A system for corneal
over 1,000 cataract surgeries. We performed collagen cross-linking in eyes with keratoco-
114 keratoplasty procedures including nus and post-refractive corneal ectasia. Julie Meier, MD
penetrating keratoplasty, endothelial kerato-
plasty, deep anterior lamellar keratoplasty, The division continues to be involved in
and keratoprosthesis. We also performed medical mission trips to Ghana and Nicara-
61 procedures at Nationwide Children’s gua. Dr. Mauger and Dr. Cate Olson traveled
Hospital including penetrating keratoplasty, to Ghana in February 2010 and performed
keratoprosthesis, anterior segment and ocular cataract surgeries. The division is also ac-
surface reconstructive surgeries, and exami- tively involved with the Columbus Medical
nations under anesthesia. Association Physicians Free Clinic and at the
monthly Havener Eye Institute Free Clinic.
The division continues to be actively involved Heidelberg Retinal Tomograph (HRT)
in both clinical and basic science research. REBECCA KUENNEN, MD Amit Tandon, MD

18 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 19


Steven Katz, MD Elson Craig MD
Division Director Division Director

Microscopic closeup of optic nerve

OPHTHALMIC
David Hirsh, MD

Dr. Katz performing an outpatient


procedure in the minor OR
TOTAL CASES INCLUDED: PATHOLOGY
NEURO-OPHTHALMOLOGY The Neuro-ophthalmology service continues Women’s Health, Eye, Anatomical Record, and
11

42
Lens, gross only

Eye, gross only


The Division of Ophthalmic Pathology in
the Department of Ophthalmology provides
support to faculty, residents, and students
sion of Abhik Ray Chaudhury, MD. Weekly
review sessions were conducted that included
faculty, residents, and students from both
to contribute to the departmental mission in Obesity Reviews; an advisor to the Chief of when preparing presentations, publications, departments. A joint report for each case was
the core areas of clinical care, teaching, and Space Medicine at NASA Johnson Space Cen- 13 Foreign body, gross only and for research projects. The Division has generated and filed.
research. Division faculty are responsible for ter and the Intracranial Hypertension Research an extensive archive of pathology cases and
the resident lecture series as well as medical Foundation; as well as being a grant reviewer 1 Nerve biopsies, eye microscopic and photographic equipment For the academic Fiscal Year July 1, 2009
student teaching in neuro-ophthalmology. for the Columbus Foundation, the American available to support these activities to June 30, 2010, 581 cases were examined,
Institute of Biological Sciences, the US Army 54 Conjunctival mass, tumor, cyst reported, and filed in the division archives of
Susan Benes, MD, with the assistance of David Medical Research and Material Command. All ophthalmic pathology specimens from ophthalmic pathology.
Hirsh, MD, organized the neuro-ophthalmol- 71 Cornea, whole our Department are processed in The Divi-
ogy morning lecture series. Drs. Benes and The division is actively enrolling patients into sion of Neuropathology under the supervi- ELSON CRAIG, MD
Hirsh continue to be active clinical instructors the Idiopathic Intracranial Hypertension Treat- 84 Cornea, biopsies
and are also regular contributors to the Grand ment Trial. This multicenter, double-blind
Rounds focused in neuro-ophthalmology. randomized placebo-controlled study hopes to 2 Bone, eye Dr. Craig demonstrating
determine if weight reduction and/or low so- the teaching microscopes
A Pseudotumor Cerebri Center of Excel- dium diet alone or combined with medication 1 Orbital exenteration
lence was created and is dedicated to the care will benefit patients with idiopathic intracra-
of patients with idiopathic and secondary nial hypertension. The study was proposed 30 Enucleation
intracranial hypertension. The group will by Neuro-Ophthalmology Research Disease
include neuro-ophthalmology, otolaryngology, Investigator Consortium (NORDIC) and is 4 Evisceration
neurosurgery, neurology, endocrinology, and sponsored by the National Eye Institute.
biomedical engineers. The group will also 132 Skin biopsies, eye
focus on clinical and basic science research to There are currently 7 other clinical trials going
provide better understanding of the underly- on in the division in the areas of multiple scle- 1 Skin, excision
ing etiology as well as more targeted treat- rosis and ocular toxicity of cancer treatments.
ment options. A tissue bank is being created 53 Soft tissue, eye
to collect blood and cerebrospinal fluid from Dr. Cindy Roberts and Dr. Katz are currently
patients for long-term studies. involved in the China Eye Project, an effort to 72 Temporal artery biopsies
develop a new surgical procedure to implant a
Many of our division faculty utilize their device for direct optic nerve stimulation. 4 Eye biopsies, immunofluorescence
unique qualifications to serve the community.
6 Eye, biopsies
Dr. Steven Katz was a reviewer for Journal of STEVEN KATZ, MD

20 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 21


OCULOPLASTICS
The Oculoplastic Division is staffed and surgery
is performed at the OSU Eye & Ear Institute, the
and neck cancer. With more aggressive resec-
tions, the multidisciplinary reconstruction of these
University Hospital Clinics, the Columbus and patients is increasingly challenging.
Dayton VAs, and Nationwide Children’s Hospital
with active involvement of all resident classes. Dr. Kenneth Cahill is on the executive commit-
Didactic lectures are provided for ophthalmology tee of the International Thyroid Eye Disease
residents and those in ENT, plastic surgery, and Study Group. He also serves on the American
family medicine. Medical student education is Academy of Ophthalmology Ophthalmic Tech-
supported with lectures in their core curriculum, nology Assessment Committee.
physical diagnosis instruction, clinical rotations, Kenneth Cahill, MD
and participation in research projects. We have made local and national presentations
and written eight book chapters covering thera-
Our American Society of Ophthalmic Plastic peutic and cosmetic botulinum toxin, cosmetic
and Reconstructive Surgery (ASOPRS) fellow- tissue fillers, blepharoplasty surgery, ptosis,
ship training program complements residency entropion, ectropion, trichiasis, eyelid recon-
training. Our recent graduate fellow, Dr. Kevin struction, bioengineered tissue grafts, thyroid
Michels, received the annual fellow teaching eye disease, anophthalmic socket reconstruc-
award. tion, brow lifts, forehead rejuvenation, and
tissue adhesives. View of Nationwide Children’s Hospital,
new main tower slated for 2012 completion

PEDIATRICS
Dr. Steven Katz continues his diligent work
with the residents by overseeing the hospital Ongoing research projects include lacrimal Steven Katz, MD
ward and emergency room consult service. outflow system imaging, botulinum toxin ef-
ficacy, new techniques of tissue filler delivery,
In 2009, Dr. Katz was a founding member of the minimally invasive facial surgery, facial anato-
Comprehensive Skull Base Center at the James my, and treatment of orbital lymphangiomas.
Cancer Hospital. The group is dedicated to
advancing the care of patients with complex head KENNETH CAHILL, MD

OPTOMETRY
The Pediatric Division once again shows strong acquired for these studies. Dr. David Rogers has
numbers with 9,621 clinic visits for the academic been active in teaching and in clinical research.
year. Faculty include Division Chief Gary Rog-
ers, MD, Don Bremer, MD, Cybil Cassady, MD, We are engaged in fMRI research for nystagmus,
Richard Golden, MD, Julie Lange, MD, Mary corneal pachymetry, amblyopia, convergence in-
Lou McGregor, MD, and David Rogers, MD. The sufficiency, and congenital cataracts. The group
clinic is staffed by one first-year and two second- is involved in three multicenter trials on retinopa-
year ophthalmology residents and two optom- thy of prematurity and is a participating center for
The Optometric Division provides general Randy McLaughlin, OD PEDIG.
Top: Drs. G. Rogers, D. etrists. We are very active surgically, consistently
ocular care, as well as, contact lens fitting. Division Director
Rogers, and Bremer showing improved numbers in the surgery center.
The new Gowdy facility has provided at least With the support of Nationwide Children's Hospi-
a 10 percent increase in patient visits. In Bottom: Drs. Cassady, tal, we have increased laboratory and clinical space
2009—2010 year, the service provided over Golden, and McGregor In addition to clinical eye care, the division sup-
and equipment to better serve our young patients.
2000 patient examinations including refrac- ports research and teaching programs that ensure
tions, contact lens fittings, low vision evalua- Newest faculty, Julie delivery of the highest quality pediatric care. The
It continues to be our goal to be a leader in the
tions, and sports vision analysis. Lange, MD with residents division participates in both funded and unfunded
research of fMRI and changes to the visual
research. Several amblyopia protocols and a cortex in patients with amblyopia and nystagmus.
The division also supported the prison clinic randomized nasolacrimal duct study are being PEDIG has recognized our previous research
rotations by providing optometric care at Sara Huffman, OD conducted in association with the Pediatric Eye with sinemet and amblyopia and has just com-
Corrections Medical Center. Disease Investigator Group (PEDIG). Drs. Don pleted the first multicenter study in amblyopia
Bremer and Rick Golden are the Principal Inves- involving the treatment of older children using a
Division faculty provided resident lectures in tigators for these PEDIG trials. similar levodopa-carbidopa combination.
optics and contact lens theory and is always
involved in resident and medical student Larry Leguire, PhD, continues to work with the I am very pleased with the progress of our divi-
education via patient consultations. division conducting functional MRI research with sion and its continued success.
Dr. Randy McLaughlin collaborating on a patient with an interest in congenital ocular motor nystagmus.
Dr. Amit Tandon from the Anterior Segment Division RANDY MCLAUGHLIN, OD Kelly Kingsbury, OD An eye tracker in the MRI scanner has been GARY ROGERS, MD

22 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 23


RETINA
Fluorescein photos of a retinal tumor
Refractive patient about
to undergo all-laser LASIK

David Castellano, MD
Division Director

The Retina Division faculty includes Colleen manager Laura Sladoje and clinical trial 2009), contributed to imaging for clinical
Cebulla, MD, PhD, John Christoforidis, MD, coordinators Jill Salerno, Jill Milliron, and trials as well as other trials performed by
Susie Chang, MD, Fred Davidorf, MD, Paul Kathy McKinney, the division was actively other departmental divisions. The imaging
Kurz MD and Alan Letson, MD. involved in clinical trials sponsored by service includes high resolution color and
National Eye Institute (AREDS 2, CATT), fluorescein angiography, ICG angiography,
Dr. Cebulla joined the faculty in September DRCR.net, and industry-sponsored trials Fundus Autofluorescence, high resolution
Amit Tandon, MD
2009 after having completed fellowships in from Genentech, Allergan, Alcon and Glax- anterior and posterior segment ocular and
Ocular Oncology and Vitreoretinal Surgery oSmithKline involving areas of wet AMD, orbital ultrasonography, time domain OCT,
at Bascom Palmer Eye Institute. She brings diabetic macular edema, retinal detachment, and spectral domain OCT.
experience in ocular melanoma and will be cataract and macular edema, and topical
doing both basic science research as well VEGF inhibitors. Dr. Cebulla obtained grant The division maintained its teaching activ-
as working with Dr. Davidorf on the ocular funding for her work in ocular melanoma ity by supporting two retinal fellows Mike
oncology service. and PVR and has been collaborating with Wells, MD, and Sunday Olatunji, MD, and
Mohamed Abdel-Rahman, MD, PhD, in the working with residents in their first- and
Patient care activity included over 8,500 pa- lab. Dr. Davidorf and Dr. Abdel-Rahman second-year retina rotations. Medical
tient visits, with over 6,200 diagnostic imag- continue their research in ocular melanoma students also rotate on the service. Retina
Rebecca Kuennen, MD ing procedures for the division. The surgical molecular genetics. Dr. Christoforidis has faculty deliver weekly retina lectures to
retina team performed over 800 major vitreo- been working on lab projects related to residents and hold imaging conferences
retinal procedures. Over 1600 intravitreal VEGF inhibitors and wound healing as well with residents and fellows. The retina fac-
injections were given for wet AMD and other as high resolution MRI for ocular imaging. ulty also serves as preceptors for resident

REFRACTIVE SURGERY
causes of CNV and macular edema. research projects and is active in the cur-
Scott Savage and his team of retinal photog- riculum of the College of Medicine.
This past year was also another strong raphers, Stephen Shelley, Amanda Barnett,
year for research. Led by clinical research and PJ Fish (who joined the team in autumn ALAN LETSON, MD
We continue to see great success from both lasers. We are in the process of
utilizing the combination of both the developing methods for our fellows to per-
IntraLase femtosecond (FS) laser and the form LASIK cases as part of their training.
ALLEGRETTO WAVE® excimer laser
platform from Alcon. The IntraLase FS The Refractive Surgery Division is also
laser creates a very thin, bladeless corneal successfully implanting both toric and
flap that has proved beneficial in LASIK multifocal intraocular lenses. The toric
treatments by preserving more corneal intraocular lenses allow patients to obtain
tissue. The ALLEGRETTO WAVE® astigmatism correction during cataract
laser uses Wavefront-Optimized software surgery and the multifocal lenses are used
to enhance each treatment to the patient’s to correct both distance and near vision.
own unique corneal curvature.
Collaborating with refractive division
Alan Letson, MD Colleen Cebulla, MD, PhD Susie Chang, MD John Christoforidis, MD
Using these lasers, our patients are able faculty is Research Division Director
Division Director
to get a truly individualized treatment Dr. Cynthia Roberts. She uses basic and
which in turn is providing excellent vi- translational research to understand the
sion acuity and quality results. Fairly biomechanical response of the cornea and
high degrees of myopia, hyperopia, and the eye as a whole to disease and medical
astigmatism are currently treatable as well and surgical therapy. This keeps the refrac-
as monovision/blended vision correction tive surgery division on the cutting edge
for patients over 40 with presbyopia. of discoveries and better able to give our
patients the latest and best refractive care.
Dr. Roberts with a few posters describing During the past year, two surgeons were
her translational biomedical research trained on the LASIK procedure using DAVID CASTELLANO, MD Frederick Davidorf, MD Paul Kurz, MD L. Carol Laxson, MD, PhD Michael Wells, MD

24 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 25


GRANTS NEW FRONTIERS IN MEDICINE

Dr. Xu selecting nanopartical


samples for further study
GLAUCOMA
NEURO-OPHTHALMOLOGY
Title: A double-blind, randomized, multicenter, placebo-con-
RETINA
Title: Comparison of Age-related Macular Degeneration Treat-
Title: Corneal Stiffness and Tonometric Measurement of IOP trolled, parallel-group study comparing the efficacy and safety of ments Trials (CATT)
Sponsor: American Health Assistance Foundation 1.25mg FTY720 administered orally once daily versus placebo in Sponsor: National Institutes of Health
Principal Investigator: Jun Liu PhD patients with primary progressive multiple sclerosis Principal Investigator: Frederick Davidorf MD
Co-Investigators: Paul Weber MD Sponsor: Novartis Co-Investigators: Susie Chang MD, John Christoforidis MD,
Principal Investigator: Aaron Boster MD Alan Letson MD
Title: Measurement and Evaluation of the Elastic and Viscous Co-Investigators: Steven Katz MD
Properties of the Cornea in Glaucoma Title: Comparison of Age-related Macular Degeneration Treat-
Sponsor: Columbus Foundation Title: Multicenter, randomized, double-blind, placebo-controlled, ments Trials (CATT) Ancillary Study: Genetics and Response to
Principal Investigator: Cynthia Roberts PhD parallel-group dose-finding study to evaluate the efficacy, safety, Anti-VEGF Treatments in Age-related Macular Degeneration.
Co-Investigators: Richard Lembach MD, Paul Weber MD and tolerability of three doses of ACT-128800, or oral S1P1 Sponsor: National Institutes of Health
receptor agonist, administered for twenty-four weeks in patients Principal Investigator: Frederick Davidorf MD
Title: The Impact of Corneal Elasticity on IOP and CCT mea- with relapsing-remitting multiple sclerosis Co-Investigators: Susie Chang MD, John Christoforidis MD,
surements in Glaucoma Management. Sponsor: Actelion Pharmaceuticals Alan Letson MD
Sponsor: Columbus Foundation Principal Investigator: Aaron Boster MD
Principal Investigator: Jun Liu PhD Co-Investigators: Steven Katz MD Title: The Action to Control Cardiovascular Risk in Diabetes
Co-Investigators: Paul Weber MD, Cynthia Roberts PhD Study Group (ACCORD)

Title: Nanoengineered in vitro trabecular meshwork (TM) model
RETINA Sponsor: National Health Institutes
Principal Investigator: Kwame Osei MD
for systematic investigation of aqueous humor outflow resistance Co-Investigators: Alan Letson MD, Elson Craig MD, Frederick
Title: Multicenter, Masked, Randomized, Sham-Controlled,
Sponsor: Glaucoma Research Foundation Davidorf MD
Parallel Group Study to Evaluate the Safety and Efficacy of
Principal Investigator: Yi Zhao PhD
Brimonidine Tartrate Posterior Segment Drug Delivery System
Co-Investigators: Paul Weber MD, Cynthia Roberts PhD, Debo- Title: Phase IIB Dose-Evaluation Study of Pazopanib Eye Drops for
Applicator System in Improving Visual Function in Patients With
rah Grzybowski PhD the Treatment of Neovascular Age-related Macular Degeneration
a Previous Rhegmatogenous Macula –Off Retinal Detachment
Sponsor: Glaxo Smith Kline
Sponsor: Allergan
Principal Investigator: Alan Letson MD
NEURO-OPHTHALMOLOGY Principal Investigator: Colleen Cebulla MD PhD
Co-Investigators: Frederick Davidorf MD, Susie Chang MD, Co-Investigators: John Christoforidis MD, Susie Chang MD,
Michael Wells MD, Colleen Cebulla MD PhD, Paul Kurz MD,
CORNEA Title: Capillary changes in Fabry disease John Christoforidis MD, Alan Letson MD, Paul Kurz MD
Frederick Davidorf MD
Sponsor: Genzyme Corporation
Title: Proteomic analysis of experimental and human retinal
Title: Corneal crosslinking in keratoconus: Crosslinking for Principal Investigator: Deborah Grzybowski, PhD
detachments with proliferative vitreoretinopathy (PVR) and po- Title: Phase III, Double Masked, Multicenter, Randomized,
corneal ectasia after refractive surgery. Co-Investigators: Alan Letson MD
tential for therapy Sham-Controlled Study of the Efficacy and Safety of Ranibizum-
Principal Investigator: Richard Lembach MD
Title: Fabry registry Sponsor: National Center for Research Resources ab in Subjects with Clinically Significant Macular Edema with
Co-Investigators: David Castellano MD
Sponsor: Genzyme Corporation Principal Investigator: Colleen Cebulla MD PhD Center Involvement Secondary to Diabetes Mellitus (RIDE)

Principal Investigator: Deborah Grzybowski PhD Sponsor: Genentech
Title: Clinical Safety and Efficacy Comparison of Nevanac 0.1% to
Title: Intravitreal Ranibizumab or Triamcinolone as Adjunctive Principal Investigator: Alan Letson MD
Vehicle following Cataract Surgery in Diabetic Retinopathy Patients.
Title: A Phase II, Double-Blind, Randomized, Placebo-Controlled Treatment to Panretinal Photocoagulation for Proliferative Dia- Co-Investigators: Frederick Davidorf MD, Colleen Cebulla MD
Sponsor: Alcon
Study to Assess the Efficacy of AZD6244 (Hyd-Sulfate) in Com- betic Retinopathy (DRCR J) PhD, Susie Chang MD, John Christoforidis MD, Michael Wells MD
Principal Investigator: Thomas Mauger MD
bination with Docetaxel, Compared with Docetaxel Alone, in 2nd Sponsor: National Institutes of Health
Co-Investigators: Alan Letson MD, Frederick Davidorf MD,
Line Patients with KRAS Mutation Positive Locally Advanced or Principal Investigator: John Christoforidis MD Title: Age-Related Eye Disease Study 2: Multicenter, Ran-
John Christoforidis MD, Susie Chang MD, Paul Kurz MD
Metastatic Non Small Cell Lung Cancer (Stage IIIB-IV) Co-Investigators: Colleen Cebulla MD PhD, Frederick Davidorf domized Trial of Lutein, Zeaxanthin and Omega-3 Long Chain

Sponsor: Astra Zeneca MD, Susie Chang MD Polyunsaturated Fatty Acids (Docosahexaenoic Acid (DHA) and
Title: Clinical evaluation Nepafenac ophthalmic suspension,
Principal Investigator: Miguel Villalona MD Eicosapentaenoic cid (EPA) in Age-Related Macular Degenera-
0.3% for prevention and treatment ocular inflammation and and
Co-Investigators: Steven Katz MD tion (AREDS2)
pain after cataract surgery Title: Phase III, Multicenter, Double Masked, Multicenter,
Sponsor: National Health Institutes
Sponsor: Alcon Randomized, Active Treatment Controlled Study of the Efficacy
Title: A Multicenter, Double-blind Randomized Placebo-con- Principal Investigator: Alan Letson MD
Principal Investigator: Thomas Mauger MD and Safety of 0.5% mg and 2.0 mg Ranibizumab Administered
trolled Study of Weight Reduction and/or Low Sodium Diet plus Co-Investigators: Frederick Davidorf MD, Susie Chang MD,
Co-Investigators: Rebecca Kuennen MD Monthly or on an as needed Basis in Patients with Subfoveal
Acetazolamide vs Diet plus Placebo in Subjects with idiopathic John Christoforidis MD, Colleen Cebulla MD PhD
Intracranial Hypertension with Mild Visual Loss. Neovascular Age-related Macular Degeneration (HARBOR)
Sponsor: Genentech
Sponsor: National Institutes of Health
GLAUCOMA Principal Investigator: Steven Katz MD Principal Investigator: John Christoforidis MD Title: Targeted Delivery of Biodegradable Multifunctional
Nanoparticles for Integrated Imaging and Therapy of Age-Related
Co-Investigators: Alan Letson MD, Frederick Davidorf MD,
Title: A retrospective, comparative, case series evaluating the Michael Wells MD, Susie Chang MD, Colleen Cebulla MD PhD Macular Degeneration.
Title: Phase 3, randomized, open-label study of the efficacy and Principal Investigator: Ronald Xu PhD
alternation flicker technology and standard stereo photography safety of PF-02341066 versus standard of care chemotherapy
viewing as methods for determining change on photographs of the Title: An Evaluation of Intravitreal Ranibizumab for Vitreous Co-Investigators: Cynthia Roberts PhD, Virginia Sanders PhD,
(pemetrexed or docetaxel) in patients with advanced non-small
optic nerve head. Hemorrhage Due to Proliferative Diabetic Retinopathy (DRCR N) Alan Letson MD
cell cancer (NSCLC) harboring a translocation or inversion event
Sponsor: EyeIC Inc. involving the Anaplastic lymphoma kinase (ALK) gene locus Sponsor: National Institutes of Health
Principal Investigator: Paul Weber MD Sponsor: Pfizer Principal Investigator: Frederick Davidorf MD
Co-Investigators: Amit Tandon MD, Gloria Fleming MD, M Principal Investigator: Greg Otterson MD Co-Investigators: Susie Chang MD, John Christoforidis MD,
Iyad Azrak MD, Michael Wells MD, Landon Colling MD Co-Investigators: Steven Katz MD Colleen Cebulla MD PhD, Paul Kurz MD

26 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 27


PUBLICATIONS SHOWING RESULTS Authors: Bhattacharya SK, Gomes J, Cebulla CM
Title: Toward failure analyses in systems biology
Journal: Wiley Interdisciplinary Reviews: Systems Biology and
Medicine
Authors: Cronau H, Kankanala RR, Mauger T.
Title: Diagnosis and management of red eye in primary care.
Journal: American Family Physician.
Pages: 15;81: 137-44
Pages: 2(5):507-17 Date: January 2010
Date: February 2010
Authors: Zhang L, Xu JS, Sanders VM, Letson A, Roberts CJ,
Authors: Richdale K, Wassenaar P, Teal Bluestein K, Abduljalil Xu R
A, Christoforidis JB, Lanz T, Knopp MV, Schmalbrock P Title: Multifunctional microbubbles for image-guided antivascu-
Title: 7 Tesla MR imaging of the human eye in vivo lar endothelial growth factor therapy
Journal: Journal of Magnetic Resonance Imaging Journal: Journal of Biomedical Optics
Pages: 30(5):924-32 Pages: 15(3):030515
Date: November 2009 Date: May 2010

Authors: Grzybowski DM, Lubow M Authors: He X, Liu J


Title: Idiopathic intracranial hypertension Title: A quantitative ultrasonic spectroscopy method for non-
Book: Ocular Disease: Mechanisms and Management invasive determination of corneal biomechanical properties
Editors: Levin LA, Albert DM Journal: Investigative Ophthalmology & Visual Science
Publisher: Elsevier Limited Pages: 50(11):5148-54
Pages: Chapter 39 Date: July 2009
Date: March 2010
Authors: Kashou NH, Leguire LE, Roberts CJ
Authors: Holman DW, Kurtcuoglu V, Grzybowski DM Title: Instruction Dependent Activation During Optokinetic Nys-
Title: Cerebrospinal Fluid Dynamics in the Human Cranial Sub- tagmus (OKN) Stimulation: an fMRI Study at 3T
arachnoid Space - An Overlooked Mediator of Cerebral Disease. Journal: Brain Research
Part II: In Vitro Arachnoid Outflow Model Pages: 8;1336:10-21
Journal: Journal of the Royal Society Interface Date: April 2010
Pages: 7:1205-18
Date: March 2010 Authors: Kass MA, et al (OSU: Weber PA)
Group: Ocular Hypertension Treatment Study Group (OHTS)
Authors: Kurz PA, Kurz DE Title: Delaying treatment of ocular hypertension
Authors: Abdel-Rahman MH, Boru G, Massengill J, Salem Authors: Bajenaru L, Pina Y, Murray T, Cebulla C, Feuer WJ, Title: Macular Hole Closure and Visual Improvement with Topi- Journal: Archives of Ophthalmology
MM, Davidorf FH Jockovich ME, Marin-Castano ME cal Non-Steroidal Treatment Pages: 128(3):276-287
Title: MET oncogene inhibition as a potential target of therapy Title: Gelatinase Expression and Modulation in Retinoblastoma Journal: Archives of Ophthalmology Date: March 2010
for uveal melanomas Journal: Investigative Ophthalmology & Visual Science Pages: 127(12):1687-8
Journal: Investigative Ophthalmology & Visual Science Pages: 51(6):2860-4 Date: December 2009 Authors: Barnett EM, et al (OSU: Weber PA)
Pages: 51(7):3333-9 Date: January 2010 Group: Ocular Hypertension Treatment Study Group (OHTS)
Date: July 2010 Authors: Lewis JR, Boguski JM, Mahmoud AM, Lembach RG, Title: The incidence of retinal vein occlusion in the Ocular Hy-
Authors: Piña Y, Boutrid H, Murray TG, Jager MJ, Cebulla CM, Roberts CJ pertension Treatment Study Group
Authors: Abdel-Rahman MH, Pilarski R, Ezzat S, Sexton J, Schefler A, Ly LV, Alegret A, Celdran M, Feuer W, Jockovich M Title: Normative database of donor keratographic readings in an Journal: Ophthalmology
Davidorf FH Title: Impact of tumor-associated macrophages in LH(BETA) eye-bank setting Pages: 117(3):484-8
Title: Cancer family history characterization in an unselected T(AG) mice on retinal tumor progression: relation to macrophage Journal: Journal of Cataract & Refractive Surgery Date: March 2010
cohort of 121 patients with uvealmelanoma. subtype Pages: 36(4):649-58.e2
Journal: Familial Cancer Journal: Investigative Ophthalmology & Visual Science Date: April 2010
Pages: 9(3):431-8 Pages: 51(5):2671-7
Date: September 2010 Date: May 2010 Authors: Frieberg T, Tolentino M (OSU: Letson AD)
Study Group: Evaluation of efficacy and safety in maintaining vi-
Authors: Yeh S, Cebulla CM, Witherspoon SR, Emerson GG, Authors: Leng T, Cebulla CM, Schefler AC, Murray TG sual acuity with sequential treatment of neovascular AMD (LEVEL)
Emerson MV, Suhler EB, Albini TA, Flaxel CJ Title: Focal periocular carboplatin chemotherapy avoids system- Title: Pagaptanib sodium as maintenance therapy in neovascular
Title: Management of fluocinolone implant dissociation during ic chemotherapy for unilateral, progressive retinoblastoma age related macular degeneration: the LEVEL Study
implant exchange. Journal: Retina Journal: British Journal of Ophthalmology
Journal: Archives of Ophthalmology Pages: 30(4 Suppl):S66-8 Pages: 94:1611-17
Pages: 127:1218-21 Date: April 2010 Date: May 2010
Date: September 2009
Authors: Cebulla C, Ruggeri M, Murray TG, Feuer WJ, Hernan- Author: Mauger T
Authors: Boutrid H, Pina Y, Cebulla C, Feuer WJ, Lampidis TJ, dez E Title: What should I do for a patient who wears soft contact
Jockovich ME, Murray T Title: Spectral domain optical coherence tomography in a murine lenses and complains of dry itchy eyes?
Title: Increased Hypoxia following Vessel Targeting in a Murine retinal detachment model Book: Curbside Consultation in Cornea and External Disease
Model of Retinoblastoma Journal: Experimental Eye Research Editors: Price FW, Price MO, Letko E, Chang DF
Journal: Investigative Ophthalmology & Visual Science Pages: 90(4):521-7 Publisher: Slack Inc.
Pages: 50:5537-43 Date: April 2010 Pages: Chapter 38
Date: December 2009 Date: April 2010

28 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 29


PRESENTATIONS
Dr. Fleming giving a lecture in the conference
room at the new OSU Eye & Ear Institute
SHARING DISCOVERIES
Roberts CJ. “Corneal Shape - The Galilei,” Imaging the Cornea
Session. United Kingdom & Ireland Society of Cataract & Refractive
Surgeons. Leeds, UK. October 2009.
ARVO
Salem MM, El-Garf I, Davidorf FH, Abdel-Rahman MH. "Antineo-
Roberts CJ. “Corneal Topography and IOL Calculations.” Refractive plastic Activity of Selected Group of Medicinal Plants Against Uveal
Surgery Didactic Course, Part 1. 14th ESCRS Winter Refractive Sur- Melanomas"
gery Meeting, Budapest, Hungary. February 2010.

Roberts CJ. “Biomechanics of the Cornea.” Refractive Surgery Didac- Abdel-Rahman MH, Pilarski R, Massengill JB, Craven MA, Sexton JL,
tic Course, Part 2. 14th ESCRS Winter Refractive Surgery Meeting, Davidorf FH. "Cancer Family History Characterization and Candidate
Budapest Hungary. February 2010. Gene Testing in an Unselected Cohort of 121 Patients With Uveal
Melanoma"
Roberts CJ. “Scheimpflug Imaging: Are two cameras better than
one?” Imaging Symposium. 14th ESCRS Winter Meeting. Budapest,
Hungary. February 2010. Verma V, Abdel-Rahman MH, Cebulla CM, Davidorf FH. "Metastasis
in Small Uveal Melanomas"
Roberts CJ. “Galilei Dual Scheimpflug: The Best of Both Worlds.”
Ziemer Refractive Symposium. EyeWorld Corporate Mornings, AS- Tang J, He1 X, Liu J. "Effect of Ocular Tissue Viscoelasticity on Intra-
CRS. Boston, MA. April 2010. ocular Pressure Elevation Under Injection at Different Rates"
Roberts CJ. “Biomechanics in Ophthalmology.” Tel Aviv Medical
Center Department of Ophthalmology. Tel Aviv, Israel. May 2010. Zhang L, Xu J, Xu R, Roberts CJ. "Targeted Delivery of Multifunc-
Abdel-Rahman AM. “Clinical Cancer Genetics.” Children Cancer Hos- Grzybowski DM. “Arachnoid pathways for CSF absorption.” Hydro- tional Microbubbles for Anti-VEGF Therapy of Neovascular Age-
pital of Egypt. Cairo, Egypt. July 2009. cephalus 2009 NIH Workshop, Improving Outcomes in Hydrocephalus: Roberts CJ. “Corneal Biomechanics.” Israeli Cornea Club. Tiberias, Related Macular Degeneration"
Bridging the Gap Between Basic Science and Clinical Management. Israel. May 2010.
Castellano D. “The Aging of the Eye/Cataracts.” Dublin Retirement Baltimore, MD. September 2009. Roberts CJ, Mahmoud AM, Small RH. "The Response of Ocular Pulse
Village. July 2010 Roberts CJ. “Dynamic Corneal Topography.” Israeli Cornea Club.
Amplitude (OPA) to an Increase in Intraocular Pressure (IOP) Generat-
Tiberias, Israel. May 2010.
Grzybowski DM, Long AC. “Retinoid signaling pathway proteins in ed by Changing Subject Position, in Order to Investigate Ocular Blood
Cebulla CM, Sisk RA, Markoe AM, Dubovy SR, Murray TG. “Com- human arachnoid membrane: Role in regulating intracranial pressure,” Flow and Validate a Novel Electrical Analog Model"
bined Pars Plana Vitrectomy, Cataract Extraction and Endolaser Ablation Roberts CJ. “Misconceptions and Misinterpretations in Corneal To-
International Society for Hydrocephalus and CSF Disorders, Baltimore, pography.” Israeli Cornea Club. Tiberias, Israel. May 2010.
for Treated Uveal Melanoma.” International Society of Ocular Oncol- MD, September 2009.
ogy. Cambridge, UK. September 2009 Qazi1 MA, Mahmoud AM, Kollbaum PS, Twa MD, Roberts CJ,
Roberts CJ. “Galilei: Dual Scheimpflug with integrated Placido.” Pepose JS. "Application of a Quantitative Method for Identifying Risk
Kim B, Grzybowski DM, Weber PA, Roberts CJ, Zhao Y. “Electrospun Israeli Cornea Club. Tiberias, Israel. May 2010.
Cebulla CM, Ruggeri M, Murray TG, Hernandez E. “Optical Coherence for Ectasia After LASIK in Normal, Suspect, and Ectatic Eyes"
Micro/Nanofiber Assisted In Vitro Construction of Trabecular Meshwork
Tomography in a Murine Retinal Detachment Model.” Leeds University
Molecular Medicine Institute. Leeds, UK. September 2009.
for Glaucoma Investigation.” 13th International Conference on Miniatur-
ized Systems for Chemistry and Life Sciences. Jeju Island, Korea. 2009. POSTGRADUATE SYMPOSIUM Kim B, Roberts CJ, Grzybowski DM, Weber PA, Zhao Y. "Nanoen-
gineered Polymer Scaffold With Controllable Porosity Towards 3D in
Cebulla CM. “Scarlet and Grey Intraocular Tumors.” Columbus Eye vitro Trabecular Meshwork Model"
Katz SE. “Ocular and Orbital Trauma.” Ohio Ophthalmological Society Cebulla CM. "Tumor Imaging"
Ear Nose Throat Society. Columbus, OH. October 2009.
Annual Meeting, Columbus, OH. January 2010. Lewis JR. "Dual vs. Single Scheimpflug Anterior Segment Imaging"
Cebulla CM. “Spectral domain optical coherence tomography in a Thiagarajasubramanian AK, Lubow M, Schultz B, Grzybowski DM.
Mauger TF. "Corneal Confocal Imaging"
murine retinal detachment and proliferative vitreoretinopathy model.” Katz SE. “Idiopathic Intracranial Hypertension: A Paradigm for Diagno- "Transcranial Orbitotomy for Ocular-Orbital Histopathology: The
Clinical Translational Science Meeting. Washington, DC. April 2010. sis and Management.” Department of Neurology, Ohio State University. Roberts CJ. "Misconceptions & Misinterpretations in Corneal Topog- FULL Autopsy Is Not Full Enough"
Columbus, Ohio. February 2010. raphy"
Cebulla CM. “Two case presentations in uveal melanoma.” First Annual Roberts CJ. "Effective Posterior Power: How Is It Used for Prediction Mahmoud AM, Roberts CJ. "The Influence of Altered Posterior Angle
Wills Intraocular Tumor Symposium. Wills Eye Hospital. Philadelphia, Katz SE. “The Pupil.” Department of Neurology, Ohio State University. of Incidence on Effective Posterior Power Calculation Before and After
PA. April 2010. Columbus, OH. April 2010. of IOL Power?"
LASIK"
Roberts CJ. "Dynamic Corneal Topography"
Chang S. “Age Related Macular Degeneration.” OSU MedNet21. Katz SE. “Pulsatile Tinnitus, Hearing Loss and Spontaneous Cerebrospi- Sawchyn AK. "Using HRT to Manage Glaucoma" Kuruvilla OC, Horne A, Qureshi Z, Weber PA, Kelley C, Mauger TF,
Center for Continuing Medical Education. The Ohio State University nal Fluid Leaks in Idiopathic Intracranial Hypertension.” Department of
Medical Center. February 2009. Weber PA. "OCT – Glaucoma Overview" Roberts CJ. "Comparison of Heidelberg Retinal Tomography Image
Otolaryngology, The Ohio State University. Columbus, OH. May 2010.
Weber PA. "How Glaucoma OCT Imaging Can Enhance Patient Care" Quality in Clear Lenses vs. Monofocal IOLs vs. Multifocal IOLs"
Christoforidis JB. “The Effect of Intravitreal Pegaptanib, Bevacizumab Katz SE. “Diplopia.” Department of Neurology, Ohio State University.
and Ranibizumab on Blood Vessel Formation During Cutaneous Wound Columbus, OH. May 2010. Kondapalli SA, Roberts CJ, Mahmoud A, Weber PA, Peterson J. "The
Healing In a Rabbit Model.” Pan-Hellenic Ophthalmology Congress.
Thessaloniki, Greece. May 2010. Zhang L, Xu J, Letson AD, Roberts CJ, Xu R. “Targeted delivery of mul-
20/20 SEMINARS Effect of Diabetes on Biomechanical Properties of the Cornea"

tifunctional microbubbles for anti-VEGF therapy of age-related macular Ready, Aim, Refract! Whitehead G, Rogers DL, McGregor M, Serna A. "Utility of the Con-
Christoforidis JB. “The Use of 7T MRI with dedicated eye coil to Image
degeneration.” The Association for Research in Vision and Ophthalmol- Castellano D. “To Flap or Not to Flap” vergence Insufficiency Symptom Survey in a Tertiary Care Center"
Retrobulbar Vascular Structures.” Pan-Hellenic Ophthalmology Con-
ogy 2010 Annual Meeting. Fort Lauderdale, FL. May 2010. Tandon A. “PresbyLASIK - Fad or the Future?”
gress. Thessaloniki, Greece. May 2010.
Hendershot AJ, Mahmoud AM, Mauger TF. "Cataract Surgery Simula-
Christoforidis JB. “Intravitreal Pegaptanib, Bevacizumab and Ranibi- Roberts CJ. “Misconceptions and Misinterpretations in Corneal Topog- Extra! Extra! Technology Stamps out Glaucoma! tors in the Training of Ophthalmology Residents"
zumab suppress angiogenesis during Cutaneous Wound Healing in a raphy.” Corneal Topographic Analysis and Anterior Segment Imaging: Fleming GP. “Fourier Domain OCT”
rabbit model.” Nantucket Retina Meeting. Nantucket, MA. July 2010. Pearls for your Clinical Practice. ASCRS Course. April 2010. Azrak MI. “Corneal Biomechanics & Glaucoma”
Lewis JR, Mahmoud A, Roberts CJ. "Recentration to the Pupil Center
Provides Consistency of Central Anterior Curvature Calculation Under
Davidorf FH. “Ocular Manifestations of Systemic Histoplasmosis.” Roberts CJ. “Biomechanics of the Cornea” Refractive Surgery Didactic New Concepts in Keratoplasty
Course, Advanced Session, XXVII Congress of the ESCRS. Barcelona, Kuennen R. “Endothelial Keratoplasty” Conditions of Misalignment"
American Academy of Ophthalmology, Fluorescein Club. San Francisco,
CA. October 2009. Spain. September 2009. Mauger TF. “PK and Beyond”
Christoforidis JB, Ricketts R, Bean S, Pratt C, Pierce J, Wells MB,
Davidorf FH. “Focus on Diabetic Retinopathy and Macular Edema from Roberts CJ. “Biomechanics of the Cornea,” Keynote Lecture, Session I Spots in Your Eyes La Perle K. "The Effect of Intravitreal Pegaptanib, Bevacizumab and
a Clinical Perspective.” 2010 Aging Eye Summit: Diabetic Eye Disease. – The Cornea. United Kingdom &Ireland Society of Cataract & Refrac- Cebulla CM. “Pigmented Lesions & Tumor Lookalikes” Ranibizumab on Blood Vessel Formation During Cutaneous Wound
Prevent Blindness Ohio. Columbus, OH. June 2010. tive Surgeons. Leeds, UK. October 2009. Wells M. “Dots, Flecks, and Spots” Healing in a Rabbit Model"

30 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 31


MISSIONS WORLDWIDE EFFORTS

BUCKEYES AROUND
THE GLOBE
BRINGING HOPE TO PATIENTS FROM UGANDA... ...TO NICARAGUA WITH UNPARALLELED EYE CARE

32 ANNUAL REPORT 2009-2010 I WWW.EYE.OSU.EDU 33


THE OHIO STATE UNIVERSITY Nonprofit Org.
HAVENER EYE INSTITUTE U.S. Postage
915 Olentangy River Rd, Suite 5000 PAID
Columbus, Ohio 43212 Columbus, Ohio
www.eye.osu.edu Permit No. 711

AMERICA’S BEST DOCTORS


Best Doctors, Inc. was founded by two Harvard Medical
School physicians over twenty years ago. Their vision was to
help patients find the best local specialists.

Once again, this year’s list for Columbus, Ohio honored the
hard work and dedication of OSU’s Ophthalmology faculty.

Charlotte Agnone* Gloria Fleming


N. Douglas Baker* Jill Foster*
Robert P. Bennett* Steven E. Katz
Robin F. Beran* Curtin G. Kelley*
John A. Burns* Rebecca A. Kuennen
Kenneth V. Cahill* L. Carol Laxson
David Castellano David M. Lehmann*
Colleen M. Cebulla Carrie Lembach*
Robert B. Chambers* Richard G. Lembach
Susie Chang Alan D. Letson
John B. Christoforidis Mark D. Lomeo*
Louis J. Chorich* Thomas F. Mauger
Frederick H. Davidorf E. Mitchel Opremcak*
Robert Derick* Karl S. Pappa*
Jack Dingle* Sugat Patel*
Alice Epitropoulos* John R. Stechschulte*
Avrom D. Epstein* Peter J. Utrata*
Kelly Everman* Paul A. Weber

*Indicates a community faculty member. For a complete list of our


community faculty visit www.eye.osu.edu/directory/community.

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