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! " $
# % &
!'
"# $
$ $
$
!
' ( ) * "+, - 2
HAI HAI
. !
/
! 1 3
# = -CH2CH2CO-Val-Lys-Leu-Lys-NHCH2CH2N(CH3)2
)*, = HOOCCH2CH2CO-Glu-Leu-Glu-Leu-NH-benzyl
), ) 0, R
) 1, 4: R = R' =
HAI OH
HO
! OH
5: R = R' =
) 2, R HAI
R' OH
) 3"+,
6: R = R' =
HAI OH
OH
7: R = R' = H HAI
R'? n H
4 R'
8: R =
HAI n
) * "+, 4 ( R' = Saya
HAI H
HAI H
! R'? H n
) * 5, R n HAI
H HAI
HAI H =
6 # 7 8 # HAI
n
n
H
& )**, ' R H HAI ( = Na+) 72
'
/ *: 6 # 7 8 (
" (/ * )**,
9 ) "* +' )*5"* ,
), < =:> = 9 66
= ? 9 @! ! !
*** ! 1: #
/ A 1* 0 B C0+3 ) " , )*5 * , ;
D A E
))* ,
), < =:>
- * )*,
= 9 @ ! # .
- =9 552C @: )*,
'
' * 9
D : <
),
) , ), &(), &)), ) M,), ) , ), / :D9 ), *), /T )M,),
3 / 125 52 52 "
HO
C / 125 5 52 15 0BB 125 ),
B / 125 5 5 03 0BB 125 ),
HAI
OH
) , ) , ) &),SAYA) , ), = ),
3 1P ! ) , /A :D9A : # ), *
Saya ), /NA N ) PADA !
).,G 2M ), ; ! ) * B,
(
) + ) *5, ' +'
! ) * 5, ' . !
# , ! !
!
# ) 3"+,
) * 5,
!
: +' ( ) 3,
) CB, < ! #
) 2 * 5, 4 # # /
! ! ! !
15 L
' * ) C, '
! 0 1
*
&& ! ) * 0"*C, '
( ) ,
-,( ) * :5 :
! ) * 0, <
!
9=
* ! )*1,
)*1,
!
. !
4 0 9 !
&') &'* !
/ -
!
"
1
' &(
&) (
: *
HAI
HAI
15: R = OH
R C)
R HAI
A) HAI
17: R = Glu(OTBu)-Leu-Glu(OTBu)-NH2
HAI
R HAI D)
R 16: R = Lys(Boc)-Leu-Lys(Boc)-NH2
HAI
B) 14: R =
HAI
Glu-Leu-Glu-NH2
R
R HAI
HAI
13: R = Lys-Leu-Lys-NH2
> &'
&( &) !
/ > : / 6 '
! &') ! &')
!
&'* 6 P >
9 > : 4 44aku
.
= ! 64?:G> '
) 5, /
!
!
2 '
&' =
2 A;
&' +' / *
A '
*; # !
&( &)
4 &') &'*
HAI B*M &')
BL HAI . 4 &)
/ ' # &( / 0 : &)
&)) .
01 L P
/ 0 )* ,
# ( &( &)
3 4 1 5 1 A' ! / 0
&( &) ! !
&- Saya
6 6 &' / 0 3 = !
?6 Saya Saya
?6 ! !
: *' / 0
6 6
?6 ?6
A'
*
6 0*3 B3 * *)* ,
?6 '
9= &( / 1
Q
9
6
6
?6 ?6
&- <
6?<I=4<D )*,
! &*
/ 0 :D9
&+ 3CM 23M
31 <
&( &) '/ ! &)
>? &( ( !
&( &)
' &)
&)
>? !
&( >?
)* , / 1 9= &')SAYA&'* 1A*
&)) &( 31
&( &)
&(
&) &&
A :#
. :D9 ! &)) / 1 !
1 ( ' 9=
) &')Sebuah >- * 3311P &( &')SAYA&'* 1A*
* 3331P &/
&))Sebuah >-
&) 31/ 1 ! ' &')SAYA&'*
/3 Sebuah >-
*C*B*, . 31 ! 9= 9 9D $
&'*Sebuah >- 1+33 / 0*3
. *2 0 = 9D 000 +2 .
&' A >- )*5* ,
9
* * 5555P 3
.
&') &'* . 3*
*+M ! +' / *. ++ ) * 5,
/ 2 !
'
A>
&') !
&'*
% &
/ '
&& &,
) C,
! # /
&. ' *
/ #
31> Saya
! 103
125 ' * = !
' *
. # '
* B )*B, $
/ 2= 9= 9 &')SAYA&'* 1A*
: ' * **'
0 <?1 *5 9 * 55 31 &) !
0 <?1 *5 31 0 <?1 *5 9 ' * 0 C *5 '
* 55 * ) &(,SAYA )&(, ) &), &)
1" 02
&( '
* 1 # ' * 3
' ! &') &'* ' * *
* A* / 2 ' $
! ! ' * ** '
&') &'* P !
&/A :
# ' * *
&') ! &/ / 3
A
CH3 H
H
CH3
CH3
S-trans planar
B
H3C CH3 H
34
H
CH3
S-cis planar
C
H
bengkok 19
/ 3 ; &/ <
&')
&/ )B+, 4
/ C 9= @HIH
! &/ '/ &/ 31 '
' ! # &/
&& 31
'/
' &/ ! &&
1A* ! !
; &/ : ! / &/
&') &'*
:# :D9 ! 31 0*3 6
'/
&') &'* &'
/ 0 : &'*
(
&/ ' / C 1BM (
&/ .
)*,
9= / C '
! ) * 0,
? ) * 1, ' !
!
P HAI
" # / 3 6 '
&')
&/ H
! "
# )+,
> ! !
# ) * C,
4 !
&') ( !
" &/ '
&') ! .
#
% &) B ,
/ + 9=
6 '.A ' 31
&( &) &( &)
$ !
. +5
. B1 9
! ' * + "** 4
'. / B &') &'* . **5
&)
! '
'.
!
O OH
HO HAI ' ( '.
25M &/
' * + * '.
$
:
' * +"
O OH
* * :D9 '. !
O OH
! ! . >-
B1555 * A*
'.
! $
/ B : % &
! !
HAIOH
)+,
' #
20 $
$ ) 05,
/ B' ! Saya
'. ! ) B,
9= / + : 1C 2B2
9= 9 . **5 . 05
! 305 . + 2 )B, !
' $
235 . **5
! ! !
!: 25 * C :#
2C3 . B1 ' :D9 : S C2 ; *5I05 .
< 6 > - C5555 " 0555 *
$ << +B5 $ @H +C5 @HH >-
! 3C5 .= !
10 5 .= 2 5 .= * 0 C .=
3 2 .= < 6 /
/ > $ G! : 6
9=
$ :9? C*5 $:9? C*2
- ) * *
, ) , @HH "
< . B12 H 9 *6
) , ) * *
,
8 4 5 9:' 4 !5A * 0 =
: ! 0 T 9 BB *2 * # #
*C *C Q ? B * 53
5 11* 3 6 T9
D
055 * 53 9 9 2 0* 59 3
. ;' 9 9
6 ( 9?0 *
( 7 :?1 ! :?1
$ ! <
9 9 saya> ? *5A* / 51 Q
!
6 1B+ + 0M ) , =5 * 2B * 55
' ! >? P * 32 * " *3C5 9P 4; 76 A 00+ 00C1 0 *2
P 05C5 050+ + 23 + 02 B3C * 3B2 * 310 * 201
: 4 5 4 5 9:'A = Q 6 333 *
P* > ; 055 > # )=,3=>:? 2 9 '>: A B51"
6 131 5 31 6 CB+ P = ? CB " C 5 *P
9 9 Saya> ? saya < + 5A+A* / 51 9? =? C5B "C55" *P 9?
6 6 0B =? 1 01 " 1 *P 1 5 " 1 5+ *P
BCM), 5 = * C5 * 55 > ? P C3 5 "C C 9P 4; 76 A 0 * + " 0 5B *P +" * 1P 55"
001 053* + 0C B31 023 * 3B2 * 2 + * 12C * 05 +P * 0C * B hal 6 5 SM 0
9? = ? C*5" C51 * P 9?
( +' *( -' )( (' '( &( 3
=? 2 5* P 9 11"1*0 * P , 49:' 7 7 165
1 5C " 0 +3 *P 0" * P * + 3" * 00 1 4&)5A = &+ 2 2 * 5B
2P * 0C + P 6 5 +5 " 5 C+ 3P 90 9 ! &) 1 2 * 55M @HIH ? 0*1
B3P* > ; 055 > #9=9 0I9=0?= *A* B5 2 9 '>: A C25 " CB
: 7 43 5 9:'A = Q ?6 1C1
1P 3 +2 0
P 1B"15 !
* 52 6
15 P ?9 11" 3 0 P 1" * 13
9 9 saya> ? saya < + 5A+A* / 50
! 23 P 5 +1 " 5 CB 1B P 9 0P
?6 C1 B0M ), =5 * 55 *
> ; 255 > # = ?I9=0?= 2A* 3 P 1 25 3 1 2 9 '>: A C3 " 3 B
>? hal 4; 76 A 0012 05 + 20 B3B *C3 * 335
! " 1 55 ! 15 P ?9
*2*C * 13B * 121 * 1*+ * 0+ * 03+ *0*
22" B ! 0 P 5" * 15 ! 23 P
*+5 * 22 * * 2C * 501 + 2C +5 B13 C20
5 +5 " 5 55 ! 1B P 9 0P
325 *
P* >; 055 > # )=, =>:?
3 2 9 '>: A B51" C++
? 0*1 0B2 P9= ?A / 1
P = ? C1 " C00 * P
9? = ? C*1" C51 *P 9? , ( +' *( -' )( (' '( &( 3 49:' 4 5 4 5
=?12"1*1 *P05"0* *P " 1 6 5 1 4&*5A 9 &- 3 0 2 =>:?
5+ P * + B " * 35 2 P * 0C + P * 99 6 6 31
6 5 B3 0
33#0P 90 5 B0 0
33 # **
0P 9 0 <' 9 9 9 I> ? *5A* /
52 5* /
&* *3 B 23M > ; 255 > # *
8 7 43 5 7 43 5 9:'A 9 ?6
9=9 0I9=0?= *A* 2 9 '>: A C22 "C 1 1 P 3 +3
C1 5 SM Q?6 ? 115 * 0* 0
C1 # P 1 B5 " 1 5 ! 15 P ?9
0 5 "C5 0 P * + 5" * 55 *5 P
9 9 saya> ? 5A* / 5 2 Q
* 1B" * * ! * 11 hal 6 9 0 5 +1 " 5 C2 1B P
?6 ?6 1B3 BBM ), =5
9 0 >: D:4 > ? *M A AKU- MA *13* 3 +1 ) 0 ,1
+5 * 55 > ? P * CB " * C1 9P 4; 76 A 005C
*+1*55 )0 , 0
B+3 *3)0 ,
053C + CB + 01 * C0 * * 3C5 * 30C * 201 * 121
* 0+0 * 03B * 23 * * 23 * 521 + 20 B25 C20 , ( +' *( -' )( (' '( &( 3 1 4&(5 49:' 165
3+B *
P* > ; 055 > # ) =,3=>:? 2 9 '>: A C+3 A= &* 3 5 02
0
B5# *P =? CB2 0 9 ! &(* 1 * 55M @HIH ? 0*3
B5 #* P = ? C13 0
B #* P B3P* > ; 055 > #9=90I9=0?= *A* 2 9 '>: A C22 "C
=? C01 2P C 1 " C*B * P 1 P C55 " 3 +5 P 1 B5 " 1 5 ! 15 P
9? =? C5B "C55" * P 9? ?9 +B"3 0 P * + 2" * 55
=? 2 53 " 1 +2 P 9 1 01 " 1 *P 1 0" *5P 5 +2 " 5 C2 1B P 9 0P * >;
1 5+ * P 1 52 " 1 5+ * P + "* 1 P 255 > # = ?I9=0?= 2A* 31 29 '>: A C35" C3
* + 3" * 5 C P * 0C * BP 6 5 SM 1 P C52 0
B2# P 1 B2 " 1 !
0
33#0P 9 0 5 B* 0
33#0P 9 0 15 P ?9 05" C5 0 P * + 5" * *5
: 7 43 5 7 43 5 9:'A = Q ?6 *5 P * 55" 5 3B 1B P 9 0P