Beruflich Dokumente
Kultur Dokumente
Dermatophyte
Dermatophytes (name based on the Greek for 'skin plants') are a common label for a group of three types of fungus
that commonly causes skin disease in animals and humans.[1] These anamorphic (asexual or imperfect fungi) genera
are: Microsporum, Epidermophyton and Trichophyton. There are about 40 species in these three genera. Species
capable of reproducing sexually belong in the teleomorphic genus Arthroderma, of the Ascomycota (see
Teleomorph, anamorph and holomorph for more information on this type of fungal life cycle).
Dermatophytes cause infections of the skin, hair and nails due to their ability to obtain nutrients from keratinized
material. The organisms colonize the keratin tissues and inflammation is caused by host response to metabolic
by-products. They are usually restricted to the nonliving cornified layer of the epidermis because of their inability to
penetrate viable tissue of an immunocompetent host. Invasion does elicit a host response ranging from mild to
severe. Acid proteinases, elastase, keratinases, and other proteinases reportedly act as virulence factors. The
development of cell-mediated immunity correlated with delayed hypersensitivity and an inflammatory response is
associated with clinical cure, whereas the lack of or a defective cell-mediated immunity predisposes the host to
chronic or recurrent dermatophyte infection.
Some of these infections are known as ringworm or tinea. Toenail and fingernail infections are referred to as
onychomycosis. Dermatophytes usually do not invade living tissues, but colonize the outer layer of the skin.
Occasionally the organisms do invade subcutaneous tissues, resulting in kerion development.
Transmission
Dermatophytes are transmitted by direct contact with infected host (human or animal) or by direct or indirect contact
with infected exfoliated skin or hair in clothing, combs, hair brushes, theatre seats, caps, furniture, bed linens,
shoes[6] , socks [6] , towels, hotel rugs, sauna, bathhouse, and locker room floors. Depending on the species the
organism may be viable in the environment for up to 15 months. There is an increased susceptibility to infection
when there is a preexisting injury to the skin such as scars, burns, excessive temperature and humidity. Adaptation to
growth on humans by most geophilic species resulted in diminished loss of sporulation, sexuality, and other
soil-associated characteristics.
Classification
Dermatophytes are classified as anthropophilic (humans), zoophilic (animals) or geophilic (soil) according to their
normal habitat.
• Anthropophilic dermatophytes are restricted to human hosts and produce a mild, chronic inflammation.
• Zoophilic organisms are found primarily in animals and cause marked inflammatory reactions in humans who
have contact with infected cats, dogs, cattle, horses, birds, or other animals. This is followed by a rapid
termination of the infection.
• Geophilic species are usually recovered from the soil but occasionally infect humans and animals. They cause a
marked inflammatory reaction, which limits the spread of the infection and may lead to a spontaneous cure but
may also leave scars.
Dermatophyte 3
Frequency of species
• About 76% of the dermatophyte species isolated are Trichophyton rubrum
• 27% are Trichophyton mentagrophytes
• 7% are Trichophyton verrucosum
• 3% are Trichophyton tonsurans
• Infrequently isolated (less than 1%) are Epidermophyton floccosum, Microsporum audouinii, Microsporum canis,
Microsporum equinum, Microsporum nanum, Microsporum versicolor, Trichophyton equinum, Trichophyton
kanei, Trichophyton raubitschekii, and Trichophyton violaceum.
Medications
• Topical medications like clotrimazole, butenafine, miconazole, and terbinafine.
• Systemic medications (oral) like fluconazole, griseofulvin, terbinafine, and itraconizole.
• Tea tree oil
Treatment
Tinea corpora (body), tinea manus (hands), tinea cruris (groin), tinea pedis (foot) and tinea facie (face) can be treated
topically.
Tinea unguum (nails) usually will require oral treatment with terbinafine, itraconizole, or griseofulvin. Griseofulvin
is usually not as effective as terbinafine or itraconizole. A lacquer (Penlac) can be used daily, but is ineffective
unless combined with aggressive debridement of the affected nail.
Tinea capitis (scalp) must be treated orally, as the medication must be present deep in the hair follicles to eradicate
the fungus. Usually griseofulvin is given orally for 2 to 3 months. Clinically dosage up to twice the recommended
dose might be used due to relative resistance of some strains of dermatophytes.
Tinea pedis is usually treated with topical medicines, like ketoconazole or terbinafine, and pills, or with medicines
that contains miconazole, clotrimazole, or tolnaftate. Antibiotics may be necessary to treat secondary bacterial
infections that occur in addition to the fungus (for example, from scratching).
References
[1] dermatophyte (http:/ / www. mercksource. com/ pp/ us/ cns/ cns_hl_dorlands_split. jsp?pg=/ ppdocs/ us/ common/ dorlands/ dorland/ three/
000028776. htm) at Dorland's Medical Dictionary
[2] http:/ / www. dermnetnz. org/ fungal/ tinea-faciei. html
[3] http:/ / www. emedicine. com/ derm/ topic420. htm
[4] http:/ / dermnetnz. org/ fungal/ tinea-manuum. html
[5] "BBL Prepared Tubed and Bottled Medium for Detection and Presumptive Identification of Dermatophytes Dermatophyte Test Medium
(DTM), Modified with Chloramphenicol" (http:/ / www. bd. com/ ds/ productCenter/ 299701. asp). Becton, Dickinson and Company. .
Retrieved 2008-12-07.
[6] Ajello L, Getz M E (1954). "Recovery of dermatophytes from shoes and a shower stall". J. Invest. Dermat. 22: 17–22.
External links
• Images and descriptions of dermatophytes (http://www.provlab.ab.ca/mycol/tutorials/derm/dermwho.htm)
Article Sources and Contributors 4
License
Creative Commons Attribution-Share Alike 3.0 Unported
http:/ / creativecommons. org/ licenses/ by-sa/ 3. 0/