Paracetamol

Paracetamol (acetaminophen) is a pain reliever and a fever reducer. The exact

mechanism of action of is not known.

Paracetamol is used to treat many conditions such as headache, muscle aches,

arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild
arthritis but has no effect on the underlying inflammation and swelling of the
joint.

Paracetamol may also be used for other purposes not listed in this medication
guide.

Procedure

This product contains:

• Methyl and propyl hydroxybenzoates. These may cause allergic reactions (possibly delayed).
• Sucrose (3g per 5ml dose). Patients with rare hereditary problems of fructose intolerance, glucose-
galactose malabsorption or sucrose-isomaltase insufficiency should not take this medicine.
• Sorbitol. This medicine contains 782.25mg per 5ml dose. The additive effect of concomitantly
administered products containing sorbitol (or fructose) and dietary intake of sorbitol (or fructose) should be
taken into account.
The content of sorbitol in medicinal products for oral use may affect the bioavailability of other medicinal
products for oral use administered concomitantly.
Patients with hereditary fructose intolerance (HFI) should not take/be given this medicinal product.
• Propylene Glycol. This medicine contains 144.8mg propylene glycol per 5ml dose. Co-administration with
any substrate for alcohol dehydrogenase such as ethanol may induce adverse effects in children less than
5 years old.
While propylene glycol has not been shown to cause reproductive or developmental toxicity in animals or
humans, it may reach the foetus and was found in milk. As a consequence, administration of propylene
glycol to pregnant or lactating patients should be considered on a case by case basis.
Medical monitoring is required in patients with impaired renal or hepatic functions because various adverse
events attributed to propylene glycol have been reported such as renal dysfunction (acute tubular
necrosis), acute renal failure and liver dysfunction.

Part I

1. Heat (PEG 6000)at 50Oc and add Paracetamol in it. ...

2. Heat Glycerin at 50oC and then add in step 1 solution ((PEG 6000)-+Paracetamol)
under continues. ...
3. Heat water at 50oC and put it under continuous stirring.
4. Add step 1 solution ((PEG 6000)+Paracetamol+Glycerin) slowly in to D.M. Water
under continuous Stirring. Transparent solutions will be obtained.

Part II
 5. Weigh accurately sucrose. Add sucrose in hot (65oC) D.M Water under continuous stirrin
g till itdissolved6. Filter above solution through filter press. Keep filtrate under stirring7. Add 
citric acid monohydrate, sodium methyl paraben, Sodium propyl paraben, Sweetener and So
diumbenzoate in it with continuous stirring for 10 minutes.
Mixing of Part I and Part II
 8. Slowly add part I in Part II under continuous stirring. Stir it till clear solution is obtained9. 
Check pH above solution. If pH is not between 3.80-6.10 than add accordingly Citric acid solu
tion toadjust pH10. Add colour solution in above solution under stirring. Now, add flvor und
er continuous stirring11. Make volume 100 ml by D.M. water if required12. Clear transparen
t Paracetamol syrup is obtained

indications
For the treatment of mild to moderate pain, including headache, migraine, neuralgia, toothache, sore throat,
period pains, aches and pains.
For the reduction of fever and to be used as an adjunctive treatment to relieve symptoms of cold and flu.

Precautions
Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic
impairment. The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease.
• Contains paracetamol.
• Do not give with any other paracetamol-containing products.
• For oral use only.
• Never give more medicine than shown in the table.
• Always use the spoon supplied with the pack. Do not overfill the spoon.
• Do not give to babies less than 2 months of age.
• For infants 2-3 months no more than 2 doses should be given.
• Do not give more than 4 doses in any 24 hour period.
• Leave at least 4 hours between doses.
• Do not give this medicine to your child for more than 3 days without speaking to your doctor or
pharmacist.
• As with all medicines, if your child is currently taking any medicine consult your doctor or pharmacist
before taking this product.
• Do not store above 25°C. Protect from light. Store in the original package.
• Immediate medical advice should be sought in the event of an overdose, even if the child seems well,
because of the risk of delayed serious liver damage.
• If symptoms persist consult your doctor.
• Keep out of the sight and reach of children
side effects
Get emergency medical help if you have any of these signs of an allergic
reaction to paracetamol: hives; difficulty breathing; swelling of your face, lips,
tongue, or throat. Stop using this medication and call your doctor at once if
you have a serious side effect such as:

 low fever with nausea, stomach pain, and loss of appetite;

 dark urine, clay-colored stools; or
 jaundice (yellowing of the skin or eyes).

Cough Expectorañt syrup

Indications

Guaifenesin is used to treat coughs and congestion caused by the common

cold, bronchitis, and other breathing illnesses. This product is usually not used for
ongoing cough from smoking or long-term breathing problems (such as chronic
bronchitis, emphysema) unless directed by your doctor. Guaifenesin is an
expectorant. It works by thinning and loosening mucus in the airways, clearing
congestion, and making breathing easier.If you are self-treating with this medication,
it is important to read the package instructions carefully before you start using this
product to be sure it is right for you. (See also Precautions section.)Cough-and-cold
products have not been shown to be safe or effective in children younger than 6
years. Therefore, do not use this product to treat cold symptoms in children younger
than 6 years unless specifically directed by the doctor. Some products (such as long-
acting tablets/capsules) are not recommended for use in children younger than 12
years. Ask your doctor or pharmacist for more details about using your product
safely.These products do not cure or shorten the length of the common cold. To
decrease the risk for side effects, carefully follow all dosage directions. Do not give
other cough-and-cold medication that might contain the same or similar ingredients
(see also Drug Interactions section). Ask the doctor or pharmacist about other ways
to relieve cough and cold symptoms (such as drinking enough fluids, using a
humidifier or saline nose drops/spray).
Sides effect
Nausea or vomiting may occur. If either of these effects persist or worsen, tell your doctor
or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that
the benefit to you is greater than the risk of side effects. Most people using this medication do
not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention
if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling
(especially of the face/tongue/throat), severe dizziness, trouble breathing.