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PATHOPHYSIOLOGY OF TIA (Transient Ischemic Attack)

Obstruction of a blood vessel


Disruption of Cerebral blood flow
Cerebral blood flow <25mL/100g/min
Ineffective
cerebral tissue
perfusion

Neurons unable to maintain aerobic respiration


Mitochondria switches to Anaerobic respiration
low ATP (energy failure)
acidosis ion imbalance
inc glutamate depolarization
intracellular calcium increased
cell membranes and proteins break down
formation of free radicals
cell injury and death
*the death of a neuron is irreversible and nonregenerative
Manifestations:
Numbness and weakness of face, arm, leg (left side numbness)
Sudden severe headache
Impaired sensory perception (tactile)

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